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Abbreviation : PERK
Long Form : protein kinase RNA-like endoplasmic reticulum kinase
No. Year Title Co-occurring Abbreviation
2020 Aberrant distribution and function of plasmacytoid dendritic cells in patients with ankylosing spondylitis are associated with unfolded protein response. AS, BM, DCs, HLA, pDCs, UPR
2020 Asparagine Synthetase Is Highly Expressed at Baseline in the Pancreas Through Heightened PERK Signaling. ASNase, ASNS
2020 Endoplasmic reticulum stress signaling in cancer and neurodegenerative disorders: Tools and strategies to understand its complexity. ATF6, ER, IRE1, UPR
2020 Intracellular proliferation of Anaplasma phagocytophilum is promoted via modulation of endoplasmic reticulum stress signaling in host cells. ATF6, ER, IRE1
2020 MuicroRNA‑421 participates in vitiligo development through regulating human melanocyte survival by targeting receptor‑interacting serine/threonine kinase 1. CHOP, ER, RIPK1, TM
2020 Naturally-derived diterpenoid sphaeropsidin C as an activator of Nrf2/ARE pathway and its potential capability of relieving intracellular oxidative stress in human lung epithelial cells. ARE, Nrf2, PI3K, PKC, SC
2020 Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy. FGF21, ISR
2020 PERK-mediated induction of microRNA-483 disrupts cellular ATP homeostasis during the unfolded protein response. ATF4, CKB, ER, miRNA, UPR
2020 STING is an essential regulator of heart inflammation and fibrosis in mice with pathological cardiac hypertrophy via endoplasmic reticulum (ER) stress. AB, Ang II, CM, Col I, Col III, eIF2alpha, ER, IRE, STING, TGF-beta1
10  2020 The kinase PERK represses translation of the G protein-coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells. AGR2, EGFR, ER, ERBB3, LGR5
11  2020 The PERK Pathway Plays a Neuroprotective Role During the Early Phase of Secondary Brain Injury Induced by Experimental Intracerebral Hemorrhage. ATF4, CHOP, ICH, p-eIF2alpha, SBI
12  2020 The Unfolded Protein Response: A Novel Therapeutic Target in Acute Leukemias. ATF6alpha, ER, IRE1alpha, MM, UPR
13  2020 TNFalpha selectively activates the IRE1alpha/XBP1 endoplasmic reticulum stress pathway in human airway smooth muscle cells. ATF6, ER, HASM, Mfn2, XBP1
14  2020 Use of small-molecule inhibitory compound of PERK-dependent signaling pathway as a promising target-based therapy for colorectal cancer. CRC, eIF2alpha, ER, LDH, UPR
15  2019 20(S)-protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK-eIF2alpha-ATF4 signaling pathway. CHOP, HUVECs, PPD
16  2019 Activation of LXR Receptors and Inhibition of TRAP1 Causes Synthetic Lethality in Solid Tumors. ATF4, GBM, LXR, TRAP1
17  2019 Activation of PERK in ET-1- and thrombin-induced pulmonary fibroblast differentiation: Inhibitory effects of curcumin. alpha-SMA, CCN2, Col I, CUR, ER, ET-1, IHC, JNK, PF, siRNA, TG
18  2019 Ameliorative effect of sevoflurane on endoplasmic reticulum stress mediates cardioprotection against ischemia-reperfusion injury 1. ATF4, CHOP, IR
19  2019 An isopentenyl-substituted flavonoid norartocarpin activates Nrf2 signalling pathway and prevents oxidative insults in human lung epithelial cells. Gclm, MAPK, NOR, NQO1, Nrf2, PI3K, PKC, QR
20  2019 Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells. ACA, ACB, FA, GCLM, MAPK, NQO1, Nrf2, PI3K, PKC
21  2019 beta-Asarone Regulates ER Stress and Autophagy Via Inhibition of the PERK/CHOP/Bcl-2/Beclin-1 Pathway in 6-OHDA-Induced Parkinsonian Rats. 6-OHDA, CHOP, ER, GRP78, p-PERK, PD
22  2019 Boric Acid Activation of eIF2alpha and Nrf2 Is PERK Dependent: a Mechanism that Explains How Boron Prevents DNA Damage and Enhances Antioxidant Status. ARE, BA, eIF2alpha
23  2019 Cadmium induces ovarian granulosa cell damage by activating PERK-eIF2alpha-ATF4 through endoplasmic reticulum stress. BiP, ER
24  2019 CHOP is dispensable for lens transparency in wild-type and connexin50 mutant mice. CHOP, Cx50
25  2019 EIF2AK3 variants in Dutch patients with Alzheimer's disease. AD
26  2019 Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling. ER, GRP94
27  2019 Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity. ER, GDM, IRE1alpha, TRB3
28  2019 Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8+ T Cells. ER, mtROS, TILs
29  2019 Endoplasmic Reticulum Stress Increases DUSP5 Expression via PERK-CHOP Pathway, Leading to Hepatocyte Death. CHOP, DUSP5, ER, ERK, GEO
30  2019 Endoplasmic Reticulum Stress-Mediated Basolateral Amygdala GABAergic Neuron Injury Is Associated With Stress-Induced Mental Disorders in Rats. BLA, E/I, ERS, GABA, Glu, HPLC, MMTC
31  2019 Expression and Clinical Significance of Protein Kinase RNA-Like Endoplasmic Reticulum Kinase and Phosphorylated Eukaryotic Initiation Factor 2alpha in Pancreatic Ductal Adenocarcinoma. eIF2alpha, p-eIF2alpha, PDAC
32  2019 Hepatitis B Surface Antigen Activates Unfolded Protein Response in Forming Ground Glass Hepatocytes of Chronic Hepatitis B. ER, GGHs, HBV, PHHs, UPR
33  2019 High glucose and bupivacaine‑induced cytotoxicity is mediated by enhanced apoptosis and impaired autophagy via the PERK‑ATF4‑CHOP and IRE1‑TRAF2 signaling pathways. IRE1, RAPA, TRAF2
34  2019 Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2alpha/ATF4 and IRE1alpha. CRC, EGCG, eIF2alpha, ER, IRE1alpha
35  2019 Japanese Encephalitis Virus Induces Apoptosis and Encephalitis by Activating the PERK Pathway. ER, JEV
36  2019 Jiang-Zhi granules decrease sensitivity to low-dose CCl4 induced liver injury in NAFLD rats through reducing endoplasmic reticulum stress. EIF2alpha, ERS, GRP78, HFD, JZG, NAFLD, NF-kappaB, TCM
37  2019 Kurarinone from Sophora Flavescens Roots Triggers ATF4 Activation and Cytostatic Effects Through PERK Phosphorylation. ATF4
38  2019 Matrine improves diabetic cardiomyopathy through TGF-beta-induced protein kinase RNA-like endoplasmic reticulum kinase signaling pathway. DCM, GPx, MDA, PPARbeta, PPARgamma1, ROS, TNF-alpha
39  2019 Methionine restriction activates the integrated stress response in triple-negative breast cancer cells by a GCN2- and PERK-independent mechanism. eIF2alpha, GCN2
40  2019 Neuroprotective mechanism of low-dose sodium nitrite in oxygen-glucose deprivation model of cerebral ischemic stroke in PC12 cells. CHOP, ER, OGD, ROS, SN
41  2019 PERK is essential for proliferation of intestinal stem cells in mice. Lgr5
42  2019 PERK regulates skeletal muscle mass and contractile function in adult mice. ER, UPR
43  2019 Porcine Circovirus Type 2 Induces ORF3-Independent Mitochondrial Apoptosis via PERK Activation and Elevation of Cytosolic Calcium. 4-PBA, Cap, eIF2alpha, ER, MMP, ORF3, PAM, PCV2, ROS, UPR
44  2019 Predictive Value of Endoplasmic Reticulum Stress Markers in Low Ejection Fractional Heart Failure. AUC, CHF, CHOP, ER, ROC
45  2019 Profile of the unfolded protein response in rat cerebellar cortical development. ATF6, ER, GRP78, GRP94, IGL, IRE1, PDI, UPR
46  2019 Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway. BAR, CHOP, CNPY2, ERS, MIRI
47  2019 Protective effects of autophagy against blue light-induced retinal degeneration in aged mice. 10 mo, hRPE, LC3, OS
48  2019 Protein translation associated to PERK arm is a new target for regulation of metainflammation: A connection with hepatocyte cholesterol. CHOP, LDLR, SREBP2, UPR
49  2019 Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection. ATF6, GP, IRE1, iTRAQ, SFTS, SFTSV, SFTSV, UPR, XBP1
50  2019 Suberoylanilide hydroxamic acid upregulates histone acetylation and activates endoplasmic reticulum stress to induce apoptosis in HepG2 liver cancer cells. ATF4, CHOP, ER, SAHA
51  2019 Suppression of Nuclear Factor-kappaB by Glucocorticoid Receptor Blocks Estrogen-Induced Apoptosis in Estrogen-Deprived Breast Cancer Cells. FADS1, GR, IRE1alpha, LTED, NF-kappaB, RPPA
52  2019 The active nuclear form of SREBP1 amplifies ER stress and autophagy via regulation of PERK. ER, UPR
53  2019 The PERK-EIF2alpha-ATF4 signaling branch regulates osteoblast differentiation and proliferation by PTH. ALP, ER, Hsp90, ISRIB, OCN, PTH
54  2019 The Superior Antitumor Effect of Self-Assembled Paclitaxel Nanofilaments for Lung Cancer Cells. CHOP, ER, IRE1alpha, NSCLC, p-JNK, PTX, SA
55  2019 Tolvaptan activates the Nrf2/HO-1 antioxidant pathway through PERK phosphorylation. BARD, CKD, HO-1, Nrf2
56  2019 Unfolded Protein Response Pathways Correlatively Modulate Endoplasmic Reticulum Stress Responses in Rat Retinal Muller Cells. ATF4, ATF6, DR, ERS, GRP78, IRE1, UPR, VEGF, XBP1
57  2019 Yinchenhao decoction attenuates obstructive jaundice-induced liver injury and hepatocyte apoptosis by suppressing protein kinase RNA-like endoplasmic reticulum kinase-induced pathway. AST, Bax, Bcl-2, CHOP, ER, OJ, qRT-PCR, TUNEL, YCHD
58  2018 A lifetime of stress: ATF6 in development and homeostasis. ATF6, ER, IRE1
59  2018 Apoptosis-Associated Speck-Like Protein Containing a CARD Deletion Ameliorates Unilateral Ureteral Obstruction Induced Renal Fibrosis and Endoplasmic Reticulum Stress in Mice. ASC, ER, UUO
60  2018 BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells. ATF, CML, eIF, ISR
61  2018 Cellular stress and apoptosis contribute to the pathogenesis of autism spectrum disorder. ATF6, CHOP, ER, IRE1alpha
62  2018 Chemical compounds that suppress hypoxia-induced stress granule formation enhance cancer drug sensitivity of human cervical cancer HeLa cells. PKR, SGs
63  2018 Cucurbitacin I induces cancer cell death through the endoplasmic reticulum stress pathway. ERS, IRE1alpha
64  2018 Deletion of endoplasmic reticulum stress-responsive co-chaperone p58IPK protects mice from diet-induced steatohepatitis. FFC, NASH
65  2018 Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults. 7-MBA, MAPK, Nrf2, PI3K, PKC, ROS, SAR
66  2018 Effects of PERK eIF2alpha Kinase Inhibitor against Toxoplasma gondii. ER, PERKi
67  2018 Endoplasmic reticulum stress contributes to the pathogenesis of stress urinary incontinence in postmenopausal women. ATF4, ATF6, Bcl-2, CHOP, ERS, IRE1, SUI
68  2018 Endurance training prevents inflammation and apoptosis in hypothalamic neurons of obese mice. HFD, Lean, T. Obese, TUNEL
69  2018 FGF21 attenuates hypoxia‑induced dysfunction and apoptosis in HPAECs through alleviating endoplasmic reticulum stress. BiP, ERS, FGF, HPAECs, NO, PAH
70  2018 FXR Inhibits Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome in Hepatocytes and Ameliorates Liver Injury. CHOP, ER, FXR, HBV, NCK-1, NLRP3, TXNIP
71  2018 Genetic Variability in eIF2alpha Gene Is Associated with Islet beta-Cell Function in the Development of Diabetes in a Chinese Han Population. eIF2alpha
72  2018 Inhibition of peptidyl-prolyl cis-trans isomerase B mediates cyclosporin A-induced apoptosis of islet beta cells. BiP, CHOP, CsA, ER, PKR, PPIB
73  2018 Inhibitory Effects of Simvastatin on Oxidized Low-Density Lipoprotein-Induced Endoplasmic Reticulum Stress and Apoptosis in Vascular Endothelial Cells. ANOVA, CHOP, eIF2alpha, ER, HUVECs, oxLDL
74  2018 Knockdown of CEMIP suppresses proliferation and induces apoptosis in colorectal cancer cells: downregulation of GRP78 and attenuation of unfolded protein response. ATF6, CEMIP, CRC, ER, IRE1, UPR
75  2018 Liquiritigenin prevents palmitate-induced beta-cell apoptosis via estrogen receptor-mediated AKT activation. ER, LQ, PA
76  2018 Mechanisms of disordered neurodegenerative function: concepts and facts about the different roles of the protein kinase RNA-like endoplasmic reticulum kinase (PERK). ER, UPR
77  2018 Melatonin ameliorates myocardial apoptosis by suppressing endoplasmic reticulum stress in rats with long‑term diabetic cardiomyopathy. DM, ER, MLT
78  2018 MLKL mediates apoptosis via a mutual regulation with PERK/eIF2alpha pathway in response to reactive oxygen species generation. CHE, eIF2alpha, MLKL, ROS
79  2018 Modulation of nuclear factor-kappa B activation by the endoplasmic reticulum stress sensor PERK to mediate estrogen-induced apoptosis in breast cancer cells. NF-kappaB, STAT3, TNF-alpha, UPR
80  2018 Montelukast inhibits hypoxia inducible factor-1alpha translation in prostate cancer cells. CQ, HIF-1
81  2018 Novel Rhodanine Derivative, 5-[4-(4-Fluorophenoxy) phenyl]methylene-3-{4-[3-(4-methylpiperazin-1-yl) propoxy]phenyl}-2-thioxo-4-thiazolidinone dihydrochloride, Induces Apoptosis via Mitochondria Dysfunction and Endoplasmic Reticulum Stress in Human Colon Cancer Cells. AIF, cyt c, EndoG, ER, IRE-1alpha
82  2018 Peptide-based sequestration of the adaptor protein Nck1 in pancreatic beta cells enhances insulin biogenesis and protects against diabetogenic stresses. ---
83  2018 PERK leads a hub dictating pancreatic betacell homoeostasis. ---
84  2018 PERK Regulates Glioblastoma Sensitivity to ER Stress Although Promoting Radiation Resistance. ER, GBM, IR
85  2018 PERK, mTORC1 and eEF2 interplay during long term potentiation: An Editorial for 'Genetic removal of eIF2a kinase PERK in mice enables hippocampal L-LTP independent of mTORC1 activity' on page 133. eEF2, HFS, LTP
86  2018 Pre-pregnancy maternal obesity associates with endoplasmic reticulum stress in human umbilical vein endothelium. ATF6, ER, HUVECs, IRE1alpha, NO, PGMO, TRB3
87  2018 Progesterone inhibited endoplasmic reticulum stress associated apoptosis induced by interleukin-1beta via the GRP78/PERK/CHOP pathway in BeWo cells. CHOP, ERS, GRP78, IL, PE
88  2018 Protective effect of resveratrol on kidney in rats with diabetic nephropathy and its effect on endoplasmic reticulum stress. ATF4, BCA, CHOP, DN, SD, SPF, STZ
89  2018 Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury. ARDS, ER, VILI
90  2018 Protein tyrosine phosphatase 1B regulates endothelial endoplasmic reticulum stress; role in endothelial dysfunction. ERS, NO, PTP1B
91  2018 Protopanaxadiol derivative DDPU improves behavior and cognitive deficit in AD mice involving regulation of both ER stress and autophagy. AD, ADL, BACE1, DDPU, eIF2alpha, ER, NFT, UPR
92  2018 Scopoletin intervention in pancreatic endoplasmic reticulum stress induced by lipotoxicity. ATF6, ER, HFFD, IRE1, RIN5f
93  2018 Significance of calreticulin as a prognostic factor in endometrial cancer. CRT, DOX, NAC, p-eIF2alpha
94  2018 Streptozotocin-Induced Autophagy Reduces Intracellular Insulin in Insulinoma INS-1E Cells. Bax, Bcl-2, IRE1alpha, LC3, p-ERK, p-mTOR, pAMPK, SOD, STZ
95  2018 Tannic Acid Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Prostate Cancer. ER, IRE1, UPR
96  2018 Tau hyperphosphorylation and P-CREB reduction are involved in acrylamide-induced spatial memory impairment: Suppression by curcumin. ACR, ATF4, BDNF, Cdk5, ERK, GSK-3beta, pCREB, PP2A
97  2018 Tetramethylpyrazine Showed Therapeutic Effects on Sepsis-Induced Acute Lung Injury in Rats by Inhibiting Endoplasmic Reticulum Stress Protein Kinase RNA-Like Endoplasmic Reticulum Kinase (PERK) Signaling-Induced Apoptosis of Pulmonary Microvascular Endothelial Cells. ALI, ARI, CLP, DC, PMVECs, TMP
98  2018 The Effect of Bornyl cis-4-Hydroxycinnamate on Melanoma Cell Apoptosis Is Associated with Mitochondrial Dysfunction and Endoplasmic Reticulum Stress. Bad, Bax, Bcl-2, ER stress, Mcl-1, protein DJ-1
99  2018 The effect of metformin treatment on endoplasmic reticulum (ER) stress induced by status epilepticus (SE) via the PERK-eIF2alpha-CHOP pathway. ER, SE
100  2018 The luminal domain of the ER stress sensor protein PERK binds misfolded proteins and thereby triggers PERK oligomerization. ER, UPR