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Abbreviation : PERK
Long Form : protein kinase RNA-like ER kinase
No. Year Title Co-occurring Abbreviation
2020 1,25-hydroxyvitamin D3 decreases endoplasmic reticulum stress-induced inflammatory response in mammary epithelial cells. DDIT3, ER, MECs, NF-kappaB, sXBP1, TG, TM, VDR
2020 Aberrant ER Stress Induced Neuronal-IFNbeta Elicits White Matter Injury Due to Microglial Activation and T-Cell Infiltration after TBI. ER, IFN, TBI, Th1
2020 Activation of endoplasmic reticulum stress mediates oxidative stress-induced apoptosis of granulosa cells in ovaries affected by endometrioma. ER, GLCs, IRE1, TUDCA, UPR
2020 Asperuloside exhibits a novel anti-leukemic activity by triggering ER stress-regulated apoptosis via targeting GRP78. AML, ASP, ATF6, CHOP, eIF2alpha, ER, GRP78, IP, p-IRE1, XBP1
2020 Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through the Activation of the PERK/Nrf2 Signaling Pathway. CHOP, Nrf2
2020 Endoplasmic Reticulum Stress Induces miR-706, A Pro-Cell Death microRNA, in A Protein Kinase RNA-Like ER Kinase (PERK) and Activating Transcription Factor 4 (ATF4) Dependent Manner. ATF4, CAAP1, ER
2020 MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System. ATF6, ER, IRE1alpha, MANF, SN, UPR
2020 Manganese activates autophagy to alleviate endoplasmic reticulum stress-induced apoptosis via PERK pathway. 3-MA, 4-PBA, ER, Mn
2020 miR-7112-3p targets PERK to regulate the endoplasmic reticulum stress pathway and apoptosis induced by photodynamic therapy in colorectal cancer CX-1 cells. CRC, ER, PDT
10  2020 Morin supplementation modulates PERK branch of UPR and mitigates 1,2-dimethylhydrazine-induced angiogenesis and oxidative stress in the colon of experimental rats. DMH, ER, GPX2, GST, HO-1, TRXN, UGT, UPR
11  2020 Porcine parvovirus replication is suppressed by activation of the PERK signaling pathway and endoplasmic reticulum stress-mediated apoptosis. ATF6, ER, PPV
12  2020 The integrated stress response promotes B7H6 expression. ER, ISR
13  2019 Astragalus polysaccharides inhibits cardiomyocyte apoptosis during diabetic cardiomyopathy via the endoplasmic reticulum stress pathway. APS, ATF6, CHOP, DCM, ER, HE, HG, OE, STZ
14  2019 Astrocyte elevated gene 1 (AEG-1) promotes anoikis resistance and metastasis by inducing autophagy in hepatocellular carcinoma. AEG-1, HCC
15  2019 Atrial natriuretic peptide attenuates endoplasmic reticulum stress in experimental acute pancreatitis. ANP, ATF6, BiP, ER, IRE1, UPR
16  2019 Berberine ameliorates lipopolysaccharide-induced acute lung injury via the PERK-mediated Nrf2/HO-1 signaling axis. ALI, ER, LPS, Nrf2, siRNA
17  2019 beta-Arrestin1-mediated decrease in endoplasmic reticulum stress impairs intestinal stem cell proliferation following radiation. beta-arr1, eIF2alpha, KO, Lgr5
18  2019 C/EBPbeta mediates palmitate-induced musclin expression via the regulation of PERK/ATF4 pathways in myotubes. ATF4, ER
19  2019 Cannabidiol Enhances the Therapeutic Effects of TRAIL by Upregulating DR5 in Colorectal Cancer. CHOP, TRAIL
20  2019 Chicoric acid (CA) induces autophagy in gastric cancer through promoting endoplasmic reticulum (ER) stress regulated by AMPK. AMPK, ATF4, CA, ER, p70S6K
21  2019 Classical Swine Fever Virus Infection Induces Endoplasmic Reticulum Stress-Mediated Autophagy to Sustain Viral Replication in vivo and in vitro. ATF6, CSFV, ER, IRE1, UPR
22  2019 Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells. ATF4, DHA, ER, GPX4, ROS
23  2019 Dysregulation of the unfolded protein response (UPR) in the dorsolateral prefrontal cortex in elderly patients with schizophrenia. ATF6, DLPFC, ER, IRE1alpha, SCZ, UPR
24  2019 Endoplasmic reticulum stress and unfolded protein response profile in quadriceps of sarcopenic patients with respiratory diseases. ATF, COPD, ER, FFMI, IRE, LC, UPR, VL
25  2019 Endoplasmic reticulum stress-dependent autophagy inhibits glycated high-density lipoprotein-induced macrophage apoptosis by inhibiting CHOP pathway. CHOP, ER, gly-HDL
26  2019 ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2alpha Axis. ER, SCAF1 or COX7A2L, SCs
27  2019 Fatty acid-induced endoplasmic reticulum stress promoted lipid accumulation in calf hepatocytes, and endoplasmic reticulum stress existed in the liver of severe fatty liver cows. ATF6, ER, IRE1alpha, TUDCA
28  2019 Hepatic Stress Response in HCV Infection Promotes STAT3-Mediated Inhibition of HNF4A-miR-122 Feedback Loop in Liver Fibrosis and Cancer Progression. DAAs, ER, HCC, HCV, HNF4A, IFN, miR-122, Nrf2, STAT3, UPR
29  2019 High glucose causes apoptosis of rabbit corneal epithelial cells involving activation of PERK-eIF2alpha-CHOP-caspase-12 signaling pathway. Bax, Bcl-2, CHOP, GRP78, HCG, RCECs
30  2019 Hydroxycamptothecin Prevents Fibrotic Pathways in Fibroblasts In Vitro. alpha-SMA, ER, HCPT, TGF
31  2019 Hypoxia-Activated Prodrugs of PERK Inhibitors. ER, UPR
32  2019 Inhibition of the dephosphorylation of eukaryotic initiation factor 2alpha ameliorates murine experimental pancreatitis. ER
33  2019 MCP-1/MCPIP-1 Signaling Modulates the Effects of IL-1beta in Renal Cell Carcinoma through ER Stress-Mediated Apoptosis. CHOP, CNX, ER, HEK, IL, MCP, MCPIP, RCC, TUNEL
34  2019 Mesenchymal stem cells reduce ER stress via PERK-Nrf2 pathway in an aged mouse model. ER, MSC, UPR
35  2019 Methylmercury exposure induces ROS/Akt inactivation-triggered endoplasmic reticulum stress-regulated neuronal cell apoptosis. AFT, CHOP, CNS, eIF2alpha, ER, GRP, IRE, NAC, ND, PS, ROS, si, XBP
36  2019 Non-Structural Protein 2B of Human Rhinovirus 16 Activates Both PERK and ATF6 Rather Than IRE1 to Trigger ER Stress. ATF6, ER, GRP78, HRV, IRE1
37  2019 Penehyclidine hydrochloride defends against LPS-induced ALI in rats by mitigating endoplasmic reticulum stress and promoting the Hes1/Notch1 pathway. ALI, ATF4, Bax, Bcl-2, CHOP, DAPT, eIF2alpha, ER, Hes1, LPS, p-eIF2alpha, p-PERK, PHC
38  2019 Pollen Typhae Total Flavone Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis in Human Aortic-Vascular Smooth Muscle Cells through Down-Regulating PERK-eIF2alpha-ATF4-CHOP Pathway. ER, HA-VSMCs, oxLDL, PTF
39  2019 Pro-apoptotic effect of haem oxygenase-1 in human colorectal carcinoma cells via endoplasmic reticular stress. CASP, CO, CoPP, CRC, DEVD, eIF2alpha, ER, FBS, HO, HSP70, PARP, SF, si, VAD
40  2019 Protective Effect of Patchouli Alcohol Against High-Fat Diet Induced Hepatic Steatosis by Alleviating Endoplasmic Reticulum Stress and Regulating VLDL Metabolism in Rats. apoB100, ATF6, ER, HFD, IRE1, MTP, NAFLD, PA, VLDL, VLDLR
41  2019 Protein arginine methyltranferase-1 induces ER stress and epithelial-mesenchymal transition in renal tubular epithelial cells and contributes to diabetic nephropathy. ATF6, EMT, IRE1alpha, PTECs, sh-PRMT1
42  2019 Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress. CHOP, cIAP, ER, GRP78, IAP, NF-kappaB, Smac, TG, TM, UPR, XBP1
43  2019 Sterile activation of invariant natural killer T cells by ER-stressed antigen-presenting cells. ER, iNKT
44  2019 The PERK/Nrf2 pathway mediates endoplasmic reticulum stress-induced injury by upregulating endoplasmic reticulophagy in H9c2 cardiomyoblasts. ATF4, CRT, ER-phagy, ERS, LC3B, Nrf2, TG, TM
45  2018 2-Chlorohexadecanoic acid induces ER stress and mitochondrial dysfunction in brain microvascular endothelial cells. 2-ClHA, 2-ClHyA, BBB, BMVEC, ER, HOCl, IL
46  2018 Activation of aldehyde dehydrogenase 2 slows down the progression of atherosclerosis via attenuation of ER stress and apoptosis in smooth muscle cells. 4-HNE, ALDH2, ATF4, CHOP, ER, GRP78, oxLDL, SMCs
47  2018 Activation of the unfolded protein response downregulates cardiac ion channels in human induced pluripotent stem cell-derived cardiomyocytes. APD, APs, hiPSC-CMs, IRE1, UPR
48  2018 Anti-ganglioside GD2 monoclonal antibody synergizes with cisplatin to induce endoplasmic reticulum-associated apoptosis in osteosarcoma cells. eIF2alpha, ER, mAb, OS
49  2018 Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78. BA, DARTS, ER, GRP78
50  2018 CHOP/caspase-3 signal pathway involves in mitigative effect of selenium on lead-induced apoptosis via endoplasmic reticulum pathway in chicken testes. ATF4, BD, DW, eIF2alpha, ER, GPx, GRP78, GST, MDA, Se, SOD
51  2018 DiDang Tang Inhibits Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Oxygen Glucose Deprivation and Intracerebral Hemorrhage Through Blockade of the GRP78-IRE1/PERK Pathways. DDT, ER, GRP78, ICH, IRE1, OGD, TM
52  2018 Ethyl Acetate Extract of Scindapsus cf. hederaceus Exerts the Inhibitory Bioactivity on Human Non-Small Cell Lung Cancer Cells through Modulating ER Stress. CHOP, ER, IRE-1alpha, ISV, NSCLC, SH-EAE, UPR
53  2018 Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces hepatic steatosis and endoplasmic reticulum stress by inducing nuclear factor erythroid-derived 2-related factor 2 nuclear translocation. eIF2alpha, ER, Ex-4, GLP-1, HFD
54  2018 Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia. ER, ISR, MCDS
55  2018 Inhibition of Nogo-B promotes cardiac hypertrophy via endoplasmic reticulum stress. ATF4, ATF6, ER, NE, NRCMs, siRNA, TAC, TGF-beta1
56  2018 Interferon gamma suppresses dentin sialophosphoprotein in oral squamous cell carcinoma cells resulting in antitumor effects, via modulation of the endoplasmic reticulum response. Ca, DSPP, ER, IFN, IRE1, MMP, OSCC, PCNA, UPR
57  2018 Intermittent-Hypoxia-Induced Autophagy Activation Through the ER-Stress-Related PERK/eIF2alpha/ATF4 Pathway is a Protective Response to Pancreatic beta-Cell Apoptosis. ATF4, ER, IH, siRNA
58  2018 Low-intensity extracorporeal shock wave therapy promotes myogenesis through PERK/ATF4 pathway. ATF4, LI-ESWT, MDSCs, MHC, Myf5, SUI, uMDSCs, ZUC-LEAN
59  2018 Microglia Polarization and Endoplasmic Reticulum Stress in Chronic Social Defeat Stress Induced Depression Mouse. CHOP, CSDS, ER, IL, iNOS, MDD, p-eIF2alpha, PSD-95, TNF, XBP1
60  2018 Mild stress induces brain region-specific alterations of selective ER stress markers' mRNA expression in Wfs1-deficient mice. ATF6alpha, CHOP, ER, IRE1alpha, WT, XBP1
61  2018 Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N‑acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress. Bax, Bcl-2, CHOP, DCM, eIF2alpha, ERS, GRP78, IRE1alpha, NAC, NADPH, NOX4, NRCMs, ROS, XBP1
62  2018 Pharmacologic inhibition of S1P attenuates ATF6 expression, causes ER stress and contributes to apoptotic cell death. ATF6, ER, IRE1alpha, PF, S1P, SREBPs, UPR
63  2018 Protective effect of 3-hydroxybutyrate against endoplasmic reticulum stress-associated vascular endothelial cell damage induced by low glucose exposure. 3HB, ATF6, ER, HUVECs, LDH, XBP1
64  2018 Role of AMPK pathway in lead-induced endoplasmic reticulum stress in kidney and in paeonol-induced protection in mice. AMPK, ER, GSK-3, IL-6, IRE1, JNK, MAPK, TNF-alpha
65  2018 Sulforaphane Improves Abnormal Lipid Metabolism via Both ERS-Dependent XBP1/ACC &SCD1 and ERS-Independent SREBP/FAS Pathways. ACC1, SCD1, SFN, SREBP-1c, XBP1
66  2018 The ER Stress Inducer l-Azetidine-2-Carboxylic Acid Elevates the Levels of Phospho-eIF2alpha and of LC3-II in a Ca2+-Dependent Manner. ATF6, AZC, BafA1, BAPTA-AM, BiP, eIF2alpha, ER, LC3, PARP, UPR
67  2018 The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life. ASNS, Bip, ER, IUGR, UPR, XBP1s
68  2018 The PERK Arm of the Unfolded Protein Response Negatively Regulates Transmissible Gastroenteritis Virus Replication by Suppressing Protein Translation and Promoting Type I Interferon Production. ATF6, eIF2alpha, ER, IRE1, siRNA, ST, TGEV, UPR
69  2018 UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response. CHOP, ER, T-ALL, Ufd1, UPR
70  2018 [Effect of oxidative stress on periprosthetic osteolysis induced by TCP wear particles in mouse calvaria and its mechanism]. eIF2alpha, GRP78, IL-1beta, IL-6, NAC, p-PERK, peIF2alpha, SOD, T-AOC, TCP, TNF-alpha, TRAP
71  2017 A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure. ---
72  2017 Antifibrotic Effect of Saturated Fatty Acids via Endoplasmic Reticulum Stress Response in Rat Pancreatic Stellate Cells. ER, HFD, PA, PSCs
73  2017 CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response. CHOP, CNPY2, ER, UPR
74  2017 Endoplasmic reticulum stress inhibits expression of genes involved in thyroid hormone synthesis and their key transcriptional regulators in FRTL-5 thyrocytes. eIF2alpha, ER, SREBPs, Tg, TM, TPO, UPR
75  2017 Endoplasmic reticulum stress participates in inflammation-accelerated, lipid-mediated injury of human glomerular mesangial cells. 4-PBA, alpha-SMA, eIF2alpha, ER, GRP78, HMCs, IL-1beta, LDL, NF
76  2017 Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway. Bcl-2, DEX, ER, GCs, MPS, ONFH, PRP, PRP
77  2017 Grape seed proanthocyanidins protect cardiomyocytes against hypoxia/reoxygenation injury by attenuating endoplasmic reticulum stress through PERK/eIF2alpha pathway. CHOP, ER, GRP78, GSPs, LDH
78  2017 HIV-1-associated inflammation and antiretroviral therapy regulate astrocyte endoplasmic reticulum stress responses. AEG-1, ARV, ATF6, BiP, CHOP, ER, HAND, HIV, IL, IRE1alpha, mPTP, UPRs
79  2017 Homocysteine Induces Apoptosis of Human Umbilical Vein Endothelial Cells via Mitochondrial Dysfunction and Endoplasmic Reticulum Stress. CHOP, GRP78, HUVEC, MMP
80  2017 Human neutrophil elastase induces endothelial cell apoptosis by activating the PERK-CHOP branch of the unfolded protein response. CHOP, UPR
81  2017 Inhibition of IRE1alpha-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response. ATF6, ER, UPR, XBP1
82  2017 Mitochondrial DNA-enriched microparticles promote acute-on-chronic alcoholic neutrophilia and hepatotoxicity. EAU, EAU - RD, MPs, mtDNA
83  2017 Molecular signal networks and regulating mechanisms of the unfolded protein response. Akt, ATF6, BiP, ER, IRE1alpha, JNK, ROS, STAT3, UPR, VEGF
84  2017 NDRG2 acts as a PERK co-factor to facilitate PERK branch and ERS-induced cell death. ---
85  2017 Novel prosurvival function of Yip1A in human cervical cancer cells: constitutive activation of the IRE1 and PERK pathways of the unfolded protein response. ER, IRE1, RNAi, UPR
86  2017 Omega-3 fatty acids increase the unfolded protein response and improve amyloid-beta phagocytosis by macrophages of patients with mild cognitive impairment. APOE, ER, MCI, MMSE, omega-3s, UPR
87  2017 Pharmacological Inhibition of PERK Attenuates Early Brain Injury After Subarachnoid Hemorrhage in Rats Through the Activation of Akt. ER, SAH, TdT
88  2017 Salidroside protects against homocysteine-induced injury in human umbilical vein endothelial cells via the regulation of endoplasmic reticulum stress. BiP, CHOP, ER stress, Hcy, HUVECs, IRE1alpha, SAL
89  2017 Sevoflurane-Induced Endoplasmic Reticulum Stress Contributes to Neuroapoptosis and BACE-1 Expression in the Developing Brain: The Role of eIF2alpha. ATF4, BACE1, eIF2alpha, ER, SEVO
90  2017 SGK3 sustains ERalpha signaling and drives acquired aromatase inhibitor resistance through maintaining endoplasmic reticulum homeostasis. AIs, EnR, ERalpha, SERCA2b, SGK3
91  2017 Sodium Arsenite-Induced Learning and Memory Impairment Is Associated with Endoplasmic Reticulum Stress-Mediated Apoptosis in Rat Hippocampus. ATF4, CHOP, eIF2alpha, ER, GRP78, MWM, UPR
92  2017 Taurine ameliorated homocysteine-induced H9C2 cardiomyocyte apoptosis by modulating endoplasmic reticulum stress. ATF6, CHOP, ER, GRP78, Hcy, IRE1, JNK
93  2017 The Role of Endoplasmic Reticulum Stress in Cardiovascular Disease and Exercise. ATF6, EC, ER, IRE1alpha, UPR
94  2017 Ursodeoxycholic Acid Attenuates Endoplasmic Reticulum Stress-Related Retinal Pericyte Loss in Streptozotocin-Induced Diabetic Mice. AGE, DR, ER, mLDL, UDCA, UPR
95  2017 Ursolic Acid Improves Liver Transplantation and Inhibits Apoptosis in Miniature Pigs Using Donation After Cardiac Death. ALT, DCD, MDA, UA
96  2017 [Protective effect of earthworm active ingredients against endoplasmic reticulum stress-induced acute liver injury in mice]. ATF4, CHOP, eIF2alpha, ERS, EWAs, GRP78, GSH-Px, MDA, SOD
97  2016 Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse. CMT1B, ER, UPR
98  2016 Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-alpha production by mononuclear phagocytes. CLEC5A, DENV, ER, TLR3, TNF
99  2016 Activation of the unfolded protein response and granulovacuolar degeneration are not common features of human prion pathology. AD, FTLD-tau, IRE1alpha, UPR
100  2016 Baicalin promoted site-2 protease and not site-1 protease in endoplasmic reticulum stress-induced apoptosis of human hepatocellular carcinoma cells. ER, HCC