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Abbreviation : PF
Long Form : Paeoniflorin
No. Year Title Co-occurring Abbreviation
2020 Mineral Elements and Active Ingredients in Root of Wild Paeonia lactiflora Growing at Duolun County, Inner Mongolia. BA, CA, Ca, Mn, Zn
2019 A Protective Role of Paeoniflorin in Fluctuant Hyperglycemia-Induced Vascular Endothelial Injuries through Antioxidative and Anti-Inflammatory Effects and Reduction of PKCbeta1. DM, HUVECs
2019 A review for the anti-inflammatory effects of paeoniflorin in inflammatory disorders. ---
2019 Anti-inflammatory effect of paeoniflorin combined with baicalin in oral inflammatory diseases. BAI, HOKs
2019 Effects of Paeoniflorin on the activity of muscle strips, intracellular calcium ion concentration and L‑type voltage‑sensitive calcium ion channels in the sphincter of Oddi of hypercholesterolemic rabbits. HC, SOD
2019 In vivo microdialysis and in vitro HPLC analysis of the impact of paeoniflorin on the monoamine levels and their metabolites in the rodent brain. HPLC
2019 Paeoniflorin Alleviates H2O2-Induced Oxidative Injury Through Down-Regulation of MicroRNA-135a in HT-22 Cells. miR-135a
2019 Paeoniflorin Ameliorates Macrophage Infiltration and Activation by Inhibiting the TLR4 Signaling Pathway in Diabetic Nephropathy. HG, STZ, TGP
2019 Paeoniflorin exhibits antitumor effects in nasopharyngeal carcinoma cells through downregulation of NEDD4. NEDD4, NPC
10  2019 Paeoniflorin improves pressure overload-induced cardiac remodeling by modulating the MAPK signaling pathway in spontaneously hypertensive rats. DEGs, SHR
11  2019 Paeoniflorin Inhibits Hepatocyte Growth Factor- (HGF-) Induced Migration and Invasion and Actin Rearrangement via Suppression of c-Met-Mediated RhoA/ROCK Signaling in Glioblastoma. ---
12  2019 Paeoniflorin inhibits MRGPRX2-mediated pseudo-allergic reaction via calcium signaling pathway. MCs, MRGPRX2
13  2019 Paeoniflorin inhibits tributyltin chloride-induced apoptosis in hypothalamic neurons via inhibition of MKK4-JNK signaling pathway. Bcl-2, JNK, MAPK, MKK4, TBTC
14  2019 Paeoniflorin Prevents Intestinal Barrier Disruption and Inhibits Lipopolysaccharide (LPS)-Induced Inflammation in Caco-2 Cell Monolayers. COX-2, IBD, IL-6, iNOS, LPS, MMP-9, NF-kappaB, TNF-alpha
15  2019 Paeoniflorin protects pancreatic beta cells from STZ-induced damage through inhibition of the p38 MAPK and JNK signaling pathways. STZ
16  2019 Paeoniflorin protects spiral ganglion neurons from cisplatin-induced ototoxicity: Possible relation to PINK1/BAD pathway. ROS, SGN
17  2019 Paeoniflorin reduced the cardiotoxicity of aconitine in h9c2 cells. ACO, LDH, MDA, SOD
18  2019 Preparation, physicochemical characterization and pharmacokinetics of paeoniflorin-phospholipid complex. DSC, FTIR, PF-PLC, XRD
19  2019 Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration. AF, DDI, GA, GL, ILA, ILT, LA, LT, SGD
20  2019 Simultaneous determination of curcumin, tetrahydrocurcumin, quercetin, and paeoniflorin by UHPLC-MS/MS in rat plasma and its application to a pharmacokinetic study. CUR, ESI, IS, QR, SRM, THC
21  2019 The mechanism of action of Lipiburn on fat metabolism. ---
22  2018 ADAM17 participates in the protective effect of paeoniflorin on mouse brain microvascular endothelial cells. A1R, ADAM17, EGFR, sTNFR1, TNFR1
23  2018 Anti-Tumor Effects of Paeoniflorin on Epithelial-To-Mesenchymal Transition in Human Colorectal Cancer Cells. CRC, E-cadherin, EMT, HDAC2
24  2018 Anxiolytic-like effects of paeoniflorin in an animal model of post traumatic stress disorder. 5-HIAA, ACTH, CFP, CORT, CRH, EPM, OF, PTSD, SPS
25  2018 Cytoprotective effects of paeoniflorin are associated with translocator protein 18 kDa. ---
26  2018 Effects of paeoniflorin on neurobehavior, oxidative stress, brain insulin signaling, and synaptic alterations in intracerebroventricular streptozotocin-induced cognitive impairment in mice. i.c.v, MMP, MWM, STZ
27  2018 Interaction between Saikosaponin D, Paeoniflorin, and Human Serum Albumin. CD, HSA, SSD
28  2018 Neuroprotection by Paeoniflorin against Nuclear Factor Kappa B-Induced Neuroinflammation on Spinal Cord Injury. COX-2, iNOS, NF-kappaB, NO, SCI
29  2018 Paeoniflorin ameliorates collagen-induced arthritis via suppressing nuclear factor-kappaB signalling pathway in osteoclast differentiation. CIA, RA
30  2018 Paeoniflorin Antagonizes TNF-alpha-Induced L929 Fibroblastoma Cells Apoptosis by Inhibiting NF-kappaBp65 Activation. RA, TNF-alpha
31  2018 Paeoniflorin attenuates atRAL-induced oxidative stress, mitochondrial dysfunction and endoplasmic reticulum stress in retinal pigment epithelial cells via triggering Ca2+/CaMKII-dependent activation of AMPK. AMD, AMPK, atRAL, CaMKII, ER, RPE
32  2018 Paeoniflorin Attenuates Inflammatory Pain by Inhibiting Microglial Activation and Akt-NF-kappaB Signaling in the Central Nervous System. ---
33  2018 Paeoniflorin augments systemic Candida albicans infection through inhibiting Th1 and Th17 cell expression in a mouse model. C. albicans, FCZ, IFN-gamma, IL, TNF-alpha
34  2018 Paeoniflorin exerts antitumor effects by inactivating S phase kinase-associated protein 2 in glioma cells. Skp
35  2018 Paeoniflorin exerts neuroprotective effects by modulating the M1/M2 subset polarization of microglia/macrophages in the hippocampal CA1 region of vascular dementia rats via cannabinoid receptor 2. CB2R, VD
36  2018 Paeoniflorin has anti-inflammation and neurogenesis functions through nicotinic acetylcholine receptors in cerebral ischemia-reperfusion injury rats. nAChR
37  2018 Paeoniflorin improves cardiac function and decreases adverse postinfarction left ventricular remodeling in a rat model of acute myocardial infarction. AMI, BNP, IL-10, IL-6, LVEF, TNF-alpha
38  2018 Paeoniflorin induces G2/M cell cycle arrest and caspase-dependent apoptosis through the upregulation of Bcl-2 X-associated protein and downregulation of B-cell lymphoma 2 in human osteosarcoma cells. ---
39  2018 Paeoniflorin influences breast cancer cell proliferation and invasion via inhibition of the Notch‑1 signaling pathway. HES, TCM
40  2018 Paeoniflorin inhibits cell growth and induces cell cycle arrest through inhibition of FoxM1 in colorectal cancer cells. ---
41  2018 Paeoniflorin inhibits IL‑1beta‑induced expression of inflammatory mediators in human osteoarthritic chondrocyte. IL, OA
42  2018 Paeoniflorin inhibits mast cell-mediated allergic inflammation in allergic rhinitis. MAPK, NF-kappaB, PMACI
43  2018 Paeoniflorin Inhibits Migration and Invasion of Human Glioblastoma Cells via Suppression Transforming Growth Factor beta-Induced Epithelial-Mesenchymal Transition. EMT
44  2018 Paeoniflorin inhibits PDGF‑BB‑induced human airway smooth muscle cell growth and migration. ASMCs, PDGF, PI3K
45  2018 Paeoniflorin Inhibits Receptor Activator for Nuclear Factor kappaB (RANK) Ligand-Induced Osteoclast Differentiation In Vitro and Particle-Induced Osteolysis In Vivo. RANK, RANKL
46  2018 Paeoniflorin inhibits Rho kinase activation in joint synovial tissues of rats with collagen-induced rheumatoid arthritis. CIA, IL-1beta, IL-6, RA, TNF-alpha
47  2018 Paeoniflorin inhibits VSMCs proliferation and migration by arresting cell cycle and activating HO-1 through MAPKs and NF-kappaB pathway. VSMCs
48  2018 Paeoniflorin prevents endoplasmic reticulum stress-associated inflammation in lipopolysaccharide-stimulated human umbilical vein endothelial cells via the IRE1alpha/NF-kappaB signaling pathway. 4-PBA, CHOP, ED, ER, HUVEC, IL-6, IRE1alpha, LPS, MCP-1, NF-kappaB, TEM
49  2018 Paeoniflorin Promotes Angiogenesis in A Vascular Insufficiency Model of Zebrafish in vivo and in Human Umbilical Vein Endothelial Cells in vitro. Flt-1, hpf, HUVECs, ISVs, KDR, kdrl, PCR, VEGF, vWF
50  2018 Paeoniflorin protects against liver ischemia/reperfusion injury in mice via inhibiting HMGB1-TLR4 signaling pathway. HMGB1, I/R, TLR4
51  2018 Paeoniflorin reduces neomycin-induced ototoxicity in hair cells by suppression of reactive oxygen species generation and extracellularly regulated kinase signalization. ERK, HCs, ROS
52  2018 Tetramethylpyrazine and Paeoniflorin Inhibit Oxidized LDL-Induced Angiogenesis in Human Umbilical Vein Endothelial Cells via VEGF and Notch Pathways. HUVECs, oxLDL, TMP, VEGF, VEGFR2
53  2018 [Experimental Study on Paeoniflorin Inhibiting mTOR Signaling Pathway in Adjuvant Arthritis Rats]. FLS
54  2017 Anti-Inflammatory Effects, SAR, and Action Mechanism of Monoterpenoids from Radix Paeoniae Alba on LPS-Stimulated RAW 264.7 Cells. AF, BAF, DAF, GAF, IL-6, iNOS, LPS, MAPK, MBPF, MPF, NF-kappaB, NO, PD, PDA, PI3K, RT-PCR, TNF-alpha
55  2017 Beneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats. AST, FFA, HFD, HOMA-IR, NAFLD, TC, TG
56  2017 Concentration‑dependent effects of paeoniflorin on proliferation and apoptosis of vascular smooth muscle cells. CDK, VSMCs
57  2017 Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo. STO
58  2017 Neuroprotection by Paeoniflorin in the MPTP mouse model of Parkinson's disease. DAT, MPTP, PD, TH
59  2017 Paeoniflorin ameliorates Adriamycin-induced nephrotic syndrome through the PPARgamma/ANGPTL4 pathway in vivo and vitro. ADR, ANGPTL4, HE, NS, PPARgamma
60  2017 Paeoniflorin ameliorates AGEs-induced mesangial cell injury through inhibiting RAGE/mTOR/autophagy pathway. AGEs, DN, LC3, LDH, TEM
61  2017 Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation. CNS, DCs, EAE, IL-6, MS
62  2017 Paeoniflorin attenuates ANIT-induced cholestasis by inhibiting apoptosis in vivo via mitochondria-dependent pathway. ANIT
63  2017 Paeoniflorin Attenuates Cerebral Ischemia-Induced Injury by Regulating Ca2+/CaMKII/CREB Signaling Pathway. CaM, CaMKII, CREB, MCAO, NMDA
64  2017 Paeoniflorin attenuates incipient diabetic nephropathy in streptozotocin-induced mice by the suppression of the Toll-like receptor-2 signaling pathway. DN, TLRs
65  2017 Paeoniflorin attenuates the neuroinflammatory response in a rat model of chronic constriction injury. CCI, IL, TNF
66  2017 Paeoniflorin exerts neuroprotective effects against glutamate‑induced PC12 cellular cytotoxicity by inhibiting apoptosis. ---
67  2017 Paeoniflorin improves regional cerebral blood flow and suppresses inflammatory factors in the hippocampus of rats with vascular dementia. BCCAO, IL-1beta, IL-6, MTT, NF-kappaB, PWI, rCBF, rCBV, TNF-alpha, VD
68  2017 Paeoniflorin suppresses lipid accumulation and alleviates insulin resistance by regulating the Rho kinase/IRS-1 pathway in palmitate-induced HepG2Cells. GSK, IRS, PA
69  2017 Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression. ---
70  2017 Preparation and Chromatographic Application of beta-Cyclodextrin Molecularly Imprinted Microspheres for Paeoniflorin. AA, AF, beta-CD, MIMs, NIMs, PGMA
71  2017 Prophylactic topical paeoniflorin prevents mechanical allodynia caused by paclitaxel in mice through adenosine A1 receptors. A1R, ER, PTX
72  2017 Reduction of Ischemic Brain Edema by Combined use of Paeoniflorin and Astragaloside IV via Down-Regulating Connexin 43. AQP4, AS-IV, Cx43, ERK, JNK
73  2017 Synergistic effects of Chuanxiong-Chishao herb-pair on promoting angiogenesis at network pharmacological and pharmacodynamic levels. CCHP, ESRalpha, HIF-1alpha, RT-PCR
74  2017 The effects of 18beta-glycyrrhetinic acid and glycyrrhizin on intestinal absorption of paeoniflorin using the everted rat gut sac model. 18beta-GA, P-gp
75  2017 [Paeoniflorin ameliorates liver injury of MRL/lpr mice through inhibition of NF-kappaB pathway]. ALT, AST, RIP140, TLR4
76  2016 Elucidation of Transport Mechanism of Paeoniflorin and the Influence of Ligustilide, Senkyunolide I and Senkyunolide A on Paeoniflorin Transport through Mdck-Mdr1 Cells as Blood-Brain Barrier in Vitro Model. LIG, SENA, SENI, TEER
77  2016 Enhancement of Exposure and Reduction of Elimination for Paeoniflorin or Albiflorin via Co-Administration with Total Peony Glucosides and Hypoxic Pharmacokinetics Comparison. AF, TPG, UPLC-MS
78  2016 Hematopoietic Effects of Paeoniflorin and Albiflorin on Radiotherapy-Induced Myelosuppression Mice. AF, GM-CSF, IL-3, TCM, TNF-alpha, WBC
79  2016 Neuroprotective Effects of Paeoniflorin on 6-OHDA-Lesioned Rat Model of Parkinson's Disease. alpha-Syn, ASICs, DA, PD
80  2016 Paeoniflorin alleviates non-alcoholic steatohepatitis in rats: Involvement with the ROCK/NF-kappaB pathway. ALT, AST, LDL, NASH, NF, TC, TGF-beta, TNF-alpha
81  2016 Paeoniflorin ameliorates symptoms of experimental Sjogren's syndrome associated with down-regulating Cyr61 expression. SS
82  2016 Paeoniflorin and Albiflorin Attenuate Neuropathic Pain via MAPK Pathway in Chronic Constriction Injury Rats. AF, IL-1beta, p-JNK, p38 MAPK, TNF-alpha
83  2016 Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke. ROS, SD
84  2016 Paeoniflorin attenuates hepatic ischemia/reperfusion injury via anti-oxidative, anti-inflammatory and anti-apoptotic pathways. ALT, AST, GSH-Px, HI/R, IL, MDA, SOD
85  2016 Paeoniflorin attenuates hippocampal damage in a rat model of vascular dementia. BCCAO, Bcl-2, BDNF, NSE, VD
86  2016 Paeoniflorin attenuates ultraviolet B-induced apoptosis in human keratinocytes by inhibiting the ROS-p38-p53 pathway. ROS, UV
87  2016 Paeoniflorin inhibits high glucose-induced macrophage activation through TLR2-dependent signal pathways. BMDM, HG, iNOS, TLR2, TLRs, Trif
88  2016 Paeoniflorin inhibits imiquimod-induced psoriasis in mice by regulating Th17 cell response and cytokine secretion. IMQ, MTX
89  2016 Paeoniflorin inhibits proliferation and invasion of breast cancer cells through suppressing Notch-1 signaling pathway. ---
90  2016 Paeoniflorin prevents hypoxia-induced epithelial-mesenchymal transition in human breast cancer cells. EMT
91  2016 Paeoniflorin protects diabetic mice against myocardial ischemic injury via the transient receptor potential vanilloid 1/calcitonin gene-related peptide pathway. CaMK, CGRP, CREB, MI, TRPV1
92  2016 Paeoniflorin protects Schwann cells against high glucose induced oxidative injury by activating Nrf2/ARE pathway and inhibiting apoptosis. ARE, Bcl-2, DPN, gamma-GCS, GPx, GST, HO-1, Keap1, MDA, Nrf2, ROS
93  2016 Paeoniflorin suppresses IL-6/Stat3 pathway via upregulation of Socs3 in dendritic cells in response to 1-chloro-2,4-dinitrobenze. ACD, DCs, DNCB, RORgammat, siRNA, SOCS3
94  2016 Paeoniflorin suppresses inflammatory response in imiquimod-induced psoriasis-like mice and peripheral blood mononuclear cells (PBMCs) from psoriasis patients. DCs, IMQ, PBMCs, TGP
95  2016 Pharmacokinetics and pharmacodynamics of glycyrrhetinic acid with Paeoniflorin after transdermal administration in dysmenorrhea model mice. GA, PK/PD
96  2016 Pharmacokinetics, Safety, and Tolerability of Amygdalin and Paeoniflorin After Single and Multiple Intravenous Infusions of Huoxue-Tongluo Lyophilized Powder for Injection in Healthy Chinese Volunteers. AD, HTLPI
97  2016 Protective Effects of Paeoniflorin Against MPP(+)-induced Neurotoxicity in PC12 Cells. LDH
98  2016 Protective effects of paeoniflorin and albiflorin on chemotherapy-induced myelosuppression in mice. AF, ELISA, GM-CSF, i.p, IL-3, IL-6, RIA, TCM, TNF-alpha, WBC
99  2016 Synergistic protective effect of paeoniflorin and beta-ecdysterone against rotenone-induced neurotoxicity in PC12 cells. beta-Ecd, NF-kappaB, Nrf2, PD, PKCdelta, ROS
100  2016 Unique immunomodulatory effect of paeoniflorin on type I and II macrophages activities. ---