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Abbreviation : PHD
Long Form : prolyl hydroxylase
No. Year Title Co-occurring Abbreviation
2020 Carcinogenicity Assessment of Daprodustat (GSK1278863), a Hypoxia-Inducible Factor (HIF)-Prolyl Hydroxylase Inhibitor. HIF
2020 DMOG, a Prolyl Hydroxylase Inhibitor, Increases Hemoglobin Levels without Exacerbating Hypertension and Renal Injury in Salt-Sensitive Hypertensive Rats. CKD, DMOG, rHuEPO
2020 Effects of a prolyl hydroxylase inhibitor on kidney and cardiovascular complications in a rat model of chronic kidney disease. CKD, CVD, HIFs
2020 HIF-1 stabilization exerts anticancer effects in breast cancer cells in vitro and in vivo. HIF-1, VEGF
2020 Hydrogen sulfide inhibits cigarette smoke-induced inflammation and injury in alveolar epithelial cells by suppressing PHD2/HIF-1alpha/MAPK signaling pathway. CS, CSE, HIF
2020 Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model. HIF, OGD
2020 Inhibition of oxygen-sensing prolyl hydroxylases increases lipid accumulation in human primary tubular epithelial cells without inducing ER stress. AMPK, CsA, ER, HIF, hPTEC, PHD2, PHDi
2020 Prolyl hydroxylase 3 controls the intestine goblet cell generation through stabilizing ATOH1. DSS
2020 Prolyl-hydroxylase inhibitors reconstitute tumor blood vessels in mice. TME
10  2020 [The effect of PHD inhibitor on tumor microenvironment and tumor immune response]. HIFs
11  2019 Acute Methylmercury Exposure and the Hypoxia-Inducible Factor-1alpha Signaling Pathway under Normoxic Conditions in the Rat Brain and Astrocytes in Vitro. DCFH-DA, EPO, GLUT1, HIF-1alpha, LDH, NAC, ROS, siRNA, UPS, VEGF-A
12  2019 Are prolyl-hydroxylase inhibitors potential alternative treatments for anaemia in patients with chronic kidney disease? CVD, EPO, ESAs
13  2019 Controlling the Phenotype of Tumor-Infiltrating Macrophages via the PHD-HIF Axis Inhibits Tumor Growth in a Mouse Model. FG, HIF, TME
14  2019 Hypoxia-inducible factor 1alpha (HIF-1alpha) is a major determinant in the enhanced function of muscle-derived progenitors from MRL/MpJ mice. HIF, HIF-1alpha, MDSPC, Pax, WT
15  2019 Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates. PHDs
16  2019 Neuroprotective action of PHD inhibitors is predominantly HIF-1-independent: An Editorial for 'Sex differences in neonatal mouse brain injury after hypoxia-ischemia and adaptaquin treatment' on page 759. ---
17  2019 Resveratrol integrates metabolic and growth effects in PC3 prostate cancer cells-involvement of prolyl hydroxylase and hypoxia inducible factor-1. RES
18  2019 RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response. HIF, PHDs, VHL
19  2019 SF-deferoxamine, a bone-seeking angiogenic drug, prevents bone loss in estrogen-deficient mice. DFO, HIF, IDA
20  2019 Stabilization of Hypoxia Inducible Factor-1alpha by Dimethyloxalylglycine Promotes Recovery from Acute Spinal Cord Injury by Inhibiting Neural Apoptosis and Enhancing Axon Regeneration. DMOG, HIF-1alpha, SCI
21  2019 Systemic silencing of PHD2 causes reversible immune regulatory dysfunction. ---
22  2019 TP0463518, a Novel Prolyl Hydroxylase Inhibitor, Specifically Induces Erythropoietin Production in the Liver. EPO, HIF-2alpha
23  2019 Yak-milk-derived exosomes promote proliferation of intestinal epithelial cells in an hypoxic environment. HSP70, IEC, VEGF
24  2018 Acetylation-mediated Siah2 stabilization enhances PHD3 degradation in Helicobacter pylori-infected gastric epithelial cancer cells. ac-Siah2, HIF-1alpha, SIAH
25  2018 Activation of Nrf2 and Hypoxic Adaptive Response Contribute to Neuroprotection Elicited by Phenylhydroxamic Acid Selective HDAC6 Inhibitors. HDAC
26  2018 Developmental abnormalities of the otic capsule and inner ear following application of prolyl-hydroxylase inhibitors in chick embryos. muCT, NCCs
27  2018 Dimethyloxalylglycine preserves the intestinal microvasculature and protects against intestinal injury in a neonatal mouse NEC model: role of VEGF signaling. DMOG, HIF-1alpha, VEGF
28  2018 Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against cisplatin-induced acute kidney injury. AKI, BUN, CKD, HIF, KIM-1, NGAL, PAS, SCr
29  2018 Inhibition of prolyl hydroxylases alters cell metabolism and reverses pre-existing diastolic dysfunction in mice. DMOG, HIF, SIRT3
30  2018 L-ascorbic acid: A true substrate for HIF prolyl hydroxylase? alpha-KG, D-Asc, L-Asc, NAC
31  2018 Loss of Prolyl-Hydroxylase 1 Protects against Biliary Fibrosis via Attenuated Activation of Hepatic Stellate Cells. HIFs, HSCs
32  2018 Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin. SOST
33  2018 Phase I Clinical Study of ZYAN1, A Novel Prolyl-Hydroxylase (PHD) Inhibitor to Evaluate the Safety, Tolerability, and Pharmacokinetics Following Oral Administration in Healthy Volunteers. EPO, t max
34  2018 Reactive Oxygen Species Formation in the Brain at Different Oxygen Levels: The Role of Hypoxia Inducible Factors. HIF, NOX, ROS, TCA cycle
35  2018 SIRT6 overexpression inhibits HIF1alpha expression and its impact on tumor angiogenesis in lung cancer. MVD, qPCR, SIRT6
36  2018 The Protein Phosphatase PPM1G Destabilizes HIF-1alpha Expression. HIFs, PPM1G, VHL
37  2018 Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function. AMPK, CKD, HIF-1alpha, HIF-PHI, HO-1, MMP, Nrf2, OCR, PD, PGC-1alpha, ROS, SOD2, TH
38  2018 [Current insights into the role of HIF-PHD axis in renal anemia]. EPO, HIF
39  2017 Andrographolide inhibits hypoxia-induced HIF-1alpha-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells. ET-1, HIF-1alpha, HO-1, PHDs, ROS
40  2017 Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia. ---
41  2017 Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin. hTRPA1, ROS, TRPA1
42  2017 Hypoxia Inducible Factor-2 Alpha and Prolinhydroxylase 2 Polymorphisms in Patients with Acute Respiratory Distress Syndrome (ARDS). ARDS, CT, HIF-2alpha, SNP
43  2017 Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2. HIF-1alpha
44  2017 PHD3 is a transcriptional coactivator of HIF-1alpha in nucleus pulposus cells independent of the PKM2-JMJD5 axis. C-TAD, HIF, NP, PKM
45  2017 Relative Contribution of Prolyl Hydroxylase-Dependent and -Independent Degradation of HIF-1alpha by Proteasomal Pathways in Cerebral Ischemia. HIF-1
46  2017 Targeting Oxygen-Sensing Prolyl Hydroxylase for Metformin-Associated Lactic Acidosis Treatment. CKD, HIF, MALA
47  2017 The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits. ---
48  2017 The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1alpha prolyl hydroxylation by regulating cellular iron levels. HIFs, V-ATPase
49  2017 Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL. AURKA, HIF-alpha, VHL
50  2017 [Research on Relationship of HIF-1 Signaling Pathway and Postmenstrual Osteoporosis]. C group, ELISA, ERK, FIH, HIF-1, NF-kappaB, PMOP
51  2016 beta-N-oxalyl-L-alpha, beta- diaminopropionic acid induces HRE expression by inhibiting HIF-prolyl hydroxylase-2 in normoxic conditions. HIF, HRE
52  2016 Cell-permeable iron inhibits vascular endothelial growth factor receptor-2 signaling and tumor angiogenesis. FAC, HIF, VEGF, VEGFR2
53  2016 Changes in Hypoxia-Inducible Factor-1 (HIF-1) and Regulatory Prolyl Hydroxylase (PHD) Enzymes Following Hypoxic-Ischemic Injury in the Neonatal Rat. HI, HIF-1
54  2016 Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS. ROS, TRPA1
55  2016 Dimethyloxaloylglycine Promotes the Angiogenic Activity of Mesenchymal Stem Cells Derived from iPSCs via Activation of the PI3K/Akt Pathway for Bone Regeneration. Akt, DMOG, HIF-1alpha, hiPSC-MSCs, MSCs, PI3K
56  2016 Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia. HIF, HIF PHD1-3
57  2016 Expanding roles of the hypoxia-response network in chronic kidney disease. CKD, ESKD, HIFs
58  2016 High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I. HDLs, HIF-1alpha, rHDL, SR-BI, VEGF
59  2016 Hyperplasia and hypertrophy of pulmonary neuroepithelial bodies, presumed airway hypoxia sensors, in hypoxia-inducible factor prolyl hydroxylase-deficient mice. NEBs
60  2016 Hypoxia inducible factor-1 alpha and prolinhydroxlase 2 polymorphisms in patients with severe sepsis: a prospective observational trial. HIF-1alpha, SNP
61  2016 Hypoxia-induced sensitisation of TRPA1 in painful dysesthesia evoked by transient hindlimb ischemia/reperfusion in mice. ROS, TRPA1
62  2016 Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche. Th
63  2016 Pharmacological Characterization of ZYAN1, a Novel Prolyl Hydroxylase Inhibitor for the Treatment of Anemia. EPO, HIF
64  2016 PHD/HIF-1 upregulates CA12 to protect against degenerative disc disease: a human sample, in vitro and ex vivo study. CA12, DMOG, HIF-1alpha, NP
65  2016 pVHL mediates K63-linked ubiquitination of IKKbeta, leading to IKKbeta inactivation. NF
66  2016 Pyrithione Zn selectively inhibits hypoxia-inducible factor prolyl hydroxylase PHD3. HIF, PZ
67  2016 Sestrin2 inhibits hypoxia-inducible factor-1alpha accumulation via AMPK-mediated prolyl hydroxylase regulation. Ad-SESN2, AMPK, DMOG, HIF-1alpha, HRE, Sesn2
68  2016 Stabilization of HIF-1alpha by FG-4592 promotes functional recovery and neural protection in experimental spinal cord injury. HIF-1alpha, PHDI, TBHP
69  2016 Tetramethylpyrazine protects CoCl2-induced apoptosis in human umbilical vein endothelial cells by regulating the PHD2/HIF/1alpha-VEGF pathway. Bcl, HIF, HUVECs, si, TMP, VEGF
70  2016 The expression and function of E3 ligase SIAH2 in acute T lymphoblastic leukemia. BMMNCs, EMI, ITP, Lv-shSIAH2, qRT-PCR, SIAH2, T-ALL
71  2016 The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells. DMOG, ESC, HIF, JNJ, mESC, SC
72  2015 Augmented 5-HT Secretion in Pulmonary Neuroepithelial Bodies from PHD1 Null Mice. HIFs, NEB
73  2015 Diacylglycerol kinase (DGK) inhibitor II (R59949) could suppress retinal neovascularization and protect retinal astrocytes in an oxygen-induced retinopathy model. DGK, HIF, NV, OIR, VEGF
74  2015 Effects of HIF prolyl-hydroxylase-2 gene silencing on HCG-induced vascular endothelial growth factor expression in luteal cells. hCG, HIF, LCs, VEGF
75  2015 Effects of Prolyl Hydroxylase Inhibitor L-mimosine on Dental Pulp in the Presence of Advanced Glycation End Products. AGEs, DPCs, IL, L-MIM, VEGF
76  2015 Expression and clinical significance of the HIF-1a/ET-2 signaling pathway during the development and treatment of polycystic ovary syndrome. ET, HIF, PCOS
77  2015 Genetic modification of hypoxia signaling in animal models and its effect on cancer. ---
78  2015 Germ-line PHD1 and PHD2 mutations detected in patients with pheochromocytoma/paraganglioma-polycythemia. EPO, EPOR, HIF2A, PHEO/PGL
79  2015 Hypoxia-Inducible Factor alpha and Hif-prolyl Hydroxylase Characterization and Gene Expression in Short-Time Air-Exposed Mytilus galloprovincialis. HIF
80  2015 Insights into the proline hydroxylase (PHD) family, molecular evolution and its impact on human health. ---
81  2015 Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin. HIF, OPG
82  2015 Phospholipase D2 promotes degradation of hypoxia-inducible factor-1alpha independent of lipase activity. HIF-1alpha, VHL
83  2015 Prolyl hydroxylase inhibition corrects functional iron deficiency and inflammation-induced anaemia in rats. DMT1, FID, MCH, MCV, PGPS, rhEPO
84  2015 Prolyl hydroxylase inhibitors act as agents to enhance the efficiency of cell therapy. HIF-1
85  2015 Prolyl-4-hydroxylase domain protein 2 controls NF-kappaB/p65 transactivation and enhances the catabolic effects of inflammatory cytokines on cells of the nucleus pulposus. HIF, NP
86  2015 The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5. EGFR, HIF-1alpha, PH, PLD, VHL
87  2014 Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis. HIF, IL, PHDi, TNF
88  2014 HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore. HIF-1, HKII, IRI, mPTP, PDK1
89  2014 In vitro release of dimethyloxaloylglycine and l-mimosine from bovine bone mineral. ---
90  2014 Modeling the dynamics of hypoxia inducible factor-1alpha (HIF-1alpha) within single cells and 3D cell culture systems. HIF, HIF-1alpha
91  2014 PHDs inhibitor DMOG promotes the vascularization process in the AV loop by HIF-1a up-regulation and the preliminary discussion on its kinetics in rat. AV loop, DMOG, HIF
92  2014 Phospholipase D1 protein coordinates dynamic assembly of HIF-1alpha-PHD-VHL to regulate HIF-1alpha stability. HIF-1alpha, PLD1, VHL
93  2014 Prolyl hydroxylase inhibitors protect from the bone loss in ovariectomy rats by increasing bone vascularity. HIF-1alpha, PI3K, VEGF
94  2014 Radiation promotes malignant progression of glioma cells through HIF-1alpha stabilization. HB-MEC, HIF-1, pVHL
95  2014 RUNX3 inhibits hypoxia-inducible factor-1alpha protein stability by interacting with prolyl hydroxylases in gastric cancer cells. HIF, VEGF
96  2014 Short-term treatment with a novel HIF-prolyl hydroxylase inhibitor (GSK1278863) failed to improve measures of performance in subjects with claudication-limited peripheral artery disease. 6MWT, HIF, PAD
97  2014 Study on the expressions of PHD and HIF in placentas from normal pregnant women and patients with preeclampsia. EP, GH, HIF, MP, PE
98  2014 The prolyl hydroxylase inhibitor dimethyloxalylglycine enhances dentin sialophoshoprotein expression through VEGF-induced Runx2 stabilization. DMOG, DSPP, VEGF
99  2014 Tight control of hypoxia-inducible factor-alpha transient dynamics is essential for cell survival in hypoxia. HIF
100  2014 TNF stimulation induces VHL overexpression and impairs angiogenic potential in skeletal muscle myocytes. COPD, GLUT1, HIF1-alpha, PCS, TNF, Ube2D1, VEGF, VHL