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Abbreviation : PHGDH
Long Form : phosphoglycerate dehydrogenase
No. Year Title Co-occurring Abbreviation
2019 Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation. DSF, SAR
2019 Azacoccone E inhibits cancer cell growth by targeting 3-phosphoglycerate dehydrogenase. CETSA, MST
2019 Cystathionine as a marker for 1p/19q codeleted gliomas by in vivo magnetic resonance spectroscopy. CTH, LC-MS, MRS
2019 Increased PHGDH expression promotes aberrant melanin accumulation. ---
2019 Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting. ---
2019 Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. ---
2019 Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis. ---
2019 Ixocarpalactone A from dietary tomatillo inhibits pancreatic cancer growth by targeting PHGDH. 3-PG, p-Pyr
2019 NRF2 SUMOylation promotes de novo serine synthesis and maintains HCC tumorigenesis. HCC, Nrf2, ROS
10  2019 Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E. ---
11  2019 Proteomic Study of a Parkinson's Disease Model of Undifferentiated SH-SY5Y Cells Induced by a Proteasome Inhibitor. AO/EB, LBP, MTHSP75, MTT, PD, PSI, PSI
12  2019 Splicing factor ESRP1 controls ER-positive breast cancer by altering metabolic pathways. EMT, ESRP1 and ESRP2, FASN, SCD1
13  2018 A Vinyl Sulfone-Based Fluorogenic Probe Capable of Selective Labeling of PHGDH in Live Mammalian Cells. ---
14  2018 Astrocytes in primary cultures express serine racemase, synthesize d-serine and acquire A1 reactive astrocyte features. GFAP, GLDC, NMDAR, SR
15  2018 Deletion of PHGDH in adipocytes improves glucose intolerance in diet-induced obese mice. ---
16  2018 Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors. ---
17  2018 Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis. TGF
18  2018 LncRNA PlncRNA-1 overexpression inhibits the growth of breast cancer by upregulating TGF-beta1 and downregulating PHGDH. ---
19  2018 Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase. EGFR-TKIs
20  2018 Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells. BCSLCs, BTICs, CSLCs, ECSLCs
21  2018 Resistant to Targeted Therapy - Aim for Metabolic Liabilities. ---
22  2018 Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism. ---
23  2018 Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells. ECs, ETC, PHGDHKD, SSP
24  2018 Shift from stochastic to spatially-ordered expression of serine-glycine synthesis enzymes in 3D microtumors. SGS
25  2018 The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis. ---
26  2018 Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer. ---
27  2017 alpha-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH). ---
28  2017 Bortezomib resistance in multiple myeloma is associated with increased serine synthesis. BTZ
29  2017 Challenges and Opportunities in the Development of Serine Synthetic Pathway Inhibitors for Cancer Therapy. PSAT1, SSP
30  2017 EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma. ---
31  2017 Glyceraldehyde-3-phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase. GAPDH, GAPDH, HCC
32  2017 PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2alpha-Targeting Therapy for Renal Cell Carcinoma. ccRCC, HIF, RCC
33  2017 PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis. ---
34  2017 Phosphoglycerate dehydrogenase (PHGDH) deficiency without epilepsy mimicking primary microcephaly. ---
35  2017 Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity. ---
36  2017 Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH). ---
37  2016 A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase. ---
38  2016 A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. ---
39  2016 Expression of serine/glycine metabolism-related proteins is different according to the thyroid cancer subtype. AC, FC, GLDC, MC, OS, PDC, PSAT, PSPH, PTC, SHMT, TMA
40  2016 High Expression of PHGDH Predicts Poor Prognosis in Non-Small Cell Lung Cancer. NSCLC
41  2016 Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Nrf2
42  2016 Increased Expression of PHGDH and Prognostic Significance in Colorectal Cancer. CRC, qRT-PCR, TMA-IHC
43  2016 Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth. ---
44  2016 PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis. BCSC
45  2016 Phosphoglycerate dehydrogenase is a novel predictor for poor prognosis in gastric cancer. GC
46  2016 Reducing the serine availability complements the inhibition of the glutamine metabolism to block leukemia cell growth. PSAT
47  2016 Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin. shRNA, TNBC
48  2016 Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox. ---
49  2016 Transforming Growth Factor (TGF)-beta Promotes de Novo Serine Synthesis for Collagen Production. IPF, PSAT1, PSPH, SHMT2, TGF
50  2016 Two new cases of serine deficiency disorders treated with l-serine. HC
51  2015 Clinical Implication of Serine Metabolism-Associated Enzymes in Colon Cancer. IHC, PDK, PKM2, pNT, PSAT, SSP, TT
52  2015 Down Regulation of Asparagine Synthetase and 3-Phosphoglycerate Dehydrogenase, and the Up-Regulation of Serine Dehydratase in Rat Liver from Intake of Excess Amount of Leucine Are Not Related to Leucine-Caused Amino Acid Imbalance. ASNS, SDS
53  2015 Downregulation of phosphoglycerate dehydrogenase inhibits proliferation and enhances cisplatin sensitivity in cervical adenocarcinoma cells by regulating Bcl-2 and caspase-3. ---
54  2015 Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate. AKG, d-2HG
55  2015 Identification of a premature stop codon mutation in the PHGDH gene in severe Neu-Laxova syndrome-evidence for phenotypic variability. MRI, NLS, US
56  2015 p53 Protein-mediated regulation of phosphoglycerate dehydrogenase (PHGDH) is crucial for the apoptotic response upon serine starvation. ---
57  2014 Bioinformatics analysis of the serine and glycine pathway in cancer cells. PSAT1, PSPH, SHMT
58  2014 Expression of serine and glycine-related enzymes in phyllodes tumor. GLDC, PSAT1, PSPH, PT, SHMT1
59  2014 p73 regulates serine biosynthesis in cancer. GLS-2, TCA
60  2014 Phosphoglycerate dehydrogenase: potential therapeutic target and putative metabolic oncogene. ---
61  2014 Requirement of the expression of 3-phosphoglycerate dehydrogenase for traversing S phase in murine T lymphocytes following immobilized anti-CD3 activation. ---
62  2014 Site-specific metabolic phenotypes in metastatic breast cancer. ASCT, CA, GDH, GLDC, GLS, MCT, PSAT, PSPH, SDH, SHMT
63  2013 Expression and clinical significance of phosphoglycerate dehydrogenase and squamous cell carcinoma antigen in cervical cancer. SCC-Ag
64  2013 Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1. ---
65  2011 Cancer's sweet tooth for serine. ---
66  2011 Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis. PSAT1, PSPH
67  2011 Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. RNAi, TCA
68  2011 PHGDH amplification and altered glucose metabolism in human melanoma. ---
69  2011 Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. ---
70  2009 Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model. ---
71  2009 Novel mutations in 3-phosphoglycerate dehydrogenase (PHGDH) are distributed throughout the protein and result in altered enzyme kinetics. CSF
72  2009 Proteome alteration of U251 human astrocytoma cell after inhibiting retinoic acid synthesis. CNS, IPA, MALDI-TOF MS, Ra
73  2008 Positive regulation of promoter activity of human 3-phosphoglycerate dehydrogenase (PHGDH) gene is mediated by transcription factors Sp1 and NF-Y. ---
74  2006 Glutamate reduces secretion of l-serine in astrocytes isolated from stroke-prone spontaneously hypertensive rats. IL-1, l-Ser, SHRSP, SNP, WKY
75  2002 V490M, a common mutation in 3-phosphoglycerate dehydrogenase deficiency, causes enzyme deficiency by decreasing the yield of mature enzyme. ---
76  2000 Assignment of human 3-phosphoglycerate dehydrogenase (PHGDH) to human chromosome band 1p12 by fluorescence in situ hybridization. ---
77  2000 Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency--a neurometabolic disorder associated with reduced L-serine biosynthesis. ---