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Abbreviation : PI 3-kinase
Long Form : phosphatidylinositol 3-kinase
No. Year Title Co-occurring Abbreviation
2021 Properties of FDA-approved small molecule phosphatidylinositol 3-kinase inhibitors prescribed for the treatment of malignancies. Ala-Pro-Glu, GPCRs, PI4,5P2, PIP3
2020 Arg-Gly-Asp-modified elastin-like polypeptide regulates cell proliferation and cell cycle proteins via the phosphorylation of Erk and Akt in pancreatic beta-cell. ECM, ELP, ERK
2020 Venous malformations: Coagulopathy control and treatment methods. DIC, LIC, LMWH, mTOR, QoL, VMs
2019 Autophagy Precedes Apoptosis in Angiotensin II-Induced Podocyte Injury. 3-MA, Ang II
2019 Insulin attenuates apoptosis in neuronal cells by an integrin-linked kinase-dependent mechanism. ILK
2019 The origins and evolution of macropinocytosis. ---
2018 IGF1 receptor signaling pathways. GRB2, IGFs, IRSs, MAP kinase, SH2, SHC
2018 Mulberry leaf extract displays antidiabetic activity in db/db mice via Akt and AMP-activated protein kinase phosphorylation. AMP, AMPK, MLE
2017 Critical role for PI3-kinase in regulating the use of proteins as an amino acid source. ---
10  2017 Strong inhibition of neutrophil-sperm interaction in cattle by selective phosphatidylinositol 3-kinase inhibitors. ---
11  2017 The Expanding Significance of Inositol Polyphosphate Multikinase as a Signaling Hub. IPMK
12  2017 The role of phosphatidylinositol-3-OH-kinase (PI3-kinase) and respiratory burst enzymes in the [omim][BF4]-mediated toxic mode of action in mussel hemocytes. ---
13  2017 Ubiquitination of the PI3-kinase VPS-34 promotes VPS-34 stability and phagosome maturation. ---
14  2016 Hydrophobic motif site-phosphorylated protein kinase CbetaII between mTORC2 and Akt regulates high glucose-induced mesangial cell hypertrophy. mTORC1
15  2016 Platelet-derived growth factor (PDGF)-induced activation of Erk5 MAP-kinase is dependent on Mekk2, Mek1/2, PKC and PI3-kinase, and affects BMP signaling. BMPs, PDGF, PDGF-BB, PKC
16  2016 The effect of phosphatidylinositol-3 kinase inhibition on matrix metalloproteinase-9 and reactive oxygen species release from chronic obstructive pulmonary disease neutrophils. COPD, MAP, MMP, ROS
17  2015 Cellular and Molecular Mechanisms of Chronic Kidney Disease with Diabetes Mellitus and Cardiovascular Diseases as Its Comorbidities. CKD, CVD, DM, RAS
18  2015 Harpagoside ameliorates the amyloid-beta-induced cognitive impairment in rats via up-regulating BDNF expression and MAPK/PI3K pathways. AD, BDNF, ChAT, ERK
19  2015 Modulation of Insulin Sensitivity of Hepatocytes by the Pharmacological Downregulation of Phospholipase D. PLD
20  2015 Propofol Treatment Inhibits Constitutive Apoptosis in Human Primary Neutrophils and Granulocyte-Differentiated Human HL60 Cells. GSK, Mcl-1
21  2015 Successful fertility preservation following ovarian tissue vitrification in patients with primary ovarian insufficiency. IVA, POI
22  2015 Transcription factor TIP27 regulates glucose homeostasis and insulin sensitivity in a PI3-kinase/Akt-dependent manner in mice. Akt, G6Pase, GTT, HFD, PEPCK, TIP27-Tg
23  2015 Vaspin alleviates dysfunction of endothelial progenitor cells induced by high glucose via PI3K/Akt/eNOS pathway. NO
24  2014 A positive feedback loop involving Erk5 and Akt turns on mesangial cell proliferation in response to PDGF. PDGFRbeta
25  2014 Aortic superoxide production at the early hyperglycemic stage in a rat type 2 diabetes model and the effects of pravastatin. cPKC, eNOS, LETO, OLETF, PKC
26  2014 Serotonin induces depolarization in lateral amygdala neurons by activation of TRPC-like current and inhibition of GIRK current depending on 5-HT(2C) receptor. GIRK
27  2014 Soluble thrombomodulin is a paracrine anti-apoptotic factor for vascular endothelial protection. EC, TM
28  2014 Steroid-induced oocyte maturation in Indian shad Tenualosa ilisha (Hamilton, 1822) is dependent on phosphatidylinositol 3 kinase but not MAP kinase activation. GVBD, MAP kinase, MEK, MIS, MPF, OM
29  2013 c-Abl-dependent molecular circuitry involving Smad5 and phosphatidylinositol 3-kinase regulates bone morphogenetic protein-2-induced osteogenesis. ---
30  2013 Dual phosphorylation of Btk by Akt/protein kinase b provides docking for 14-3-3zeta, regulates shuttling, and attenuates both tonic and induced signaling in B cells. BCR, BTK, PKB, xid, XLA
31  2013 Focal adhesion kinase regulates collagen I-induced airway smooth muscle phenotype switching. ASM, ECM, FAK, FAT, FRNK, MAPK, MEK
32  2013 Gastrin induces sodium-hydrogen exchanger 3 phosphorylation and mTOR activation via a phosphoinositide 3-kinase-/protein kinase C-dependent but AKT-independent pathway in renal proximal tubule cells derived from a normotensive male human. cPKC
33  2013 Ginsenoside rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell. HUVEC, ICAM-1, JNK, LPS, MEK/ERK, NF-kappaB, p38 MAPK, VCAM-1
34  2013 Opioid mu-receptors as new target for insulin resistance. IRS, MOR
35  2013 Platelet-derived growth factor negatively regulates the insulin-like growth factor signaling pathway through the coordinated action of phosphatidylinositol 3-kinase and protein kinase C beta I. ERK, PDGF, PKD1
36  2013 Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway. EJC
37  2013 Role of herpes simplex virus VP11/12 tyrosine-based motifs in binding and activation of the Src family kinase Lck and recruitment of p85, Grb2, and Shc. HSV-1, PTB, SFK
38  2013 Role of PON2 in innate immune response in an acute infection model. PON2
39  2013 The PDZ-interaction of the intestinal anion exchanger downregulated in adenoma (DRA; SLC26A3) facilitates its movement into Rab11a-positive recycling endosomes. DRA, EGFP, HA
40  2013 The preventive effect of uncarboxylated osteocalcin against free fatty acid-induced endothelial apoptosis through the activation of phosphatidylinositol 3-kinase/Akt signaling pathway. eNOS, LA, OC, ucOC
41  2013 Treponema denticola major outer sheath protein impairs the cellular phosphoinositide balance that regulates neutrophil chemotaxis. fMLP, Msp, PIP3
42  2012 4-O-carboxymethyl ascochlorin causes ER stress and induced autophagy in human hepatocellular carcinoma cells. 3-MA
43  2012 Activation of phosphatidylinositol-3 kinase, AMP-activated kinase and Akt substrate-160 kDa by trans-10, cis-12 conjugated linoleic acid mediates skeletal muscle glucose uptake. AICAR, AMPK, AS160, c9,t11, CLA, GLUT4, t10,c12
44  2012 An amino acid mixture is essential to optimize insulin-stimulated glucose uptake and GLUT4 translocation in perfused rodent hindlimb muscle. AS160
45  2012 Augmentation of ADAMTS9 gene expression by IL-1beta is reversed by NFkappaB and MAPK inhibitors, but not PI3 kinase inhibitors. MAPK, NF-kappaB, PCR
46  2012 Berry fruits modulated endothelial cell migration and angiogenesis via phosphoinositide-3 kinase/protein kinase B pathway in vitro in endothelial cells. CB, SB, WBB
47  2012 Calorie restriction prevents the development of insulin resistance and impaired insulin signaling in skeletal muscle of ovariectomized rats. IRS-1, MAPK, PF, SHAM
48  2012 Evidence for phosphatidylinositol-3-OH-kinase (PI3-kinase) involvement in Cd-mediated oxidative effects on hemocytes of mussels. NO, PKC, PMA
49  2012 Foot-and-mouth disease virus induces autophagosomes during cell entry via a class III phosphatidylinositol 3-kinase-independent pathway. FMDV
50  2012 Functional analysis of non-hotspot AKT1 mutants found in human breast cancers identifies novel driver mutations: implications for personalized medicine. ---
51  2012 Interleukin 10 antioxidant effect decreases leukocytes/endothelial interaction induced by tumor necrosis factor alpha. HUVECs, ICAM-1, IL-10, ROS, TNF-alpha
52  2012 Involvement of c-Src tyrosine kinase upstream of class I phosphatidylinositol (PI) 3-kinases in Salmonella Enteritidis Rck protein-mediated invasion. PI
53  2012 Involvement of PI3 kinase and MAP kinase in IGF-I and insulin-induced ovarian steroidogenesis in common carp Cyprinus carpio. b-insulin, IGF-I, MAP kinase
54  2012 NF-kappaB is the transcription factor for FGF-2 that causes endothelial mesenchymal transformation in cornea. CECs, EMT, IKK, IL, IRAK, MTT, NF-kappaB, TRAF6
55  2012 Phosphatidylinositol 3-kinase and protein kinase D1 specifically cooperate to negatively regulate the insulin-like growth factor signaling pathway. EGF, ERK, FGF, IGF, IRS-1, PKD1
56  2012 PI3 Kinase in Cancer: From Biology to Clinic. ---
57  2012 Preclinical activity of the novel orally bioavailable HSP90 inhibitor NVP-HSP990 against multiple myeloma cells. MM, mTOR
58  2012 Role of phosphatidylinositol 3,4,5-trisphosphate (PIP3) 5-phosphatase skeletal muscle- and kidney-enriched inositol polyphosphate phosphatase (SKIP) in myoblast differentiation. IGFs, PIP3, SKIP
59  2012 Transient receptor potential vanilloid 1 (TRPV1), TRPV4, and the kidney. AKI, TRPV1
60  2012 Valproic acid induces cutaneous wound healing in vivo and enhances keratinocyte motility. alpha-SMA, ERK, TUNEL, VPA
61  2011 A key role for KCl cotransport in cell volume regulation in human erythroleukemia cells. EGFR, MAP, PKC, PTK, RVD
62  2011 Activation of PI3 kinase/Akt signaling in chronic subdural hematoma outer membranes. CSDH, eNOS, VE-cadherin, VEGF
63  2011 Angiotensin-(1-7) attenuates the chronotropic response to angiotensin II via stimulation of PTEN in the spontaneously hypertensive rat neurons. Ang II, PTEN, SHR, WKY
64  2011 Cytosolic phospholipase A2 induction and prostaglandin E2 release by interleukin-1beta via the myeloid differentiation factor 88-dependent pathway and cooperation of p300, Akt, and NF-kappaB activity in human rheumatoid arthritis synovial fibroblasts. cPLA2, EGFR, HB-EGF, IL-1beta, MMP, MyD88, PGE2, RASFs
65  2011 GAIP-interacting protein, C-terminus is involved in the induction of zinc-finger protein 143 in response to insulin-like growth factor-1 in colon cancer cells. GIPC, IGF-1, MAPKs, ROS, ZNF143
66  2011 Genipin up-regulates heme oxygenase-1 via PI3-kinase-JNK1/2-Nrf2 signaling pathway to enhance the anti-inflammatory capacity in RAW264.7 macrophages. ARE, HO-1, Nrf2
67  2011 Human umbilical cord blood-derived mesenchymal stem cells improve glucose homeostasis in rats with liver cirrhosis. G6P, GSK-3, PKB, PKCzeta
68  2011 Morphine and remifentanil-induced cardioprotection: its experimental and clinical outcomes. GSK-3beta, I/R, IPost, Ipre, mPTP, OIC, OPRs, PKC
69  2011 Phosphatidylinositol 3'-kinase, mTOR, and glycogen synthase kinase-3beta mediated regulation of p21 in human urothelial carcinoma cells. ---
70  2011 Ptenb mediates gastrulation cell movements via Cdc42/AKT1 in zebrafish. MOs
71  2011 Signaling of reactive oxygen and nitrogen species in Diabetes mellitus. RNS, ROS, SOD
72  2011 Specific epidermal growth factor receptor autophosphorylation sites promote mouse colon epithelial cell chemotaxis and restitution. EGF, PKC, PLC
73  2011 Suppression of inflammation response by a novel A₃ adenosine receptor agonist thio-Cl-IB-MECA through inhibition of Akt and NF-kappaB signaling. IL-1beta, iNOS, LPS
74  2011 Survival of motor neuron protein over-expression prevents calpain-mediated cleavage and activation of procaspase-3 in differentiated human SH-SY5Y cells. SMA, SMN
75  2011 Transgenic expression of polyomavirus middle T antigen in the mouse prostate gives rise to carcinoma. MMTV, mPIN, MT, RTK
76  2010 Activity and PI3-kinase dependent trafficking of the intestinal anion exchanger downregulated in adenoma depend on its PDZ interaction and on lipid rafts. DRA, LR
77  2010 Agonist monoclonal antibodies against HGF receptor protect cardiac muscle cells from apoptosis. HGF, mAb, shRNA
78  2010 Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L. ER, PI3P
79  2010 Bone morphogenetic protein 4 stimulates attachment of neurospheres and astrogenesis of neural stem cells in neurospheres via phosphatidylinositol 3 kinase-mediated upregulation of N-cadherin. BMP4, NSCs
80  2010 Caffeine and theophylline block insulin-stimulated glucose uptake and PKB phosphorylation in rat skeletal muscles. GLUT4, PKB
81  2010 Cardioprotective PKG-independent NO signaling at reperfusion. CPT-cGMP, GSK-3beta, IPC, l-NAME, NO, SNAP
82  2010 Cellular depletion of atypical PKC{lambda} is associated with enhanced insulin sensitivity and glucose uptake in L6 rat skeletal muscle cells. aPKC, GLUT, IRS-1, PKB
83  2010 Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue. mTOR, mTORC1, PGC-1alpha, S6K1
84  2010 Effects of physiological electric fields on migration of human dermal fibroblasts. ---
85  2010 Evidence that alpha-lipoic acid inhibits NF-kappaB activation independent of its antioxidant function. COX-2, HUVECs, IkappaBalpha, IKK2, LA, NF-kappaB, TNF-alpha
86  2010 Ginsenoside Rg3 increases nitric oxide production via increases in phosphorylation and expression of endothelial nitric oxide synthase: essential roles of estrogen receptor-dependent PI3-kinase and AMP-activated protein kinase. AMPK, eNOS, ER, GR, JNK, NO
87  2010 Identification of focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3-kinase) as Par3 partners by proteomic analysis. FAK, Par3
88  2010 IGF-1 induces expression of zinc-finger protein 143 in colon cancer cells through phosphatidylinositide 3-kinase and reactive oxygen species. DPI, IGF-1, MDC, ZNF143
89  2010 Impact of anti-apoptotic and anti-oxidative effects of bone marrow mesenchymal stem cells with transient overexpression of heme oxygenase-1 on myocardial ischemia. HO-1, MSCs, VEGF
90  2010 Local angiotensin II aggravates cardiac remodeling in hypertension. Ang II, DOCA, NTg, SBP
91  2010 META060 inhibits osteoclastogenesis and matrix metalloproteinases in vitro and reduces bone and cartilage degradation in a mouse model of rheumatoid arthritis. BTK, CIA, GSK-3beta, IL-1beta, RASFs, Syk, TRAP
92  2010 Monocyte chemoattractant protein-1/CC chemokine ligand 2 enhances apoptotic cell removal by macrophages through Rac1 activation. AMs, PMs
93  2010 Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes. GLUT4, IRS
94  2010 Phosphatidylinositol 3-phosphate, an essential lipid in Plasmodium, localizes to the food vacuole membrane and the apicoplast. PI3P
95  2010 PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac. COX-2, DMH, GSK-3beta, NSAIDs, RT-PCR
96  2010 Plumbagin activates ERK1/2 and Akt via superoxide, Src and PI3-kinase in 3T3-L1 cells. ---
97  2010 Poly(I:C) induces BLyS-expression of airway fibroblasts through phosphatidylinositol 3-kinase. BLyS, ERK, JNK, p38 MAPK, Syk, TLR
98  2010 Reciprocal regulation of natriuretic peptide receptors by insulin in adipose cells. NPRs, WAT
99  2010 Role of phosphatidylinositol 3-kinase in friend spleen focus-forming virus-induced erythroid disease. EPO, sf-Stk, SFFV
100  2010 Role of the PI3-kinase signaling pathway in trafficking of the surfactant protein A receptor P63 (CKAP4) on type II pneumocytes. ER, PM, SP-A