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Abbreviation : PI-3 kinase
Long Form : phosphoinositide-3 kinase
No. Year Title Co-occurring Abbreviation
2014 Mechanisms underlying the inhibitory effect of the feed contaminant deoxynivalenol on glucose absorption in broiler chickens. DON
2014 Protein kinase C and P2Y12 take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets. ADP, IGF-1, mTORC1, PKC, TSC2
2012 Antihyperglycemic effect of Annona squamosa hexane extract in type 2 diabetes animal model: PTP1B inhibition, a possible mechanism of action? DPP-IV, GLUT4, GPR40, IR-beta, IRS-1, PTP1B, SIRT1
2011 Bisphenol A impairs insulin signaling and glucose homeostasis and decreases steroidogenesis in rat testis: an in vivo and in silico study. 17beta-HSD, 3beta-HSD, BPA, GLUT2, GLUT8, IR, IRS-1, IRS2, StAR
2010 Bradykinin-induced cell migration and COX-2 production mediated by the bradykinin B1 receptor in glioma cells. B1R, COX-2
2010 PI3 kinase-dependent stimulation of platelet migration by stromal cell-derived factor 1 (SDF-1). SDF-1
2009 Activation of native TRPC1/C5/C6 channels by endothelin-1 is mediated by both PIP3 and PIP2 in rabbit coronary artery myocytes. DAG, ET-1, OAG, PI-PLC, PKC
2009 Antioxidants attenuate hyperglycaemia-mediated brain endothelial cell dysfunction and blood-brain barrier hyperpermeability. BBB, HBMEC, HG, p38 MAPK
2009 Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30. ERK, MR, PKA, VSMC
10  2008 Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. BAT, ERK, STAT3
11  2008 LY 294002 inhibits adenosine receptor activation by a mechanism independent of effects on PI-3 kinase or casein kinase II. ACh, EPPs, MEPP
12  2008 Rapid tumor necrosis factor alpha-induced exocytosis of glutamate receptor 2-lacking AMPA receptors to extrasynaptic plasma membrane potentiates excitotoxicity. AMPARs, GluR2, TNF-alpha
13  2008 The novel orally bioavailable inhibitor of phosphoinositol-3-kinase and mammalian target of rapamycin, NVP-BEZ235, inhibits growth and proliferation in multiple myeloma. CD40L, IGF-1, IL-6, mTOR
14  2007 Critical role for Rsk2 in T-lymphocyte activation. DN, IL-2, KO, MAPK, TCR
15  2007 Interaction and inhibitory cross-talk between endothelin and ErbB receptors in the adult heart. ERK, ET-1, MEK, NRG1beta, PKC, T-tubules
16  2007 Phosphoinositide 3-kinase is not overexpressed in melanocytic lesions. ---
17  2007 Survivin mediates the anti-apoptotic effect of delta-opioid receptor stimulation in cardiomyocytes. DEPV, ERK, RNAi, ROS
18  2006 B-RAF and PI-3 kinase signaling protect melanoma cells from anoikis. ---
19  2006 PI3-kinase-dependent electrogenic intestinal transport of glucose and amino acids. ---
20  2005 EGFR enhances Survivin expression through the phosphoinositide 3 (PI-3) kinase signaling pathway. EGFR, IAP, MAP kinase, PI-3
21  2005 Identification of a novel pathway essential for the immediate-early, interferon-independent antiviral response to enveloped virions. IRF3, ISG56
22  2005 In high glucose protein kinase C-zeta activation is required for mesangial cell generation of reactive oxygen species. NADPH, PDGF, PKCzeta, ROS
23  2004 Dissecting the basis of nongenomic activation of endothelial nitric oxide synthase by estradiol: role of ERalpha domains with known nuclear functions. eNOS, ER, NLS, PM
24  2004 Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase. ---
25  2004 Increased IL-1beta in cortex of aged rats is accompanied by downregulation of ERK and PI-3 kinase. IL-1beta
26  2004 Insulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in motile carcinoma cells. IGF-I, IGF-IR, ROCK
27  2004 NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a. ALCL, NPM-ALK
28  2004 PI 3-kinase, Akt and cell survival. ---
29  2004 The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathway. PTEN, ROS
30  2003 A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling. IRS-1
31  2003 Analysis of triptolide-regulated gene expression in Jurkat cells by complementary DNA microarray. MAP kinase 5
32  2003 C-peptide enhances insulin-mediated cell growth and protection against high glucose-induced apoptosis in SH-SY5Y cells. DAPI, IGF-1R, IR, JNK, MAP, NF-kappaB, TUNEL
33  2003 Decay-accelerating factor induction by tumour necrosis factor-alpha, through a phosphatidylinositol-3 kinase and protein kinase C-dependent pathway, protects murine vascular endothelial cells against complement deposition. Crry, DAF, EC, GPI, mAb, MAPK, NF-kappaB, PKC, RT-PCR, TNF-alpha
34  2003 Evidence for a direct effect of captopril on early steps of insulin action in BC3H-1 myocytes. ACE, AKT, IR, IRS-1
35  2003 Genetic evidence for convergence of c-Kit- and alpha4 integrin-mediated signals on class IA PI-3kinase and the Rac pathway in regulating integrin-directed migration in mast cells. MAPK, SCF
36  2003 High density lipoprotein-induced endothelial nitric-oxide synthase activation is mediated by Akt and MAP kinases. eNOS, HDL, MAP
37  2003 Lysophosphatidylcholine regulates human microvascular endothelial cell expression of chemokines. EC, LPC, MVEC
38  2003 Mechanism of mitochondrial dysfunction in diabetic sensory neuropathy. CREB, NT-3
39  2003 PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. mGluRIs
40  2003 Targeting tumor cells by enhancing radiation sensitivity. EGFR
41  2003 The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3. TCR
42  2002 Human macrophage adhesion on fibronectin: the role of substratum and intracellular signalling kinases. MAPKK, PHSRN, PKC, PSK, PTK, TCPS
43  2002 Lipoarabinomannan-induced cell signaling involves ceramide and mitogen-activated protein kinase. LAM
44  2001 Blocking of c-FLIP(L)--independent cycloheximide-induced apoptosis or Fas-mediated apoptosis by the CC chemokine receptor 9/TECK interaction. CCR9, CHX, GSK-3beta, MAPKs, TECK
45  2001 Rebamipide suppresses formyl-methionyl-leucyl-phenylalanine (fMLP)-induced superoxide production by inhibiting fMLP-receptor binding in human neutrophils. fMLP
46  2000 Cellular signaling in macrophage migration and chemotaxis. WASP
47  2000 Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. AKT2
48  2000 Inhibition of PDK-1 activity causes a reduction in cell proliferation and survival. PDK-1, PKB
49  2000 Role of alpha1A-adrenoceptor in the regulation of glucose uptake into white adipocyte of rats in vitro. CEC, PKC, PLC, WAT
50  2000 The PI3 kinase, p38 SAP kinase, and NF-kappaB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells. DC, ERK, LPS, moDCs, NF, p38SAPK
51  2000 Transcriptional regulation of the TATA-binding protein by Ras cellular signaling. HBV, MEK, RalGDS, TBP
52  1999 Signals from the Ras, Rac, and Rho GTPases converge on the Pak protein kinase in Rat-1 fibroblasts. ERK
53  1999 The oncogenic TEL/PDGFR beta fusion protein induces cell death through JNK/SAPK pathway. JNK/SAPK, MKK4, T/P
54  1998 A phosphatidylinositol 3-kinase inhibitor induces a senescent-like growth arrest in human diploid fibroblasts. MEK-1
55  1998 Akt-dependent and -independent survival signaling pathways utilized by insulin-like growth factor I. IGF-I, PKB
56  1998 Distinct signal transduction pathways are utilized during the tube formation and survival phases of in vitro angiogenesis. ECM, HUVEC, MAPK, PKB
57  1998 Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity. IL-2, PLC-gamma1
58  1998 Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase. NGF
59  1998 Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway. ERK2, HGF/SF, MAP, PKB
60  1998 Phosphoinositide 3-OH kinase activates the beta2 integrin adhesion pathway and induces membrane recruitment of cytohesin-1. BTK, PH
61  1998 Platelet-derived growth factor-BB, insulin-like growth factor-I, and phorbol ester activate different signaling pathways for stimulation of vascular smooth muscle cell migration. IGF-I, PDGF-BB, PKC, PMA, VSMC
62  1997 Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. EPO
63  1997 Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. ---
64  1996 Requirement for phosphoinositide 3-OH kinase in growth hormone signalling to the mitogen-activated protein kinase and p70s6k pathways. GH, IRS-1, MAP
65  1994 Cyclic peptide inhibitors of phosphatidylinositol 3-kinase p85 SH2 domain binding. pTyr