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Abbreviation : PI 3-kinase
Long Form : phosphoinositide 3-kinase
No. Year Title Co-occurring Abbreviation
2020 P-Rex1 Mediates Glucose-Stimulated Rac1 Activation and Insulin Secretion in Pancreatic β-Cells. GSIS, P-Rex1
2019 Control of Muscle Fibro-Adipogenic Progenitors by Myogenic Lineage is Altered in Aging and Duchenne Muscular Dystrophy. DMD, FAPs, GLI1, MPs
2018 PI3-kinase pathway biomarkers in oral cancer and tumor immune cells. CI, HR, mTOR, p-mTOR, PTEN, SCC
2018 Unveiling novel 2-cyclopropyl-3-ethynyl-4-(4-fluorophenyl)quinolines as GPCR ligands via PI3-kinase/PAR-1 antagonism and platelet aggregation valuations; development of a new class of anticancer drugs with thrombolytic effects. GPCR
2017 Neuroblast niche position is controlled by Phosphoinositide 3-kinase-dependent DE-Cadherin adhesion. NBs
2016 Induction of varicella zoster virus DNA replication in dissociated human trigeminal ganglia. NGF, VZV
2016 Long-lasting reduction in clonogenic potential of colorectal cancer cells by sequential treatments with 5-azanucleosides and topoisomerase inhibitors. CRC, ER
2016 RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression. ---
2016 Salinomycin causes migration and invasion of human fibrosarcoma cells by inducing MMP-2 expression via PI3-kinase, ERK-1/2 and p38 kinase pathways. MAPK, MMP, SAL
10  2016 Ursolic acid and rosiglitazone combination improves insulin sensitivity by increasing the skeletal muscle insulin-stimulated IRS-1 tyrosine phosphorylation in high-fat diet-fed C57BL/6J mice. GLUT, HFD, HOMA, IRS, RSG, UA
11  2015 A specific A/T polymorphism in Western tyrosine phosphorylation B-motifs regulates Helicobacter pylori CagA epithelial cell interactions. TPMs
12  2015 Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER. FOXO3, GPER, SERMs and SERDs
13  2015 Growth-stimulatory activity of TIMP-2 is mediated through c-Src activation followed by activation of FAK, PI3-kinase/AKT, and ERK1/2 independent of MMP inhibition in lung adenocarcinoma cells. ECM, MMPs, TIMPs
14  2015 Inhibition of the phosphoinositide 3-kinase pathway for the treatment of patients with metastatic metaplastic breast cancer. CR, MpBCs, PCR, PR, PTEN, SD
15  2014 Lipid droplet formation in response to oleic acid in Huh-7 cells is mediated by the fatty acid receptor FFAR4. PLD
16  2013 Combined inhibition of the phosphoinosityl-3-kinase (PI3Kinase) P110delta subunit and mitogen-extracellular activated protein kinase (MEKinase) shows synergistic cytotoxicity against human acute myeloid leukemia progenitors. AML, MEKinase
17  2013 The phosphoinositide-3-kinase-Akt-mTOR pathway as a therapeutic target in breast cancer. ---
18  2012 The PI3-kinase/mTOR-targeting drug NVP-BEZ235 inhibits growth and IgE-dependent activation of human mast cells and basophils. BA, IgE, MC, mTOR
19  2011 Identification of components of the host type IA phosphoinositide 3-kinase pathway that promote internalization of Listeria monocytogenes. mTOR, PDK1, RNAi
20  2011 Involvement of phosphatidylinositol 5-phosphate in insulin-stimulated glucose uptake in the L6 myotube model of skeletal muscle. ---
21  2011 PDGF-induced vascular smooth muscle cell proliferation is associated with dysregulation of insulin receptor substrates. IRS, PDGF, VSMCs
22  2011 PI 3-kinase and PKCzeta mediate insulin-induced potentiation of NMDA receptor currents in Xenopus oocytes. NMDA, PTKs
23  2011 Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy. HCV, NS4B
24  2011 Repression of cancer cell senescence by PKCiota. PKCiota
25  2011 Tamoxifen promotes superoxide production in platelets by activation of PI3-kinase and NADPH oxidase pathways. ---
26  2011 The c-Fes protein tyrosine kinase as a potential anti-angiogenic target in cancer. VEGFs
27  2010 Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: impact on neuronal viability. ---
28  2010 Effects of interleukin-18 on cardiac fibroblast function and gene expression. JNK
29  2010 GPIbalpha-selective activation of platelets induces platelet signaling events comparable to GPVI activation events. CRP, GP, vWF
30  2010 Second AKT: the rise of SGK in cancer signalling. SGK
31  2010 Thyroid hormone potentiates insulin signaling and attenuates hyperglycemia and insulin resistance in a mouse model of type 2 diabetes. IRS, siRNA, TRalpha1
32  2009 Analysis of phosphatidylinositol 3,4,5 trisphosphate 5-phosphatase activity by in vitro and in vivo assays. ---
33  2009 Apelin inhibits insulin secretion in pancreatic beta-cells by activation of PI3-kinase-phosphodiesterase 3B. GLP-1, PDE3B
34  2009 Branched-chain amino acid-containing dipeptides, identified from whey protein hydrolysates, stimulate glucose uptake rate in L6 myotubes and isolated skeletal muscles. aPKC, BCAA
35  2009 COUP-TFII is regulated by high glucose in endothelial cells. COUP-TFII, HUVECs
36  2009 Enamel matrix derivative protein stimulated wound healing via phosphoinositide 3-kinase. EMD
37  2009 Functional association of phosphoinositide-3-kinase with platelet glycoprotein Ibalpha, the major ligand-binding subunit of the glycoprotein Ib-IX-V complex. GP, GST, vWF
38  2009 Imatinib induces apoptosis by inhibiting PDGF- but not insulin-induced PI 3-kinase/Akt survival signaling in RGC-5 retinal ganglion cells. IRS, PARP, PDGF, RGCs
39  2009 Localization of phosphatidylinositol (3,4,5)-trisphosphate to phagosomes in entamoeba histolytica achieved using glutathione S-transferase- and green fluorescent protein-tagged lipid biosensors. GFP, GST, PH
40  2009 Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase Cbeta2 in the regulation of physiologic developmental hypertrophy and heart function. CA, dn, PKCbeta2
41  2009 RhoA effector mDia1 is required for PI 3-kinase-dependent actin remodeling and spreading by thrombin in platelets. ---
42  2008 A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex. bcr, CHO, GP, GST, PKA, vWF
43  2008 Amyloid beta peptide-activated signal pathways in human platelets. amyloid-beta, cPLA2, ERK2, JNK1, MAPK, PAR1, TXA2
44  2008 Blockade of hexokinase activity and binding to mitochondria inhibits neurite outgrowth in cultured adult rat sensory neurons. DRG
45  2008 Differential induction of apoptosis and inhibition of the PI3-kinase pathway by saturated, monounsaturated and polyunsaturated fatty acids in a colon cancer cell model. DHA
46  2008 Neuroprotective actions of leptin on central and peripheral neurons in vitro. MAPK, NF-kappaB, TNF-alpha
47  2008 Regulation of Akt signaling by O-GlcNAc in euglycemia. HBP, O-GlcNAc, PEPCK, sWGA
48  2008 The PI 3-kinase and mTOR signaling pathways are important modulators of epithelial tubule formation. mTOR
49  2007 Activity of beta3-beta4 loop of the PH domain is required for the membrane targeting of SWAP-70. GFP
50  2007 Application of meso scale technology for the measurement of phosphoproteins in human tumor xenografts. ELISA, MSD, PD
51  2007 Cdc42 and phosphoinositide 3-kinase drive Rac-mediated actin polymerization downstream of c-Met in distinct and common pathways. HGF, InlB
52  2007 Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. APOE
53  2007 Extracellular matrix regulation of drug resistance in small-cell lung cancer. ECM, SCLC
54  2007 Genetic removal of Smad3 from inhibin-null mice attenuates tumor progression by uncoupling extracellular mitogenic signals from the cell cycle machinery. ---
55  2007 Inhibition of ADP-induced platelet adhesion to immobilised fibrinogen by nitric oxide: evidence for cGMP-independent mechanisms. ADP, BAPTA, IIb, NO
56  2007 Inhibitors of phosphatidylinositide 3-kinase: effects on reactive oxygen species and platelet aggregation. PRP, ROS
57  2007 Lower phosphoinositide 3-kinase (PI 3-kinase) activity and differential expression levels of selective catalytic and regulatory PI 3-kinase subunit isoforms in prefrontal cortex and hippocampus of suicide subjects. PFC, PI3
58  2007 Mechanical force modulates global gene expression and beta-catenin signaling in colon cancer cells. MAPK
59  2007 Ras and phosphoinositide 3-kinase: partners in development and tumorigenesis. RTKs
60  2007 Small molecule disruption of G protein beta gamma subunit signaling inhibits neutrophil chemotaxis and inflammation. ---
61  2007 The acute phase protein alpha2-macroglobulin induces rat ventricular cardiomyocyte hypertrophy via ERK1,2 and PI3-kinase/Akt pathways. alpha2M, ANF, beta-MHC, BNP, ERK1,2, LRP1, MLC2, mTOR, RAP, SERCA-2a
62  2006 Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCalpha. ---
63  2006 Expression of PTEN and Akt phosphorylation in lipopolysaccharide-treated NIH3T3 cells. ---
64  2006 Inhibition of Ras/ERK1/2 signaling protects against postischemic renal injury. GFR
65  2006 Melatonin stimulates glucose transport via insulin receptor substrate-1/phosphatidylinositol 3-kinase pathway in C2C12 murine skeletal muscle cells. AMPK, IRS-1, MAPK
66  2006 Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Hhs, PKA, Shh
67  2006 Phosphorylation of eukaryotic elongation factor 2 can be regulated by phosphoinositide 3-kinase in the early stages of myoblast differentiation. DM, eEF2, GM
68  2006 T lymphocytes on the move: chemokines, PI 3-kinase and beyond. ---
69  2006 Toxoplasma gondii triggers Gi-dependent PI 3-kinase signaling required for inhibition of host cell apoptosis. ---
70  2006 TRAF6 activation of PI 3-kinase-dependent cytoskeletal changes is cooperative with Ras and is mediated by an interaction with cytoplasmic Src. IL-1, SH3
71  2005 Arachidonic acid inhibits the insulin induction of glucose-6-phosphate dehydrogenase via p38 MAP kinase. G6PD, MAPK
72  2005 Biological significance of c-erbB family oncogenes in head and neck cancer. SCCHN
73  2005 Burkholderia pseudomallei invasion and activation of epithelial cells requires activation of p38 mitogen-activated protein kinase. MAP
74  2005 Inhibition of phosphoinositide 3 kinase-Akt (protein kinase B)-nuclear factor-kappa B pathway by lovastatin limits endothelial-monocyte cell interaction. NF-kappaB, TNF-alpha
75  2005 Laminin-5-integrin interaction signals through PI 3-kinase and Rac1b to promote assembly of adherens junctions in HT-29 cells. ---
76  2005 Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels. ---
77  2005 Lipid products of phosphoinositide 3-kinase abrogate genistein-induced fusion inhibition in myoblasts. FAK
78  2005 Phosphatidylinositol 3,4,5-trisphosphate modulation in SHIP2-deficient mouse embryonic fibroblasts. MEF
79  2005 PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways. AML
80  2005 PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas. GM, mTOR
81  2005 Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets. vWF
82  2005 Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells. ALK, MAP kinase, PLCgamma, PTK
83  2005 The inositol polyphosphate 5-phosphatase, PIPP, Is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation. RNAi
84  2005 The phosphoinositide 3-kinase pathway and cancer. ---
85  2004 ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner. ECM, GAP, SAM, SFKs
86  2004 Changes in sperm glycogen synthase kinase-3 serine phosphorylation and activity accompany motility initiation and stimulation. GSK-3 alpha, PKB
87  2004 Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt. ---
88  2004 Dissociation between fat-induced in vivo insulin resistance and proximal insulin signaling in skeletal muscle in men at risk for type 2 diabetes. IGT
89  2004 Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. alpha-SMA, ET-1
90  2004 Flavonoids: antioxidants or signalling molecules? MAP kinase, PKC
91  2004 Gas1 is induced by VE-cadherin and vascular endothelial growth factor and inhibits endothelial cell apoptosis. Gas1, siRNA, VE, VEGF
92  2004 Gbetagamma subunits stimulate p21-activated kinase 1 (PAK1) through activation of PI3-kinase and Akt but act independently of Rac1/Cdc42. PAK, PAK1, Ste20
93  2004 Glutamate signaling to Ras-MAPK in striatal neurons: mechanisms for inducible gene expression and plasticity. CaMKII, MAPK, mGluRs
94  2004 IGF-I inhibits apoptosis through the activation of the phosphatidylinositol 3-kinase/Akt pathway in pituitary cells. ---
95  2004 Insulin, not leptin, promotes in vitro cell migration to heal monolayer wounds in human corneal epithelium. HCEC, MAP
96  2004 Ligand- and cell-specific effects of signal transduction pathway inhibitors on progestin-induced vascular endothelial growth factor levels in human breast cancer cells. MPA, PR, Sp1, VEGF
97  2004 Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells. ---
98  2004 PDGF and FGF induce focal adhesion kinase (FAK) phosphorylation at Ser-910: dissociation from Tyr-397 phosphorylation and requirement for ERK activation. FAK, FGF, PDGF
99  2004 Performance in long-term memory tasks is augmented by a phosphorylated growth factor receptor fragment. ---
100  2004 PI 3-kinase and MAP kinase regulate bradykinin induced prostaglandin E(2) release in human pulmonary artery by modulating COX-2 activity. BK, COX, HPASMC, MAP, PGES