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Abbreviation : PIC
Long Form : polyinosinic-polycytidylic acid
No. Year Title Co-occurring Abbreviation
2020 Neuronal CXCL10/CXCR3 Axis Mediates the Induction of Cerebral Hyperexcitability by Peripheral Viral Challenge. i.p, LTD, LTP, PPF
2020 Prophylactic (R,S)-ketamine selectively protects against inflammatory stressors. CFC, FST, LPS, R,S, VEH
2020 VEGF Treatment Ameliorates Depression-Like Behavior in Adult Offspring After Maternal Immune Activation. ERK, i.c.v, MIA, SPT, TST, VEGF
2019 DEXI, a candidate gene for type 1 diabetes, modulates rat and human pancreatic beta cell inflammation via regulation of the type I IFN/STAT signalling pathway. DEXI, STAT
2019 Epigenetic Priming of Human Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Accelerates Cardiomyocyte Maturation. CPCs, hPSC-CMs
2019 Peripheral viral challenge exacerbates experimental autoimmune encephalomyelitis. APR, EAE, HR, LR, MS
2018 Novel methods for nucleotide length control in double-stranded polyinosinic-polycytidylic acid production using uneven length components. ---
2018 Prior exposure to corticosterone markedly enhances and prolongs the neuroinflammatory response to systemic challenge with LPS. CORT, LPS
2017 Adjuvant-Loaded Spiky Gold Nanoparticles for Activation of Innate Immune Cells. BMDCs, CpG, SGNPs
10  2017 Peripheral viral challenge elevates extracellular glutamate in the hippocampus leading to seizure hypersusceptibility. i.p
11  2017 Peripheral viral challenge triggers hippocampal production of inflammatory proteins. i.p, KA
12  2017 Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions. dsRNA
13  2017 The TLR3 Agonist Inhibit Drug Efflux and Sequentially Consolidates Low-Dose Cisplatin-Based Chemoimmunotherapy while Reducing Side Effects. CAF, MDSC, OSCC, TAM, TLR
14  2016 Anti-inflammatory effects of oroxylin A on RAW 264.7 mouse macrophages induced with polyinosinic-polycytidylic acid. CSF, IL, LIX, MIP, NO, STAT1
15  2016 Cerebral Response to Peripheral Challenge with a Viral Mimetic. ---
16  2016 Peripherally restricted viral challenge elevates extracellular glutamate and enhances synaptic transmission in the hippocampus. KA
17  2016 Pro-epileptogenic effects of viral-like inflammation in both mature and immature brains. IL-1beta, TLR3
18  2016 The viral dsRNA analogue poly (I:C) induces necrotizing enterocolitis in neonatal mice. FO, LPS, NEC
19  2015 Peripheral challenge with a viral mimic upregulates expression of the complement genes in the hippocampus. CFB
20  2015 TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic beta-Cells. IFN, MHC, TYK2
21  2014 Peripherally restricted acute phase response to a viral mimic alters hippocampal gene expression. APR, i.p, KA, miRs
22  2013 Maternal immune activation promotes hippocampal kindling epileptogenesis in mice. IL, MIA
23  2012 Eradication of large tumors expressing human papillomavirus E7 protein by therapeutic vaccination with E7 fused to the extra domain a from fibronectin. EDA, HPV
24  2012 Oral vitamin A and retinoic acid supplementation stimulates antibody production and splenic Stra6 expression in tetanus toxoid-immunized mice. anti-TT, RA, RBP, STRA6, VA
25  2012 Transcriptional analysis of orange-spotted grouper reacting to experimental grouper iridovirus infection. GIV, LPS, PLAUR, VLIG1
26  2011 A broad upregulation of cerebral chemokine genes by peripherally-generated inflammatory mediators. dsRNA
27  2011 Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats. KRV
28  2011 Peripheral immune challenge with dsRNA enhances kainic acid-induced status epilepticus. KA
29  2011 Peripheral immune challenge with viral mimic during early postnatal period robustly enhances anxiety-like behavior in young adult rats. ---
30  2011 Toll-like receptor 3 regulates neural stem cell proliferation by modulating the Sonic Hedgehog pathway. EGF, NPC, Shh, TLR3
31  2010 Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats. BBDR, KRV, T1D
32  2009 Characterization of the interferon regulatory factor 3-mediated antiviral response in a cell line deficient for IFN production. IFN, IRF3
33  2009 Peripheral challenge with double-stranded RNA elicits global up-regulation of cytokine gene expression in the brain. dsRNA, IFN-beta, IL-1beta, IL-6, NOS, TNF-alpha
34  2006 Activation of common antiviral pathways can potentiate inflammatory responses to septic shock. NF-kappaB
35  2006 Inhibitory effect of the polyinosinic-polycytidylic acid/cationic liposome on the progression of murine B16F10 melanoma. DC, PIC liposome, TRP-2
36  2004 Interaction of classical swine fever virus with dendritic cells. CSFV, DCs, IL
37  2001 Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport. APOE, CAT, NO
38  2001 Double-stranded ribonucleic acid (RNA) induces beta-cell Fas messenger RNA expression and increases cytokine-induced beta-cell apoptosis. IFN-gamma, IL-1beta, NO, RNA, T1DM
39  2000 Retinoic acid and polyriboinosinic acid act synergistically to enhance the antibody response to tetanus toxoid during vitamin A deficiency: possible involvement of interleukin-2 receptor-beta, signal transducer and activator of transcription-1, and interferon regulatory factor-1. IL, RA, VA
40  1996 Strain differences in the somnogenic effects of interferon inducers in mice. IFN, NDV
41  1985 Natural killer (NK) cells and graft-versus-host disease (GVHD): no correlation between the NK cell levels and GVHD in the murine P----F1 model. GVHD, NK, NW
42  1984 Highly increased natural killer cell number and lytic activity in the murine peripheral blood and lungs after interferon induction in vivo. LGL, NK, TBC
43  1983 Studies on the mechanism of natural killer cytotoxicity. III. Activation of NK cells by interferon augments the lytic activity of released natural killer cytotoxic factors (NKCF). CMC, IFN, NK, NKCF
44  1975 Retention of antimelanoma effect of polyinosinic-polycytidylic acid in neonatally thymectomized, irradiated, leukopenic mice. ---
45  1972 Studies on the mechanism of the anti-melanoma effect of polyinosinic-polycytidylic acid (PIC). II. Decreased growth of B-16 melanoma from prior exposure to the tumor. Abrogation of this response by PIC. ---