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Abbreviation : PIM
Long Form : proviral integration site for Moloney murine leukemia virus
No. Year Title Co-occurring Abbreviation
2019 Hematopoietic cytokines mediate resistance to targeted therapy in FLT3-ITD acute myeloid leukemia. AML, FLT3, GM-CSF, IL-3
2019 PIM-1 kinase is a novel regulator of proinflammatory cytokine-mediated responses in rheumatoid arthritis fibroblast-like synoviocytes. FLSs
2019 Targeting PIM Kinases Affects Maintenance of CD133 Tumor Cell Population in Hepatoblastoma. SCLCCs
2018 PIM Kinases and Their Relevance to the PI3K/AKT/mTOR Pathway in the Regulation of Ovarian Cancer. mTOR, PI3K
2018 Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies. JAK/STAT, PI3K
2017 Inhibition of PIM1 kinase attenuates inflammation-induced pro-labour mediators in human foetal membranes in vitro. IL-6, LPS, MMP9, NHMRC, PGF2 alpha, PPROM, TNF
2016 Expression and function of PIM kinases in osteosarcoma. OS
2016 PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species. Nrf2, ROS
2016 Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer. ---
10  2015 Binding site identification and role of permanent water molecule of PIM-3 kinase: A molecular dynamics study. MD, RDF
11  2015 Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies. ---
12  2015 The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression. AML, HSF1, mTOR
13  2014 A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas. ---
14  2014 Heat shock protein 90 inhibitor NVP-AUY922 exerts potent activity against adult T-cell leukemia-lymphoma cells. ATL, Hsp90
15  2014 PIM kinases as potential therapeutic targets in a subset of peripheral T cell lymphoma cases. PIMi, PTCL
16  2013 Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation. T-BET, Th1
17  2009 Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases. ---