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Abbreviation : PLB
Long Form : phospholamban
No. Year Title Co-occurring Abbreviation
2020 Ageing-associated increase in SGLT2 disrupts mitochondrial/sarcoplasmic reticulum Ca2+ homeostasis and promotes cardiac dysfunction. ROS
2020 Association with SERCA2a directs phospholamban trafficking to sarcoplasmic reticulum from a nuclear envelope pool. CMs, dPLB, JCN, NE, SERCA2a, SR
2020 Atomistic Structure and Dynamics of the Ca2+-ATPase Bound to Phosphorylated Phospholamban. pSer16
2020 Ca2+/calmodulin-dependent protein kinase II is essential in hyperacute pressure overload. AiP, CaMKII, ECC, TAC
2020 Effects of feeding and digestion on myocardial contractility and expression of calcium-handling proteins in Burmese pythons (Python molurus). Fc, SDA
2020 Effects of Standardized Green Tea Extract and Its Main Component, EGCG, on Mitochondrial Function and Contractile Performance of Healthy Rat Cardiomyocytes. EGCG, GTE
2020 Heart failure-induced atrial remodelling promotes electrical and conduction alternans. AF, AP, HF, SR
2020 HuR regulates phospholamban expression in isoproterenol-induced cardiac remodelling. ISO
2020 Live-Cell Cardiac-Specific High-Throughput Screening Platform for Drug-Like Molecules that Enhance Ca2+ Transport. FLT, FRET, HTS
10  2020 O-GlcNAc transferase affects the signal transduction of beta1 adrenoceptor in adult rat cardiomyocytes by increasing the O-GlcNAcylation of beta1 adrenoceptor. beta1-AR, Co-IP, DCM, ISO, OGA, OGT
11  2020 Phosphoproteomic analysis identifies phospho-Threonine-17 site of phospholamban important in low molecular weight isoform of fibroblast growth factor 2-induced protection against post-ischemic cardiac dysfunction. FGF-2, HMW, I/R, LMW, MS, SR, Thr17
12  2020 Protein docking and steered molecular dynamics suggest alternative phospholamban-binding sites on the SERCA calcium transporter. SERCA
13  2020 Region-specific mechanisms of corticosteroid-mediated inotropy in rat cardiomyocytes. AP, APD, MR
14  2020 Resistance training promotes reduction in Visceral Adiposity without improvements in Cardiomyocyte Contractility and Calcium handling in Obese Rats. RT, SERCA2a
15  2020 Sustaining Circulating Regulatory T Cell Subset Contributes to the Therapeutic Effect of Paroxetine on Mice With Diabetic Cardiomyopathy. DCM, GRK2, HFD, TnI, Treg
16  2019 Ca2+/calmodulin-dependent protein kinase II regulation by inhibitor 1 of protein phosphatase 1 alleviates necroptosis in high glucose-induced cardiomyocytes injury. ATP, CaMKII, DHE, Drp1, I1PP1, LDH, MLKL, p-CaMKII, p-MLKL, PP1, RIPK1, RIPK3, ROS
17  2019 Ca2+/Calmodulin-Dependent Protein Kinase II Regulation by Inhibitor 1 of Protein Phosphatase 1 Protects Against Myocardial Ischemia-Reperfusion Injury. CaMKIIdelta, CK, Drp1, I/R, I1PP1, LDH, OPA1
18  2019 Cardiac function and intracellular Ca2+ handling proteins are not impaired by high-saturated-fat diet-induced obesity. ---
19  2019 Cardioprotective effects of triiodothyronine supplementation against ischemia reperfusion injury by preserving calcium cycling proteins in isolated rat hearts. I/R
20  2019 Effect of the peptides Relaxin, Neuregulin, Ghrelin and Glucagon-like peptide-1, on cardiomyocyte factors involved in the molecular mechanisms leading to diastolic dysfunction and/or heart failure with preserved ejection fraction. HFpEF, SR
21  2019 Kv4.3 expression abrogates and reverses norepinephrine-induced myocyte hypertrophy by CaMKII inhibition. NE, NRVMs
22  2019 Long-term treatment with kefir probiotics ameliorates cardiac function in spontaneously hypertensive rats. CNS, HR, MAP, PVN, RVLM, SERCA2a, SHR, TH, WKYs
23  2019 Newly Discovered Micropeptide Regulators of SERCA Form Oligomers but Bind to the Pump asMonomers. ALN, DWORF, ELN, FRET, MLN, SLN
24  2019 Resveratrol prevents palmitic-acid-induced cardiomyocyte contractile impairment. PA, pTnI, RESV, SERCA2a, TnI
25  2019 The Drug Candidate BGP-15 Delays the Onset of Diastolic Dysfunction in the Goto-Kakizaki Rat Model of Diabetic Cardiomyopathy. DCM, GotoK, PDE9A, SERCA2a, VASP
26  2019 The Role of Adenosine A2b Receptor in Mediating the Cardioprotection of Electroacupuncture Pretreatment via Influencing Ca2+ Key Regulators. A2b, EA, NC, p-PLB, RyR2, SERCA2a
27  2018 17beta-Estradiol and/or estrogen receptor alpha signaling blocks protein phosphatase 1 mediated ISO induced cardiac hypertrophy. ISO, PP1
28  2018 Diazoxide Improves Mitochondrial Connexin 43 Expression in a Mouse Model of Doxorubicin-Induced Cardiotoxicity. Cx43, DOXO, DZX
29  2018 Effect of Phosphorylation on Interactions between Transmembrane Domains of SERCA and Phospholamban. EPR, TM
30  2018 Human cardiomyocyte calcium handling and transverse tubules in mid-stage of post-myocardial-infarction heart failure. HF, MI, non-MI, SERCA2a
31  2018 Influence of Long-Term Salt Diets on Cardiac Ca2+ Handling and Contractility Proteins in Hypertensive Rats. MHC, SHRs
32  2018 Lipopolysaccharide acutely suppresses right-ventricular strain in rats with pulmonary artery hypertension. LPS, LV, PAH, RV, TNF-alpha, TTE
33  2018 Long-Term Oral Administration of Theaphenon-E Improves Cardiomyocyte Mechanics and Calcium Dynamics by Affecting Phospholamban Phosphorylation and ATP Production. CTRL, GTE, SERCA2
34  2018 Loss of Protein Kinase Novel 1 (PKN1) is associated with mild systolic and diastolic contractile dysfunction, increased phospholamban Thr17 phosphorylation, and exacerbated ischaemia-reperfusion injury. EDP, I/R, JPH2, KD, KO, NRVM, PKN1, SERCA2, SR, WT
35  2018 Phospholamban regulates nuclear Ca2+ stores and inositol 1,4,5-trisphosphate mediated nuclear Ca2+ cycling in cardiomyocytes. 2-APB, CMs, NE, PLB-KO, WT
36  2018 Structural basis for relief of phospholamban-mediated inhibition of the sarcoplasmic reticulum Ca2+-ATPase at saturating Ca2+ conditions. ---
37  2018 Targeting protein-protein interactions for therapeutic discovery via FRET-based high-throughput screening in living cells. HTS, TR-FRET
38  2018 Type 3 iodothyronine deiodinase is expressed in human induced pluripotent stem cell derived cardiomyocytes. hiPS-CMs, hiPSCs, qPCR, SERCA
39  2018 Unique Ca2+-Cycling Protein Abundance and Regulation Sustains Local Ca2+ Releases and Spontaneous Firing of Rabbit Sinoatrial Node Cells. DD, RyR, SANC, SERCA2, SR, VM
40  2017 C33(S), a novel PDE9A inhibitor, protects against rat cardiac hypertrophy through upregulating cGMP signaling. AAC, NRCMs, PDE9A
41  2017 Cardiotoxic Effects of Short-Term Doxorubicin Administration: Involvement of Connexin 43 in Calcium Impairment. Cx43, DOXO
42  2017 Caryocar brasiliense oil improves cardiac function by increasing Serca2a/PLB ratio despite no significant changes in cardiovascular risk factors in rats. MUFA, TG
43  2017 Effects of exercise training on excitation-contraction coupling, calcium dynamics and protein expression in the heart of the Neotropical fish Brycon amazonicus. CT, E-C, SERCA2, SR
44  2017 Effects of Wenxin Keli on Cardiac Hypertrophy and Arrhythmia via Regulation of the Calcium/Calmodulin Dependent Kinase II Signaling Pathway. CaMK II, RyR2, TAC, WXKL
45  2017 Exendin-4 inhibits structural remodeling and improves Ca2+ homeostasis in rats with heart failure via the GLP-1 receptor through the eNOS/cGMP/PKG pathway. CaMKII, GLP-1R, HF, MI, RyR, SERCA2a
46  2017 Inhibition of mevalonate pathway prevents ischemia-induced cardiac dysfunction in rats via RhoA-independent signaling pathway. MI, PSer16-PLB, RyR2
47  2017 Liguzinediol Enhances the Inotropic Effect of Rat Hearts via Inhibition of Protein Phosphatase (PP1 and PP2A) Activities. Ser-16, Thr-17
48  2017 Luteolin improves cardiac dysfunction in heart failure rats by regulating sarcoplasmic reticulum Ca2+-ATPase 2a. Akt, HF, LUT, SERCA2a, Sp1, SUMO
49  2017 Role of SERCA Pump in Muscle Thermogenesis and Metabolism. SLN, SR
50  2017 The Impact of Sevoflurane on Coupling of the Left Ventricular-to-Systemic Vasculature in Rats With Chronic Pulmonary Hypertension. MCT, PH, SERCA2a
51  2017 [L-VDCC autoregulation abnormality contributes to calcium overload in myocardial ischemia-reperfusion injury]. CDF, CDI, DCT, L-VDCC, SERCA2a
52  2016 A bifunctional spin label reports the structural topology of phospholamban in magnetically-aligned bicelles. ---
53  2016 CaMKII-dependent phosphorylation regulates basal cardiac pacemaker function via modulation of local Ca2+ releases. AP, CaMKII, DD, RyR, SANC, VM
54  2016 Cardiac Calcium ATPase Dimerization Measured by Cross-Linking and Fluorescence Energy Transfer. SERCA
55  2016 Effects of Growth Hormone on Cardiac Remodeling During Resistance Training in Rats. CK-MB, CSA, CT, CT and GH, FBW, GH, LVW, RT, RTGH
56  2016 Ischemic postconditioning protects the heart against ischemia-reperfusion injury via neuronal nitric oxide synthase in the sarcoplasmic reticulum and mitochondria. AMPK, I/R, IPostC, nNOS, SR
57  2016 Loss of myocardial retinoic acid receptor alpha induces diastolic dysfunction by promoting intracellular oxidative stress and calcium mishandling in adult mice. CaMKIIdelta, LVEF, NOX2, RAR, ROS, STZ, WT
58  2016 Low-Level Vagus Nerve Stimulation Reverses Cardiac Dysfunction and Subcellular Calcium Handling in Rats With Post-Myocardial Infarction Heart Failure. ECC, HF, LAD, LL-VNS, LVEF, NCX1, RyR2, SERCA2a, VNS
59  2016 Malonate in the nucleotide-binding site traps human AKAP18gamma/delta in a novel conformational state. AKAPs, PKA, SERCA2
60  2016 Phospholamban is concentrated in the nuclear envelope of cardiomyocytes and involved in perinuclear/nuclear calcium handling. CMs, NE, SR
61  2016 Resveratrol protects against lipopolysaccharide-induced cardiac dysfunction by enhancing SERCA2a activity through promoting the phospholamban oligomerization. 4-HNE, LPS, MDA, Nrf2, SERCA2a
62  2016 Sarcoplasmic reticulum Ca(2+) ATPase 2 (SERCA2) reduces the migratory capacity of CCL21-treated monocyte-derived dendritic cells. DCs, mDCs, SERCA2
63  2016 Thioredoxin-1 Attenuates Ventricular and Mitochondrial Postischemic Dysfunction in the Stunned Myocardium of Transgenic Mice. I/R, p-PLB, Trx1
64  2016 Vasopressin type1A receptor deletion enhances cardiac contractility, beta-adrenergic receptor sensitivity and acute cardiac injury-induced dysfunction. beta-AR, cTnI, HF, V1AR, V1AR KO
65  2016 [Effects of hydrogen sulfide on contraction capacity of diaphragm from type 1 diabetic rats]. DW/BW, LDH, NaHS, Pt, SDH
66  2015 A low-dose beta1-blocker in combination with milrinone improves intracellular Ca2+ handling in failing cardiomyocytes by inhibition of milrinone-induced diastolic Ca2+ leakage from the sarcoplasmic reticulum. CS
67  2015 A single resistance exercise session improves myocardial contractility in spontaneously hypertensive rats. CT, EX, LVISP, SHRs
68  2015 Acute inotropic and lusitropic effects of cardiomyopathic R9C mutation of phospholamban. SERCA
69  2015 Acute reversal of phospholamban inhibition facilitates the rhythmic whole-cell propagating calcium waves in isolated ventricular myocytes. SR, VMs
70  2015 Atomic-level mechanisms for phospholamban regulation of the calcium pump. MD
71  2015 Computational analysis of the regulation of Ca(2+) dynamics in rat ventricular myocytes. CaMKII, LCC
72  2015 Depressed calcium cycling contributes to lower ischemia tolerance in hearts of estrogen-deficient rats. IT, SERCA2a
73  2015 Effects of Shenmai injection and its bioactive components following ischemia/reperfusion in cardiomyocytes. I/R, SM, TSPG
74  2015 Exenatide exerts a PKA-dependent positive inotropic effect in human atrial myocardium: GLP-1R mediated effects in human myocardium. GLP-1R, qRT-PCR
75  2015 Impaired oxidative metabolism and calcium mishandling underlie cardiac dysfunction in a rat model of post-acute isoproterenol-induced cardiomyopathy. ISO, MPI, OV
76  2015 Low-dose ouabain administration increases Na⁺,K⁺-ATPase activity and reduces cardiac force development in rats. NCX, NKA, OUA15
77  2015 Nitric oxide enhances extracellular ATP induced Ca⁺ oscillation in HeLa cells. eATP, ER-eNOS, NO
78  2015 Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs. Ad, CMs, ESCs, hvCMTs, iPSCs
79  2015 Phospholamban phosphorylation, mutation, and structural dynamics: a biophysical approach to understanding and treating cardiomyopathy. SR, U-PLB
80  2015 Phosphorylation state-dependent interaction between AKAP7delta/gamma and phospholamban increases phospholamban phosphorylation. AKAPs, PKA
81  2015 Regular exercise improves cardiac contractile activation by modulating MHC isoforms and SERCA activity in orchidectomized rats. MHC, TOM
82  2015 Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2. HMW, LMW, PDE3, PDE3A, SERCA2, SR
83  2015 Role of nucleotides in stabilization of the phospholamban/cardiac Ca⁺ pump inhibitory complex examined with use of metal fluorides. ---
84  2015 The N Terminus of Sarcolipin Plays an Important Role in Uncoupling Sarco-endoplasmic Reticulum Ca2+-ATPase (SERCA) ATP Hydrolysis from Ca2+ Transport. SLN, TM
85  2014 A novel artificial microRNA expressing AAV vector for phospholamban silencing in cardiomyocytes improves Ca2+ uptake into the sarcoplasmic reticulum. CM, shPLBr, SR
86  2014 Comparison of the structure and function of phospholamban and the arginine-14 deficient mutant associated with dilated cardiomyopathy. DCM
87  2014 Competitive displacement of wild-type phospholamban from the Ca2+-free cardiac calcium pump by phospholamban mutants with different binding affinities. ---
88  2014 Decreased polycystin 2 expression alters calcium-contraction coupling and changes beta-adrenergic signaling pathways. ADPKD, beta-AR, ISO, PC2, PKA
89  2014 Delayed phospholamban phosphorylation in post-conditioned heart favours Ca2+ normalization and contributes to protection. PKA, PKG, PoCo, SERCA, sGC
90  2014 Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle. CNP, LR, NIR, NPs, PDE, TnI
91  2014 Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium. cGMP, CNP, LR, NIR, PDEs, TnI
92  2014 FGF-23 dysregulates calcium homeostasis and electrophysiological properties in HL-1 atrial cells. FGF
93  2014 Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction. CABG, SERCA2a
94  2014 Long-term obesity promotes alterations in diastolic function induced by reduction of phospholamban phosphorylation at serine-16 without affecting calcium handling. SR
95  2014 Molecular and cellular correlates of cardiac function in end-stage DCM: a study using speckle tracking echocardiography. DCM, LV, mRNA, PCWP, SERCA2a, SRE, SRS, TTN
96  2014 N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity. A2AR, EC, eNOS, MCT, PAH, RV
97  2014 Neuronostatin attenuates myocardial contractile function through inhibition of sarcoplasmic reticulum Ca2+-ATPase in murine heart. ---
98  2014 Obesity does not lead to imbalance between myocardial phospholamban phosphorylation and dephosphorylation. cAMP, PKA, PP-1, PPLB-Ser16
99  2014 p38alpha regulates SERCA2a function. PKA
100  2014 Phospholamban C-terminal residues are critical determinants of the structure and function of the calcium ATPase regulatory complex. FRET, SERCA, V49A