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Abbreviation : PP1alpha
Long Form : protein phosphatase 1alpha
No. Year Title Co-occurring Abbreviation
2022 Phosphatase inhibition by sodium orthovanadate displays anti-inflammatory action by suppressing AKT-IKKβ signaling in RAW264.7 cells. NF, NO, PP2A
2021 Downregulation of lncRNA TSLNC8 promotes melanoma resistance to BRAF inhibitor PLX4720 through binding with PP1alpha to re-activate MAPK signaling. RIP, TSLNC8
2021 Long-term depression-related tau phosphorylation is enhanced by methylene blue in healthy rat hippocampus. DG, EPSP, GC, GSK-3beta, LTP
2020 Protein phosphatase 1 alpha enhances glucocorticoid receptor activity by a mechanism involving phosphorylation of serine-211. GR, GSK-3
2019 Differential contribution of protein phosphatase 1alpha to cell transformation of different cell types. HURP
2019 Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis. ---
2019 Parathyroid hormone initiates dynamic NHERF1 phosphorylation cycling and conformational changes that regulate NPT2A-dependent phosphate transport. FLIM, NHERF1, NPT2A, PTH
2019 The ICP0 Protein of Herpes Simplex Virus 1 (HSV-1) Downregulates Major Autophagy Adaptor Proteins Sequestosome 1 and Optineurin during the Early Stages of HSV-1 Infection. HSV-1, ICP0, OPTN
2018 Protein Phosphatase 1alpha and Cofilin Regulate Nuclear Translocation of NF-kappaB and Promote Expression of the Anti-Inflammatory Cytokine Interleukin-10 by T Cells. IL-10, siRNA
10  2018 The effect of herpes simplex virus vector-mediated gene therapy of protein phosphatase 1alpha on bladder overactivity and nociception. GFP, HSV, ICI
11  2017 Effects of herpes simplex virus vectors encoding poreless TRPV1 or protein phosphatase 1alpha in a rat cystitis model induced by hydrogen peroxide. HP, HSV, IC/BPS, TRPV1
12  2017 Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1alpha complex to activate its deacetylase function. Ars, SIRT1
13  2017 Positive feedback loop mediated by protein phosphatase 1alpha mobilization of P-TEFb and basal CDK1 drives androgen receptor in prostate cancer. AR, CRPC
14  2017 Steady-State Levels of Phosphorylated Mitogen-Activated Protein Kinase Kinase 1/2 Determined by Mortalin/HSPA9 and Protein Phosphatase 1 Alpha in KRAS and BRAF Tumor Cells. ERK, HSP70
15  2016 An HSV-based library screen identifies PP1alpha as a negative TRPV1 regulator with analgesic activity in models of pain. HSV, PL, TRPV1
16  2016 Resveratrol augments ER stress and the cytotoxic effects of glycolytic inhibition in neuroblastoma by downregulating Akt in a mechanism independent of SIRT1. 2-DG, CHOP, ER, NB, RSV
17  2015 Histone Deacetylase Inhibitors Target the Leukemic Microenvironment by Enhancing a Nherf1-Protein Phosphatase 1alpha-TAZ Signaling Pathway in Osteoblasts. AML, HDACi
18  2014 14-3-3zeta regulates nuclear trafficking of protein phosphatase 1alpha (PP1alpha) in HEK-293 cells. PP1
19  2014 Histone cross-talk connects protein phosphatase 1alpha (PP1alpha) and histone deacetylase (HDAC) pathways to regulate the functional transition of bromodomain-containing 4 (BRD4) for inducible gene expression. BRD4, HDAC
20  2014 The IKAROS interaction with a complex including chromatin remodeling and transcription elongation activities is required for hematopoiesis. NuRD, P-TEFb
21  2014 The K898E germline variant in the PP1-binding motif of BRCA1 causes defects in DNA Repair. IR
22  2013 Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation. ADPKD, PC1, PC2, PKA
23  2012 A novel RhoA/ROCK-CPI-17-MEF2C signaling pathway regulates vascular smooth muscle cell gene expression. MLCP, VSMC
24  2012 Protein phosphatase-1alpha interacts with and dephosphorylates polycystin-1. ADPKD
25  2010 PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha. PINCH1
26  2009 Critical roles of T-LAK cell-originated protein kinase in cytokinesis. CDK1, TOPK
27  2009 Direct interaction between myocyte enhancer factor 2 (MEF2) and protein phosphatase 1alpha represses MEF2-dependent gene expression. MEF2
28  2009 Increased eIF2alpha phosphorylation attenuates replication of herpes simplex virus 2 vhs mutants in mouse embryonic fibroblasts and correlates with reduced accumulation of the PKR antagonist ICP34.5. eIF2alpha, HSV-2, MEFs, PKR, vhs
29  2009 Protein phosphatase 1alpha associates with protein tyrosine phosphatase-PEST inducing dephosphorylation of phospho-serine 39. PTP, TPA
30  2009 Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion. DLC-1
31  2008 A PP1-binding motif present in BRCA1 plays a role in its DNA repair function. ---
32  2008 PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. HMBA, P-TEFb, PP2B
33  2008 [Effects of valsartan on sarcoplasmic reticulum calcium adenosine triphosphatase, protein kinase A and protein phosphatase 1 alpha in a rabbit model of heart failure]. EF, LVFS, PKA
34  2007 Identification and functional characterization of a PP1-binding site in BRCA1. ---
35  2007 Regulation of intracellular calcium release and PP1alpha in a mechanism for 4-hydroxytamoxifen-induced cytotoxicity. ERalpha
36  2007 Scavenger receptor expressed by endothelial cells (SREC)-I interacts with protein phosphatase 1alpha in L cells to induce neurite-like outgrowth. SREC
37  2006 Gene amplification and overexpression of protein phosphatase 1alpha in oral squamous cell carcinoma cell lines. OSCC
38  2006 Protein phosphatase 1alpha activity prevents oncogenic transformation. CA, CDK2, GFP, pRb, WB, WT
39  2006 Smad7 and protein phosphatase 1alpha are critical determinants in the duration of TGF-beta/ALK1 signaling in endothelial cells. EC, TGF-beta
40  2005 Protein phosphatase 1alpha is tyrosine-phosphorylated and inactivated by peroxynitrite in erythrocytes through the src family kinase fgr. ---
41  2004 Association of type 1 inositol 1,4,5-trisphosphate receptor with AKAP9 (Yotiao) and protein kinase A. LIZ, PKA
42  2004 GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein. PRIP-1
43  2003 Modulation of type 1 inositol (1,4,5)-trisphosphate receptor function by protein kinase a and protein phosphatase 1alpha. PKA
44  2003 PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance. PTG
45  2002 Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha. ATM, ATR, BF4, GST
46  2001 Centrosome cohesion is regulated by a balance of kinase and phosphatase activities. ---
47  2000 Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis. GST, IL-2
48  1989 Cloning and chromosomal localization of Drosophila cDNA encoding the catalytic subunit of protein phosphatase 1 alpha. High conservation between mammalian and insect sequences. ---