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Abbreviation : PRMT5
Long Form : protein arginine methyltransferase 5
No. Year Title Co-occurring Abbreviation
2019 Curcumin ameliorates PRMT5-MEP50 arginine methyltransferase expression by decreasing the Sp1 and NF-YA transcription factors in the A549 and MCF-7 cells. SDMA
2019 Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation. ---
2019 Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations. LISA
2019 Dual regulation of Arabidopsis AGO2 by arginine methylation. Ago, RNAi, sRNAs
2019 LKB1 regulates PRMT5 activity in breast cancer. LKB1
2019 MEP50/PRMT5-mediated methylation activates GLI1 in Hedgehog signalling through inhibition of ubiquitination by the ITCH/NUMB complex. Hh, MEP50
2019 NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression. 5-FU, CRC, N-acH4, NAA40
2019 Nucleoside protein arginine methyltransferase 5 (PRMT5) inhibitors. SAM
2019 PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis. FBW7
10  2019 PRMT5 is essential for B cell development and germinal center dynamics. GC
11  2019 PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells. HSC, mTOR
12  2019 PRMT5-mediated H4R3sme2 Confers Cell Differentiation in Pediatric B-cell Precursor Acute Lymphoblastic Leukemia. ALL, BCP-ALL, H4R3
13  2019 Protein Arginine Methyltransferase 5 (PRMT5) Promotes Survival of Lymphoma Cells via Activation of WNT/beta-CATENIN and AKT/GSK3beta Proliferative Signaling. NHL
14  2019 Protein arginine methyltransferase 5: A novel therapeutic target for triple-negative breast cancers. ---
15  2019 PU.1 and epigenetic signals modulate 1,25-dihydroxyvitamin D3 and C/EBPalpha regulation of the human cathelicidin antimicrobial peptide gene in lung epithelial cells. BRG1, CAMP, CEBPalpha, SWI/SNF
16  2019 Targeting PRMT5/Akt signalling axis prevents human lung cancer cell growth. ---
17  2018 Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing. ---
18  2018 Arginine methyltransferase inhibitor 1 exhibits antitumor effects against cervical cancer in vitro and in vivo. AMI-1
19  2018 CARM1-mediated methylation of protein arginine methyltransferase 5 represses human gamma-globin gene expression in erythroleukemia cells. CARM1, PTMs
20  2018 Cryo-electron microscopy structure of a human PRMT5:MEP50 complex. cryo-EM, SP
21  2018 Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors. ---
22  2018 Histone arginine methylation by Prmt5 is required for lung branching morphogenesis through repression of BMP signaling. BMP
23  2018 Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations. SAR
24  2018 Identification of a Novel Protein Arginine Methyltransferase 5 Inhibitor in Non-small Cell Lung Cancer by Structure-Based Virtual Screening. H4R3me2s, SAM
25  2018 Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations. PRMT, SAR, SPA
26  2018 Identification of Selective, Cell Active Inhibitors of Protein Arginine Methyltransferase 5 through Structure-Based Virtual Screening and Biological Assays. ---
27  2018 Inhibition of protein arginine methyltransferase 5 enhances hepatic mitochondrial biogenesis. PPARalpha
28  2018 Interaction assessments of the first S-adenosylmethionine competitive inhibitor and the essential interacting partner methylosome protein 50 with protein arginine methyltransferase 5 by combined computational methods. MEP50, SAM
29  2018 Late cornified envelope 1C (LCE1C), a transcriptional target of TAp63 phosphorylated at T46/T281, interacts with PRMT5. GAK, LCE1C
30  2018 Lead induces the up-regulation of the protein arginine methyltransferase 5 possibly by its promoter demethylation. MEP50, SDMA
31  2018 LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ---
32  2018 MPTAC Determines APP Fragmentation via Sensing Sulfur Amino Acid Catabolism. acetyl-CoA, AD, APP, SNRP
33  2018 Overexpression of HOXC10 promotes angiogenesis in human glioma via interaction with PRMT5 and upregulation of VEGFA expression. CAMs, HOXC10, HUVECs, VEGF-A, WDR5
34  2018 PRMT5 as a druggable target for glioblastoma therapy. CMP5, GBM
35  2018 PRMT5 determines the sensitivity to chemotherapeutics by governing stemness in breast cancer. ---
36  2018 PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival. GC
37  2018 PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes. HR
38  2018 Prognostic impact of SET domain-containing protein 8 and protein arginine methyltransferase 5 in patients with hepatocellular carcinoma following curative resection. HCC, SET8
39  2018 Protein Arginine Methyltransferase 5 (PRMT5) as an Anticancer Target and Its Inhibitor Discovery. MCL, SAR
40  2018 Protein arginine methyltransferase 5 (PRMT5) dysregulation in cancer. PRMTs
41  2018 Protein arginine methyltransferase 5 has prognostic relevance and is a druggable target in multiple myeloma. MM
42  2018 Protein arginine methyltransferase 5 is implicated in the aggressiveness of human hepatocellular carcinoma and controls the invasive activity of cancer cells. HCC
43  2018 Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells. ENO-1, LPS, PTMs, TD
44  2018 Protein arginine methyltransferase 5 promotes bladder cancer growth through inhibiting NF-kB dependent apoptosis. ---
45  2018 Protein arginine methyltransferase 5 promotes lung cancer metastasis via the epigenetic regulation of miR-99 family/FGFR3 signaling. ---
46  2018 Protein arginine methyltransferase 5-mediated epigenetic silencing of IRX1 contributes to tumorigenicity and metastasis of gastric cancer. GC
47  2018 Sirtuin 7-mediated deacetylation of WD repeat domain 77 (WDR77) suppresses cancer cell growth by reducing WDR77/PRMT5 transmethylase complex activity. H4R3, SIRT7, WDR77
48  2018 The methylation induced by protein arginine methyltransferase 5 promotes tumorigenesis and progression of lung cancer. ---
49  2018 The persistent organochlorine pesticide endosulfan modulates multiple epigenetic regulators with oncogenic potential in MCF-7 cells. DNMTs, ERalpha, EZH2, HDAC
50  2017 A Genetic Variant Ameliorates beta-Thalassemia Severity by Epigenetic-Mediated Elevation of Human Fetal Hemoglobin Expression. DNMT3A, Hb, HBG1, LD, rSNPs
51  2017 A novel SHARPIN-PRMT5-H3R2me1 axis is essential for lung cancer cell invasion. LUBAC, SHARPIN
52  2017 A TGFbeta-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression. EMT
53  2017 Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers. CRC, NF-kappaB, PDAC
54  2017 Discovery and optimization of selective inhibitors of protein arginine methyltransferase 5 by docking-based virtual screening. SAR
55  2017 Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations. ---
56  2017 Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression. S/T
57  2017 Impaired spliceosomal UsnRNP assembly leads to Sm mRNA down-regulation and Sm protein degradation. SMN, UsnRNPs
58  2017 Inhibition of PRMT5 suppresses osteoclast differentiation and partially protects against ovariectomy-induced bone loss through downregulation of CXCL10 and RSAD2. BMMs, CXCL10, RANKL
59  2017 KSHV encoded ORF59 modulates histone arginine methylation of the viral genome to promote viral reactivation. COPR5, KSHV
60  2017 Menin and PRMT5 suppress GLP1 receptor transcript and PKA-mediated phosphorylation of FOXO1 and CREB. CREB, FOXO1, GLP-1, GLP-1R, MEN1
61  2017 Myosin phosphatase and RhoA-activated kinase modulate arginine methylation by the regulation of protein arginine methyltransferase 5 in hepatocellular carcinoma cells. MP, MYPT1, PP1, PP1c
62  2017 Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response. IL-12, LM
63  2017 Nuclear PRMT5, cyclin D1 and IL-6 are associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with p16-status. OPSCC
64  2017 Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization. ---
65  2017 PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation. cccDNA, HBV
66  2017 PRMT5-PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells. GBM, GBMDC, GBMNS
67  2017 Protein arginine methyltransferase 5 functions as an epigenetic activator of the androgen receptor to promote prostate cancer cell growth. AR
68  2017 Role of protein arginine methyltransferase 5 in inflammation and migration of fibroblast-like synoviocytes in rheumatoid arthritis. ELISA, FLSs, OA, PCR, RA, siRNA, STs
69  2017 Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity. ---
70  2017 Spinal Muscular Atrophy: From Defective Chaperoning of snRNP Assembly to Neuromuscular Dysfunction. SMA, SMN, snRNAs, snRNPs
71  2017 Sulforaphane suppresses PRMT5/MEP50 function in epidermal squamous cell carcinoma leading to reduced tumor formation. MEP50, SFN
72  2017 The protein arginine methyltransferase 5 promotes malignant phenotype of hepatocellular carcinoma cells and is associated with adverse patient outcomes after curative hepatectomy. HCC
73  2017 The Structure and Function of the PRMT5:MEP50 Complex. ---
74  2017 Ulva pertusa lectin 1 delivery through adenovirus vector affects multiple signaling pathways in cancer cells. GlcNAc, MAPK, MEP50, PI3K, UPL1
75  2017 UsnRNP biogenesis: mechanisms and regulation. SMN
76  2016 Anguilla japonica lectin 1 delivery through adenovirus vector induces apoptotic cancer cell death through interaction with PRMT5. AJL1
77  2016 Arginine Methylation of SREBP1a via PRMT5 Promotes De Novo Lipogenesis and Tumor Growth. SREBP
78  2016 Expression of mep50 in adult and embryos of medaka fish (Oryzias latipes). Mep50
79  2016 GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer. GLIPR1, WDR77
80  2016 Identification of Methylosome Components as Negative Regulators of Plant Immunity Using Chemical Genetics. NLR, PR, rim, SmD3b, snRNPs
81  2016 Identification of Protein Arginine Methyltransferase 5 as a Regulator for Encystation of Acanthamoeba. ---
82  2016 MEP50/PRMT5 Reduces Gene Expression by Histone Arginine Methylation and this Is Reversed by PKCdelta/p38delta Signaling. MEP50, PKCdelta
83  2016 MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells. MTAP
84  2016 PRMT5 competitively binds to CDK4 to promote G1-S transition upon glucose induction in hepatocellular carcinoma. CDK4, HCC
85  2016 Protein arginine methyltransferase 5 is associated with malignant phenotype and peritoneal metastasis in gastric cancer. GC
86  2016 Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation. WDR77
87  2016 Protein N-arginine methyltransferase 5 promotes the tumor progression and radioresistance of nasopharyngeal carcinoma. FGFR3, NPC
88  2016 SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination. CTD, RNAPII
89  2016 Species differences in metabolism of EPZ015666, an oxetane-containing protein arginine methyltransferase-5 (PRMT5) inhibitor. DLM
90  2016 Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia. CML, DVL3, LSCs, LTC-ICs
91  2016 The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5. BiFC
92  2016 The Fanconi anemia pathway controls oncogenic response in hematopoietic stem and progenitor cells by regulating PRMT5-mediated p53 arginine methylation. FA, HSPCs
93  2016 [Structure and Function of the Nuclear Receptor Constitutive Androstane Receptor]. CAR
94  2015 A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. MCL
95  2015 Aberrant expression of cyclin D1 in cancer. HDACs, Rb
96  2015 Coronin 2A (CRN5) expression is associated with colorectal adenoma-adenocarcinoma sequence and oncogenic signalling. ---
97  2015 Differential expression, distinct localization and opposite effect on Golgi structure and cell differentiation by a novel splice variant of human PRMT5. ---
98  2015 High nuclear expression of protein arginine methyltransferase-5 is a potentially useful marker to estimate submucosal invasion in endoscopically resected early colorectal carcinoma. CRCs
99  2015 Identification of protein arginine N-methyltransferase 5 (PRMT5) as a novel interacting protein with the tumor suppressor protein RASSF1A. ---
100  2015 Methylosome Protein 50 and PKCdelta/p38delta Protein Signaling Control Keratinocyte Proliferation via Opposing Effects on p21Cip1 Gene Expression. Cip1, MEP50