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Abbreviation : PS
Long Form : pregnenolone sulfate
No. Year Title Co-occurring Abbreviation
2019 Activation of the cation channel TRPM3 in perivascular nerves induces vasodilation of resistance arteries. KO, TRPM3, VSMC, WT
2019 L-3,3',5-triiodothyronine and pregnenolone sulfate inhibit Torpedo nicotinic acetylcholine receptors. GABA, nAChR, pLGIC
2019 The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators. CTDs, NMDARs
2017 Decreased allopregnanolone levels in cerebrospinal fluid obtained during status epilepticus. AP, CSF, SE
2016 Amyloid Beta Peptides Affect Pregnenolone and Pregnenolone Sulfate Levels in PC-12 and SH-SY5Y Cells Depending on Cholesterol. Ab
2016 Pregnenolone sulfate regulates prolactin production in the rat pituitary. PRL
2016 Stimulation-dependent gating of TRPM3 channel in planar lipid bilayers. NIF, TRPM
2015 Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release. CGRP, TRP
2015 Bidirectional Effect of Pregnenolone Sulfate on GluN1/GluN2A N-Methyl-D-Aspartate Receptor Gating Depending on Extracellular Calcium and Intracellular Milieu. NMDARs
10  2015 Hypotonic stress induces RANKL via transient receptor potential melastatin 3 (TRPM3) and vaniloid 4 (TRPV4) in human PDL cells. 4 alpha-PDD, mRNA, NF-kappaB, Ono, OPG, PDL, RR, siRNA, TRPM3
11  2015 Inhibition of the GABAA Receptor by Sulfated Neurosteroids: A Mechanistic Comparison Study between Pregnenolone Sulfate and Dehydroepiandrosterone Sulfate. DHEAS, GABAAR
12  2015 Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel. PAMs
13  2015 TRPM3 expression in mouse retina. IPL, TRP
14  2013 Pregnenolone sulfate activates NMDA receptor channels. NMDAR
15  2013 Pregnenolone sulfate modulates glycinergic transmission in rat medullary dorsal horn neurons. mIPSCs, TRP
16  2013 Simultaneous determination of pregnenolone sulphate, dehydroepiandrosterone and allopregnanolone in rat brain areas by liquid chromatography-electrospray tandem mass spectrometry. AP, DHEA, NSs
17  2012 Neurosteroid binding to the amino terminal and glutamate binding domains of ionotropic glutamate receptors. ATD, iGluR, PREGAS
18  2012 Steroid hormones specifically modify the activity of organic anion transporting polypeptides. DHEAS
19  2011 A steroid modulatory domain in NR2A collaborates with NR1 exon-5 to control NMDAR modulation by pregnenolone sulfate and protons. NMDAR
20  2011 Chronic administration of the anabolic androgenic steroid nandrolone alters neurosteroid action at the sigma-1 receptor but not at the sigma-2 or NMDA receptors. AASs, DHEAS, NMDA
21  2011 Neurosteroids and GABA-A Receptor Function. 3alpha5alpha-THDOC
22  2011 TRPM3 is a nociceptor channel involved in the detection of noxious heat. TRPM3
23  2010 Allosteric modulation of the NMDA receptor by neurosteroids in rat brain and the impact of long term morphine administration. DHEAS, NMDA
24  2010 Multiple roles for the first transmembrane domain of GABAA receptor subunits in neurosteroid modulation and spontaneous channel activity. TM
25  2010 Pregnenolone sulfate enhances spontaneous glutamate release by inducing presynaptic Ca2+-induced Ca2+ release. DG, sEPSCs, TRP
26  2009 Pregnenolone protects the PC-12 cell line against amyloid beta peptide toxicity but its sulfate ester does not. ---
27  2009 Pregnenolone sulfate modulation of N-methyl-D-aspartate receptors is phosphorylation dependent. NMDAR, PKA, PKC
28  2008 Involvement of sigma (sigma1) receptors in modulating the anti-depressant effect of neurosteroids (dehydroepiandrosterone or pregnenolone) in mouse tail-suspension test. DHEAS, TST
29  2008 Molecular mechanisms for nanomolar concentrations of neurosteroids at NR1/NR2B receptors. NMDA
30  2008 Nanomolar concentrations of pregnenolone sulfate enhance striatal dopamine overflow in vivo. DA, NMDA
31  2008 Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission. AMPA, NMDA
32  2008 Neurosteroids 3beta, 20 (R/S)-pregnandiols decrease offset rate of the GABA-site activation at the recombinant GABA A receptor. ---
33  2008 Neurosteroids allosterically modulate the ion pore of the NMDA receptor consisting of NR1/NR2B but not NR1/NR2A. ---
34  2008 Pregnenolone sulfate induces NMDA receptor dependent release of dopamine from synaptic terminals in the striatum. DAT, NMDAR
35  2007 Neurosteroids alter glutamate-induced changes in neurite morphology of NG108-15 cells. ---
36  2007 The neurosteroids dehydroepiandrosterone sulfate and pregnenolone sulfate inhibit the UNC-49 GABA receptor through a common set of residues. DHEAS
37  2006 Action by and sensitivity to neuroactive steroids in menstrual cycle related CNS disorders. ALLO, DHEAS, GABA, PMDD, THDOC
38  2006 Intradermal pregnenolone sulfate attenuates capsaicin-induced nociception in rats. ---
39  2006 Pregnenolone sulphate and Zn2+ inhibit recombinant rat GABA(A) receptor through different channel property. ---
40  2006 Residues in the first transmembrane domain of the Caenorhabditis elegans GABA(A) receptor confer sensitivity to the neurosteroid pregnenolone sulfate. ---
41  2005 Low concentrations of neuroactive steroids alter kinetics of [3H]ifenprodil binding to the NMDA receptor in rat frontal cortex. NMDA
42  2005 Pregnenolone sulphate attenuates AMPA cytotoxicity on rat cortical neurons. NMDA, PHS
43  2005 [Effects of morphine dependence on the levels of neurosteroids in rat brain]. AP, CPP, DHEA, DS, HT, LC-MS, NAc, PREG
44  2004 A steroid modulatory domain on NR2B controls N-methyl-D-aspartate receptor proton sensitivity. AMPA, NMDA
45  2004 Characterization of the convulsant action of pregnenolone sulfate. BSS, SE
46  2004 Identification of a neurosteroid binding site contained within the GluR2-S1S2 domain. AMPA, iGluR, NMDA
47  2004 Mechanism underlying inhibition of the capsaicin receptor-mediated current by pregnenolone sulfate in rat dorsal root ganglion neurons. ---
48  2004 Molecular mechanism of pregnenolone sulfate action at NR1/NR2B receptors. ---
49  2004 Pregnenolone sulfate potentiates the effects of NMDA on hippocampal alanine and dopamine. ---
50  2003 A presynaptic action of the neurosteroid pregnenolone sulfate on GABAergic synaptic transmission. RS
51  2003 Activation-dependent properties of pregnenolone sulfate inhibition of GABAA receptor-mediated current. ---
52  2003 Effects of neurosteroids on epileptiform activity induced by picrotoxin and 4-aminopyridine in the rat hippocampal slice. 4-AP, PTX
53  2003 Increased neurosteroid sensitivity of hippocampal GABAA receptors during postnatal development. DGCs
54  2003 Intact synaptic GABAergic inhibition and altered neurosteroid modulation of thalamic relay neurons in mice lacking delta subunit. eIPSCs, IPSCs, sIPSCs, TC, THDOC, VB
55  2003 Pharmacology of endogenous neuroactive steroids. DHEAS
56  2002 A caspase-3-dependent pathway is predominantly activated by the excitotoxin pregnenolone sulfate and requires early and late cytochrome c release and cell-specific caspase-2 activation in the retinal cell death. ---
57  2002 Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids. NMDA
58  2002 Pregnenolone sulfate, dehydroepiandrosterone sulfate and allotetrahydrodeoxycorticosterone affect rapid tolerance to the hypothermic effect of ethanol. ALLOT, DHEAS
59  2001 Distinct effect of pregnenolone sulfate on NMDA receptor subtypes. ---
60  2001 Pregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the alpha subunit. ---
61  2000 Pregnenolone sulfate modulates inhibitory synaptic transmission by enhancing GABA(A) receptor desensitization. ---
62  2000 Pregnenolone sulfate, a naturally occurring excitotoxin involved in delayed retinal cell death. LDH, SOD, TBARS, TUNEL
63  2000 The effects of neurosteroids on picrotoxin-, bicuculline- and NMDA-induced seizures, and a hypnotic effect of ethanol. 5beta-THDOC, AP, BIC, DHEAS, DZP, i.c.v, i.p, NMDA, PREG, PROG, PTX
64  1999 Convulsant actions of the neurosteroid pregnenolone sulfate in mice. ---
65  1999 Ethanol-like discriminative stimulus effects of endogenous neuroactive steroids: effect of ethanol training dose and dosing procedure. GABAA, NMDA
66  1999 Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABA(A) receptors. DHEAS, GABA
67  1998 Differential regulation by pregnenolone sulfate of intracellular Ca2+ increase by amino acids in primary cultured rat cortical neurons. ACh, GABA, NMDA
68  1998 Modulation of cloned human neuronal voltage-gated potassium channels (hKv1.1 and hKv2.1) by neurosteroids. 5alpha3alphaP, 5beta3alphaP
69  1998 Neurosteroid modulation of recombinant ionotropic glutamate receptors. ---
70  1998 Possible role of nitric oxide in the nootropic and antiamnesic effects of neurosteroids on aging- and dizocilpine-induced learning impairment. DHEAS, L-NAME, NO
71  1998 Pregnenolone sulfate exacerbates NMDA-induced death of hippocampal neurons. CNS, NMDA
72  1998 Pregnenolone sulfate modulates NMDA receptors, inducing and potentiating acute excitotoxicity in isolated retina. CNQX, DIDS, LDH, NMDA
73  1998 Sigma (sigma1) receptor mediated anti-depressant-like effects of neurosteroids in the Porsolt forced swim test. DHEAS
74  1998 Supraoptic oxytocin and vasopressin neurones show differential sensitivity to the neurosteroid pregnenolone sulphate. OT, VP
75  1998 The effects of neurosteroids on acquisition and retention of a modified passive-avoidance learning task in mice. DHEAS
76  1998 The neurosteroid pregnenolone sulfate excites medial vestibular nucleus neurons. MVN
77  1998 The role of GABA-A and mitochondrial diazepam-binding inhibitor receptors on the effects of neurosteroids on food intake in mice. BZD, DBI, DHEAS, GABA-A
78  1997 Competitive inhibition of the glycine-induced current by pregnenolone sulfate in cultured chick spinal cord neurons. ---
79  1997 Differential anxiolytic effects of neurosteroids in the mirrored chamber behavior test in mice. 4'-CD, AP, BZD, DBI, DHEAS, PROG
80  1997 Differential effects of neuroactive steroids on somatostatin and dopamine secretion from primary hypothalamic cell cultures. DA, DHEAS, THDOC
81  1997 Effects of PKC activation and receptor desensitization on neurosteroid modulation of GABA(A) receptors. PMA, PMM
82  1997 Neurosteroid coadministration prevents development of tolerance and augments recovery from benzodiazepine withdrawal anxiety and hyperactivity in mice. AP, DBI
83  1997 Neurosteroid inhibition of cell death. 17 alpha-OH-AP, AP, DHEAS, GABAA, PREG
84  1997 Presynaptic action of the neurosteroid pregnenolone sulfate on inhibitory transmitter release in cultured hippocampal neurons. AP5, CNQX, sIPSCs
85  1997 The neurosteroid pregnenolone sulphate enhances NMDA-induced phasic firing of vasopressin neurones in the rat supraoptic nucleus. NMDA, VP
86  1997 [Effect of pregnenolone sulfate on delayed rectifier K+ channel in pyramidial neuron of cerebral cortex]. ---
87  1996 Neurosteroids block the memory-impairing effects of ethanol in mice. DHEA, DHEAS, EPI, Pe
88  1996 Relationship between symptom severity and steroid variation in women with premenstrual syndrome: study on serum pregnenolone, pregnenolone sulfate, 5 alpha-pregnane-3,20-dione and 3 alpha-hydroxy-5 alpha-pregnan-20-one. Pe, PMS
89  1996 The neurosteroid pregnenolone sulfate reduces learning deficits induced by scopolamine and has promnestic effects in mice performing an appetitive learning task. i.c.v, s.c
90  1995 An autoradiographic study comparing the interactions of 3 alpha-OH-5 alpha-pregnan-20-one, pregnenolone sulfate and pentobarbital with [3S]-TBPS binding sites and their modulation by GABA in different structures of the rat brain. 3 alpha 5 alpha P
91  1995 Male preference for the odors of estrous female mice is reduced by the neurosteroid pregnenolone sulfate. NMDA
92  1995 Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive. ME
93  1995 Pregnenolone sulfate potentiation of NMDA-mediated increases in intracellular calcium in cultured chick cortical neurons. ---
94  1995 The effects of pregnenolone sulfate and ethylestrenol on retention of a passive avoidance task. ---
95  1994 Patch-clamp analysis of direct steroidal modulation of glutamate receptor-channels. NMDA
96  1994 Photoaffinity labeling with progesterone-11 alpha-hemisuccinate- (2-[125I]iodohistamine) identifies four protein bands in mouse brain membranes. CHO, COR, EST, Pg, TES
97  1994 The neurosteroid pregnenolone sulfate blocks NMDA antagonist-induced deficits in a passive avoidance memory task. ---
98  1993 Does neurosteroid modulatory efficacy depend on GABAA receptor subunit composition? ---
99  1993 Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons. NMDA
100  1992 Biochemical and behavioral effects of steroids on GABAA receptor function in long- and short-sleep mice. LS, SS, THDOC