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Abbreviation : PS
Long Form : presenilin
No. Year Title Co-occurring Abbreviation
2018 Abeta and the dementia syndrome: Simple versus complex perspectives. ACH, APP
2018 Glycosylation status of nicastrin influences catalytic activity and substrate preference of gamma-secretase. APH-1, Lec, NCT, PEN-2
2018 Presenilin Regulates Retinotectal Synapse Formation through EphB2 Receptor Processing. AMPAR, NMDAR
2018 Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity. APP, Syt7
2018 Proteolytic Processing of Neurexins by Presenilins Sustains Synaptic Vesicle Release. Nrxn-CTF
2018 The presenilin loop region is essential for glycogen synthase kinase 3 beta (GSK3beta) mediated functions on motor proteins during axonal transport. AD, GSK3beta
2017 APP mouse models for Alzheimer's disease preclinical studies. AD, APP, FAD, Tg
2017 Mutant presenilin2 promotes apoptosis through the p53/miR-34a axis in neuronal cells. AD
2017 Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2. APOE, FAD, gamma-CTF, LDL, WT
10  2016 Anti-Alzheimer Therapeutic Drugs Targeting gamma-Secretase. FAD, GSIs, GSMs
11  2016 Binding of transcription factors to Presenilin 1 and 2 promoter cis-acting elements varies during the development of mouse cerebral cortex. ---
12  2016 Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression. APP
13  2016 Characterization of FRM-36143 as a new gamma-secretase modulator for the potential treatment of familial Alzheimer's disease. APP, CNS, DHCR24, FAD, GSMs
14  2016 Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating gamma-Secretase Activity. APH-1, NCT, PEN-2
15  2016 Folic Acid Supplementation Mitigates Alzheimer's Disease by Reducing Inflammation: A Randomized Controlled Trial. AD, Hcy, IL-6, MMSE, SAH, SAM, TNF-alpha
16  2016 Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of gamma-secretase. AD, APH1, APP, NCT, NICD, Pen2
17  2015 Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzheimer's Disease-Causing Mutants in Presenilins. FAD
18  2015 APP intracellular domain derived from amyloidogenic beta- and gamma-secretase cleavage regulates neprilysin expression. AD, AICD, APLP2, APP, NEP
19  2015 Distribution of LIM domain kinase 1 in the olfactory bulb, cerebral cortex, hippocampus, and cerebellum of the App/PS+/- mice. AD, APP, LIMK1
20  2015 Epigenetic regulation of presenilin 1 and 2 in the cerebral cortex of mice during development. ---
21  2015 Exposure to As-, Cd-, and Pb-mixture induces Abeta, amyloidogenic APP processing and cognitive impairments via oxidative stress-dependent neuroinflammation in young rats. AD, APP, BACE, Cd
22  2015 Loss of Spatial Memory, Learning, and Motor Function During Normal Aging Is Accompanied by Changes in Brain Presenilin 1 and 2 Expression Levels. ---
23  2015 Molecular cloning and characterization of presenilin gene in Bombyx mori. B. mori, BmPS, UTR
24  2015 Peptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce ss-amyloid in Alzheimer's disease. AD, APP
25  2015 The topology of pen-2, a gamma-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain. APH, NCT, Pen-2
26  2015 Twenty Years of Presenilins--Important Proteins in Health and Disease. AD, APP
27  2014 Allosteric regulation of gamma-secretase activity by a phenylimidazole-type gamma-secretase modulator. GSMs
28  2014 Analysis of Presenilin 1 and 2 interacting proteins in mouse cerebral cortex during development. Co-IP
29  2014 Binding of longer Abeta to transmembrane domain 1 of presenilin 1 impacts on Abeta42 generation. Abeta42, GSMs, TMD
30  2014 Chronic neurodegenerative consequences of traumatic brain injury. APOE, APP, CTE, DP, NEP, TBI
31  2014 Development of CBAP-BPyne, a probe for gamma-secretase and presenilinase. PSase, SPP
32  2014 Function and dysfunction of presenilin. ---
33  2014 Inhibition of presenilins attenuates proliferation and invasion in bladder cancer cells through multiple pathways. DAPT, UCB
34  2014 Physiological functions of presenilins; beyond gamma-secretase. ER, FAD
35  2014 PS dependent APP cleavage regulates glucosylceramide synthase and is affected in Alzheimer's disease. AD, APP, GCS
36  2014 The E280A presenilin mutation reduces voltage-gated sodium channel levels in neuronal cells. FAD, wtPS1
37  2014 The gamma-secretase complex: from structure to function. AD, APH-1, APP, PEN-2, TM
38  2014 Upregulation of PGC-1alpha expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP. AD, AICD, APP, FAD
39  2014 [Effects of grain-sized moxibustion on learning and memory ability and amyloid deposition of transgenic Alzheimer's disease mice]. AD, APP
40  2013 BACE1 and presenilin/gamma-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels. CTF
41  2013 Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model. AD, APP
42  2013 Critical role of presenilin-dependent gamma-secretase activity in DNA damage-induced promyelocytic leukemia protein expression and apoptosis. AD, AICD, CPT, KO, PML, PML-NBs
43  2013 Disaggregation of amyloid plaque in brain of Alzheimer's disease transgenic mice with daily subcutaneous administration of a tetravalent bispecific antibody that targets the transferrin receptor and the Abeta amyloid peptide. AAA, AD, APP, BBB, mAb, s.c, scFv, TfR
44  2013 gamma-secretase modulators and presenilin 1 mutants act differently on presenilin/gamma-secretase function to cleave Abeta42 and Abeta43. AD, GSMs
45  2013 Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of gamma-secretase. APP
46  2013 Interactome analyses of mature gamma-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2. AD
47  2013 Presenilin 1/gamma-secretase modulates P-cadherin processing and influences cell adhesion in oral squamous cell carcinoma cell lines. OSCC, POK
48  2013 Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo. AD, APP
49  2013 Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons. RyR
50  2013 Presenilins regulate the cellular activity of ryanodine receptors differentially through isotype-specific N-terminal cysteines. AD, ER, NTF, RyR
51  2013 Serum beta-amyloid peptide levels spike in the early stage of Alzheimer-like plaque pathology in an APP/PS1 double transgenic mouse model. AD, APP, ELISA
52  2013 The senescence hypothesis of disease progression in Alzheimer disease: an integrated matrix of disease pathways for FAD and SAD. AD, APP, SAD
53  2012 Contribution of the gamma-secretase subunits to the formation of catalytic pore of presenilin 1 protein. ---
54  2012 Differential regulation of amyloid precursor protein/presenilin 1 interaction during Abeta40/42 [corrected] production detected using fusion constructs. AD, APP, FAD
55  2012 Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice. AD, LTD, LTP, non-Tg, RyR
56  2012 Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels. ER, FAD
57  2012 Modulation of transient receptor potential melastatin related 7 channel by presenilins. APP, FAD, TRPM7
58  2012 Neuronal calcium signaling and Alzheimer's disease. APP, FAD
59  2012 Ocular manifestations of Alzheimer's disease in animal models. AD, APP, NFTs, SPs
60  2012 Presenilin 1 and 2 are expressed differentially in the cerebral cortex of mice during development. ---
61  2012 Presenilins: a novel link between intracellular calcium signaling and lysosomal function? FAD
62  2012 Stabilizing ER Ca2+ channel function as an early preventative strategy for Alzheimer's disease. AD, RyR
63  2011 Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. AD, TVs
64  2011 Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds. GSMs, NSAID
65  2011 Characterization of nectin processing mediated by presenilin-dependent gamma-secretase. ---
66  2011 Comparison of presenilin 1 and presenilin 2 gamma-secretase activities using a yeast reconstitution system. NCT
67  2011 Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling. AD, CaMKIV, CREB, FAD
68  2011 gamma-Secretase-mediated regulation of neprilysin: influence of cell density and aging and modulation by imatinib. AbetaPP, AD, NEP
69  2011 Hippocampal synaptic plasticity in Alzheimer's disease: what have we learned so far from transgenic models? AD, Tg
70  2011 Mechanisms of AD neurodegeneration may be independent of Abeta and its derivatives. AD, APP
71  2011 Minor contribution of presenilin 2 for gamma-secretase activity in mouse embryonic fibroblasts and adult mouse brain. APP
72  2011 Presenilin regulates insulin signaling via a gamma-secretase-independent mechanism. IR
73  2011 Presenilin-2 modulation of ER-mitochondria interactions: FAD mutations, mechanisms and pathological consequences. FAD
74  2011 Presenilin/gamma-secretase regulates neurexin processing at synapses. CTFs, FAD, PS cDKO, PS1
75  2011 Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age. AD, APP, CT, NFTs, SPs
76  2011 Surface trafficking of sodium channels in cells and in hippocampal slices. ---
77  2011 The many substrates of presenilin/gamma-secretase. AbetaPP, AD
78  2010 Activation and intrinsic gamma-secretase activity of presenilin 1. FAD, rPS
79  2010 Affinity pulldown of gamma-secretase and associated proteins from human and rat brain. APP, GSAPs
80  2010 Alzheimer's secretases regulate voltage-gated sodium channels. ---
81  2010 Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. AD, WtTau
82  2010 Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex. APP, WT
83  2010 Evidence for the involvement of calbindin D28k in the presenilin 1 model of Alzheimer's disease. AD, ER, LTP, MWM
84  2010 Exploring Alzheimer's disease in zebrafish. AbetaPP, AD, APOE
85  2010 Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase. TMDs
86  2010 Glutamate carboxypeptidase II: an amyloid peptide-degrading enzyme with physiological function in the brain. APP, GCPII
87  2010 Impaired neurotransmitter release in Alzheimer's and Parkinson's diseases. AD, PD
88  2010 Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function. AD, DmGluRA, FAD, mGluR, psn
89  2010 Presenilin 1-related alterations in DNA integrity in a transgenic mouse model of Alzheimer's disease. APP, SSB
90  2010 Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7. EGFR
91  2010 Presenilin/gamma-Secretase and Inflammation. AD, APP
92  2010 Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage. ---
93  2010 The production ratios of AICDepsilon51 and Abeta42 by intramembrane proteolysis of betaAPP do not always change in parallel. AD, AICD, beta-APP
94  2009 Accumulation of phosphorylated beta-catenin enhances ROS-induced cell death in presenilin-deficient cells. ---
95  2009 Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains. NCT, TAP
96  2009 Comparison of Abeta levels in the brain of familial and sporadic Alzheimer's disease. AD, APP, SAD
97  2009 Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor. BACE, beta-APP, Dx-E
98  2009 Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease. AD, APP, PS1
99  2009 Increased levels of NMDA receptor NR2A subunits at pre- and postsynaptic sites of the hippocampal CA1: an early response to conditional double knockout of presenilin 1 and 2. AD, NMDAR
100  2009 Indirect regulation of presenilins in CREB-mediated transcription. cDKO, CREB, MEFs