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Abbreviation : PTECs
Long Form : proximal tubular epithelial cells
No. Year Title Co-occurring Abbreviation
2020 An Improved Vascularized, Dual-Channel Microphysiological System Facilitates Modeling of Proximal Tubular Solute Secretion. FITC, HUVECs, PAH, VPT-MPS
2020 Blocking Connexin-43 mediated hemichannel activity protects against early tubular injury in experimental chronic kidney disease. ATP, CKD, Cx43, EMT, GJIC, HC, hPTECs, NLR, TGF-beta1, UUO, ZO-1
2020 Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia. FSS, P-gp
2020 Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity. DIKI
2020 IL-4 Receptor alpha Chain Protects the Kidney Against Tubule-Interstitial Injury Induced by Albumin Overload. AKI, BSA, IL, TII
2020 Inhibiting Rab27a in renal tubular epithelial cells attenuates the inflammation of diabetic kidney disease through the miR-26a-5p/CHAC1/NF-kB pathway. BSA, DKD, UTR
2020 Integrative Omics Analyses Reveal Epigenetic Memory in Diabetic Renal Cells Regulating Genes Associated With Kidney Dysfunction. DKD, T2D, TAGs
2020 Macrophage interactions with collecting duct epithelial cells are capable of driving tubulointerstitial inflammation and fibrosis in immunoglobulin Anephropathy. CDECs, IgA, MCM, miR, NGAL
2020 Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells. ---
10  2020 miR-196b-5p-enriched extracellular vesicles from tubular epithelial cells mediated aldosterone-induced renal fibrosis in mice with diabetes. DKD, ECM, EVs, miRNA
11  2020 Peritoneal M2 macrophage transplantation as a potential cell therapy for enhancing renal repair in acute kidney injury. AKI, IL, IRI
12  2020 Podocyte-derived extracellular vesicles mediate renal proximal tubule cells dedifferentiation via microRNA-221 in diabetic nephropathy. DN, EVs, miRNA
13  2019 AMPK alleviates high uric acid-induced Na+-K+-ATPase signaling impairment and cell injury in renal tubules. AICAR, AMP, HUA, IL-1beta, LKB1, mTOR, NKA, UA
14  2019 Calcium-sensing receptor activation attenuates collagen expression in renal proximal tubular epithelial cells. CaSR, TGF
15  2019 Correlation of prechemotherapy urinary megalin ectodomain (A-megalin) levels with the development of cisplatin-induced nephrotoxicity: a prospective observational study. A-megalin, A-megalin, eGFR, HRs
16  2019 Establishment of renal proximal tubule cell lines derived from the kidney of p53 knockout mice. ---
17  2019 GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells. AON, ASGPR
18  2019 Hepatocyte nuclear factor 4alpha regulates megalin expression in proximal tubular cells. CKD, HNF4alpha
19  2019 Human Tissue-Resident Mucosal-Associated Invariant T (MAIT) Cells in Renal Fibrosis and CKD. MAIT
20  2019 Long term safety of targeted internalization of cell penetrating peptide crotamine into renal proximal tubular epithelial cells in vivo. i.p
21  2019 Mitochondria transfer from mesenchymal stem cells structurally and functionally repairs renal proximal tubular epithelial cells in diabetic nephropathy in vivo. BM-MSCs, DN, HG, mt, ROS, STZ
22  2019 PGC-1alpha, a potential therapeutic target against kidney aging. PGC-1alpha
23  2019 Protein arginine methyltranferase-1 induces ER stress and epithelial-mesenchymal transition in renal tubular epithelial cells and contributes to diabetic nephropathy. ATF6, EMT, IRE1alpha, PERK, sh-PRMT1
24  2019 Protein O-GlcNAcylation Is Essential for the Maintenance of Renal Energy Homeostasis and Function via Lipolysis during Fasting and Diabetes. OGT
25  2019 Proximal Tubule Autophagy Differs in Type 1 and 2 Diabetes. mTOR, STZ
26  2019 Pterostilbene alleviates fructose-induced renal fibrosis by suppressing TGF-beta1/TGF-beta type I receptor/Smads signaling in proximal tubular epithelial cells. EMT, IR, IRS-1, Smad2, TGF-beta1
27  2019 Renal proximal tubular epithelial cells exert immunomodulatory function by driving inflammatory CD4+ T cell responses. CGN, MHC-II
28  2019 Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis. Ab, CKD, HGF
29  2019 The protective role of estrogen and its receptors in gentamicin-induced acute kidney injury in rats. ---
30  2019 Upregulation of HER2 in tubular epithelial cell drives fibroblast activation and renal fibrosis. CTGF, HER2, STZ
31  2018 A bioartificial kidney device with polarized secretion of immune modulators. BAK
32  2018 Circulating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption. FABP4
33  2018 Different sulfonylureas induce the apoptosis of proximal tubular epithelial cell differently via closing KATP channel. SURs, SUs
34  2018 Impaired Na+-K+-ATPase signaling in renal proximal tubule contributes to hyperuricemia-induced renal tubular injury. FEB, IL-1beta, NKA, NLRP3, UA
35  2018 Indoxyl Sulfate Induces Apoptosis and Hypertrophy in Human Kidney Proximal Tubular Cells. IS
36  2018 Inducible nitric oxide synthase inhibitor 1400W increases Na+ ,K+ -ATPase levels and activity and ameliorates mitochondrial dysfunction in Ctns null kidney proximal tubular epithelial cells. iNOS, NO
37  2018 Podocyte-derived microparticles promote proximal tubule fibrotic signaling via p38 MAPK and CD36. ECM, hPODs, MPs, TGF-beta
38  2018 Protective Effect of Salidroside Against Diabetic Kidney Disease Through Inhibiting BIM-Mediated Apoptosis of Proximal Renal Tubular Cells in Rats. BUN, DKD, HG, Sal, SCr
39  2018 Repeated exposure of epithelial cells to apoptotic cells induces the specific selection of an adaptive phenotype: Implications for tumorigenesis. ---
40  2018 Role of Mesangial-Podocytic-Tubular Cross-Talk in IgA Nephropathy. IgAN
41  2018 Tctex-1, a novel interaction partner of Kidney Injury Molecule-1, is required for efferocytosis. KIM-1
42  2018 The Potential Role of Bile Acids in Acquired Laryngotracheal Stenosis. EMT, MMP, TGF
43  2018 Uric acid upregulates the adiponectin‑adiponectin receptor1 pathway in renal proximal tubule epithelial cells. APN, HUA, NLRP, sUA
44  2018 Urinary Iron Excretion is Associated with Urinary Full-Length Megalin and Renal Oxidative Stress in Chronic Kidney Disease. CKD
45  2017 Autophagy Inhibits the Accumulation of Advanced Glycation End Products by Promoting Lysosomal Biogenesis and Function in the Kidney Proximal Tubules. AGEs
46  2017 Calcium Dobesilate Prevents Diabetic Kidney Disease by Decreasing Bim and Inhibiting Apoptosis of Renal Proximal Tubular Epithelial Cells. DKD
47  2017 Epigenetic memory of oxidative stress: does nephrilin exert its protective effects via Rac1? NOX, ROS, UVA
48  2017 HK2 Proximal Tubule Epithelial Cells Synthesize and Secrete Plasma Proteins Predominantly Through the Apical Surface. ---
49  2017 Inhibiting post-translational core fucosylation protects against albumin-induced proximal tubular epithelial cell injury. BSA, RIF
50  2017 ORAI channels are critical for receptor-mediated endocytosis of albumin. AMN, DN
51  2017 Parietal cells-new perspectives in glomerular disease. PECs
52  2017 Possible role of mitochondrial injury in Caulis Aristolochia manshuriensis-induced chronic aristolochic acid nephropathy. AAN, CAM, mtDNA, PGC-1alpha
53  2017 Sulodexide Protects Renal Tubular Epithelial Cells from Oxidative Stress-Induced Injury via Upregulating Klotho Expression at an Early Stage of Diabetic Kidney Disease. AGEs, DKD, SDX
54  2017 TGF-beta1 stimulates movement of renal proximal tubular epithelial cells in a three-dimensional cell culture via an autocrine TGF-beta2 production. ---
55  2016 Boiogito Increases the Metabolism of Fatty Acids in Proximal Tubular Cells through Peroxisome Proliferators-Activated Receptor (PPAR) alpha Agonistic Activity. AsR, BO, BSA, CREB, ELISA, PCR, PPAR
56  2016 Effect of clofibrate on fatty acid metabolism in the kidney of puromycin-induced nephrotic rats. ERRalpha, LCAD, MCAD, NAG, PAN, PGC-1alpha, PPARalpha, VLCAD
57  2016 Egr-1 deficiency protects from renal inflammation and fibrosis. Egr-1, TIN
58  2016 Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell Carcinoma. ccRCC, SETD2
59  2016 Hyperglycemia Does Not Affect Iron Mediated Toxicity of Cultured Endothelial and Renal Tubular Epithelial Cells: Influence of L-Carnosine. DMT1, HG, HUVECs, ROS
60  2016 Lysosomal cystine accumulation promotes mitochondrial depolarization and induction of redox-sensitive genes in human kidney proximal tubular cells. OS, ROS
61  2016 Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes. DKD, KIM-1, MPT, OCR, OXPHOS
62  2016 Megalin-Mediated Tubuloglomerular Alterations in High-Fat Diet-Induced Kidney Disease. HFD, KO, MetS
63  2016 Monomeric C-reactive protein inhibits renal cell-directed complement activation mediated by properdin. AP, CRP
64  2016 Role of serotonin in the regulation of renal proximal tubular epithelial cells. PL
65  2015 Apoptotic cells activate AMP-activated protein kinase (AMPK) and inhibit epithelial cell growth without change in intracellular energy stores. AMPK, p70S6K
66  2015 BMP7 reduces inflammation and oxidative stress in diabetic tubulopathy. AGEs, BMP-7, ICAM-1, IL-6, IL-8, MAPK, MCP-1
67  2015 Fractalkine-CX3CR1-dependent recruitment and retention of human CD1c+ myeloid dendritic cells by in vitro-activated proximal tubular epithelial cells. CKD, DCs, TGF-beta
68  2015 HMGB1 Enhances the AGE-Induced Expression of CTGF and TGF-beta via RAGE-Dependent Signaling in Renal Tubular Epithelial Cells. AGEs, CTGF, EMT, HMGB1, RAGE, TGF-beta
69  2015 In vivo sodium tungstate treatment prevents E-cadherin loss induced by diabetic serum in HK-2 cell line. DN, EMT, TGF, VEGF
70  2015 The long noncoding RNA landscape in hypoxic and inflammatory renal epithelial injury. lncRNAs
71  2015 The Regulation of TGFbeta1 Induced Fibronectin EDA Exon Alternative Splicing in Human Renal Proximal Tubule Epithelial Cells. FN
72  2015 The renoprotective role of autophagy activation in proximal tubular epithelial cells in diabetic nephropathy. 3-MA, CQ, DN, EMT, mTOR
73  2015 Tubular reabsorption of high, middle and low molecular weight proteins according to the tubulo-interstitial damage marker N-acetyl-beta-D-glucosaminidase in glomerulonephritis. CIgAN, eGFR, ESRD, FSGS, GFB, GNs, IMN, MCD, MW, NAG
74  2014 Accelerated receptor shedding inhibits kidney injury molecule-1 (KIM-1)-mediated efferocytosis. AKI, KIM-1
75  2014 BMP-7 represses albumin-induced chemokine synthesis in kidney tubular epithelial cells through destabilization of NF-kappaB-inducing kinase. BMP-7, cIAP1, HSA, NF, NIK, TRAF
76  2014 Extracellular vesicles released from mesenchymal stromal cells modulate miRNA in renal tubular cells and inhibit ATP depletion injury. EVs, miRNAs, MSCs
77  2014 Megalin-mediated specific uptake of chitosan/siRNA nanoparticles in mouse kidney proximal tubule epithelial cells enables AQP1 gene silencing. AQP1
78  2014 Mesenchymal stem cells modulate albumin-induced renal tubular inflammation and fibrosis. BM-MSCs, CKD, EMT, HGF, TSG
79  2014 Properdin has an ascendancy over factor H regulation in complement-mediated renal tubular damage. AP, ELISA, FH, MAC, NHS, PCR, PDS
80  2014 Proximal tubule toll-like receptor 4 expression linked to inflammation and apoptosis following hypoxia/reoxygenation injury. I/R, IL, TLR4, TNF
81  2014 Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling. AGEs, DN, ER, GRP78, RAGE, SA-beta-gal
82  2014 The endocytic receptor megalin and its associated proteins in proximal tubule epithelial cells. ---
83  2013 Albumin upregulates eNOS mRNA through ETRA/B in human proximal tubular epithelial cells. ET, NO
84  2013 Notch4-dependent antagonism of canonical TGF-beta1 signaling defines unique temporal fluctuations of SMAD3 activity in sheared proximal tubular epithelial cells. TGF-beta1
85  2013 The entire miR-200 seed family is strongly deregulated in clear cell renal cell cancer compared to the proximal tubular epithelial cells of the kidney. ccRCC, miRNA
86  2012 18S rRNA is a reliable normalisation gene for real time PCR based on influenza virus infected cells. 18S rRNA, ACTB, GAPDH, HBECs, qRT-PCR
87  2012 Disorder of fatty acid metabolism in the kidney of PAN-induced nephrotic rats. CYP, ERR, MCAD, NARs, PAN, PPAR, SDRs
88  2012 Epithelial-mesenchymal transition and fibrosis are mutually exclusive reponses in shear-activated proximal tubular epithelial cells. EMT, RF
89  2012 Heparanase and syndecan-1 interplay orchestrates fibroblast growth factor-2-induced epithelial-mesenchymal transition in renal tubular cells. EMT, HK2, HS
90  2011 Eicosapentaenoic acid regulates IkappaBalpha and prevents tubulointerstitial injury in kidney. DHA, EPA, LPS, NF-kappaB, siRNA
91  2011 Epithelial-mesenchymal transition in renal fibrosis - evidence for and against. EMT, RFP
92  2011 Tissue specificity of cross-reactive allogeneic responses by EBV EBNA3A-specific memory T cells. EBNA3A, HLA, HUVECs
93  2011 Tubular toxicity of proteinuria. ---
94  2010 High-mobility group box protein 1: a novel mediator of inflammatory-induced renal epithelial-mesenchymal transition. aPBMCs, EMT, HMGB-1
95  2010 Molecular mechanisms of receptor-mediated endocytosis in the renal proximal tubular epithelium. ---
96  2010 [Construction of recombinant adenovirus containing BMP-7 gene and its expression in proximal tubule epithelial cells]. alpha-SMA, BMP-7
97  2009 Hypoxia response and VEGF-A expression in human proximal tubular epithelial cells in stable and progressive renal disease. EGF, HIF, IGF-1, VEGF
98  2009 Protection against oxidative stress, inflammation, and apoptosis of high-glucose-exposed proximal tubular epithelial cells by astaxanthin. COX-2, iNOS, NF-kappaB, RS
99  2008 Albumin induces interleukin-6 release from primary human proximal tubule epithelial cells. ELISA, IL-6, PDTC, TGF-beta1
100  2008 BMP-7 and proximal tubule epithelial cells: activation of multiple signaling pathways reveals a novel anti-fibrotic mechanism. BMP-7, FN, MAP, TGF-beta