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Abbreviation : PTEN
Long Form : phosphatase and tensin homolog deleted on chromosome ten
No. Year Title Co-occurring Abbreviation
2020 An outlined review for the role of Nedd4-1 and Nedd4-2 in lung disorders. AMPAR, cAMP, CRTC3, Dvl2, ENaC, GCN2
2020 Berberine ameliorates renal injury in a rat model of D-galactose-induced aging through a PTEN/Akt-dependent mechanism. BBR, D-gal
2020 Effects of miR-21 on proliferation and apoptosis of WT cells via PTEN/Akt pathway. CCK-8, miR, mRNA, NC, p-Akt, RT-qPCR, UTR, WT
2020 Inhibition of MiR-122 Decreases Cerebral Ischemia-reperfusion Injury by Upregulating DJ-1-Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN)/Phosphonosinol-3 Kinase (PI3K)/AKT. MDA, mNSS, PI3K, ROS, SOD
2020 Long Non-Coding RNA PART1 Exerts Tumor Suppressive Functions in Glioma via Sponging miR-190a-3p and Inactivation of PTEN/AKT Pathway. lncRNA, PART1, RT-qPCR
2020 MicroRNA-181c provides neuroprotection in an intracerebral hemorrhage model. PI3K
2020 miR-130a alleviates neuronal apoptosis and changes in expression of Bcl-2/Bax and caspase-3 in cerebral infarction rats through PTEN/PI3K/Akt signaling pathway. CI, ELISA, IL-6, miR, PI3K, qPCR, SD, TNF-alpha, TUNEL
2020 miR-136-3p targets PTEN to regulate vascularization and bone formation and ameliorates alcohol-induced osteopenia. BMSCs, HUVECs
2020 MiR-19 enhances pancreatic cancer progression by targeting PTEN through PI3K/AKT signaling pathway. miRNAs, MTT, qRT-PCR, TNM
10  2020 Molecular Characteristics, Phylogeny and Expression Profile of the PTEN Gene in Goats. qPCR, RT-PCR
11  2020 SNHG1 promotes MPP+-induced cytotoxicity by regulating PTEN/AKT/mTOR signaling pathway in SH-SY5Y cells via sponging miR-153-3p. ceRNA, MPTP, PD, SNHG1
12  2020 The Metabolic Reprogramming Profiles in the Liver Fibrosis of Mice Infected with Schistosoma japonicum. AST, S. japonicum, SEA
13  2019 A clinical study on the expression of PTEN in renal cell carcinoma in children. RCC, RT-qPCR
14  2019 A comparative analysis of gene expression induced by the embryo in the caprine endometrium. DEGs, ED15, ED5, GO, NTS, PTN, TES
15  2019 Adipose PTEN regulates adult adipose tissue homeostasis and redistribution via a PTEN-leptin-sympathetic loop. rAAV
16  2019 Association between PTEN and clinical-pathological features of osteosarcoma. CBM, CIs, CNKI, OR, OS
17  2019 ATG7 regulates hepatic Akt phosphorylation through the c-JUN/PTEN pathway in high fat diet-induced metabolic disorder. ATG7, HFD
18  2019 Beyond Trophic Factors: Exploiting the Intrinsic Regenerative Properties of Adult Neurons. APC, PNS, SC
19  2019 Bisperoxovanadium protects against spinal cord injury by regulating autophagy via activation of ERK1/2 signaling. ASC, SCI
20  2019 Botulinum toxin type A prevents the phenotypic transformation of fibroblasts induced by TGF‑beta1 via the PTEN/PI3K/Akt signaling pathway. BTX-A, DNMT, ECM, EMT, HS, MSP, PI3K, TGF
21  2019 Catalpol improves axonal outgrowth and reinnervation of injured sciatic nerve by activating Akt/mTOR pathway and regulating BDNF and PTEN expression. BDNF, GAP-43, SNCI, TEM
22  2019 Circ-0104631 promotes cell proliferation and invasion in colorectal cancer and predicts poor prognosis. CCK-8, CRC, mTOR, qRT-PCR, TNM
23  2019 Coelonin, an Anti-Inflammation Active Component of Bletilla striata and Its Potential Mechanism. IL-1beta, IL-6, LPS, NF-kappaB, TNF-alpha
24  2019 Correlation between PTEN gene polymorphism and oral squamous cell carcinoma. OSCC, PCR-RFLP, qPCR
25  2019 CYP1A2 contributes to alcohol-induced abnormal lipid metabolism through the PTEN/AKT/SREBP-1c pathway. CYP1A2, SREBP-1c
26  2019 Dihydromyricetin promotes autophagy and attenuates renal interstitial fibrosis by regulating miR-155-5p/PTEN signaling in diabetic nephropathy. DHM, DN, HE, HG, IHC, NG, qRT, RIF
27  2019 Downregulated miRNA-26a-5p induces the apoptosis of endothelial cells in coronary heart disease by inhibiting PI3K/AKT pathway. CAD, CCK-8, miRNAs, PI3K, VEGF
28  2019 Downregulation of miR-183 inhibits the growth of PANC-1 pancreatic cancer cells in vitro and in vivo, and increases chemosensitivity to 5-fluorouracil and gemcitabine. Bcl-2, miR, PC, PI3K
29  2019 Effect of adenovirus-mediated overexpression of PTEN on brain oxidative damage and neuroinflammation in a rat kindling model of epilepsy. Ad, ANOVA, Iba1, MDA, ROS, SE, SOD
30  2019 Effect of miR-26a on diabetic rats with myocardial injury by targeting PTEN. Bax, Bcl-2, Caspase-3, HE, miR, mRNA, qRT-PCR, TUNEL
31  2019 Effects of miR-21 on hypertensive rats through PTEN/PI3K/Akt/mTOR signaling pathway. HE, miR, mTOR, PI3K, qRT-PCR, SHRs, TUNEL
32  2019 FOXF2 aggravates the progression of non-small cell lung cancer through targeting lncRNA H19 to downregulate PTEN. ChIP, lncRNA, NSCLC, qRT-PCR
33  2019 Heterogeneity of PTEN and PPAR-gamma in cancer and their prognostic application to bladder cancer. PPARgamma
34  2019 Impaired cerebellar plasticity and eye-blink conditioning in calpain-1 knock-out mice. CRs, DHPG, EBC, ERK, KO, LTD, LTP, PP2A, WT
35  2019 LINC01116 promotes proliferation, invasion and migration of osteosarcoma cells by silencing p53 and EZH2. CCK-8, ChIP, EZH2, pcDNA, qRT-PCR, RIP
36  2019 MicroRNA-142 promotes the development of nasopharyngeal carcinoma through targeting PTEN. CCK-8, NPC, qRT-PCR
37  2019 microRNA-21 expressions impact on liver fibrosis in biliary atresia patients. alpha-SMA, BA, miRNAs, qPCR
38  2019 MicroRNA-3651 promotes the growth and invasion of hepatocellular carcinoma cells by targeting PTEN. HCC, miR-3651
39  2019 MiR-19b-3p regulates osteogenic differentiation of PDGFRalpha+ muscle cells by specifically targeting PTEN. HO
40  2019 miR-21 regulates the proliferation and apoptosis of ovarian cancer cells through PTEN/PI3K/AKT. PI3K
41  2019 MiR-92b-3p promotes neurite growth and functional recovery via the PTEN/AKT pathway in acute spinal cord injury. ASCI, BBB
42  2019 miRNA-21 inhibition suppresses the human epithelial ovarian cancer by targeting PTEN signal pathway. EOC
43  2019 Over-expression of DJ-1 attenuates effects of curcumin on colorectal cancer cell proliferation and apoptosis. CUR, RT-PCR
44  2019 Overexpression of DJ-1 expression protects cardiomyocyte apoptosis induced by ischemia reperfusion. IR, MDA, OS, p-AKT, ROS, SOD
45  2019 Overexpression of tensin homolog deleted on chromosome ten (PTEN) by ciglitazone sensitizes doxorubicin-resistance leukemia cancer cells to treatment. DOX, MDR, MTT, P-gp, PPARs, qRT-PCR, Rho123
46  2019 Pharmacological Inhibition of PTEN Restores Remote Ischemic Postconditioning Cardioprotection in Hypercholesterolemic Mice: Potential Role of PTEN/AKT/GSK3beta SIGNALS. AMI, bpV, I/R, RIPC
47  2019 Polyoxometalate SbW9 regulates proliferation and apoptosis of NSCLC cells via PTEN-dependent AKT signaling pathway. Bax, Bcl-2, NSCLC, p-AKT, t-AKT, TUNEL, XTT
48  2019 Prognostic and Predictive Implications of PTEN in Breast Cancer: Unfulfilled Promises but Intriguing Perspectives. BC, PI3K
49  2019 PTEN improve renal fibrosis in vitro and in vivo through inhibiting FAK/AKT signaling pathway. ECM, FAK, UUO
50  2019 PTEN interacts with the transcription machinery on chromatin and regulates RNA polymerase II-mediated transcription. RNAPII
51  2019 Seed targeting with tiny anti-miR-1297 inhibits EMT in melanoma cells. EMT, IHC, miRNAs
52  2019 SP1-regulated LINC01638 promotes proliferation and inhibits apoptosis in non-small cell lung cancer. CCK, NSCLC, qRT-PCR, Sp1
53  2019 The pseudogene PTENP1 regulates smooth muscle cells as a competing endogenous RNA. AA, AD, Ang II, HASMCs, lncRNA, SMC
54  2019 Therapeutic Delivery of miR-29b Enhances Radiosensitivity in Cervical Cancer. HR
55  2019 Therapeutic effect of bevacizumab combined with paclitaxel and carboplatin on recurrent ovarian cancer. BEV, CR, ORR, OS, PD, PFS, PR, QOL, SD
56  2019 Valproic acid attenuates sepsis-induced myocardial dysfunction in rats by accelerating autophagy through the PTEN/AKT/mTOR pathway. ATP, HDAC, mtDNA, RT-PCR, SIMD, VPA
57  2019 XBP1 inhibits mesangial cell apoptosis in response to oxidative stress via the PTEN/AKT pathway in diabetic nephropathy. DM, DN, HG, MCs, ROS, XBP1
58  2019 [Effect of downregulation of phosphatase and tensin homolog gene expression on p130crk- related substrate protein and paxillin signal transduction in activated hepatic stellate cells in vitro]. GFP, HSC, p130Cas, shRNA
59  2019 [Phosphatase and tensin homolog deleted on chromosome ten deficiency sensitizes tumor cells to lithium chloride treatment]. LiCl, MEF, mTOR
60  2018 Aberrant Akt Activation During Implantation Window in Infertile Women With Intramural Uterine Fibroids. PI3K
61  2018 Activation of peroxisome proliferation-activated receptor-gamma inhibits transforming growth factor-beta1-induced airway smooth muscle cell proliferation by suppressing Smad-miR-21 signaling. ASMC, FOXO1, miR-21, PPARgamma, TGF-beta1
62  2018 Age-related NMDA signaling alterations in SOD2 deficient mice. NMDAR, STEP
63  2018 Association of PTEN expression with liver function and inflammatory changes in patients with liver cancer after chemotherapy. AFP, ALB, ALP, PTA
64  2018 Benefit of everolimus as a monotherapy for a refractory breast cancer patient bearing multiple genetic mutations in the PI3K/AKT/mTOR signaling pathway. ER, HER2, mTOR, NGS, PI3K, PR, PR, SD
65  2018 beta-elemene induced anticancer effect in bladder cancer through upregulation of PTEN and suppression of AKT phosphorylation. AKT, p-AKT
66  2018 Correlation analysis of expressions of PTEN and p53 with the value obtained by magnetic resonance spectroscopy and apparent diffusion coefficient in the tumor and the tumor-adjacent area in magnetic resonance imaging for glioblastoma. ADC, Cho, Cr, DWI, GBM, IHC, MRI, MRS, NAA
67  2018 Dipeptidyl peptidase IV (DPP-4) inhibition alleviates pulmonary arterial remodeling in experimental pulmonary hypertension. DPP-4i, EndMT, MCT, PASMCs, PDGF, PH, RVSP
68  2018 Downregulation of microRNA‑198 suppresses cell proliferation and invasion in retinoblastoma by directly targeting PTEN. PI3K, Rb
69  2018 Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver. 4-HNE, AFL, CMZ, CYP2E1, CYP2E1-HepG2, IGF-1, MDA, NAC, NAFLD, NC-HepG2, PI3K
70  2018 Increased miR-142 and decreased DJ-1 enhance the sensitivity of pancreatic cancer cell to adriamycin. ADM, MiR-142, p-AKT, PI3K, si-NC
71  2018 LncRNA-p21 inhibited the proliferation of osteosarcoma cells via the miR-130b/PTEN/AKT signaling pathway. OS
72  2018 Local Cortisol Elevation Contributes to Endometrial Insulin Resistance in Polycystic Ovary Syndrome. 11beta-HSDs, EECs, IR, PCOS
73  2018 Long non-coding RNA ASAP1-IT1 promotes cell proliferation, invasion and metastasis through the PTEN/AKT signaling axis in non-small cell lung cancer. CCK-8, lncRNA, NSCLC, qRT-PCR
74  2018 MicroRNA-126 regulates the phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT) pathway in SLK cells in vitro and the expression of its pathway members in Kaposi's sarcoma tissue. KS, miR-126, PI3K
75  2018 MicroRNA-92a antagonism attenuates lipopolysaccharide (LPS)-induced pulmonary inflammation and injury in mice through suppressing the PTEN/AKT/NF-kappaB signaling pathway. ALI, BALF, IL-1beta, LPS, miRNAs, TNF-alpha
76  2018 mir-106a regulates cell proliferation and apoptosis of colon cancer cells through targeting the PTEN/PI3K/AKT signaling pathway. CRC, RT-qPCR, UTR
77  2018 MiR-122 regulates cell apoptosis and ROS by targeting DJ-1 in renal ischemic reperfusion injury rat models. BUN, IR, miR-122, p-AKT, qRT-PCR, ROS, SCr
78  2018 MiR-150-3p targets SP1 and suppresses the growth of glioma cells. Sp1
79  2018 miR-21 Inhibitors Modulate Biological Functions of Gastric Cancer Cells via PTEN/PI3K/mTOR Pathway. Bcl-2, miRNAs, mRNA
80  2018 Mir-22-3p Enhances the Chemosensitivity of Gastrointestinal Stromal Tumor Cell Lines to Cisplatin through PTEN/PI3K/Akt Pathway. CCK-8, PI3K
81  2018 Naringenin improve hepatitis C virus infection induced insulin resistance by increase PTEN expression via p53-dependent manner. HCC, HCV, HCVcp, IR, NGEN
82  2018 New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response. Akt, PI3K
83  2018 Notch1 regulates PTEN expression to exacerbate renal tubulointerstitial fibrosis in diabetic nephropathy by inhibiting autophagy via interactions with Hes1. DN
84  2018 Ochratoxin A exposure decreased sperm motility via the AMPK and PTEN signaling pathways. AMP, OTA, ROS
85  2018 PINK1 suppresses alpha-synuclein-induced neuronal injury: a novel mechanism in protein phosphatase 2A activation. alpha-Syn, PD, PINK, PP
86  2018 Pten regulates neural crest proliferation and differentiation during mouse craniofacial development. ---
87  2018 PTEN-L promotes type I interferon responses and antiviral immunity. PTEN-L
88  2018 Role of miR-21 in the growth and metastasis of human salivary adenoid cystic carcinoma. Bcl, PDCD4, SACC
89  2018 Silver nanoparticles induce SH-SY5Y cell apoptosis via endoplasmic reticulum- and mitochondrial pathways that lengthen endoplasmic reticulum-mitochondria contact sites and alter inositol-3-phosphate receptor function. CHOP, ER, GRP78, p-eIF2alpha, p-IRE, p-PERK, XBP1
90  2018 The targeted regulation of miR-26a on PTEN-PI3K/AKT signaling pathway in myocardial fibrosis after myocardial infarction. AMI, HCF, SD
91  2018 Up-Regulation of miR-130b-3p Activates the PTEN/PI3K/AKT/NF-kappaB Pathway to Defense against Mycoplasma gallisepticum (HS Strain) Infection of Chicken. CRD, MG, NF-kappaB, PI3K
92  2018 Up-Regulation of Phosphatase in Regenerating Liver-3 (PRL-3) Contributes to Malignant Progression of Hepatocellular Carcinoma by Activating Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN)/Phosphoinositide 3-Kinase (PI3K)/AKT Signaling Pathway. HCC, PI3K, PRL-3, qRT-PCR
93  2018 Upregulation of HOXA10 Protein Expression Predicts Poor Prognosis for Colorectal Cancer. 5-FU, CRC, DFS, HOX
94  2018 [Effect of Huazhuo Jiedu formula on HIF-1alpha, VEGF, and PTEN in chronic erosive gastritis patients with syndrome of accumulation of turbidity and toxicity]. CEG, VEGF
95  2018 [Effect of phosphatase and tensin homolog deleted on chromosome ten on the neurological function induced by cadmium of mice]. ---
96  2018 [Expression and Significance of PTEN and BCL-2 in Acute Myeloid Leukemia]. AML, Bcl-2
97  2018 [Expression and Significance of PTEN and Survivin in Acute Lymphoblastic Leukemia]. ALL
98  2018 [Expressions and prognostic significance of PTEN and PD-1 protein in patients with classical Hodgkin's lymphoma]. cHL, EBER
99  2018 [The Expression of microRNA-221 in Endometriosis and Its Impact on Endometrial Stromal Cells]. miR-221
100  2017 Anti-Oxidative Stress Activity Is Essential for Amanita caesarea Mediated Neuroprotection on Glutamate-Induced Apoptotic HT22 Cells and an Alzheimer's Disease Mouse Model. AC, ACh, AChE, AD, AIF, Akt, ChAT, d-gal, l-Glu, mTOR, ROS, SOD