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Abbreviation : PTEN
Long Form : phosphatase and tensin homolog
No. Year Title Co-occurring Abbreviation
2020 A Phase Ib/II, open-label, multicenter study of INC280 (capmatinib) alone and in combination with buparlisib (BKM120) in adult patients with recurrent glioblastoma. AEs, MTD
2020 Activating Transcription Factor 3 (ATF3) Protects Retinal Ganglion Cells and Promotes Functional Preservation After Optic Nerve Crush. ATF3, ONC, rAAVs, RBPMS, RGC
2020 Allopregnanolone Reverses Bioenergetic Deficits in Female Triple Transgenic Alzheimer's Mouse Model. AD, ALLO, PPARG, PSEN1, TNF
2020 Anti-Tumor Activity of the IGF-1/IGF-2-Neutralizing Antibody Xentuzumab (BI 836845) in Combination with Enzalutamide in Prostate Cancer Models. AKT, ENZA, IGF, IGF-1R, PDX, XENT
2020 Bone mesenchymal stem cell-derived exosomal microRNA-29b-3p prevents hypoxic-ischemic injury in rat brain by activating the PTEN-mediated Akt signaling pathway. BMEC, BMSCs, MCAO, MSCs, OGD
2020 Catalpol suppresses osteoclastogenesis and attenuates osteoclast-derived bone resorption by modulating PTEN activity. NF-kappaB
2020 Contribution of mTOR and PTEN to Radioresistance in Sporadic and NF2-Associated Vestibular Schwannomas: A Microarray and Pathway Analysis. mTOR, NF2, VEGF, VS
2020 Downregulation of long non-coding RNA NR2F2-AS1 inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cells by upregulating the expression of PTEN. NPC
2020 Downregulation of PTEN promotes podocyte endocytosis of lipids aggravating obesity-related glomerulopathy. F-actin, ORG
10  2020 Dysregulated Expression of Phosphorylated Epidermal Growth Factor Receptor and Phosphatase and Tensin Homologue in Canine Cutaneous Papillomas and Squamous Cell Carcinomas. CPs, cSCCs, pEGFR
11  2020 Evaluation of the PIK3 pathway in peripheral T-cell lymphoma and NK/T-cell lymphoma. IPI, NK, PIK3, PTCL
12  2020 Exosomes derived from normal human bronchial epithelial cells down-regulate proliferation and migration of hydroquinone-transformed malignant recipient cells via up-regulating PTEN expression. ---
13  2020 Exosomes Derived From Schwann Cells Ameliorate Peripheral Neuropathy in Type II Diabetic Mice. DPN, DRG, miR, NF-kappaB, RhoA, SEMA6A
14  2020 Immunohistochemical Analysis of mTOR Pathway-Related Proteins in Kaposiform Hemangioendothelioma. IH, KHE, LM, mTOR, p-4eBP1, p-mTOR, TA, TSC2
15  2020 Inhibition of microRNA-103 attenuates inflammation and endoplasmic reticulum stress in atherosclerosis through disrupting the PTEN-mediated MAPK signaling. AS, ERS, HAECs, HFD, miRs, oxLDL, RT-qPCR
16  2020 Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation. ---
17  2020 Liquiritigenin suppresses the activation of hepatic stellate cells via targeting miR-181b/PTEN axis. HSC, LQ, miR-181b
18  2020 LncRNA CASC2 inhibits astrocytic activation and adenosine metabolism by regulating PTEN in pentylenetetrazol-induced epilepsy model. ADK, ENT1, lncRNAs, PTZ
19  2020 LncRNA growth arrest-specific transcript 5 targets miR-21 gene and regulates bladder cancer cell proliferation and apoptosis through PTEN. GAS5
20  2020 LncRNA MACC1-AS1 Promotes Lung Adenocarcinoma Cell Proliferation by Downregulating PTEN. AMPK, LUAD
21  2020 Long noncoding RNA TCL6 binds to miR-106a-5p to regulate hepatocellular carcinoma cells through PI3K/AKT signaling pathway. HCC, lncRNAs, miR-106a-5p, PI3K, TCL6
22  2020 Loss of PTEN-induced kinase 1 (Pink1) reduces hippocampal tyrosine hydroxylase and impairs learning and memory. PD, PINK1, TH
23  2020 Low‑intensity ultrasound enhances the antitumor effects of doxorubicin on hepatocellular carcinoma cells through the ROS‑miR‑21‑PTEN axis. DOX, HCC, LIUS, ROS
24  2020 Mesenchymal stem cells promote human melanocytes proliferation and resistance to apoptosis through PTEN pathway in vitiligo. MC, MSCs, PI3K
25  2020 Metabolic Role of PTEN in Insulin Signaling and Resistance. KO, T2D
26  2020 MicroRNA-23a-3p improves traumatic brain injury through modulating the neurological apoptosis and inflammation response in mice. miRNAs, TBI
27  2020 miR-130b is a potent stimulator of hepatic very-low-density lipoprotein assembly and secretion via marked induction of microsomal triglyceride transfer protein. FAS, LDs, MTP, TG, VLDL
28  2020 miR-17-5p knockdown inhibits proliferation, autophagy and promotes apoptosis in thyroid cancer via targeting PTEN. Akt, miRNAs, mTOR
29  2020 MiR-21, EGFR and PTEN in non-small cell lung cancer: an in situ hybridisation and immunohistochemistry study. miR, NSCLC
30  2020 miR-552 Regulates Liver Tumor-Initiating Cell Expansion and Sorafenib Resistance. Akt, HCC, miR, miRNAs, PDXs, TICs
31  2020 miR-885 mediated cardioprotection against hypoxia/reoxygenation-induced apoptosis in human cardiomyocytes via inhibition of PTEN and BCL2L11 and modulation of AKT/mTOR signaling. BCL2L11, HCMs, I/R, miRNAs
32  2020 miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6. DKD, ESRD, FN, MCs, SOX6, TGF
33  2020 MuicroRNA-221 participates in cerebral ischemic stroke by modulating endothelial cell function by regulating the PTEN/PI3K/AKT pathway. CIS, HUVECs, miR, RT-qPCR
34  2020 Overcoming cisplatin resistance by targeting the MTDH-PTEN interaction in ovarian cancer with sera derived from rats exposed to Guizhi Fuling wan extract. Co-IP, GFW, GFWE, MTDH
35  2020 Oxidative Stress and Cancer Development: Are Noncoding RNAs the Missing Links? EGFR, FOXO3, GSK3beta, Keap1, lncRNAs, ncRNAs, NF-kappaB, Nrf2, ROS, Wnt
36  2020 Phosphatase and tensin homolog deletion enhances neurite outgrowth during neural stem cell differentiation. NSC, p-S6R
37  2020 Phospho Tensin Homolog in Human and Lipid Peroxides in Peripheral Blood Mononuclear Cells Following Exposure to Flavonoids. LP, PBMCs
38  2020 Photobiomodulation therapy decreases free fatty acid generation and release in adipocytes to ameliorate insulin resistance in type 2 diabetes. FFA, HFD, PBMT, ROS, TG, WAT
39  2020 PI3K/AKT/mTOR signaling as a molecular target in head and neck cancer. EGFR, HNSCC, HPV, mTOR, PD-1, PI3K, PIK3CA
40  2020 PTEN Expression as a Complementary Biomarker for Mismatch Repair Testing in Breast Cancer. dMMR, ER, hMMR, IHC, MMR, pMMR
41  2020 PTEN in Chromatin Remodeling. ---
42  2020 PTEN inhibition attenuates endothelial cell apoptosis in coronary heart disease via modulating the AMPK-CREB-Mfn2-mitophagy signaling pathway. AMPK, AS, ED, HUVEC, oxLDL
43  2020 Repression of microRNA-21 inhibits retinal vascular endothelial cell growth and angiogenesis via PTEN dependent-PI3K/Akt/VEGF signaling pathway in diabetic retinopathy. DR, miR-21, RVEC, SD, VEGF
44  2020 Role and mechanism of PTEN in Burkitt's lymphoma. ---
45  2020 Role of HIF-1alpha in Cold Ischemia Injury of Rat Donor Heart Via the miR-21/PDCD4 Pathway. HIF-1alpha, miR-21, PDCD4
46  2020 Rosmarinic acid exerts an anticancer effect on osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway. EMT, MMP, MMP-2 and -9, RA, ROS
47  2020 Silencing of PTEN inhibits the oxidative stress damage and hippocampal cell apoptosis induced by Sevoflurane through activating MEK1/ERK signaling pathway in infant rats. NC, OS
48  2020 Topical MTII Therapy Suppresses Melanoma Through PTEN Upregulation and Cyclooxygenase II Inhibition. alpha-MSH, MC1R, MTII, NF-kappaB, PGE2
49  2020 Triple-high expression of phosphatase and tensin homolog (PTEN), estrogen receptor (ER) and progesterone receptor (PR) may predict favorable prognosis for patients with Type I endometrial carcinoma. EC, ER, PR, UCEC
50  2020 Tumor Suppression in Asymptomatic Postmenopausal Endometrial Polyps. ---
51  2020 Vascular miR-181b controls tissue factor-dependent thrombogenicity and inflammation in type 2 diabetes. BMDM, FL, HMEC, LPS, miR, NF, TF, TNF, VCAM
52  2020 Zinc protects chondrocytes from monosodium iodoacetate-induced damage by enhancing ATP and mitophagy. ATG5, LC3-II, MIA, OA, PINK1
53  2019 5-Aza-2'-deoxycytidine, a DNA methylation inhibitor, attenuates hypoxic pulmonary hypertension via demethylation of the PTEN promoter. 5-aza-dC, DNMT, HPH, PASMCs
54  2019 A novel missense PTEN mutation identified in a patient with macrocephaly and developmental delay. ---
55  2019 A phase II, randomised study of mFOLFOX6 with or without the Akt inhibitor ipatasertib in patients with locally advanced or metastatic gastric or gastroesophageal junction cancer. 5-FU, CI, GC/GEJC, ITT, PFS
56  2019 A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway. ACh, AD, ADAS-COG 11, HSP, LF, MMSE, PBL, PI3K
57  2019 AAV-Anti-miR-214 Prevents Collapse of the Femoral Head in Osteonecrosis by Regulating Osteoblast and Osteoclast Activities. AAV, ATF4, miRNA
58  2019 Aberrant expression and mechanism of miR-130b-3p/phosphatase and tensin homolog in nephroblastoma in children. miRs
59  2019 Aberrant expression of TNRC6a and miR-21 during myocardial infarction. TNRC6a
60  2019 Activation of angiotensin type 2 (AT2) receptors prevents myocardial hypertrophy in Zucker diabetic fatty rats. AT2, ZDF
61  2019 Activation of the oncogenic miR-21-5p promotes HCV replication and steatosis induced by the viral core 3a protein. HCV
62  2019 Activation of the STAT3/microRNA-21 pathway participates in angiotensin II-induced angiogenesis. Ang II, HMECs, miR-21, miRNAs
63  2019 Activation of type 4 metabotropic glutamate receptor promotes cell apoptosis and inhibits proliferation in bladder cancer. cAMP, mGluR4, mGluRs
64  2019 ADAR1p150 Forms a Complex with Dicer to Promote miRNA-222 Activity and Regulate PTEN Expression in CVB3-Induced Viral Myocarditis. ADAR, VMC
65  2019 AKT-dependent and -independent pathways mediate PTEN deletion-induced CNS axon regeneration. CNS, mTORC1
66  2019 An ATF3-CreERT2 Knock-In Mouse for Axotomy-Induced Genetic Editing: Proof of Principle. ATF3
67  2019 An integrated genomic and metabolomic approach for defining survival time in adult oligodendrogliomas patients. 2-HG, EGFR, GPC/PC, HR-MAS, IDH1, MGMT, NAA, NMR, TP53
68  2019 Analysis of the promoter region of the human miR-32 gene in colorectal cancer. CRC, Foxk1, GO, KEGG, miR, MS, SMAD1, STAT1, TF, TMEM245
69  2019 Annexin A2 Regulates AKT Upon H₂O₂-Dependent Signaling Activation in Cancer Cells. ANXA2, Cys
70  2019 Answer to Controversy: miR-10a Replacement Approaches Do Not Offer Protection against Chemotherapy-Induced Gonadotoxicity in Mouse Model. PI3K, TUNEL
71  2019 Anticancer Activities of Thymus vulgaris L. in Experimental Breast Carcinoma in Vivo and in Vitro. ATM, BrdU, MDA, MTS, RASSF1, TIMP3
72  2019 Antitumor activity of sevoflurane in HCC cell line is mediated by miR-29a-induced suppression of Dnmt3a. DNMT3a, HCC, miR, PI3K, SEVO
73  2019 Assessment of biochemical recurrence of prostate cancer (Review). BCR, EMT, PC
74  2019 Assessment of epigenetic alterations and in silico analysis of mutation affecting PTEN expression among Indian cervical cancer patients. IHC, LN, MS-PCR
75  2019 ATM Regulated PTEN Degradation Is XIAP E3 Ubiquitin Ligase Mediated in p85alpha Deficient Cancer Cells and Influence Platinum Sensitivity. ATM, KD, KO, XIAP
76  2019 Biochemical and molecular evidence on the role of vaspin in early detection of the insulin resistance in a rat model of high-fat diet and use of diazinon. ChE, DZN, FBG, FOXO1, HFD, HOMA-IR, OGTT, ROS, TNF-alpha
77  2019 Bioinformatics analysis of microRNA expression between patients with and without latent tuberculosis infections. ACTA1, cdc, DC, DEMs, FOS, hsa, KEGG, LTBI, miRs, PI3K, TB
78  2019 Bisperoxovanadium Mediates Neuronal Protection through Inhibition of PTEN and Activation of PI3K/AKT-mTOR Signaling after Traumatic Spinal Injuries. bpV, ERK, mTOR, PI3K, pS6, SCI
79  2019 Blocking ROR1 enhances the roles of erlotinib in lung adenocarcinoma cell lines. EGFR, mTOR, NSCLC, ROR1, TKIs
80  2019 BMI1 promotes cardiac fibrosis in ischemia-induced heart failure via the PTEN-PI3K/Akt-mTOR signaling pathway. BMI1, MI, mTOR, PI3K
81  2019 BpV(pic) confers neuroprotection by inhibiting M1 microglial polarization and MCP-1 expression in rat traumatic brain injury. pic, TBI
82  2019 Brain Tumors of Glial Origin. IDH, PDGFRA, TERT
83  2019 CagA increases DNA methylation and decreases PTEN expression in human gastric cancer. APOBEC, CagA, qPCR, Tet1
84  2019 Cardiac troponin I autoantibody induces myocardial dysfunction by PTEN signaling activation. AMI, cTnIAAb
85  2019 CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction. GEF, PI3K, PIP3
86  2019 Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer. BRG1, PCa
87  2019 CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p. circRNAs, GC
88  2019 Class I histone deacetylase inhibitor suppresses vasculogenic mimicry by enhancing the expression of tumor suppressor and anti-angiogenesis genes in aggressive human TNBC cells. EMT, HDACs, OS, SERPINB5, SERPINF1, THBS2, TNBC, VM
89  2019 Clofarabine‑phytochemical combination exposures in CML cells inhibit DNA methylation machinery, upregulate tumor suppressor genes and promote caspase‑dependent apoptosis. ATRA, CDKN1A, CML, DNMT1, RARB, RSV, TSGs
90  2019 Clusterin enhances AKT2-mediated motility of normal and cancer prostate cells through a PTEN and PHLPP1 circuit. CLU, PC3, PI3K, PNT1A, RPPA
91  2019 Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia. B-ALL
92  2019 Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases. WBP2
93  2019 Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. BM, PI3K, SCI
94  2019 Comprehensive assessment the expression of core elements related to IGFIR/PI3K pathway in granulosa cells of women with polycystic ovary syndrome. AFC, AMH, BMI, FINS, FPG, FSH, HOMA-IR, IRS-1, IRS2, LH, PCOS, PI3K, RT-PCR, WB
95  2019 Conditional Inactivation of Nf1 and Pten in Schwann Cells Results in Abnormal Neuromuscular Junction Maturation. Chrna1, Dag1, Dmd, LAMB2, NF1, NMJ, PSCs, SCs
96  2019 Conjunctival Melanoma: Genetic and Epigenetic Insights of a Distinct Type of Melanoma. CjM, Hsp90, mTOR, NF1, TERT
97  2019 Coordination of miR-192 and miR-22 in p53-Mediated Cell Fate Decision. miRNAs
98  2019 Curcumin Inhibits Joint Contracture through PTEN Demethylation and Targeting PI3K/Akt/mTOR Pathway in Myofibroblasts from Human Joint Capsule. ---
99  2019 Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells. miR-21, p-Akt
100  2019 Curcumin-Gene Expression Response in Hormone Dependent and Independent Metastatic Prostate Cancer Cells. bHLH, NF-kB, TGF-beta, Wnt