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Abbreviation : PTPN22
Long Form : protein tyrosine phosphatase nonreceptor 22
No. Year Title Co-occurring Abbreviation
2019 Association of common type 1 and type 2 diabetes gene variants with latent autoimmune diabetes in adults: A meta-analysis. CIs, INS, LADA, ORs, T1D, T2D, TCF7L2
2019 Dual Role of PTPN22 but Not NLRP3 Inflammasome Polymorphisms in Type 1 Diabetes and Celiac Disease in Children. CARD8, CD, HLA, NLRP3, T1D
2019 Effects of phosphorylation on the NLRP3 inflammasome. JNK, NLRPs, PKA, PKD
2019 The Contribution of PTPN22 to Rheumatic Disease. RA
2018 Association between the functional PTPN22 G788A (R263Q) polymorphism and susceptibility to autoimmune diseases: A meta-analysis. CD, RA, SLE, UC
2018 PTPN22 1858 C/T Exon Polymorphism is not Associated with Graves' Disease in Kashmiri population. GD, SNP
2018 Role of C1858T polymorphism of Lymphoid Tyrosine Phosphatase in Egyptian children and adolescents with type 1 diabetes. RFLP, T1DM, TCR
2018 The Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) R620W Functional Polymorphism in Psoriasis. RR
2018 The PTPN22 C1858T (R620W) functional polymorphism in inflammatory bowel disease. CD, IBD, UC
10  2017 Association of STAT4 and PTPN22 polymorphisms and their interactions with type-1 autoimmune hepatitis susceptibility in Chinese Han children. AIH, GMDR, SNPs, STAT4
11  2017 Extrinsic Protein Tyrosine Phosphatase Non-Receptor 22 Signals Contribute to CD8 T Cell Exhaustion and Promote Persistence of Chronic Lymphocytic Choriomeningitis Virus Infection. ---
12  2017 Protein tyrosine phosphatase non-receptor 22 and C-Src tyrosine kinase genes are down-regulated in patients with rheumatoid arthritis. CSK, RA, SNPs
13  2017 PTPN22 and islet-specific autoimmunity: What have the mouse models taught us? T1D
14  2017 Role of PTPN22 1858 C/T Polymorphisms in Juvenile Idiopathic Arthritis in Egyptian Patients. JIA
15  2017 The common, autoimmunity-predisposing 620Arg>Trp variant of PTPN22 modulates macrophage function and morphology. SNP, T1D
16  2017 The PTPN22 gene is associated with idiopathic inflammatory myopathy. AH, DM, IBM, IIM, MAA, PM, SNP
17  2017 TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22. Csk, TRAF
18  2016 Association between PTPN22/CTLA-4 Gene Polymorphism and Allergic Rhinitis with Asthma in Children. AR, CTLA-4
19  2016 Genetic Association of PTPN22 Polymorphisms with Autoimmune Hepatitis and Primary Biliary Cholangitis in Japan. AIH, OR, PBC, SNP
20  2016 NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22. IBD
21  2016 PTPN22 Is a Critical Regulator of Fcgamma Receptor-Mediated Neutrophil Activation. ---
22  2016 PTPN22 is not associated with Behcet's disease. Study spanning the complete gene region in the Spanish population and meta-analysis of the functional variant R620W. BD
23  2015 Association Between PTPN22 Polymorphisms and IgE Responses to Staphylococcal Superantigens in Chronic Urticaria. CU, LYP, SEA, TSST-1
24  2015 Association of PTPN22 gene polymorphisms with chronic hepatitis B virus infection in Chinese Han population. ASC, HBV, HCC
25  2015 Lack of the protein tyrosine phosphatase PTPN22 strengthens transplant tolerance to pancreatic islets in mice. FoxP3, Treg, WT
26  2015 Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schonlein purpura (IgA vasculitis). CSK, HSP, SNP
27  2015 STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C polymorphisms influence the risk of developing juvenile idiopathic arthritis in Han Chinese patients. JIA, JIA, SNP, STAT4
28  2014 A functional variant of PTPN22 confers risk for Vogt-Koyanagi-Harada syndrome but not for ankylosing spondylitis. AAU, AS, Pc, VKH
29  2014 A novel single nucleotide polymorphism in the protein tyrosine phosphatase N22 gene (PTPN22) is associated with Type 1 diabetes in a Chinese population. ---
30  2014 Assessment of protein tyrosine phosphatases number 22 polymorphism prevalence among rheumatoid arthritis patients: A study on Iranian patients. RA, SNP
31  2014 Associations of the PTPN22 and CTLA-4 genetic polymorphisms with Taiwanese ankylosing spondylitis. AS, CTLA-4
32  2014 Influence of molecular genetics in Vogt-Koyanagi-Harada disease. CTLA-4, KIR, MIF, PDCD1, TNFAIP3, VKH
33  2014 Influence of protein tyrosine phosphatase gene (PTPN22) polymorphisms on rheumatic heart disease susceptibility in North Indian population. RHD, SNPs
34  2014 PTPN22 profile indicates a novel risk group in Alopecia areata. AA, C1858T, RC, UrC
35  2014 Study of factors influencing susceptibility and age at onset of type 1 diabetes: A review of data from Continental Italy and Sardinia. T1D
36  2014 The role of PTPN22 in autoimmunity: learning from mice. ---
37  2014 Zinc transporter 8 autoantibodies in patients with type 1 diabetes from a multiethnic population and their first degree relatives. FDR, INS, RBA, SNP, ZnT8A
38  2013 A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. PEP
39  2013 Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways. ---
40  2013 Expression and clinical significance of protein tyrosine phosphatase nonreceptor 22 in resected thymoma. MG
41  2013 Meta-analysis of the family-based association between the PTPN22 C1858T polymorphism and type 1 diabetes. T1D, TDT
42  2013 Metaanalysis of the association of smoking and PTPN22 R620W genotype on autoantibody status and radiological erosions in rheumatoid arthritis. ACPA, RA
43  2013 Pathway analysis of genome-wide association studies on rheumatoid arthritis. GWAS, HLA, RA, SNPs, TNFAIP3
44  2013 PTPN22 gene polymorphism (C1858T) is associated with susceptibility to type 1 diabetes: a meta-analysis of 19,495 cases and 25,341 controls. CI, OR, T1D
45  2013 The CTLA-4 +49 A/G, CT60 A/G and PTPN22 1858 C/T polymorphisms and susceptibility to vitiligo: a meta-analysis. CTLA-4
46  2013 The PTPN22 1858T allele but not variants in the proximal promoter region of IL-21 gene is associated with the susceptibility to type 1 diabetes and the presence of autoantibodies in a Brazilian cohort. ANA, ASM, bp, HC, HLA, IL, OR, T1AD, Tg, TPO, TRAb
47  2013 The PTPN22 C1858T polymorphism and rheumatoid arthritis: a meta-analysis. RA, RF
48  2012 Association of Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) C1858T gene polymorphism with susceptibility to autoimmune thyroid diseases: a meta-analysis. CNKI, GD, HT
49  2012 Association of PTPN22 C1858T polymorphism and type 1 diabetes: a meta-analysis. OR, T1D
50  2012 Association of PTPN22 gene polymorphism and systemic lupus erythematosus in a cohort of Egyptian patients: impact on clinical and laboratory results. PCR, SLE
51  2012 Combined influence of genetic and environmental factors in age of rheumatoid arthritis onset. STAT4
52  2012 High basal activity of the PTPN22 gain-of-function variant blunts leukocyte responsiveness negatively affecting IL-10 production in ANCA vasculitis. ANCA
53  2012 HLA, PTPN22 and PD-1 associations as markers of autoimmunity in neuromyelitis optica. MS, NMO, PD-1
54  2012 No association of PTPN22 polymorphisms with susceptibility to ocular Behcet's disease in two Chinese Han populations. PCR-RFLP, SNPs
55  2012 PTPN22 and CTLA-4 gene polymorphisms in resected thymomas and thymus for myasthenia gravis. CI, CTLA-4, MG, OR, PCR-RFLP, SASP-PCR
56  2012 PTPN22 polymorphism presumably plays a role in the genetic background of chronic spontaneous autoreactive urticaria. CU
57  2012 Sex differences and genomics in autoimmune diseases. AIDs, GD, MHC, MS, RA, SLE
58  2012 The -1123G>C variant of PTPN22 gene promoter is associated with latent autoimmune diabetes in adult Chinese Hans. LADA
59  2012 The association between the functional PTPN22 1858 C/T and MIF -173 C/G polymorphisms and juvenile idiopathic arthritis: a meta-analysis. CI, JIA, MIF, OR
60  2012 The association between the PTPN22 C1858T polymorphism and rheumatoid arthritis: a meta-analysis update. CI, OR, RA, RF
61  2012 The association between the PTPN22 C1858T polymorphism and systemic sclerosis: a meta-analysis. ACA, ATA, CI, OR, SSc
62  2012 The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls. RA
63  2012 The protein tyrosine phosphatase nonreceptor 22 C1858T polymorphism and vasculitis: a meta-analysis. ANCA, CI, OR, WG
64  2011 Association of protein tyrosine phosphatase non-receptor 22 (PTPN22) rs2476601 and Kruppel-like factor 12 (KLF12) rs1324913 single nucleotide polymorphisms with rheumatoid arthritis in a Latvian population. KLF12
65  2011 No association of PTPN22 R620W gene polymorphism with rheumatic heart disease and systemic lupus erythematosus. ARF, HC, RHD
66  2011 PTPN22 1858T is not a risk factor for North American pemphigus vulgaris. anti-Dsg, non-Ashkenazi, PV
67  2011 The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update. CI, OR, SLE
68  2010 Association between the 1858T allele of the protein tyrosine phosphatase nonreceptor type 22 and type 1 diabetes in a Brazilian population. ---
69  2010 Association of a functional polymorphism of PTPN22 encoding a lymphoid protein phosphatase in bilateral Meniere's disease. BMD, SNPs
70  2010 Association of PTPN22 haplotypes with type 1 diabetes in the Japanese population. RA, SNPs, T1D
71  2010 Association of the protein tyrosine phosphatase nonreceptor 22 haplotypes with autoimmune thyroid disease in the Japanese population. AITD, GD, IL2RA, SNP
72  2010 [Correlation between PTPN22 gene polymorphism and systemic lupus erythematosus in Chinese Han patients]. PCR-RFLP
73  2009 Conjugation of antisense oligonucleotides to PEGylated carbon nanotubes enables efficient knockdown of PTPN22 in T lymphocytes. ASOs, PNTs
74  2009 Genetics of Graves' disease: the lost concept. HLA-DR, RSG, SNPs, TSHR
75  2009 Genotype analysis of polymorphisms in autoimmune susceptibility genes, CTLA-4 and PTPN22, in an acute anterior uveitis cohort. AAU, CTLA-4, SNPs, SSP-PCR
76  2009 The PTPN22 C1858T (R620W) functional polymorphism in kidney transplantation. ARE
77  2009 [Pathogenesis of autoimmune thyroid diseases]. AITD, CTLA-4, MHC, Tg, TSHR
78  2008 Associations of protein tyrosine phosphatase nonreceptor 22 (PTPN22) gene polymorphisms with susceptibility to Graves' disease in a Japanese population. GD, GO, PCR
79  2008 Contribution of the R620W polymorphism of protein tyrosine phosphatase non-receptor 22 to systemic lupus erythematosus in Poland. SLE
80  2008 PTPN22 allele polymorphisms in 15 Chinese populations. LYP, SNP
81  2008 Recent advances in the genetics of RA susceptibility. ---
82  2008 Role of HLA-DRB1 and PTPN22 genes in susceptibility to juvenile idiopathic arthritis in Hungarian patients. HLA, JIA, SNP
83  2008 The functional R620W variant of the PTPN22 gene is associated with celiac disease. CD
84  2008 The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients. DM, IIMs, PM, SNPs
85  2008 The protein tyrosine phosphatase nonreceptor 22 (PTPN22) is associated with high GAD antibody titer in latent autoimmune diabetes in adults: Non Insulin Requiring Autoimmune Diabetes (NIRAD) Study 3. GAD, NIRAD
86  2008 [Genetic and humoral autoimmunity markers of type 1 diabetes: from theory to practice]. T1AD, VNTR
87  2007 Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status. anti-CCP, IL-1, RA, RF
88  2007 Gender-specific association of the PTPN22 C1858T polymorphism with achalasia. Lyp
89  2007 Mechanisms of disease: genetics of rheumatoid arthritis--ethnic differences in disease-associated genes. PADI4
90  2007 PTPN22: its role in SLE and autoimmunity. SLE
91  2007 Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population. Lyp, T1D
92  2007 The genetic basis of thyroid autoimmunity. AITDs, GD, HLA-DR, HT, TSHR
93  2007 The PTPN22 C1858T functional polymorphism and autoimmune diseases--a meta-analysis. GD, IBD, JIA, ORs, RA, SLE, T1D
94  2007 The PTPN22 promoter polymorphism -1123G>C association cannot be distinguished from the 1858C>T association in a Norwegian rheumatoid arthritis material. RA, SNP
95  2006 Association between protein tyrosine phosphatase 22 variant R620W in conjunction with the HLA-DRB1 shared epitope and humoral autoimmunity to an immunodominant epitope of cartilage-specific type II collagen in early rheumatoid arthritis. RA, SE
96  2006 Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population. SNP, SSc
97  2006 Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease. GD, SNPs
98  2005 A case-control study of tyrosine phosphatase (PTPN22) confirms the lack of association with Crohn's disease. CD, RFLP
99  2005 Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene. JIA, MS, PsA, RA, SNP
100  2005 Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes. Csk, T1D