A Search Service for Abbreviation / Long Form

■ Related PubMed/MEDLINE Info.

[Related PubMed/MEDLINE]
Total Number of Papers: 1490
[Display Entries]
100 entries :
      (Publication year, Descending)
100 entries :
      (Publication year, Ascending)
all entries
[Entries Per Page]
 per page
Page Control
Page: of
Abbreviation : PXR
Long Form : pregnane X receptor
No. Year Title Co-occurring Abbreviation
2022 A biologically based model to quantitatively assess the role of the nuclear receptors liver X (LXR), and pregnane X (PXR) on chemically induced hepatic steatosis. FFAs, LXR, LXR, PBPK, QTS
2022 A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies. LAMPS, NAFLD, QSP
2022 Bacterial Indole as a Multifunctional Regulator of Klebsiella oxytoca Complex Enterotoxicity. ---
2022 Chinese herbal component, Praeruptorin E, enhances anti-asthma efficacy and prevents toxicity of aminophylline by targeting the NF-κB/PXR/CYP3A4 pathway. 1,3-DMU, BALF, ChIP, CYP3A, ELISA, IL, NF-kappaB, OVA, PE
2022 Comparison of antagonistic effects of nanoparticle-selenium, selenium-enriched yeast and sodium selenite against cadmium-induced cardiotoxicity via AHR/CAR/PXR/Nrf2 pathways activation. AhR, CAR, CAT, Cd, GSH-Px, GST, MDA, Nrf2, Se, SS, T-AOC, T-SOD
2022 Comparison of Sweated and Non-Sweated Ethanol Extracts of Salvia miltiorrhiza Bge. (Danshen) Effects on Human and rat Hepatic UDP-Glucuronosyltransferase and Preclinic Herb-Drug Interaction Potential Evaluation. CAR, PPARalpha
2022 Crosstalk between bile acid-activated receptors and microbiome in entero-hepatic inflammation. CAR, FXR, RORgammat, S1PR2, TGR5, VDR
2022 CYP450 drug inducibility in NAFLD via an in vitro hepatic model: Understanding drug-drug interactions in the fatty liver. AhR, CAR, DDIs, NAFLD
2022 Development and Experimental Validation of Regularized Machine Learning Models Detecting New, Structurally Distinct Activators of PXR. MCCs, ML
10  2022 Discrepancy in interactions and conformational dynamics of pregnane X receptor (PXR) bound to an agonist and a novel competitive antagonist. MD
11  2022 Distinct Roles of the Sister Nuclear Receptors PXR and CAR in Liver Cancer Development. CAR
12  2022 Effects of Concomitant Administration of PXR Ligand Drugs on the Anticoagulant Effects of Warfarin. PT-INR
13  2022 Epifriedelanol enhances adriamycin-induced cytotoxicity towards K562/ADM cells by down regulating of P-gp and MRP2. ADR, CAR, Epi, MDR, MRPs, P-gp
14  2022 Frankincense vinegar-processing improves the absorption of boswellic acids by regulating bile acid metabolism. CAR, LCA, MRP2, OATP1B3, PF, RF, UC
15  2022 Gardenia jasminoides Ellis polysaccharide ameliorates cholestatic liver injury by alleviating gut microbiota dysbiosis and inhibiting the TLR4/NF-κB signaling pathway. ANIT, BAs, FXR, GPS, NF-kappaB, TLR4
16  2022 Gene Expression and Protein Abundance of Nuclear Receptors in Human Intestine and Liver: A New Application for Mass Spectrometry-Based Targeted Proteomics. AhR, CAR, DDIs, FXR, GR, HNF4alpha, SHP
17  2022 Gene Expression Profiling of 1α,25(OH)2 D3 Treatment in 2D/3D Human Hepatocyte Models Reveals CYP3A4 Induction but Minor Changes in Other Xenobiotic-Metabolizing Genes. CAR, VDR
18  2022 Hepatoprotective Effects of Glycyrrhetinic Acid on Lithocholic Acid-Induced Cholestatic Liver Injury Through Choleretic and Anti-Inflammatory Mechanisms. FXR, GA, LCA
19  2022 Implication of metabolomics and transporter modulation based strategies to minimize multidrug resistance and enhance site-specific bioavailability: a needful consideration toward modern anticancer drug discovery. BCRP, DMET, MRP 1 and 2, p-gp
20  2022 Insights into the critical role of the PXR in preventing carcinogenesis and chemotherapeutic drug resistance. MDR1, SNPs
21  2022 Long-term treatment with the mPXR agonist PCN promotes hepatomegaly and lipid accumulation without hepatocyte proliferation in mice. TGs, UHPLC-ESI-HRMS
22  2022 Mice blocking Ser347 phosphorylation of pregnane x receptor develop hepatic fasting-induced steatosis and hypertriglyceridemia. ---
23  2022 Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation. CAR, NRs, RXR
24  2022 Niclosamide induces miR-148a to inhibit PXR and sensitize colon cancer stem cells to chemotherapy. CSCs
25  2022 No Effect of PXR (8055C>T) Polymorphism on the Pharmacokinetic Profiles of Piperaquine in Healthy Chinese Subjects. PQ
26  2022 Nuclear Receptor PXR Confers Irradiation Resistance by Promoting DNA Damage Response Through Stabilization of ATF3. ATF3, ATM, DBD, IR, MDM2, NF-kappaB, PPARgamma
27  2022 Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia. LDL
28  2022 Oxidative stress-mediated up-regulation of ABC transporters in lung cancer cells. ROS
29  2022 Panaxytriol upregulates CYP3A4 expression based on the interaction of PXR, CAR, HSP90α, and RXRα. CAR, CYP3A4, HSP90alpha, RXRalpha
30  2022 Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis. CDK2
31  2022 Pregnane X receptor (PXR) represses osteoblast differentiation through repression of the Hedgehog signaling pathway. SAG
32  2022 Pregnane X Receptor Activation in Liver Perfusion. NMP
33  2022 Pregnane X Receptor Mediates Atherosclerosis Induced by Dicyclohexyl Phthalate in LDL Receptor-Deficient Mice. CVD, DCHP, EDCs
34  2022 Pregnane X Receptor‒4β-Hydroxycholesterol Axis in the Regulation of Overweight- and Obesity-Induced Hypertension. 4betaHC, BP, LXR, SBP
35  2022 Probing PXR activation and modulation of CYP3A4 by Tinospora crispa and Tinospora sinensis. ---
36  2022 Protective Effect of Eurotium cristatum Fermented Loose Dark Tea and Eurotium cristatum Particle on MAPK and PXR/AhR Signaling Pathways Induced by Electronic Cigarette Exposure in Mice. AhR, ECP, eCS, ECT, ERK, JNK, p38 MAPK
37  2022 PXR activation impairs hepatic glucose metabolism partly via inhibiting the HNF4α-GLUT2 pathway. HNF4alpha, PCN
38  2022 PXR as the tipping point between innate immune response, microbial infections, and drug metabolism. NF-kB, TLRs
39  2022 Resveratrol ameliorates nutritional steatohepatitis through the mmu‑miR‑599/PXR pathway. IL, MCD, miR, NASH
40  2022 Significance of the Vitamin D Receptor on Crosstalk with Nuclear Receptors and Regulation of Enzymes and Transporters. CAR, CYP7A1, DDI, LRP1, MDR1, MRPs, OAT3, PTH, RAGE, SULT2A1, VDR
41  2022 Systems Biology of Gut Microbiota-Human Receptor Interactions: Toward Anti-inflammatory Probiotics. AhR, GPCRs, TLR4
42  2022 Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library. TuKIC
43  2022 The Effects of Cumulative Dose and Polymorphisms in CYP2B6 on the Mitotane Plasma Trough Concentrations in Chinese Patients With Advanced Adrenocortical Carcinoma. ACC
44  2022 The Nuclear Receptor PXR in Chronic Liver Disease. CAR, DMETs
45  2022 Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice. BAs, CAR
46  2021 A Comparative Study of Human and Zebrafish Pregnane X Receptor Activities of Pesticides and Steroids Using In Vitro Reporter Gene Assays. hPXR, zfPXR
47  2021 A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction. AhR, CAR
48  2021 Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism. IDL, LDL, PCSK9, SREBP2
49  2021 Adenosine deaminases acting on RNA modulate the expression of the human pregnane X receptor. ADAR, CYP3A4, UGT1A1, UTR
50  2021 Alpha-Tocopherol Metabolites (the Vitamin E Metabolome) and Their Interindividual Variability during Supplementation. ---
51  2021 An adverse outcome pathway based in vitro characterization of novel flame retardants-induced hepatic steatosis. AOP, EHDPP, KEs, MIEs, NAFLD, nFRs, OPFRs, PPARgamma, TDCIPP, TPHP
52  2021 An optimized protocol with a stepwise approach to identify specific nuclear receptor ligands from cultured mammalian cells. CAR
53  2021 Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). CAR, MOA, PB
54  2021 Bioinformatis analysis reveals possible molecular mechanism of PXR on regulating ulcerative colitis. ABCG2, CES2, CXCL8, CYP2B6, DEGs, GEO, GI, IBD, PPARGC1A, RT-qPCR, UC
55  2021 Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70. hPXR
56  2021 Cadmium induced Fak -mediated anoikis activation in kidney via nuclear receptors (AHR/CAR/PXR)-mediated xenobiotic detoxification pathway. ABC, AhR, CAR, Cd, CYP450s, FAK, GSH-Px, GST, NXRs, P-gp
57  2021 Constitutive Androstane Receptor-Mediated Inhibition of Metformin on Phase II Metabolic Enzyme SULT2A1. AMPK, CAR, p-AMPK
58  2021 Corrigendum to "Pregnane X receptor (PXR) protects against cisplatin-induced acute kidney injury in mice" [Biochim. Biophys. Acta, Mol. Basis Dis. 1867(3) 2021 Mar 1, 165996./BBADIS-20-505]. ---
59  2021 Curcuma zedoaria petroleum ether extract reverses the resistance of triple-negative breast cancer to docetaxel via pregnane X receptor. BCRP, CCK-8, HE, MDR1, PECZ, qRT-PCR, TNBC
60  2021 Deciphering structural bases of intestinal and hepatic selectivity in targeting pregnane X receptor with indole-based microbial mimics. AhR, SAR
61  2021 Deconvolution of Cytochrome P450 Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells. CAR, DKO, KO, NHR
62  2021 Dietary phytochemicals as modulators of human pregnane X receptor. ---
63  2021 Different Inductive Effects of Praziquantel Racemate and its Enantiomers on the Enzyme CYP3A4 Mediated by Pregnane X Receptor and its Variants. PCR, PZQ
64  2021 Effect of Lactobacillus rhamnosus MN-431 Producing Indole Derivatives on Complementary Feeding-Induced Diarrhea Rat Pups Through the Enhancement of the Intestinal Barrier Function. CFID, L. oris FN-448, L. rhamnosus MN-431
65  2021 Effect of Pregnane X Receptor on CYP3A29 Expression in Porcine Alveolar Macrophages during Mycoplasma hyopneumoniae Infection. CYP, CYP3A29, MPS, PAM
66  2021 Effect of Vitamin K-Mediated PXR Activation on Drug-Metabolizing Gene Expression in Human Intestinal Carcinoma LS180 Cell Line. ---
67  2021 Effects of Dicyclohexyl Phthalate Exposure on PXR Activation and Lipid Homeostasis in Mice. CVD, DCHP, EDCs
68  2021 Eurotium cristatum Fermented Loose Dark Tea Ameliorates Cigarette Smoke-Induced Lung Injury by MAPK Pathway and Enhances Hepatic Metabolic Detoxification by PXR/AhR Pathway in Mice. AhR, CYP450, ECP, ECT, GSH-Px, IL-6, MAPK, MDA, SOD, TNF-alpha
69  2021 Exposure to High-Altitude Environment Is Associated with Drug Transporters Change: microRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia. BCRP, MDR1, miRNA, miRNAs, MRP2, NC, OATP2B1, PEPT1
70  2021 Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids. PHHs
71  2021 Helix 12 stabilization contributes to basal transcriptional activity of PXR. ---
72  2021 Hepatoprotective effect of Sophora moorcroftiana (Benth.) Benth.Ex baker seeds in vivo and in vitro. ALP, ALT, AST, CYP3A11, MAPK, MRP2, NC, SM, UGT1A1
73  2021 High Pregnane X Receptor (PXR) Expression Is Correlated with Poor Prognosis in Invasive Breast Carcinoma. ---
74  2021 Identification of novel pregnane X receptor (PXR) agonists by In silico and biological activity analyses and reversal of cigarette smoke-induced PXR downregulation. CCBs, CS, GSTs, LBD, MDR1
75  2021 IL-6 downregulates hepatic carboxylesterases via NF-κB activation in dextran sulfate sodium-induced colitis. CAR, CESs, DSS, UC
76  2021 In vitro evidence suggesting that the toll-like receptor 7 and 8 agonist resiquimod (R-848) unlikely affects drug levels of co-administered compounds. BCRP, CYP3A4, NF-B, P-gp, UGT1A1
77  2021 Influence of Bisphenol Compounds at Nanomolar Concentrations on Chromosome Damage Induced by Metabolically Activated Carcinogens in HepG2 Cells. AhR, BP, mRNA, NRs
78  2021 Influence of HNF4α and HNF4α-AS1 gene variants on the risk of anti-tuberculosis drugs-induced hepatotoxicity. ATDH, HNF4alpha, HNF4alpha-AS1, TB, WHO
79  2021 Interaction of Hepatitis B Virus X Protein with the Pregnane X Receptor Enhances the Synergistic Effects of Aflatoxin B1 and Hepatitis B Virus on Promoting Hepatocarcinogenesis. AFB1, CYP3A4, GSTM1, HBV, HBx, IL
80  2021 Involvement of ABC transporters in the detoxification of non-substrate nanoparticles in lung and cervical cancer cells. HeLa, MRP1, Nrf2, P-gp, ROS
81  2021 Lathyrane Diterpenoids as Novel hPXR Agonists: Isolation, Structural Modification, and Structure-Activity Relationships. hPXR, SARs
82  2021 Lipidomic profiling reveals triacylglycerol accumulation in the liver during pregnane X receptor activation-induced hepatomegaly. TG, UHPLC-Q Exactive Orbitrap HRMS
83  2021 Liver Toxicity Observed With Lorlatinib When Combined With Strong CYP3A Inducers: Evaluation of Cynomolgus Monkey as a Nonclinical Model for Assessing the Mechanism of Combinational Toxicity. ---
84  2021 Long Noncoding RNAs Hepatocyte Nuclear Factor 4A Antisense RNA 1 and Hepatocyte Nuclear Factor 1A Antisense RNA 1 Are Involved in Ritonavir-Induced Cytotoxicity in Hepatoma Cells. CYP3A4, HNF1A-AS1, HNF4A-AS1, RTV
85  2021 Low risk of the TMPRSS2 inhibitor camostat mesylate and its metabolite GBPA to act as perpetrators of drug-drug interactions. AhR, CYP3A4, GBPA, TMPRSS2
86  2021 Lycium Barbarum Polysaccharides and Wolfberry Juice Prevent DEHP-Induced Hepatotoxicity via PXR-Regulated Detoxification Pathway. CYP2E1, CYP3A1, DEHP, ELISA, GST, GSTpi, LBP, RXRalpha, UGT1, WJ
87  2021 Lycopene prevents DEHP-induced hepatic oxidative stress damage by crosstalk between AHR-Nrf2 pathway. AhR, CAR, CYP450s, LYC, Nrf2, NXRs, ROS
88  2021 MDM2 Binding Protein Induces the Resistance of Hepatocellular Carcinoma Cells to Molecular Targeting Agents via Enhancing the Transcription Factor Activity of the Pregnane X Receptor. HCC
89  2021 Metabolites isolated from the human intestinal fungus Penicillium oxalicum SL2 and their agonistic effects on PXR and FXR. BSEP, FGF, FXR, SHP1
90  2021 Mitochondrial DAMPs and altered mitochondrial dynamics in OxLDL burden in atherosclerosis. AMPK, HSP60, IL-1beta, LDL, mtDAMPs, mtDNA, NLRP3, oxLDL, PP2A, TXNIP
91  2021 Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity. hPXR
92  2021 Nelfinavir and Its Active Metabolite M8 Are Partial Agonists and Competitive Antagonists of the Human Pregnane X Receptor. ---
93  2021 Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction. CaSR
94  2021 Patchouli Alcohol Modulates the Pregnancy X Receptor/Toll-like Receptor 4/Nuclear Factor Kappa B Axis to Suppress Osteoclastogenesis. OC, PA, RANKL, TLR4
95  2021 Phenobarbital Induces SLC13A5 Expression through Activation of PXR but Not CAR in Human Primary Hepatocytes. PB, SLC13A5
96  2021 Phthalates promote the invasion of hepatocellular carcinoma cells by enhancing the interaction between Pregnane X receptor and E26 transformation specific sequence 1. BBP, DBP, DEP, DMP, EDCs, ETS-1, HCC, PAEs
97  2021 Pregnane X Receptor (PXR) Polymorphisms and Cancer Treatment. ---
98  2021 Pregnane X Receptor and the Gut-Liver Axis: A Recent Update. BAs, IPA, LBD
99  2021 Pregnane X receptor exacerbates nonalcoholic fatty liver disease accompanied by obesity- and inflammation-prone gut microbiome signature. BA, HFD, NAFLD, PXR-KO
100  2021 Prenatal ethanol exposure increases maternal bile acids through placental transport pathway. BCRP, FXR, MRP3, Oatp2b1, PEE, TBA