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Abbreviation : PXR
Long Form : pregnane X
No. Year Title Co-occurring Abbreviation
2022 A biologically based model to quantitatively assess the role of the nuclear receptors liver X (LXR), and pregnane X (PXR) on chemically induced hepatic steatosis. FFAs, LXR, LXR, PBPK, QTS
2020 Attenuation of bile acid-mediated FXR and PXR activation in patients with Crohn's disease. 4beta-OHC, CD, FGF, FXR, IBD
2020 Interaction of Hydroxychloroquine with Pharmacokinetically Important Drug Transporters. AhR, BCRP, OATP, P-gp
2020 Weight of evidence and human relevance evaluation of the benfluralin mode of action in rodents (Part I): Liver carcinogenesis. CAR, MOA
2018 Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors. CAR, RSV
2017 Iron depletion induces hepatic secretion of biliary lipids and glutathione in rats. BA, FXR, ID
2017 Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation. AhR, CAR, FXR, GR
2016 2-(3-Methoxyphenyl)quinazoline Derivatives: A New Class of Direct Constitutive Androstane Receptor (CAR) Agonists. AhR, CAR, CITCO
2016 Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. CA, FXR
10  2016 Expression of organic cation transporter 1 (OCT1): unique patterns of indirect regulation by nuclear receptors and hepatospecific gene regulation. FXR, HNF4alpha, OCT1
11  2014 Thyroid tumor formation in the male mouse induced by fluopyram is mediated by activation of hepatic CAR/PXR nuclear receptors. CAR, MOA, TFC, TSH
12  2013 Nuclear receptors in regulation of biotransformation enzymes and drug transporters in the placental barrier. AhR, BCRP, GR
13  2013 Profiling of enantiopure drugs towards aryl hydrocarbon (AhR), glucocorticoid (GR) and pregnane X (PXR) receptors in human reporter cell lines. AhR, GR
14  2011 Fate of steroid hormones and endocrine activities in swine manure disposal and treatment facilities. AhR, AR, EDCs, ER, NP, PAHs, PPARgamma
15  2010 Kavalactone pharmacophores for major cellular drug targets. COX, P-gp
16  2009 Bioanalytical characterisation of multiple endocrine- and dioxin-like activities in sediments from reference and impacted small rivers. AR, ED, EDCs, ER
17  2009 Biological analysis of endocrine-disrupting compounds in Tunisian sewage treatment plants. AhR, AR, EDCs, GR, MR, PR, WWTPs
18  2009 Mode of action for reproductive and hepatic toxicity inferred from a genomic study of triazole antifungals. CAR
19  2008 Developmental reprogramming of rat GLUT5 requires glucocorticoid receptor translocation to the nucleus. GR, PR
20  2006 Comparison of homology models and X-ray structures of the nuclear receptor CAR: assessing the structural basis of constitutive activity. CAR, LBD, MD
21  2006 Expression, microsomal and mitochondrial activities of cytochrome P450 enzymes in brain regions from control and phenobarbital-treated rabbits. CAR
22  2004 Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity. CAR, LBD, MD, VDR
23  2002 Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man. CAR, GR