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Abbreviation : PXR
Long Form : pregnane xenobiotic receptor
No. Year Title Co-occurring Abbreviation
2021 Designing Out PXR Activity on Drug Discovery Projects: A Review of Structure-Based Methods, Empirical and Computational Approaches. ---
2021 In Vivo Induction of P-Glycoprotein Function can be Measured with [18F]MC225 and PET. BBB, P-gp, PET, VT
2021 Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis. CAR, NAFLD, PCBs
2020 Effect of P-glycoprotein (P-gp) Inducers on Exposure of P-gp Substrates: Review of Clinical Drug-Drug Interaction Studies. CAR, CYP450, DDIs, P-gp, PK
2020 Smallest Maximum Intramolecular Distance: A Novel Method to Mitigate Pregnane Xenobiotic Receptor Activation. SMID
2019 A comprehensive evaluation of anti-diabetic drugs on nuclear receptor PXR platform. DDIs, DMD
2018 Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 1: Establishing Induction Relationships Using Ascending Dose Rifampin. BCRP, OATP, P-gp
2018 Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. ---
2017 Heterodimerization of Retinoid X Receptor with Xenobiotic Receptor partners occurs in the cytoplasmic compartment: Mechanistic insights of events in living cells. CAR, NLS, RXR
10  2017 Influence of a critical single nucleotide polymorphism on nuclear receptor PXR-promoter function. EMSA, IBD
11  2016 A comprehensive analysis and functional characterization of naturally occurring non-synonymous variants of nuclear receptor PXR. CYP450
12  2016 Nuclear receptors and nonalcoholic fatty liver disease. CAR, FXR, LXR, NAFLD, PPARs, RXR
14  2015 Identification and interplay of sequence specific DNA binding proteins involved in regulation of human Pregnane and Xenobiotic Receptor gene. CE, hnRNP K
15  2015 Transcription regulation of nuclear receptor PXR: Role of SUMO-1 modification and NDSM in receptor function. ---
16  2014 Cytochrome P450 enzyme mediated herbal drug interactions (Part 1). ---
17  2014 Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture. AhR, CAR, FXR, NAFLD, PCBs, PPARs
18  2014 Involvement of pregnane xenobiotic receptor in mating-induced allopregnanolone formation in the midbrain and hippocampus and brain-derived neurotrophic factor in the hippocampus among female rats. AS-ODNs, BDNF
19  2014 Novel receptor targets for production and action of allopregnanolone in the central nervous system: a focus on pregnane xenobiotic receptor. VTA
20  2014 Role of pregnane xenobiotic receptor in the midbrain ventral tegmental area for estradiol- and 3alpha,5alpha-THP-facilitated lordosis of female rats. VTA
21  2014 The pregnane xenobiotic receptor, a prominent liver factor, has actions in the midbrain for neurosteroid synthesis and behavioral/neural plasticity of female rats. 3alpha,5alpha-THP, AS-ODNs, TSPO, VTA
22  2013 High-throughput evaluation method for drug association with pregnane X receptor (PXR) using differential scanning fluorometry. DSC, DSF
23  2013 Motivated behaviors and levels of 3alpha,5alpha-THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the midbrain ventral tegmental area of proestrous rats. AS-ODNs, DHP, VTA
24  2013 Pregnane xenobiotic receptors and membrane progestin receptors: role in neurosteroid-mediated motivated behaviours. mPRs, VTA
25  2012 Effects and Mechanisms of 3alpha,5alpha,-THP on Emotion, Motivation, and Reward Functions Involving Pregnane Xenobiotic Receptor. VTA
26  2012 Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response. ---
27  2012 Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo. SFN
28  2010 Cross-talk between androgen receptor and pregnane and xenobiotic receptor reveals existence of a novel modulatory action of anti-androgenic drugs. AR, NRs
29  2010 Endocrine disruptors provoke differential modulatory responses on androgen receptor and pregnane and xenobiotic receptor: potential implications in metabolic disorders. AR, EDs
30  2010 Evaluation of liver and thyroid toxicity in Sprague-Dawley rats after exposure to polybrominated diphenyl ether BDE-209. CAR, PBDE, PND
31  2009 Association of pregnane X receptor with multidrug resistance-related protein 3 and its role in human colon cancer chemoresistance. mRNA, MRP3
32  2009 Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes. CAR, PGC
33  2008 ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier. ABC, AhR, BBB, BCRP, CAR, NG2
34  2008 Dexamethasone increases expression and activity of multidrug resistance transporters at the rat blood-brain barrier. GR, MDR
35  2008 Nutritional calcium modulates colonic expression of vitamin D receptor and pregnane X receptor target genes. CYP3A11, SXR
36  2007 (Far) Outside the box: genomic approach to acute porphyria. CAR, GH, GR, HNF-4, PGC-1alpha
37  2007 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. BFC, PCR
38  2006 Induction of human UDP-glucuronosyltransferase 1A1 by cortisol-GR. GR
39  2005 Pregnane and Xenobiotic Receptor (PXR/SXR) resides predominantly in the nuclear compartment of the interphase cell and associates with the condensed chromosomes during mitosis. ---
40  2005 Purification of full-length human pregnane and xenobiotic receptor: polyclonal antibody preparation for immunological characterization. ---