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Abbreviation : S1P
Long Form : sphingosine-1-phosphate
No. Year Title Co-occurring Abbreviation
2020 A 50-Hz magnetic-field exposure promotes human amniotic cells proliferation via SphK-S1P-S1PR cascade mediated ERK signaling pathway. ELF-EMFs, ERK, MF, S1PR, SphK1
2020 A novel sphingosylphosphorylcholine and sphingosine-1-phosphate receptor 1 antagonist, KRO-105714, for alleviating atopic dermatitis. HTS, S1P1, SM, SPC
2020 A Novel Type of Stem Cells Double-Positive for SSEA-3 and CD45 in Human Peripheral Blood. Muse, PB
2020 A Sphingosine 1-Phosphate Gradient Is Linked to the Cerebral Recruitment of T Helper and Regulatory T Helper Cells during Acute Ischemic Stroke. MCAO, S1PR, Th, Treg
2020 A Sphingosine-1-Phosphate Modulator Ameliorates Polycystic Kidney Disease in Han:SPRD Rats. PKD, STAT3
2020 Activation of sphingosine 1-phosphate receptor 2 attenuates chemotherapy-induced neuropathy. ---
2020 Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents. OIH, S1PR1, S1PR1-5
2020 Adenosine A2B receptors inhibit K+ currents and cell differentiation in cultured oligodendrocyte precursor cells and modulate sphingosine-1-phosphate signaling pathway. A2BR, SphK1
2020 Advancements in understanding the role of lysophospholipids and their receptors in lung disorders including bronchopulmonary dysplasia. BPD, LPA, LPL
10  2020 Advances in Neurobiology and Pharmacology of GPR12. CBD, CNS, IUPHAR, SPC
11  2020 Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair. apoM, HDL, S1PR1
12  2020 Amitriptyline inhibits nonalcoholic steatohepatitis and atherosclerosis induced by high-fat diet and LPS through modulation of sphingolipid metabolism. ASMase, HP-HFD, LPS, NASH, PA
13  2020 An adiponectin-S1P autocrine axis protects skeletal muscle cells from palmitate-induced cell death. ROS
14  2020 Angiocrine Sphingosine-1-Phosphate Activation of S1PR2-YAP Signaling Axis in Alveolar Type II Cells Is Essential for Lung Repair. LMVECs, SphK1, YAP
15  2020 Antiproliferative Effects of Thymoquinone in MCF-7 Breast and HepG2 Liver Cancer Cells: Possible Role of Ceramide and ER Stress. C1P, Cer, GRP78, NFkappaB1, nSMase, SM, TQ
16  2020 Apolipoprotein M: new connections with diet, adipose tissue and metabolic syndrome. apoM
17  2020 Apolipoprotein M: Research Progress and Clinical Perspective. apoM, HDL, MHC
18  2020 Association of circulating levels of total and protein-bound sphingosine 1-phosphate with osteoporotic fracture. BMD, HDL, LDL, OF
19  2020 Associations with metabolites in Chinese suggest new metabolic roles in Alzheimer's and Parkinson's diseases. ---
20  2020 beta3-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2/S1P2 modulation. beta3-AR, NB, S1P2, SK2
21  2020 Blockage of sphingosine-1-phosphate receptor 2 attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice. BMDCs, DNCB, S1P2
22  2020 Blocking sphingosine 1-phosphate receptor 2 accelerates hepatocellular carcinoma progression in a mouse model of NASH. DG, GNMT, HCC, MC4R, NASH, S1PRs, TG, WD
23  2020 Bone regenerative potential of the selective sphingosine 1-phosphate receptor modulator siponimod: In vitro characterisation using osteoblast and endothelial cells. ---
24  2020 Cardiovascular Effects of Pharmacological Targeting of Sphingosine Kinase 1. PKC
25  2020 Cell Death in the Tumor Microenvironment: Implications for Cancer Immunotherapy. LPC
26  2020 Ceramide and Sphingosine 1-Phosphate in Liver Diseases. ---
27  2020 Chemical genetic analysis of FTY720- and Ca2+ -sensitive mutants reveals a functional connection between FTY720 and membrane trafficking. fcs mutants
28  2020 Chronic Cannabidiol Administration Attenuates Skeletal Muscle De Novo Ceramide Synthesis Pathway and Related Metabolic Effects in a Rat Model of High-Fat Diet-Induced Obesity. CBD, Cer, HFD, HPLC, IR
29  2020 Circulating cord blood HDL-S1P complex preserves the integrity of the feto-placental vasculature. PLC
30  2020 Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex. ---
31  2020 Current, New and Future Therapeutic Targets in Inflammatory Bowel Disease: A Systematic Review. CD, IBD, IL, JAK, TNF, UC
32  2020 Dabigatran Suppresses PAR-1/SphK/S1P Activation of Astrocytes in Experimental Autoimmune Encephalomyelitis Model. CNS, EAE, MS, PAR-1, SphKs
33  2020 Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate. DSB, WT
34  2020 Decoding the Role of Sphingosine-1-Phosphate in Asthma and Other Respiratory System Diseases Using Next Generation Knowledge Discovery Platforms Coupled With Luminex Multiple Analyte Profiling Technology. S1PRs, SphK1
35  2020 Defects in High Density Lipoprotein metabolism and hepatic steatosis in mice with liver-specific ablation of Hepatocyte Nuclear Factor 4A. ChIP, HDL, NAFLD
36  2020 Dental regenerative therapy targeting sphingosine-1-phosphate (S1P) signaling pathway in endodontics. DPSCs
37  2020 Detrimental role of sphingosine kinase 1 in kidney damage in DOCA-salt hypertensive model: evidence from knockout mice. DOCA, KO, WT, WT-C
38  2020 Development and validation of a QTrap method for sensitive quantification of sphingosine 1-phosphate. EPI, MRM
39  2020 Development of electrospun polymer scaffolds for the localized and controlled delivery of siponimod for the management of critical bone defects. PLGA
40  2020 Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity. Sph
41  2020 Discovery of fingolimod based on the chemical modification of a natural product from the fungus, Isaria sinclairii. MS, S1P1
42  2020 Downregulation of S1P Lyase Improves Barrier Function in Human Cerebral Microvascular Endothelial Cells Following an Inflammatory Challenge. iS1P
43  2020 Druggable Lipid GPCRs: Past, Present, and Prospects. FFAs, GPCRs, mAbs, PAF, SPMs
44  2020 Druggable Sphingolipid Pathways: Experimental Models and Clinical Opportunities. ---
45  2020 Effect of sphingosine-1-phosphate on activation of dormant follicles in murine and human ovarian tissue. ---
46  2020 Effects of fingolimod, a sphingosine-1-phosphate (S1P) receptor agonist, on white matter microstructure, cognition and symptoms in schizophrenia. DTI, FA, MS, WM
47  2020 Effects of sphingolipids overload on red blood cell properties in Gaucher disease. GD, RBCs, SL, Sph
48  2020 Effects of triptolide on the sphingosine kinase - Sphingosine-1-phosphate signaling pathway in colitis-associated colon cancer. AOM, CACC, DSS, SphK, TP
49  2020 Endothelial S1pr1 regulates pressure overload-induced cardiac remodelling through AKT-eNOS pathway. Ang II, CM, ECs, NO, TAC
50  2020 Enhanced inflammasome activation and reduced sphingosine-1 phosphate S1P signalling in a respiratory mucoobstructive disease model. betaENaC, SphK1, Spns2
51  2020 Entosis and apical cell extrusion constitute a tumor-suppressive mechanism downstream of Matriptase. PLD
52  2020 Erythrocyte adaptive metabolic reprogramming under physiological and pathological hypoxia. 2,3-BPG, CKD, deoxyHbS, eENT1, SCD
53  2020 Erythrocyte Metabolic Reprogramming by Sphingosine 1-Phosphate in Chronic Kidney Disease and Therapies. AMPK, CKD, PP2A
54  2020 Establishment of a Measurement System for Sphingolipids in the Cerebrospinal Fluid Based on Liquid Chromatography-Tandem Mass Spectrometry, and Its Application in the Diagnosis of Carcinomatous Meningitis. CSF, dhS1P
55  2020 Evaluating the antitumor activity of sphingosine-1-phosphate against human triple-negative breast cancer cells with basal-like morphology. TNBC-BL
56  2020 Evaluation of oxysterol levels of patients with silicosis by LC-MS/MS method. 4-HNE, MDA
57  2020 Evidence for Altered Metabolism of Sphingosine-1-Phosphate in the Corpus Callosum of Patients with Schizophrenia. ---
58  2020 Evidence that ABC transporter-mediated autocrine export of an eicosanoid signaling molecule enhances germ cell chemotaxis in the colonial tunicate Botryllus schlosseri. GSCs, LOX, PLA2
59  2020 Exogenous dihydrosphingosine 1 phosphate mediates collagen synthesis in cardiac fibroblasts through JAK/STAT signalling and regulation of TIMP1. dhS1P, HDL, HF, JAK/STAT, NCFs, NCMs, S1PR1, TGF-beta, TIMP1
60  2020 Expression and role of Sphingosine 1-phosphate receptors in intervertebral disc degeneration. ADAMTS4, IVD, MMP-3, NP
61  2020 Finding a Way Out: S1P Signaling and Immune Cell Migration. ---
62  2020 Fingolimod as a Treatment in Neurologic Disorders Beyond Multiple Sclerosis. MS
63  2020 Fingolimod inhibits multiple stages of the HIV-1 life cycle. ART, HIV
64  2020 Floralozone Ameliorated Atherosclerosis in Experimental Atherosclerotic Rats Involved with Sphingosine 1-Phosphate 1 Enhancement. AS, IL
65  2020 From molecular mechanism to pre-clinical results: Anti-epileptic effects of Fingolimod. AEDs, RRMS
66  2020 FTY720 (Fingolimod) Ameliorates Brain Injury through Multiple Mechanisms and is a Strong Candidate for Stroke Treatment. BBB, FDA
67  2020 FTY720 ameliorates GvHD by blocking T lymphocyte migration to target organs and by skin fibrosis inhibition. GVHD
68  2020 FTY720 reactivates cryptococcal granulomas in mice through S1P receptor 3 on macrophages. MS
69  2020 FTY720 Regulates Mitochondria Biogenesis in Dendritic Cells to Prevent Kidney Ischemic Reperfusion Injury. BMDCs, DCs, FTY-DCs, IRI, Veh-DCs, WT
70  2020 Functional contribution of sphingosine-1-phosphate to airway pathology in cigarette smoke-exposed mice. COPD
71  2020 Generation of sphingosine-1-phosphate by sphingosine kinase 1 protects nonalcoholic fatty liver from ischemia/reperfusion injury through alleviating reactive oxygen species production in hepatocytes. I/R, NAFL, ROS, SphK1
72  2020 Glycans Meet Sphingolipids: Structure-Based Design of Glycan Containing Analogues of a Sphingosine Kinase Inhibitor. ---
73  2020 Glycation of HDL Polymerizes Apolipoprotein M and Attenuates Its Capacity to Bind to Sphingosine 1-Phosphate. apoM, HDL
74  2020 HDL-S1P protects endothelial function and reduces lung injury during sepsis in vivo and in vitro. CLP, HDL, LPS
75  2020 Hepatic insulin resistance induced by mitochondrial oxidative stress can be ameliorated by sphingosine 1-phosphate. IR, ROS
76  2020 High Circulating Sphingosine 1-Phosphate is a Risk Factor for Osteoporotic Fracture Independent of Fracture Risk Assessment Tool. AUC, CI, OF, OR
77  2020 Identification of a 22bp DNA cis Element that Plays a Critical Role in Colony Stimulating Factor 1-Dependent Transcriptional Activation of the SPHK1 Gene. CSF1, SphK1
78  2020 Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism. HP-beta-CD, HPTLC, iPSCs, NPC1, qRT-PCR, S1PR
79  2020 Impact of S1P Mimetics on Mesenteric Ischemia/Reperfusion Injury. I/R
80  2020 In silico Docking Studies of Fingolimod and S1P1 Agonists. EDG-1, GPCRs, MOE, S1P1, S1PR
81  2020 Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation. 5-FU, CRC, ER, PM, S1PRs
82  2020 Inflammatory Conditions Disrupt Constitutive Endothelial Cell Barrier Stabilization by Alleviating Autonomous Secretion of Sphingosine 1-Phosphate. BALF, EC, ECIS, FITC, HUVEC, LPS, S1PR1
83  2020 Inhibition of S1P Receptor 2 Attenuates Endothelial Dysfunction and Inhibits Atherogenesis in Apolipoprotein E-Deficient Mice. HUVEC, S1P2, WTD
84  2020 Inhibition of sphingosine 1-phosphate lyase activates human keratinocyte differentiation and attenuates psoriasis in mice. HEKn, IL, siSGPL1
85  2020 Inhibition of store-operated calcium channels by N-arachidonoyl glycine (NAGly): no evidence for the involvement of lipid-sensing G protein coupled receptors. AEA, CNS, GPCRs, LPA, NAGly
86  2020 Inhibitors of Ceramide- and Sphingosine-Metabolizing Enzymes as Sensitizers in Radiotherapy and Chemotherapy for Head and Neck Squamous Cell Carcinoma. C1P, HNSCC
87  2020 Interaction between nitric oxide and storage temperature on sphingolipid metabolism of postharvest peach fruit. ALP, AP, C1P, Cer, CERK, CerS, KDSR, NO, PLA, PLC, PLD, SM, SMS, Sph, SphK
88  2020 Interleukin-22 Mediates the Chemotactic Migration of Breast Cancer Cells and Macrophage Infiltration of the Bone Microenvironment by Potentiating S1P/SIPR Signaling. IL-22, IL-22R1, MMP-9, MSCs, S1PR1
89  2020 Intra-Tumoral Angiogenesis Is Associated with Inflammation, Immune Reaction and Metastatic Recurrence in Breast Cancer. IL, METABRIC, TNF
90  2020 Ion Binding Properties of a Naturally Occurring Metalloantibody. FAAS, ICP-MS, ITC
91  2020 Is there a role for therapeutic sphingolipids in inflammatory bowel disease? IBD
92  2020 JTE-013 supplementation improves erectile dysfunction in rats with streptozotocin-induced type Ⅰ diabetes through the inhibition of the rho-kinase pathway, fibrosis, and apoptosis. DM, DMED, ED, p-MYPT1, S1PR2
93  2020 L-cysteine/cystathionine-beta-synthase-induced relaxation in mouse aorta involves a L-serine/sphingosine-1-phosphate/NO pathway. CBS, SPT
94  2020 Lipid metabolism adaptations are reduced in human compared to murine Schwann cells following injury. SC
95  2020 Lipid Phosphate Phosphatases and Cancer. LPA, LPPs, Plpp
96  2020 Long-term use of fluoxetine accelerates bone loss through the disruption of sphingolipids metabolism in bone marrow adipose tissue. ASM, BMAT, RANKL
97  2020 Lysophospholipids and Their G-Coupled Protein Signaling in Alzheimer's Disease: From Physiological Performance to Pathological Impairment. AD, GPCR, LPA, LPLs, NFTs, PLs, SLs
98  2020 Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome. BM, GeRP, NLRP3, S1PR, SphK1
99  2020 Mechanism of action of s1p receptor modulators in multiple sclerosis: The double requirement. MS
100  2020 Mechanism of sphingosine 1-phosphate clearance from blood. SphK2