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Abbreviation : SAR
Long Form : structure-activity relationship
No. Year Title Co-occurring Abbreviation
2019 ()-trans-Dihydronarciclasine and ()-trans-dihydrolycoricidine analogues modified in their ring A: Evaluation of their anticancer activity and a SAR study. ---
2019 1,2,4-Triazole-quinoline/quinolone hybrids as potential anti-bacterial agents. ---
2019 18F-branched chain amino acids: structure-activity relationships and PET imaging potential. FBCAAs
2019 5-Aminothiophene-2,4-dicarboxamide analogues as hepatitis B virus capsid assembly effectors. ADME, ATDC, CAEs, CP, HBV, PK, SPR
2019 A New Sesquiterpenoid Aminoquinone from an Indonesian Marine Sponge. MIC
2019 A Review on Bioactivities of Tobacco Cembranoid Diterpenes. ---
2019 An update on polyphenol disposition via coupled metabolic pathways. DMEs, ETs, NRs, PBPK
2019 Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation. DSF, PHGDH
2019 Antibacterial activity of resveratrol structural analogues: A mechanistic evaluation of the structure-activity relationship. ---
10  2019 Anticancer and DNA binding studies of potential amino acids based quinazolinone analogs: Synthesis, SAR and molecular docking. ---
11  2019 Are the short cationic lipopeptides bacterial membrane disruptors? Structure-Activity Relationship and molecular dynamic evaluation. CMC, MD
12  2019 Artemisia campestris L.: review on taxonomical aspects, cytogeography, biological activities and bioactive compounds. ---
13  2019 Aryl quinolinyl hydrazone derivatives as anti-inflammatory agents that inhibit TLR4 activation in the macrophages. LPS
14  2019 Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms). GPCR, LXs, NF-kB, sLXms
15  2019 Bio-Organometallic Derivatives of Antibacterial Drugs. BOAMPs
16  2019 Bioactive polyoxygenated cembranoids from a novel Hainan chemotype of the soft coral Sinularia flexibilis. ---
17  2019 Bioassay-guided isolation of active compounds from Adenosma buchneroides essential oil as mosquito repellent against Aedes albopictus. DEET, MED
18  2019 Biology-oriented drug synthesis (BIODS), in vitro urease inhibitory activity, and in silico study of S-naproxen derivatives. BIODS
19  2019 C-6alpha- vs C-7alpha-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure-Activity Relationships. ---
20  2019 Chemistry-oriented synthesis (ChOS) and target deconvolution on neuroprotective effect of a novel scaffold, oxaza spiroquinone. ChOS, NO
21  2019 Comprehensive review on the anti-bacterial activity of 1,2,3-triazole hybrids. ---
22  2019 Comprehensive Structure-Activity Relationship Studies of Macrocyclic Natural Products Enabled by Their Total Syntheses. ---
23  2019 Comprehensive structure-activity-relationship of azaindoles as highly potent FLT3 inhibitors. AML, FLT3
24  2019 Conversion of Quinazoline Modulators from Inhibitors to Activators of beta-Glucocerebrosidase. PD
25  2019 Crystallographic and SAR analyses reveal the high requirements needed to selectively and potently inhibit SIRT2 deacetylase and decanoylase. ---
26  2019 Cynaropicrin and inhibition of NF-kappaB activation: A structure activity relationship study. NF-kappaB, RLU
27  2019 Design and synthesis of a novel 1H-pyrrolo[3,2-b]pyridine-3-carboxamide derivative as an orally available ACC1 inhibitor. PD, PK
28  2019 Design and Synthesis of Novel Heterocyclic-Based 4H-benzo[h]chromene Moieties: Targeting Antitumor Caspase 3/7 Activities and Cell Cycle Analysis. ---
29  2019 Design and synthesis of novel potent anticoagulant and anti-tyrosinase pyranopyrimidines and pyranotriazolopyrimidines: Insights from molecular docking and SAR analysis. ---
30  2019 Design of Hedgehog pathway inhibitors for cancer treatment. Hh, Smo
31  2019 Design, synthesis and antitrypanosomatid activities of 3,5-diaryl-isoxazole analogues based on neolignans veraguensin, grandisin and machilin G. ---
32  2019 Design, synthesis and biological evaluation of (E)-5-styryl-1,2,4-oxadiazoles as anti-tubercular agents. Mtb
33  2019 Design, synthesis and biological evaluation of novel benzothiadiazine derivatives as potent PI3Kdelta-selective inhibitors for treating B-cell-mediated malignancies. PK
34  2019 Design, synthesis and biological evaluation of novel neuchromenin analogues as potential antifungal agents. ---
35  2019 Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitors. HIV, RNase H, RT
36  2019 Design, Synthesis, and Biological Activities of Novel 1,3,5-Trimethylpyrazole-Containing Malonamide Derivatives. HRMS
37  2019 Design, synthesis, and biological evaluation of radioiodinated benzo[d]imidazole-quinoline derivatives for platelet-derived growth factor receptor beta (PDGFRbeta) imaging. PDGFRbeta
38  2019 Designing of acyl sulphonamide based quinoxalinones as multifunctional aldose reductase inhibitors. ---
39  2019 Development of an anti-hepatitis B virus (HBV) agent through the structure-activity relationship of the interferon-like small compound CDM-3008. HBV, IFN
40  2019 Development of Anthraquinone Analogues as Phosphoglycerate Mutase 1 Inhibitors. PGAM1
41  2019 Development of Fibrates as Important Scaffold in Medicinal Chemistry. ---
42  2019 Development of Novel Anticancer Agents with a Scaffold of Tetrahydropyrido[4,3-d]pyrimidine-2,4-dione. ATF4
43  2019 Discovery and Development of Cyclin-Dependent Kinase 8 Inhibitors. CDK8
44  2019 Discovery and structure-activity relationship of imidazolinylindole derivatives as kallikrein 7 inhibitors. ---
45  2019 Discovery and synthesis of novel beesioside I derivatives with potent anti-HIV activity. ---
46  2019 Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor. Hsp90
47  2019 Discovery of a new class of valosine containing protein (VCP/P97) inhibitors for the treatment of non-small cell lung cancer. ---
48  2019 Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER). ER, PROTAC, SERD
49  2019 Discovery of novel 2,3-dihydro-1H-inden-1-amine derivatives as selective monoamine oxidase B inhibitors. ---
50  2019 Discovery of potent indoleamine 2,3-dioxygenase (IDO) inhibitor from alkaloids in Picrasma quassioides by virtual screening and in vitro evaluation. IDO
51  2019 Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology. HGFA, kbt, PS-SCL, TTSPs
52  2019 Discovery of selective Mcl-1 inhibitors via structure-based design and structure-activity relationship analysis. ELISA
53  2019 Discovery of thiazolidin-4-one urea analogues as novel multikinase inhibitors that potently inhibit FLT3 and VEGFR2. ---
54  2019 Discovery of trans-3-(pyridin-3-yl)acrylamide-derived sulfamides as potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors for the potential treatment of cancer. NAMPT
55  2019 Discovery, Optimization, and Biological Characterization of 2,3,6-Trisubstituted Pyridine-Containing M4 Positive Allosteric Modulators. PAMs
56  2019 Drug-1,3,4-Thiadiazole Conjugates as Novel Mixed-Type Inhibitors of Acetylcholinesterase: Synthesis, Molecular Docking, Pharmacokinetics, and ADMET Evaluation. AChE
57  2019 Dual activity of amphiphilic Zn(II) nitroporphyrin derivatives as HIV-1 entry inhibitors and in cancer photodynamic therapy. ---
58  2019 Dual inhibitors of RAF-MEK-ERK and PI3K-PDK1-AKT pathways: Design, synthesis and preliminary anticancer activity studies of 3-substituted-5-(phenylamino) indolone derivatives. ---
59  2019 Dual Pharmacophores Explored via Structure-Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design. DOR, MOR
60  2019 Dual-reporter high-throughput screen for small-molecule in vivo inhibitors of plasminogen activator inhibitor type-1 yields a clinical lead candidate. HTS, NPEs, PAI-1
61  2019 Electrostatic Complementarity as a Fast and Effective Tool to Optimize Binding and Selectivity of Protein-Ligand Complexes. EC
62  2019 Evolution and Biological Evaluation of Matrinic Derivatives with Amantadine Fragments As New Anti-Influenza Virus Agents. PK
63  2019 Expanding the Chemical Space of Withaferin A by Incorporating Silicon To Improve Its Clinical Potential on Human Ovarian Carcinoma Cells. ---
64  2019 Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: is aromatic N-oxide a structural alert for predicting DNA-reactive mutagenicity? ---
65  2019 GABA allosteric modulators: An overview of recent developments in non-benzodiazepine modulators. CNS, GABA
66  2019 Gallate-induced nanoparticle uptake by tumor cells: Structure-activity relationships. MNPs
67  2019 Gram-Scale Total Synthesis of Sarpagine Alkaloids and Non-Natural Derivatives. ---
68  2019 High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition. EDSP, HTS, NIS, RAIU, TH
69  2019 Identification and Characterization of Inhibitors of a Neutral Amino Acid Transporter, SLC6A19, Using Two Functional Cell-Based Assays. FLIPR, hSLC6A19
70  2019 Identification and Structure-Activity Relationship (SAR) of potent and selective oxadiazole-based agonists of sphingosine-1-phosphate receptor (S1P1). PK, S1P1
71  2019 Identification of novel uracil derivatives incorporating benzoic acid moieties as highly potent Dipeptidyl Peptidase-IV inhibitors. ---
72  2019 Identification of TAK-632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3. DARTS, MLKL, SIRS
73  2019 In Vitro and in Vivo Antitumor Effects of Plant-Derived Miliusanes and Their Induction of Cellular Senescence. ---
74  2019 Inhibition of alpha-amylase by flavonoids: Structure activity relationship (SAR). ACA, CAT, HES, LUT, Que, RUT
75  2019 Inhibition of the Alanine-Serine-Cysteine-1 Transporter by BMS-466442. asc1
76  2019 Investigation of the molecular characteristics of bisindole inhibitors as HIV-1 glycoprotein-41 fusion inhibitors. ---
77  2019 Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid. NMDAR
78  2019 Isocostic Acid, a Promising Bioactive Agent from the Essential Oil of Inula viscosa (L.): Insights from Drug Likeness Properties, Molecular Docking and SAR Analysis. LEO
79  2019 Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents. MbtAtb
80  2019 Kinetics of the Hydrogen Abstraction PAH + •OH → PAH Radical + H2O Reaction Class: An Application of the Reaction Class Transition State Theory (RC-TST) and Structure-Activity Relationship (SAR). ARMGs, CVT, PAHs, RC-TST, SCT
81  2019 Lead optimization of selective tubulin inhibitors as anti-trypanosomal agents. ---
82  2019 Ligand design for somatostatin receptor isoforms 4 and 5. SSTR
83  2019 Low molecular weight PEI-based fluorinated polymers for efficient gene delivery. FBAs, PEI
84  2019 Marine Alkaloid 2,2-Bis(6-bromo-3-indolyl) Ethylamine and Its Synthetic Derivatives Inhibit Microbial Biofilms Formation and Disaggregate Developed Biofilms. CV, MIC
85  2019 Mechanism-based structure-activity relationship (SAR) analysis of aromatic amines and nitroaromatics carcinogenicity via statistical analyses based on CPDB. ---
86  2019 Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multidrug-Resistance Proteins. MDR
87  2019 Modular Total Synthesis and Cell-Based Anticancer Activity Evaluation of Ouabagenin and Other Cardiotonic Steroids with Varying Degrees of Oxygenation. ---
88  2019 Molecular mechanism of crolibulin in complex with tubulin provides a rationale for drug design. MTAs, MTs
89  2019 Mosquito Acetylcholinesterase as a Target for Novel Phenyl-Substituted Carbamates. AChE, WHO
90  2019 Mother Knows Best: Deciphering the Antibacterial Properties of Human Milk Oligosaccharides. HMOs, MIC
91  2019 N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships, and in Vitro Pharmacology. ---
92  2019 New tailored substituted benzothiazole Schiff base Cu(II)/Zn(II) antitumor drug entities: effect of substituents on DNA binding profile, antimicrobial and cytotoxic activity. ---
93  2019 Norharmane as a potential chemical entity for development of anticancer drugs. ---
94  2019 Novel 1-Methyl-1 H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity. ---
95  2019 Novel acyl thiourea derivatives: Synthesis, antifungal activity, gene toxicity, drug-like and molecular docking screening. NMT
96  2019 Novel coumarin derivatives as potent acetylcholinesterase inhibitors: insight into efficacy, mode and site of inhibition. AChE, CC, DON, HSA, PAS, ThT
97  2019 Novel nannocystin A analogues as anticancer therapeutics: Synthesis, biological evaluations and structure-activity relationship studies. ---
98  2019 Optimization of Drug Candidates That Inhibit the D-Loop Activity of RAD51. HR
99  2019 Optimization techniques for novel c-Met kinase inhibitors. ---
100  2019 Optimizing TRPM4 inhibitors in the MHFP6 chemical space. ---