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Abbreviation : SCD1
Long Form : stearoyl-CoA desaturase 1
No. Year Title Co-occurring Abbreviation
2020 Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation. FA, NASH, TCA
2020 BAI1 acts as a tumor suppressor in lung cancer A549 cells by inducing metabolic reprogramming via the SCD1/HMGCR module. BAI1, BAI1, HMGCR
2020 Bovine Stearoyl-CoA Desaturase 1 Promotes Adipogenesis by Activating the PPARgamma Receptor. MUFAs, SFAs, SVF
2020 Combined use of milk infrared spectra and genotypes can improve prediction of milk fat composition. DGAT1, FASN, IR
2020 CytoMatrix for a reliable and simple characterization of lung cancer stem cells from malignant pleural effusions. CSCs, MPEs, NSCLC, YAP-TAZ
2020 Effects of dietary carbohydrate sources on lipid metabolism and SUMOylation modification in the liver tissues of yellow catfish. SREBP1, SUMO
2020 Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production. CHO, ER, LMM, SREBF1
2020 Fatty acid biosynthesis and transcriptional regulation of Stearoyl-CoA Desaturase 1 (SCD1) in buffalo milk. BMECs, FA, TAG, UFA
2020 Glycerol kinase stimulates uncoupling protein 1 expression by regulating fatty acid metabolism in beige adipocytes. beta-AR, CREB, Gyk, ISO, iWAT, KD, POA, UCP1
10  2020 Impact of SNPs in ACACA, SCD1, and DGAT1 Genes on Fatty Acid Profile in Bovine Milk with Regard to Lactation Phases. ACACA, DGAT1, FA, SNPs
11  2020 Inositol requiring enzyme 1alpha promotes Zika virus infection through regulating stearoyl-CoA desaturase 1 mediated lipid metabolism. ER, IRE1alpha, MUFA, UPR, ZIKV, ZIKV
12  2020 Insulin activates hepatic Wnt/beta-catenin signaling through stearoyl-CoA desaturase 1 and Porcupine. iLIRKO
13  2020 Lactobacillus Strains Alleviated Hyperlipidemia and Liver Steatosis in Aging Rats via Activation of AMPK. AMPK, HFD, ND
14  2020 Lipid desaturation-associated endoplasmic reticulum stress regulates MYCN gene expression in hepatocellular carcinoma cells. ACR, CSC, ER, HCC, MYCN, MYCNhigh
15  2020 Lipidomic profiling of plasma free fatty acids in type-1 diabetes highlights specific changes in lipid metabolism. D5D, FFA, T1DM
16  2020 Menin‑MLL inhibitors induce ferroptosis and enhance the anti‑proliferative activity of auranofin in several types of cancer cells. MLL, ROS
17  2020 Placental Accumulation of Triacylglycerols in Gestational Diabetes Mellitus and Its Association with Altered Fetal Growth are Related to the Differential Expressions of Proteins of Lipid Metabolism. CPW, FAS, FFA, GDM, LPL, PI3K, PPAR, SREBP1, TG
18  2020 Potential role of aryl hydrocarbon receptor signaling in childhood obesity. AhR, AHRR, PPARgamma2, ROC
19  2020 Preventive Action of Sterculic Oil on Metabolic Syndrome Development on a Fructose-Induced Rat Model. MS, SO
20  2020 SCD1 activity promotes cell migration via a PLD-mTOR pathway in the MDA-MB-231 triple-negative breast cancer cell line. OA, PLD, TNBC
21  2020 SCD1 Promotes Lipid Mobilization in Subcutaneous White Adipose Tissue. scWAT
22  2020 Sciadonic acid derived from pine nuts as a food component to reduce plasma triglycerides by inhibiting the rat hepatic Delta9-desaturase. Scia
23  2020 Selenoneine Ameliorates Hepatocellular Injury and Hepatic Steatosis in a Mouse Model of NAFLD. ACC1, FXR, GPX1, Gsta1, HMOX1, NAFLD
24  2020 Slow-Release H2S Donor Anethole Dithiolethione Protects Liver From Lipotoxicity by Improving Fatty Acid Metabolism. ACC1, CPT1alpha, FADS, FAs, FAS, FATPs, HFD, L-FABP
25  2020 SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/beta-catenin signaling pathway. ESCC, SREBP1
26  2020 Stearoyl-CoA desaturase 1 (SCD1) facilitates the growth and anti-ferroptosis of gastric cancer cells and predicts poor prognosis of gastric cancer. MUFAs
27  2020 Stearoyl-CoA Desaturase 1 Activity Determines the Maintenance of DNMT1-Mediated DNA Methylation Patterns in Pancreatic beta-Cells. AMPK, DNMT1, SIRT1, T2D
28  2020 Stearoyl-CoA desaturase 5 (SCD5), a Delta-9 fatty acyl desaturase in search of a function. SCD5, SFA
29  2020 Stearoyl-CoA Desaturase-1 Enzyme Inhibition by Grape Skin Extracts Affects Membrane Fluidity in Human Colon Cancer Cell Lines. GSEs, HPLC
30  2020 Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain. ---
31  2020 Stearoyl-CoA-desaturase-1 regulates gastric cancer stem-like properties and promotes tumour metastasis via Hippo/YAP pathway. GCSCs, siRNA, YAP
32  2020 Sterculic Acid: The Mechanisms of Action beyond Stearoyl-CoA Desaturase Inhibition and Therapeutic Opportunities in Human Diseases. AMD, MUFAs, SA, SCD, SFA
33  2020 Structure and Mechanism of a Unique Diiron Center in Mammalian Stearoyl-CoA Desaturase. b5R, cyt b5
34  2020 Vitamins Modulate the Expression of Antioxidant Genes in Progesterone-Treated Pancreatic beta Cells: Perspectives for Gestational Diabetes Management. DUOX1, GD, GPx6, HMOX1, Hspa1a
35  2019 (5R)-5-hydroxytriptolide ameliorates liver lipid accumulation by suppressing lipid synthesis and promoting lipid oxidation in mice. ACOX1, AST, CPT1a, FAO, FAs, HFHFr, NAFLD, PPARalpha
36  2019 Alterations of Fatty Acid Profile May Contribute to Dyslipidemia in Chronic Kidney Disease by Influencing Hepatocyte Metabolism. apoB, CKD, FA, FASN, MTTP, MUFA, VLDL
37  2019 Angiotensin II promotes ovarian cancer spheroid formation and metastasis by upregulation of lipid desaturation and suppression of endoplasmic reticulum stress. Ang II, EGFR, EOC, MCS
38  2019 Arazyme Suppresses Hepatic Steatosis and Steatohepatitis in Diet-Induced Non-Alcoholic Fatty Liver Disease-Like Mouse Model. ACC1, DGAT1, FAS, HFD, IL-1B, MT, PA, TC, TG, TNFA
39  2019 Berberine Inhibits Adipogenesis in Porcine Adipocytes via AMP-Activated Protein Kinase-Dependent and -Independent Mechanisms. Acc-1, AMPK, Ampka1, FABP4, FAS, PPARg2, RT-PCR, SREBF1
40  2019 Chitinase-3-like-1 deficiency attenuates ethanol-induced liver injury by inhibition of sterol regulatory element binding protein 1-dependent triglyceride synthesis. ACC, ALD, CHI3L1, FAS, KO, TG
41  2019 Clinical and biochemical relevance of monounsaturated fatty acid metabolism targeting strategy for cancer stem cell elimination in colon cancer. BCCs, CSCs, MUFAs, PC, SFAs, SM
42  2019 Co-administration of 20(S)-protopanaxatriol (g-PPT) and EGFR-TKI overcomes EGFR-TKI resistance by decreasing SCD1 induced lipid accumulation in non-small cell lung cancer. EGFR, EGFR-TKIs, MUFA, NSCLC
43  2019 Dietary polyunsaturated fatty acids mediate the inverse association of stearoyl-CoA desaturase activity with the risk of fatty liver in dyslipidaemic individuals. FLI, NAFLD, OR, PUFA
44  2019 Effect of Breed on Transcriptional and Protein Expression of Lipogenic Enzymes in Tail and Subcutaneous Adipose Tissue from Two Grazing Breeds of Lambs. ACC, FAS, SCF, SFA, SREBP1c, TF
45  2019 Expression patterns of hepatic genes involved in lipid metabolism in cows with subclinical or clinical ketosis. ACC1, ACSL1, BHB, CK, CPT1A, CPT2, DGAT1, DGAT2, FAS, PPARA, SCK, SREBP1, TG
46  2019 Fatty Acid Elongase 7 (ELOVL7) Plays a Role in the Synthesis of Long-Chain Unsaturated Fatty Acids in Goat Mammary Epithelial Cells. DGAT2, FABP3, FADS2, GMEC
47  2019 Gnotobiotic mice inoculated with Firmicutes, but not Bacteroidetes, deteriorate nonalcoholic fatty liver disease severity by modulating hepatic lipid metabolism. CD36, DGAT2, FAS, HFD, NAFLD
48  2019 Hepatic stearoyl CoA desaturase 1 deficiency increases glucose uptake in adipose tissue partially through the PGC-1alpha-FGF21 axis in mice. FGF21, GLUT1, PGC-1alpha
49  2019 Hepatic Stearoyl-CoA desaturase-1 deficiency-mediated activation of mTORC1- PGC-1alpha axis regulates ER stress during high-carbohydrate feeding. ER, mTORC1, MUFAs, SFA, UPR
50  2019 Induction of Stearoyl-CoA 9-Desaturase 1 Protects Human Mesenchymal Stromal Cells Against Palmitic Acid-Induced Lipotoxicity and Inflammation. hMSC, LXRs, MSC, MUFA, Ole, Palm, SFA
51  2019 Influences of sterol regulatory element binding protein-1c silencing on glucose production in HepG2 cells treated with free fatty acid. CPT-1, FAS, FFA, G6PC, IR, PEPCK, SREBP-1c
52  2019 Interleukin-1alpha deficiency reduces adiposity, glucose intolerance and hepatic de-novo lipogenesis in diet-induced obese mice. ACC, DMSO, eWAT, FASN, HFD, IL, IR, KO, TG
53  2019 Interleukin-6 derived from cutaneous deficiency of stearoyl-CoA desaturase- 1 may mediate metabolic organ crosstalk among skin, adipose tissue and liver. IL-6
54  2019 Maternal high-fat diet during suckling programs visceral adiposity and epigenetic regulation of adipose tissue stearoyl-CoA desaturase-1 in offspring. BW, FA, HF, WAT
55  2019 Metabolic Activation of Elemicin Leads to the Inhibition of Stearoyl-CoA Desaturase 1. ---
56  2019 Metabolomic Studies of Live Single Cancer Stem Cells Using Mass Spectrometry. CSCs, MS, NF-kappaB, NSCCs, TCA
57  2019 Oleic acid increases the transcriptional activity of FoxO1 by promoting its nuclear translocation and beta-catenin binding in pancreatic beta-cells. FOXO1
58  2019 Pinolenic acid ameliorates oleic acid-induced lipogenesis and oxidative stress via AMPK/SIRT1 signaling pathway in HepG2 cells. AMPK, FASN, GPx, HO-1, MDA, NAFLD, NO, Nrf2, OA, PLA, PPARalpha, ROS, SOD, TC, TG
59  2019 Polymorphisms rs2167444 and rs508384 in the SCD1 Gene Are Linked with High ApoB-48 Levels and Adverse Profile of Cardiometabolic Risk Factors. apoB-48, MetS
60  2019 Reduction of Hepatic Lipogenesis by Loliolide and Pinoresinol from Lysimachia vulgaris via Degrading Liver X Receptors. ACC, FAS, LV, LVE, LXRs, NAFLD, PCR, SREBP
61  2019 Resveratrol Treatment Enhances the Cellular Response to Leptin by Increasing OBRb Content in Palmitate-Induced Steatotic HepG2 Cells. FAS, RSV, SIRT1, STAT3
62  2019 Role of Oleic Acid in the Gut-Liver Axis: From Diet to the Regulation of Its Synthesis via Stearoyl-CoA Desaturase 1 (SCD1). MUFA
63  2019 Sirt1 counteracts decrease in membrane phospholipid unsaturation and diastolic dysfunction during saturated fatty acid overload. FA, KD, LV, LXR, MUFA, NMN, SFA
64  2019 Splicing factor ESRP1 controls ER-positive breast cancer by altering metabolic pathways. EMT, ESRP1 and ESRP2, FASN, PHGDH
65  2019 Stearoyl-CoA Desaturase 1 as a Therapeutic Target for the Treatment of Cancer. ---
66  2019 Stearoyl-CoA desaturase-1 is required for flavivirus RNA replication. DENV
67  2019 Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: agonist or inverse agonist? ccRCC, FA, FASN, HDL, LDLR, LXR, SREBP-1c
68  2019 The Combination of 'Benifuuki' with Quercetin Suppresses Hepatic Fat Accumulation in High-Fat High-Cholesterol Diet-Fed Rats. FAS, TG
69  2019 The TRPV1 channel regulates glucose metabolism. CPT2, ECs, EDL, FAAH, FADS2, HFD, LIPE, PDK4, SLD, SOL, TRPV1, UCP3
70  2019 Vitamin A deficiency increases the oleic acid (C18:1) levels in the kidney of high fructose diet-fed rats. HFr, MUFA, VAD
71  2019 Yangonin protects against non-alcoholic fatty liver disease through farnesoid X receptor. ACC1, FAS, FXR, G6Pase, GSK3beta, HFD, NAFLD, PDase, PEPCK, SREBP-1c
72  2019 [Inhibition of SCD1 Activity Blocks Cell Cycle Progression and Impairs Proliferation in Breast Cancer Cells]. ---
73  2018 Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy. ADME
74  2018 Alpinetin improved high fat diet-induced non-alcoholic fatty liver disease (NAFLD) through improving oxidative stress, inflammatory response and lipid metabolism. ALP, FAS, HF, IRS-1, LXR, NAFLD, SREBP-1c, TLR4-NF-kappaB, TXNIP, XO
75  2018 Central leptin regulates heart lipid content by selectively increasing PPAR beta/delta expression. ACOX1, DGAT1, i.c.v, PDK4, TAG
76  2018 Cloning, expression pattern analysis, and subcellular localization of Capra hircus SCD1 gene with production of transgenic mice. CDS, PEI, RT-PCR
77  2018 CRISPR/Cas9-mediated Stearoyl-CoA Desaturase 1 (SCD1) Deficiency Affects Fatty Acid Metabolism in Goat Mammary Epithelial Cells. GMEC, HDR, NHEJ
78  2018 Decrease in membrane phospholipids unsaturation correlates with myocardial diastolic dysfunction. HFDs, MUFA, SFA, UPR
79  2018 Discovery of potent liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitors, thiazole-4-acetic acid derivatives, for the treatment of diabetes, hepatic steatosis, and obesity. ---
80  2018 Down-regulation of stearoyl-CoA desaturase-1 increases susceptibility to palmitic-acid-induced lipotoxicity in human trophoblast cells. DGAT1, PA
81  2018 Epigenetic mechanisms contribute to decrease stearoyl-CoA desaturase 1 expression in the liver of dairy cows after prolonged feeding of high-concentrate diet. SARA
82  2018 Fatty acid elongase 5 (ELOVL5) alters the synthesis of long-chain unsaturated fatty acids in goat mammary epithelial cells. DGAT2, FADS2, LCUFA, PLIN2
83  2018 Flavonones from Penthorum chinense Ameliorate Hepatic Steatosis by Activating the SIRT1/AMPK Pathway in HepG2 Cells. ACC, AMPK, AST, FAS, FFA, GSH-Px, MDA, MPG, P. chinense, PCB, PCBG, PPARalpha, SIRT1, SOD, SREBP-1c
84  2018 Increased expression of the gene encoding stearoyl-CoA desaturase 1 in human bladder cancer. ---
85  2018 Increased hydrophilic plasma bile acids are correlated with protection from adiposity in skin-specific stearoyl-CoA desaturase-1 deficient mice. SKO
86  2018 IRE1alpha RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers. ER, IRE1alpha, XBP1
87  2018 Long-chain n-3 PUFA supplied by the usual diet decrease plasma stearoyl-CoA desaturase index in non-hypertriglyceridemic older adults at high vascular risk. LC n-3 PUFA, MUFA, PREDIMED, PUFA
88  2018 Lung fibroblasts promote metastatic colonization through upregulation of stearoyl-CoA desaturase 1 in tumor cells. ANXA2, CTSB
89  2018 Melatonin Modulates lipid Metabolism in HepG2 Cells Cultured in High Concentrations of Oleic Acid: AMPK Pathway Activation may Play an Important Role. ACC, AMPK, CPT1, FAS, HMGR, PPARalpha, SREBP-1c
90  2018 Metabolic features of cancer stem cells: the emerging role of lipid metabolism. CSCs, HMG-CoAR
91  2018 Milk fatty acid variability and association with polymorphisms in SCD1 and DGAT1 genes in White Fulani and Borgou cattle breeds. DGAT1, SFA
92  2018 miR‑127 aggravates myocardial failure by promoting the TGF‑beta1/Smad3 signaling. FASN, miR, UCP1
93  2018 Neonatal overfeeding induced glucocorticoid overexposure accelerates hepatic lipogenesis in male rats. DNL, FASN, GC, GR, HF, Mi, NAFLD, OA, SREBP-1c, TG
94  2018 Partitioning of adipose lipid metabolism by altered expression and function of PPAR isoforms after bariatric surgery. CPT1, FABP, PPAR, UCP2
95  2018 Peroxisome proliferator-activated receptor gamma (PPARgamma) agonist fails to overcome trans-10, cis-12 conjugated linoleic acid (CLA) inhibition of milk fat in dairy sheep. CLA, PPARgamma, SREBP1, TZD
96  2018 Pivotal role of human stearoyl-CoA desaturases (SCD1 and 5) in breast cancer progression: oleic acid-based effect of SCD1 on cell migration and a novel pro-cell survival role for SCD5. CAFs
97  2018 Potential contribution of monounsaturated fatty acids to cardiovascular risk in chronic kidney disease. CKD, CVD, MUFAs
98  2018 Reduced expression of stearoyl-CoA desaturase-1, but not free fatty acid receptor 2 or 4 in subcutaneous adipose tissue of patients with newly diagnosed type 2 diabetes mellitus. FFAR, SAT
99  2018 Responses of MAC-T Cells to Inhibited Stearoyl-CoA Desaturase 1 during cis-9, trans-11 Conjugated Linoleic Acid Synthesis. ACSS2, CLA, CON, LPIN1
100  2018 Role of the pregnane X receptor in binge ethanol-induced steatosis and hepatotoxicity. ADH1, Akr1b7, ALDH, EtOH, SREBP-1c, WT