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Abbreviation : SCD1
Long Form : stearoyl-coenzyme A desaturase 1
No. Year Title Co-occurring Abbreviation
2020 Association of the PNPLA2, SCD1 and Leptin Expression with Fat Distribution in Liver and Adipose Tissue From Obese Subjects. ATGL, LEP, PNPLA2, SREBF1, SREBP-1c, subcutaneous-omental
2020 Betulinic acid induces apoptosis of gallbladder cancer cells via repressing SCD1. BetA, GBC
2020 Cadmium transcriptionally regulates Scd1 expression in silver pomfret. Cd, SREBP-1
2020 MiR-1908/EXO1 and MiR-203a/FOS, regulated by scd1, are associated with fracture risk and bone health in postmenopausal diabetic women. BM-MSCs, T2DM
2020 Saturated and monounsaturated fatty acids in membranes are determined by the gene expression of their metabolizing enzymes SCD1 and ELOVL6 regulated by the intake of dietary fat. GC, MUFAs, NHRs, qRT-PCR
2020 Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II. ---
2020 Structure-based virtual screening of natural products as potential stearoyl-coenzyme a desaturase 1 (SCD1) inhibitors. MD, MUFA, SFA
2019 Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway. AMPK, BBR, HFD, mRNA, NAFLD, SRE, SREBP-1c, TG
2019 Deep Lipidomics and Molecular Imaging of Unsaturated Lipid Isomers: A Universal Strategy Initiated by mCPBA Epoxidation. LC-MS
10  2019 Human charcoal-stripped serum supplementation enhances both the stearoyl-coenzyme a desaturase 1 activity of cumulus cells and the in vitro maturation of oocytes. IVF, IVM, PCR
11  2019 Lipidomics reveal aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis. AhR, ANIT, Chk, SMPD, UPLC-ESI-QTOF MS
12  2019 Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway. FAs, mTOR, SREBP1
13  2019 Stearoyl-coenzyme A desaturase 1 is required for lipid droplet formation in pig embryo. LD
14  2018 Ablation of prolactin receptor increases hepatic triglyceride accumulation. NAFLD, PRL, PRLR, TG
15  2018 Implantation of Neural Probes in the Brain Elicits Oxidative Stress. NOXA1
16  2018 Metformin attenuates triglyceride accumulation in HepG2 cells through decreasing stearyl-coenzyme A desaturase 1 expression. FAS, NAFLD, SREBP-1c, TG
17  2018 Primary Culture of Human Cumulus Cells Requires Stearoyl-Coenzyme A Desaturase 1 Activity for Steroidogenesis and Enhancing Oocyte In Vitro Maturation. GV
18  2018 Protection by the Total Flavonoids from Rosa laevigata Michx Fruit against Lipopolysaccharide-Induced Liver Injury in Mice via Modulation of FXR Signaling. ACC1, ALT, AST, COX-2, CPT1, FASN, FXR, GCLC, GCLM, HMGB-1, HO-1, LPS, nuclear factor-kappa B, TC, TFs
19  2018 Substrate specificity and membrane topologies of the iron-containing omega3 and omega6 desaturases from Mortierella alpina. DHA, EPA, LC-PUFAs, PUFAs
20  2018 The role of suppression of hepatic SCD1 expression in the metabolic effects of dietary methionine restriction. EE, FGF21, MR
21  2017 Alternation of plasma fatty acids composition and desaturase activities in children with liver steatosis. BMI, HOMA-IR
22  2017 Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents. PD, PK, SCD
23  2017 Insights into Stearoyl-CoA Desaturase-1 Regulation of Systemic Metabolism. MUFAs
24  2017 Lipid Emulsion Added to a Liquid High-Carbohydrate Diet and Voluntary Running Exercise Reduce Lipogenesis and Ameliorate Early-Stage Hepatic Steatosis in Mice. EXE, FAs, FASN, HCD, LE, SFP, TG
25  2017 Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells. MUFAs, NCOR1, SFAs
26  2017 SCD1 Confers Temozolomide Resistance to Human Glioma Cells via the Akt/GSK3beta/beta-Catenin Signaling Axis. GBM, TMZ
27  2016 A lipidomics investigation into the intervention of celastrol in experimental colitis. DSS, IBD, SM
28  2016 Antilipidemic effects and gene expression profiling of the glycosaminoglycans from cricket in rats on a high fat diet. A2M, CRP, GAG, Lcn2
29  2016 Characterization of the liver X receptor-dependent regulatory mechanism of goat stearoyl-coenzyme A desaturase 1 gene by linoleic acid. NF-Y, PUFA, SRE, SREBF1
30  2016 Liver X receptor alpha promotes the synthesis of monounsaturated fatty acids in goat mammary epithelial cells via the control of stearoyl-coenzyme A desaturase 1 in an SREBP-1-dependent manner. GMEC, LXRalpha, LXRE, MUFA, NF-Y, SRE, SREBF1
31  2016 Novel single nucleotide polymorphisms in the 5' regulatory region of the duck SCD1 gene and their associations with serum biochemical levels and fatty acid composition. SNPs
32  2016 Patatin-like phospholipase domain-containing protein 3 is involved in hepatic fatty acid and triglyceride metabolism through X-box binding protein 1 and modulation of endoplasmic reticulum stress in mice. ER, KO, NASH, PNPLA3, WT, XBP1
33  2016 Thyroid hormone responsive (THRSP) promotes the synthesis of medium-chain fatty acids in goat mammary epithelial cells. DGAT2, FASN, SREBF1, TAG, THRSP
34  2015 Crystal structure of human stearoyl-coenzyme A desaturase in complex with substrate. ---
35  2015 Hepatic SirT1-Dependent Gain of Function of Stearoyl-CoA Desaturase-1 Conveys Dysmetabolic and Tumor Progression Functions. DBC-1
36  2015 Prosteatotic genes are associated with unsaturated fat suppression of saturated fat-induced hepatic steatosis in C57BL/6 mice. CD36, SFA, USFA
37  2015 Regulation of Stearoyl Coenzyme A Desaturase 1 Gene Promoter in Bovine Mammary Cells. ---
38  2015 The green algal carotenoid siphonaxanthin inhibits adipogenesis in 3T3-L1 preadipocytes and the accumulation of lipids in white adipose tissue of KK-Ay mice. FABP4, WAT
39  2014 Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway. MEFs, MUFA, SFA
40  2014 Effect of high versus low doses of fat and vitamin A dietary supplementation on fatty acid composition of phospholipids in mice. MUFA, SAFA
41  2014 Effect of high-fat diet prior to pregnancy on hepatic gene expression and histology in mouse offspring. CTR, Fabp5, HFD, PP, PP, RT-PCR
42  2014 Lipid content in hepatic and gonadal adipose tissue parallel aortic cholesterol accumulation in mice fed diets with different omega-6 PUFA to EPA plus DHA ratios. DHA, EPA, GAT, HMGCR, PUFA, TC
43  2014 Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease. ---
44  2013 cAMP response element binding protein1 is essential for activation of steroyl co-enzyme a desaturase 1 (Scd1) in mouse lung type II epithelial cells. cAMP, Creb1, FASN
45  2013 COH-SR4 reduces body weight, improves glycemic control and prevents hepatic steatosis in high fat diet-induced obese mice. CaMKKbeta, CPT1a, FASN, G6PC, HFD, LKB1, PCK1, SR4
46  2013 Down-regulation of hepatic stearoyl-CoA desaturase-1 expression by fucoxanthin via leptin signaling in diabetic/obese KK-A(y) mice. ---
47  2013 Effect of taurine and N-acetylcysteine on methionine restriction-mediated adiposity resistance. CF, MR, NAC, SAA, tCys
48  2013 Genetic correlation between composition of bovine milk fat in winter and summer, and DGAT1 and SCD1 by season interactions. FA
49  2013 Overexpression of stearoyl-coenzyme A desaturase 1 in macrophages promotes reverse cholesterol transport. RCT
50  2013 Plasma stearoyl-CoA desaturase indices: association with lifestyle, diet, and body composition. ---
51  2012 Stearoyl-CoA desaturase-1 (SCD1) augments saturated fatty acid-induced lipid accumulation and inhibits apoptosis in cardiac myocytes. ROS, SFAs
52  2012 TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function. TCF
53  2011 Adipose tissue palmitoleic acid and obesity in humans: does it behave as a lipokine? PRs
54  2011 Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide. DAG, DGAT1, DIWL, EX, IMTG
55  2010 Insulin resistance in African-American and Caucasian women: differences in lipotoxicity, adipokines, and gene expression in adipose tissue and muscle. AA, AGPAT 2, IMCL, PPARgamma, SAT
56  2009 Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios. FASN, SREBP-1
57  2009 Influence of stearoyl-coenzyme A desaturase 1 genotype and stage of lactation on fatty acid composition of Canadian Jersey cows. CLAI, SFA
58  2009 Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity. MUFA
59  2009 The Decrease of n-3 Fatty Acid Energy Percentage in an Equicaloric Diet Fed to B6C3Fe Mice for Three Generations Elicits Obesity. ---
60  2008 Adipose tissue gene expression profiles in ob/ob mice treated with leptin. ADR3, Ang-2, FAS, HSL, Mfn2, RBP4, Sirt3, SREBF1, TNF-alpha, UCP2
61  2008 Compartmentalization of stearoyl-coenzyme A desaturase 1 activity in HepG2 cells. CLA
62  2008 Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis. ---
63  2007 Conjugated linoleic acid reduces adipose depots without reduction of stearoyl coenzyme A desaturase 1 gene expression. BT, CLA, FO, TG
64  2007 Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells. ACC, FAS, GPAT, SREBP-1
65  2007 Subtle metabolic and liver gene transcriptional changes underlie diet-induced fatty liver susceptibility in insulin-resistant mice. HFD, NAFLD, Srebf1c
66  2006 A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis. ---
67  2006 Stearoyl-coenzyme A desaturase 1, sterol regulatory element binding protein-1c and peroxisome proliferator-activated receptor-alpha: independent and interactive roles in the regulation of lipid metabolism. PPARalpha
68  2006 The expression of genes related to adipocyte differentiation in pigs. ACE, ATM
69  2005 A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria. flk, MUFA, TLR2
70  2003 Microarray analysis of gene expression in the kidneys of new- and post-onset diabetic NOD mice. ---
71  2001 Stearoyl coenzyme A desaturase 1 expression and activity are increased in the liver during iron overload. ---