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Abbreviation : SGK1
Long Form : serum- and glucocorticoid-inducible kinase 1
No. Year Title Co-occurring Abbreviation
2020 Acute Hyperglycemia Aggravates Lung Injury via Activation of the SGK1-NKCC1 Pathway. ALI, AM, SPAK
2020 Anti-invasive effect and pharmacological mechanism of genistein against colorectal cancer. CRC, lncRNA, TGF-beta1
2020 Behavioral effects of SGK1 knockout in VTA and dopamine neurons. DA, KO, VTA
2020 Bisphenol A-induced mechanistic impairment of decidualization. BPA, Egr-1, eNOS, ER, NO, PR
2020 CASZ1b is a novel transcriptional corepressor of mineralocorticoid receptor. ENaCalpha, MR
2020 Circular RNA circ_0007142 regulates cell proliferation, apoptosis, migration and invasion via miR-455-5p/SGK1 axis in colorectal cancer. circ_0007142, CRC, miR-455-5p
2020 Clinical characteristics of colorectal cancer patients and anti-neoplasm activity of genistein. Bcl-2, CRC, Erk1, LDH, TUNEL
2020 Combination therapy with mTOR kinase inhibitor and dasatinib as a novel therapeutic strategy for vestibular schwannoma. MN, NF2, SCs, VS
2020 Discovery of a novel rhein-SAHA hybrid as a multi-targeted anti-glioblastoma drug. CNS, GBM, HDAC, SAHA
10  2020 Genome-wide integration of microRNA and transcriptomic profiles of differentiating human alveolar epithelial cells. AT1, hAT2, miRNAs
11  2020 Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA. DM, GC, HREM
12  2020 Glucocorticoid receptor and serum- and glucocorticoid-induced kinase-1 in esophageal adenocarcinoma and adjacent Barrett's esophagus. BE, EAC, GR
13  2020 Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea. cAMP, cGMP, DEXA, GC, Nedd4-2, PI3K
14  2020 GR, Sgk1, and NDRG1 in esophageal squamous cell carcinoma: their correlation with therapeutic outcome of neoadjuvant chemotherapy. DFS, ESCC, GC, NAC, NDRG1, OS
15  2020 Hippocampal overexpression of SGK1 ameliorates spatial memory, rescues Abeta pathology and actin cytoskeleton polymerization in middle-aged APP/PS1 mice. AD, oSGK1
16  2020 Knockdown of SGK1 alleviates the IL-1beta-induced chondrocyte anabolic and catabolic imbalance by activating FoxO1-mediated autophagy in human chondrocytes. FOXO1, IL-1beta, OA
17  2020 Low Circulating Levels of GR, FKBP5, and SGK1 in Medicated Patients With Depression Are Not Altered by Electroconvulsive Therapy. ECT, GC, GR
18  2020 Monocyte Chemotactic Protein-1 Regulates Proliferation and Contractility of Human Bladder Smooth Muscle Cells Under Hydrostatic Pressure. hBSMCs, HP, MCP-1, MCPIP1, PBOO, rhMCP-1, ROS
19  2020 PO-322 exerts potent immunosuppressive effects in vitro and in vivo by selectively inhibiting SGK1 activity. DTH
20  2020 Role of SGK1 in the Osteogenic Transdifferentiation and Calcification of Vascular Smooth Muscle Cells Promoted by Hyperglycemic Conditions. AGEs, VSMCs
21  2020 Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3+ Regulatory T Cells. HS, Treg
22  2020 Serum- and glucocorticoid-induced kinase 1, a new therapeutic target for autophagy modulation in chronic diseases. ---
23  2020 Serum- and glucocorticoid-inducible kinase 1 activity reduces dendritic spines in dorsal hippocampus. ---
24  2020 Serum- and Glucocorticoid-inducible Kinase 1 is Essential for Osteoclastogenesis and Promotes Breast Cancer Bone Metastasis. ---
25  2020 SGK1 activation exacerbates diet-induced obesity, metabolic syndrome and hypertension. MetS
26  2020 SGK1 mediates the hypotonic protective effect against H2O2-induced apoptosis of rat basilar artery smooth muscle cells by inhibiting the FOXO3a/Bim signaling pathway. BASMCs, Bim, FOXO3a, MMP, VRCCs
27  2020 Significance of glucocorticoid signaling in triple-negative breast cancer patients: a newly revealed interaction with androgen signaling. 11beta-HSD, DEX, DHT, GCs, GR, AR, TNBC
28  2020 Sodium butyrate ameliorates deoxycorticosterone acetate/salt-induced hypertension and renal damage by inhibiting the MR/SGK1 pathway. DOCA, MR, SD
29  2020 Targeting SGK1 enhances the efficacy of radiotherapy in locally advanced rectal cancer. ATF3, IHC, LARC, non-pCR, RT
30  2020 TCRP1 induces tamoxifen resistance by promoting the activation of SGK1 in MCF‑7 cells. ER, PDK1, TCRP1
31  2020 The Emerging Role of SGK1 (Serum- and Glucocorticoid-Regulated Kinase 1) in Major Depressive Disorder: Hypothesis and Mechanisms. BDNF, HPA, MDD, VEGF
32  2020 The functional duality of SGK1 in the regulation of hyperglycemia. ---
33  2020 The prospect of serum and glucocorticoid-inducible kinase 1 (SGK1) in cancer therapy: a rising star. mTOR, PI3K
34  2020 Transcriptome sequencing identifies genes associated with invasion of ovarian cancer. AKT3, ANGPT2, CD19, CSF3, DEGs, FGF-1, FGF18, ITGA11, ITGA2, ITGB4, ITGB8, LAMA3, MYB, PCK2, PGF, PIK3AP1, SYK, TLR4, TP53
35  2020 Upregulation of serum and glucocorticoid-regulated kinase 1 exacerbates brain injury and neurological deficits after cardiac arrest. ACA, CA
36  2020 Urethral meatus stricture BOO stimulates bladder smooth muscle cell proliferation and pyroptosis via IL‑1beta and the SGK1‑NFAT2 signaling pathway. BOO, MBSMC
37  2020 Virtual Screening Approach to Identify High-Affinity Inhibitors of Serum and Glucocorticoid-Regulated Kinase 1 among Bioactive Natural Products: Combined Molecular Docking and Simulation Studies. ADMET
38  2019 Acupuncture Inhibits the Increase in Alpha-Synuclein by Modulating SGK1 in an MPTP Induced Parkinsonism Mouse Model. MPTP, PD, SN
39  2019 Administration of dexamethasone disrupts endometrial receptivity by alteration of expression of miRNA 223, 200a, LIF, Muc1, SGK1, and ENaC via the ERK1/2-mTOR pathway. ENaC, LIF, mTOR
40  2019 Association of SGK1 Polymorphisms With Susceptibility to Coronary Heart Disease in Chinese Han Patients With Comorbid Depression. CHD, CI, OR, PCR-LDR, PHQ-9, SNPs
41  2019 Celastrol suppresses experimental autoimmune encephalomyelitis via MAPK/SGK1-regulated mediators of autoimmune pathology. BDNF, EAE, MAPK, MOG, MS, Th17, Treg
42  2019 Comprehensive analysis of microRNA-messenger RNA regulatory network in gemcitabine-resistant bladder cancer cells. DEGs, miRNAs, PPI, qRT-PCR
43  2019 Computational insights into the active structure of SGK1 and its implication for ligand design. ---
44  2019 Effects of the Ethanol Extract of Dipterocarpus alatus Leaf on the Unpredictable Chronic Mild Stress-Induced Depression in ICR Mice and Its Possible Mechanism of Action. BDNF, CREB, FST, HPA, MAO, TST, UCMS
45  2019 Glucocorticoid stimulation increases cardiac contractility by SGK1-dependent SOCE-activation in rat cardiac myocytes. Ca, DEX, GC, SOCE
46  2019 Impact of Zn2+ on ABC Transporter Function in Intact Isolated Rat Brain Microvessels, Human Brain Capillary Endothelial Cells, and in Rat in Vivo. BBB, BCRP, ETB, MRP2, mTOR, NOS, P-gp, PI3K, PKC, Zn
47  2019 In Preclinical Model of Ovarian Cancer, the SGK1 Inhibitor SI113 Counteracts the Development of Paclitaxel Resistance and Restores Drug Sensitivity. Sp1
48  2019 Insulin ameliorates pulmonary edema through the upregulation of epithelial sodium channel via the PI3K/SGK1 pathway in mice with lipopolysaccharide‑induced lung injury. ALI, ENaC, LPS, PI3K, siRNA
49  2019 Intracarotid cold saline infusion contributes to neuroprotection in MCAO‑induced ischemic stroke in rats via serum and glucocorticoid‑regulated kinase 1. ICSI, IOD, MCAO
50  2019 Investigation of the underling mechanism of ketamine for antidepressant effects in treatment-refractory affective disorders via molecular profile analysis. Dcaf12l1, DEGs, KLF2, Plin4, PPIs
51  2019 Jixuepaidu Tang-1 inhibits epithelial-mesenchymal transition and alleviates renal damage in DN mice through suppressing long non-coding RNA LOC498759. DN, EMT, HG, lnRNAs, TGF-beta1
52  2019 Leonurine promotes neurite outgrowth and neurotrophic activity by modulating the GR/SGK1 signaling pathway in cultured PC12 cells. Bcl-2, BDNF, GR, NT-3
53  2019 Lovastatin attenuates hypertension induced by renal tubule-specific knockout of ATP-binding cassette transporter A1, by inhibiting epithelial sodium channels. CCD, ENaC, Nedd4-2
54  2019 p38MAPK/SGK1 signaling regulates macrophage polarization in experimental autoimmune encephalomyelitis. AAV, EAE, MAPK, MS
55  2019 Perfluorooctanoic acid induces migration and invasion and inhibits apoptosis through the PI3K/AKT signaling pathway in human rhabdomyosarcoma cells. CDK, PFOA, PI3K, RMS
56  2019 Postnatal gene expression of airway epithelial sodium transporters associated with birth stress in humans. AQP, ENaC
57  2019 Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death. Akt, Cdk5, CK2, GSK-3, iGluRs, JNK, MEK, Rock
58  2019 Radiation-induced glucocorticoid receptor promotes CD44+ prostate cancer stem cell growth through activation of SGK1-Wnt/beta-catenin signaling. CSC, GR, PCa
59  2019 Rosiglitazone promotes ENaC-mediated alveolar fluid clearance in acute lung injury through the PPARgamma/SGK1 signaling pathway. AFC, ALI, ARDS, BALF, ENaC, LPS, PPARgamma
60  2019 SGK1 Attenuates Oxidative Stress-Induced Renal Tubular Epithelial Cell Injury by Regulating Mitochondrial Function. ATP, ROS
61  2019 SGK1 Mediates Hypoxic Pulmonary Hypertension through Promoting Macrophage Infiltration and Activation. PAH, RVHI, RVSP
62  2019 SGK1 protein expression is a prognostic factor of lung adenocarcinoma that regulates cell proliferation and survival. ---
63  2019 SGK1-dependent stimulation of vascular smooth muscle cell osteo-/chondrogenic transdifferentiation by interleukin-18. ALPL, HAoSMCs, IL-18, VSMCs
64  2019 Small nucleolar RNA host gene 1 promotes development and progression of colorectal cancer through negative regulation of miR-137. CRC, FCM, RISC, SNHG1
65  2019 Spinal Serum- and Glucocorticoid-Regulated Kinase 1 (SGK1) Signaling Contributes to Morphine-Induced Analgesic Tolerance in Rats. NF-kappaB, NMDARs
66  2019 Targeting of SGK1 by miR-576-3p Inhibits Lung Adenocarcinoma Migration and Invasion. NDRG1
67  2019 The GCs-SGK1-ATP Signaling Pathway in Spinal Astrocytes Underlied Presurgical Anxiety-Induced Postsurgical Hyperalgesia. ATP, FC, RU486, SPS
68  2019 Trichostatin A blocks aldosterone-induced Na+ transport and control of serum- and glucocorticoid-inducible kinase 1 in cortical collecting duct cells. CCD, ENaC
69  2018 A Large-Scale RNAi Screen Identifies SGK1 as a Key Survival Kinase for GBM Stem Cells. GBM, GBM-SC
70  2018 Aldosterone, SGK1, and ion channels in the kidney. ASDN, MR
71  2018 Could Sodium Chloride be an Environmental Trigger for Immune-Mediated Diseases? An Overview of the Experimental and Clinical Evidence. ACPA, CD, IL-23R, IMDs, MS, RA, Th
72  2018 Decreased expression of serum- and glucocorticoid-inducible kinase 1 (SGK1) promotes alpha-synuclein increase related with down-regulation of dopaminergic cell in the Substantia Nigra of chronic MPTP-induced Parkinsonism mice and in SH-SY5Y cells. alpha-syn, MPTP, PD, SN
73  2018 Environmentally relevant levels of bisphenol A affect uterine decidualization and embryo implantation through the estrogen receptor/serum and glucocorticoid-regulated kinase 1/epithelial sodium ion channel alpha-subunit pathway in a mouse model. BPA, ENaCalpha
74  2018 Increased intracellular Cl- concentration promotes ongoing inflammation in airway epithelium. CFTR, LPS, NF-kappaB
75  2018 Inflammation in Salt-Sensitive Hypertension and Renal Damage. BP, DCs, IFN-gamma, IL-17a, TNF-alpha
76  2018 Inhibitors of the proteasome stimulate the epithelial sodium channel (ENaC) through SGK1 and mimic the effect of aldosterone. ASDN, ENaC
77  2018 Knockdown of Long Non-Coding RNA XIST Inhibited Doxorubicin Resistance in Colorectal Cancer by Upregulation of miR-124 and Downregulation of SGK1. CRC, DOX, GST-pi, P-gp, XIST
78  2018 Knockdown of the long non-coding RNA HOTTIP inhibits colorectal cancer cell proliferation and migration and induces apoptosis by targeting SGK1. CRC, lncRNA
79  2018 Mechanisms Underpinning Adaptations in Placental Calcium Transport in Normal Mice and Those With Fetal Growth Restriction. FGR, LvH, PTHrP, WT, WTL
80  2018 N-Myc Downstream-Regulated Gene 1 Restricts Hepatitis C Virus Propagation by Regulating Lipid Droplet Biogenesis and Viral Assembly. HCV, NDRG1
81  2018 Na+ /H+ exchanger 3 blockade ameliorates type 2 diabetes mellitus via inhibition of sodium-glucose co-transporter 1-mediated glucose absorption in the small intestine. BBM, NHE3, SGLT1, T2DM
82  2018 Regulation of Kv1.4 potassium channels by PKC and AMPK kinases. AMPK, MDCK, PI3K, PKC
83  2018 Role of PKB/SGK-dependent phosphorylation of GSK-3alpha/beta in vascular calcification during cholecalciferol overload in mice. ALPL, GSK-3, gsk-3KI, PAI-1, PKB
84  2018 Salt, inflammatory joint disease, and autoimmunity. ---
85  2018 Serum and glucocorticoid-regulated kinase 1 (SGK1) is a predictor of poor prognosis in non-small cell lung cancer, and its dynamic pattern following treatment with SGK1 inhibitor and gamma-ray irradiation was elucidated. ---
86  2018 Serum- and glucocorticoid-inducible kinase 1 and the response to cell stress. AP-1, CREB, FOXO3a, mTOR, NCC, NF-kappaB, PDK1, PI3K
87  2018 Serum-glucocorticoid-regulated kinase 1 contributes to mechanical stretch-induced inflammatory responses in cardiac fibroblasts. NF-kappaB, WT
88  2018 Serum/glucocorticoid-regulated kinase 1 as a novel transcriptional target of bone morphogenetic protein-ALK1 receptor signaling in vascular endothelial cells. BMP9
89  2018 SGK1 Governs the Reciprocal Development of Th17 and Regulatory T Cells. ---
90  2018 SGK1 induces vascular smooth muscle cell calcification through NF-kappaB signaling. CKD, VSMCs
91  2018 SGK1 Inhibits Autophagy in Murine Muscle Tissue. LC3
92  2018 SGK1 inhibits PM2.5-induced apoptosis and oxidative stress in human lung alveolar epithelial A549 cells. PM2.5, ROS
93  2018 SGK1-FoxO1 Signaling Pathway Mediates Th17/Treg Imbalance and Target Organ Inflammation in Angiotensin II-Induced Hypertension. Ang II, FOXO1, TNF-alpha
94  2018 SGK1/FOXO3 Signaling in Hypothalamic POMC Neurons Mediates Glucocorticoid-Increased Adiposity. alpha-MSH, DEX, POMC
95  2018 The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice. AD
96  2018 The phosphorylation site T613 in the beta-subunit of rat epithelial Na+ channel (ENaC) modulates channel inhibition by Nedd4-2. ENaC, ERK
97  2017 Akt3 inhibits adipogenesis and protects from diet-induced obesity via WNK1/SGK1 signaling. ---
98  2017 Akt3 kinase suppresses pinocytosis of low-density lipoprotein by macrophages via a novel WNK/SGK1/Cdc42 protein pathway. ---
99  2017 Aldosterone Modulates the Association between NCC and ENaC. ALDO, ENaC
100  2017 Aldosterone signaling regulates the over-expression of claudin-4 and -8 at the distal nephron from type 1 diabetic rats. ALD, HSP72, KIM-1, SPL, STZ, TJ, WT1