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Abbreviation : SIRT2
Long Form : Sirtuin 2
No. Year Title Co-occurring Abbreviation
2020 Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins. ---
2020 AGK2 ameliorates mast cell-mediated allergic airway inflammation and fibrosis by inhibiting FcepsilonRI/TGF-beta signaling pathway. Ig, IL, OVA, TNF
2020 AK-1, a Sirt2 inhibitor, alleviates carbon tetrachloride-induced hepatotoxicity invivo and invitro. ALI, JNK, Nrf2
2020 Alternatively Polarized Macrophages Regulate the Growth and Differentiation of Ependymal Stem Cells through the SIRT2 Pathway. EpSCs, SCI
2020 An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases. cccDNA, HBV, NES, Sirt2.1, Sirt2.5
2020 Correlation Between SIRT2 3'UTR Gene Polymorphism and the Susceptibility to Alzheimer's Disease. AD, CI, miRNAs, qRT-PCR, SNP, UTR
2020 Depletion of microRNA-451 in response to allergen exposure accentuates asthmatic inflammation by regulating Sirtuin2. DRA, miRNAs
2020 Design and in vitro analysis of SIRT2 inhibitor targeting Parkinson's disease. PD, SIRT1
2020 Discovery of Selective SIRT2 Inhibitors as Therapeutic Agents in B-Cell Lymphoma and Other Malignancies. ---
10  2020 E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation. HMG-CoA
11  2020 Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model. AD, SAMP8, SAMR1
12  2020 Ferulic Acid Ameliorates MPP+/MPTP-Induced Oxidative Stress via ERK1/2-Dependent Nrf2 Activation: Translational Implications for Parkinson Disease Treatment. FA, Nrf2, PD
13  2020 HaloTag-Targeted Sirtuin-Rearranging Ligand (SirReal) for the Development of Proteolysis-Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 (Sirt2). PROTAC, PROTACs, SirReal, SirReals
14  2020 Haplotypes of the Mutated SIRT2 Promoter Contributing to Transcription Factor Binding and Type 2 Diabetes Susceptibility. STAT1, T2D
15  2020 Host sirtuin 2 as an immunotherapeutic target against tuberculosis. Mtb
16  2020 Interpretable SMILES-based QSAR model of inhibitory activity of sirtuins 1 and 2. QSAR, SIRT1, SMILES
17  2020 Microglial Sirtuin 2 Shapes Long-Term Potentiation in Hippocampal Slices. LPS, LTP, NMDA
18  2020 Proteomic analysis of the monkey hippocampus for elucidating ischemic resistance. CA1, DG, DRP-2, Hsp70.1, LDHB, NAD
19  2020 RTN4B-mediated suppression of Sirtuin 2 activity ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer's disease mouse model. AD, RTN4B
20  2020 SIRT2 Contributes to the Regulation of Intestinal Cell Proliferation and Differentiation. IBD, IEC, IHC
21  2020 SIRT2 expression exhibits potential to serve as a biomarker for disease surveillance and prognosis in the management of cervical cancer patients. DFS, IHC, OS
22  2020 Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells. TILs
23  2020 SIRT2 Inhibition Improves Functional Motor Recovery After Peripheral Nerve Injury. ---
24  2020 SIRT2 is involved in cisplatin-induced acute kidney injury through regulation of mitogen-activated protein kinase phosphatase-1. JNK, KO, MKP-1, Tg, WT
25  2020 SIRT2 modulates VEGFD-associated lymphangiogenesis by deacetylating EPAS1 in human head and neck cancer. EPAS1, HNC, Sir2, VEGF-D
26  2020 SIRT2, a direct target of miR-212-5p, suppresses the proliferation and metastasis of colorectal cancer cells. 3'-UTR, AJCC, CRC
27  2020 SIRT2-dependent IDH1 deacetylation inhibits colorectal cancer and liver metastases. CRC, IDH1
28  2020 Sirtuin 2 Inhibition Attenuates Sevoflurane-Induced Learning and Memory Deficits in Developing Rats via Modulating Microglial Activation. ---
29  2020 Tanshinone IIA prevents LPS-induced inflammatory responses in mice via inactivation of succinate dehydrogenase in macrophages. BMDMs, HIF-1alpha, LPS, SDH, Tan IIA
30  2020 The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene? HDACs
31  2020 The clinical significance of the SIRT2 expression level in the early stage of sepsis patients. AUC, hs-CRP, ICU, LPS, PCR, PCT, ROC
32  2020 The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response. ---
33  2020 The SIRT2-mediated deacetylation of AKR1C1 is required for suppressing its pro-metastasis function in Non-Small Cell Lung Cancer. AKR1C1, NSCLC, STAT3
34  2020 Upregulated tumor sirtuin 2 expression correlates with reduced TNM stage and better overall survival in surgical breast cancer patients. IHC, OS
35  2020 Yin Yang 1 Is Essential for Transcriptional Activation of the Bovine Sirt2 Gene in Preadipocytes. CpG, TSS, YY1
36  2019 Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology. aSyn, MTs, PD, PTMs
37  2019 Chemical Probes Reveal Sirt2's New Function as a Robust "Eraser" of Lysine Lipoylation. PDH
38  2019 Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis. DIO
39  2019 Diesel exhaust exposure intensifies inflammatory and structural changes associated with lung aging in mice. BALF, DE, GPx, GR, GST, IL-10, RT-PCR, SIRT1, SIRT6, TNF
40  2019 Discovery of (5-Phenylfuran-2-yl)methanamine Derivatives as New Human Sirtuin 2 Inhibitors. SAR
41  2019 Distinct role of Sirtuin 1 (SIRT1) and Sirtuin 2 (SIRT2) in inhibiting cargo-loading and release of extracellular vesicles. EVs, MVBs, SIRT1, TGN
42  2019 Dual Deletion of the Sirtuins SIRT2 and SIRT3 Impacts on Metabolism and Inflammatory Responses of Macrophages and Protects From Endotoxemia. FAO
43  2019 Emerging Role of Sirtuin 2 in Parkinson's Disease. DA, HDACs, PD
44  2019 Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease. ACLY, HF/HS, NAFLD
45  2019 Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD+-Binding Site. H-bond
46  2019 Immunohistochemistry and clinical value of sirtuin 2 in non-metastasized non-small cell lung cancer. ADC, KM, MST, NSCLC, OS, SCC
47  2019 Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possible involvement of ER stress and S6K1 activation. ER, S6K1
48  2019 Inhibition of SIRT2 by Targeting GSK3beta-Mediated Phosphorylation Alleviates SIRT2 Toxicity in SH-SY5Y Cells. LBs, MS, PD
49  2019 LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis. LMO2, NAMPT, T-ALL
50  2019 MicroRNA-140-5p aggravates hypertension and oxidative stress of atherosclerosis via targeting Nrf2 and Sirt2. KEAP1, miR, Nrf2, ROS
51  2019 Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model. ---
52  2019 PADI3 induces cell cycle arrest via the Sirt2/AKT/p21 pathway and acts as a tumor suppressor gene in colon cancer. FCM, PAD
53  2019 SIRT2 deacetylates GRASP55 to facilitate post-mitotic Golgi assembly. ---
54  2019 SIRT2 deficiency prevents age-related bone loss in rats by inhibiting osteoclastogenesis. BMMs, HDACs, Tb.N
55  2019 Sirt2 Regulates Radiation-Induced Injury. KD, KO, MEFs
56  2019 SIRT2: Controversy and multiple roles in disease and physiology. ---
57  2019 Sirtuin 2 enhances allergic asthmatic inflammation. DRA
58  2019 Sirtuin 2 expression suppresses oxidative stress and senescence of nucleus pulposus cells through inhibition of the p53/p21 pathway. IDD, IL-1beta, NP
59  2019 Sirtuin 2-mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses. CDK9, IFNs, ISGs, JAK, STAT
60  2019 Sirtuin2 enhances the tumoricidal function of liver natural killer cells in a mouse hepatocellular carcinoma model. HCC, MAPK, NK
61  2019 The SIRT2 inhibitor AK-7 decreases cochlear cell apoptosis and attenuates noise-induced hearing loss. NIHL
62  2019 Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy. PD-MARCKS
63  2018 AGK2, A SIRT2 Inhibitor, Inhibits Hepatitis B Virus Replication In Vitro And In Vivo. HBc, HBeAg, HBsAg, NTCP
64  2018 Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals). PROTAC, SirReals
65  2018 Does Sirt2 Regulate Cholesterol Biosynthesis During Oligodendroglial Differentiation In Vitro and In Vivo? CNS, OL, SREBP
66  2018 HBx-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis. ---
67  2018 Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2. HDAC, TIF, UUO
68  2018 miR-486-3p Influences the Neurotoxicity of a-Synuclein by Targeting the SIRT2 Gene and the Polymorphisms at Target Sites Contributing to Parkinson's Disease. miRNAs, PD, SNPs
69  2018 Neuroprotective Effect of Sirt2-specific Inhibitor AK-7 Against Acute Cerebral Ischemia is P38 Activation-dependent in Mice. ---
70  2018 Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines. ATL, HTLV
71  2018 Overexpression of SIRT2 Alleviates Neuropathic Pain and Neuroinflammation Through Deacetylation of Transcription Factor Nuclear Factor-Kappa B. CCI, DRG, IL-1beta, NF-kappaB, TNF-alpha
72  2018 Overexpression of Sirtuin2 prevents high glucose-induced vascular endothelial cell injury by regulating the p53 and NF-kappaB signaling pathways. HG, HUVECs
73  2018 Salmonella escapes adaptive immune response via SIRT2 mediated modulation of innate immune response in dendritic cells. DC, NO
74  2018 Silybin inhibits NLRP3 inflammasome assembly through the NAD+/SIRT2 pathway in mice with nonalcoholic fatty liver disease. HFD, IRE, NAFLD, NLRP3, Tom20
75  2018 SIRT2 deacetylase represses NFAT transcription factor to maintain cardiac homeostasis. NFAT
76  2018 SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke. HD, MCAO, OGD, PD
77  2018 SIRT2 Promotes the Migration and Invasion of Gastric Cancer through RAS/ERK/JNK/MMP-9 Pathway by Increasing PEPCK1-Related Metabolism. GC, HDAC
78  2018 Sirtuin 2 (Sirt2) Expression Predicts Lymph Node Metastasis and Poor Overall Survival of Patients with Esophageal Squamous Cell Carcinoma. ESCC
79  2018 Sirtuin 2 Isoform 1 Enhances Hepatitis B Virus RNA Transcription and DNA Synthesis through the AKT/GSK-3beta/beta-Catenin Signaling Pathway. GSK-3beta, HCCs, shRNAs
80  2018 X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. ---
81  2017 Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory. AMPARs
82  2017 Discovery of 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-phenylacetamide derivatives as new potent and selective human sirtuin 2 inhibitors. ---
83  2017 Downregulation of NAD-Dependent Deacetylase SIRT2 Protects Mouse Brain Against Ischemic Stroke. tMCAO
84  2017 Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes. PCa, PSA
85  2017 Inclusion Body Fusion of Human Parainfluenza Virus Type 3 Regulated by Acetylated alpha-Tubulin Enhances Viral Replication. alpha-TAT1, HDAC6, HPIV3, IBs, IBs, RNAi, TSA
86  2017 Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy. ---
87  2017 Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance. CNS, HDAC
88  2017 Modulation Of Microtubule Acetylation By The Interplay Of TPPP/p25, SIRT2 And New Anticancer Agents With Anti-SIRT2 Potency. ---
89  2017 Mutant A53T alpha-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways. alpha-Syn, NEFA, PD
90  2017 Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site. ---
91  2017 RNA-binding Protein Quaking Stabilizes Sirt2 mRNA during Oligodendroglial Differentiation. OLs, OPCs, QKI, QRE, UTR
92  2017 SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a. NAD
93  2017 SIRT2 inhibition modulate glutamate and serotonin systems in the prefrontal cortex and induces antidepressant-like action. CMS, p-GluA1, PFC
94  2017 Sirtuin 2 aggravates postischemic liver injury by deacetylating mitogen-activated protein kinase phosphatase-1. I/R
95  2017 Sirtuin 2 Deficiency Increases Bacterial Phagocytosis by Macrophages and Protects from Chronic Staphylococcal Infection. ---
96  2017 Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3beta/beta-catenin pathway. DA
97  2017 Sirtuin 2 mutations in human cancers impair its function in genome maintenance. ATRIP
98  2017 The tubulin deacetylase sirtuin-2 regulates neuronal differentiation through the ERK/CREB signaling pathway. AGK-MSCs, HDAC6, MT, Tubastatin A-MSCs
99  2017 Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket. SIRTs
100  2016 5-((3-Amidobenzyl)oxy)nicotinamides as Sirtuin 2 Inhibitors. ---