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Abbreviation : SNX27
Long Form : sorting nexin 27
No. Year Title Co-occurring Abbreviation
2020 Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS. APC, DAG, DGKzeta, IS, MTOC, TCR
2020 SNX27 regulates DRA activity and mediates its direct recycling by PDZ-interaction in early endosomes at the apical pole of Caco2 cells. KD
2020 Sorting nexin 27 (SNX27) variants associated with seizures, developmental delay, behavioral disturbance, and subcortical brain abnormalities. ---
2019 Characterization of the interaction between beta-catenin and sorting nexin 27: contribution of the type I PDZ-binding motif to Wnt signaling. mpkCCD
2019 Deletion of sorting nexin 27 suppresses proliferation in highly aggressive breast cancer MDA-MB-231 cells in vitro and in vivo. EMT, KD, WT
2019 Diacylglycerol kinase control of protein kinase C. AD, DAG, DGK, PA, PKC
2019 HTLV-1 Tax-1 interacts with SNX27 to regulate cellular localization of the HTLV-1 receptor molecule, GLUT1. ATL, GLUT1, HTLV-1, PBM
2019 Regulation of the endosomal SNX27-retromer by OTULIN. LUBAC, Met1, PDZbm
2018 GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization. VTA
10  2018 Snx27 Deletion Promotes Recovery From Spinal Cord Injury by Neuroprotection and Reduces Macrophage/Microglia Proliferation. BMS, CST, SCI
11  2018 Sorting nexin 27 (SNX27) regulates the trafficking and activity of the glutamine transporter ASCT2. KO, mTOR, mTORC1
12  2017 Several adaptor proteins promote intracellular localisation of the transporter MRP4/ABCC4 in platelets and haematopoietic cells. AP3B1, PSD-95
13  2017 SNX27 links DGKzeta to the control of transcriptional and metabolic programs in T lymphocytes. AP-1, DAG, DGKzeta, mTOR, NF-kappaB, PDZ, TCR
14  2017 Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse. IS, PDZ, ZO-2
15  2017 Two barcodes encoded by the type-1 PDZ and by phospho-Ser312 regulate retromer/WASH-mediated sorting of the ss1-adrenergic receptor from endosomes to the plasma membrane. Ser312, WT
16  2016 A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex. NMDA, PDZ
17  2016 Actin-Sorting Nexin 27 (SNX27)-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling. PTH, PTHR
18  2016 Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways. HPVs, PBM
19  2016 Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth. ---
20  2015 A Novel PDZ Domain Interaction Mediates the Binding between Human Papillomavirus 16 L2 and Sorting Nexin 27 and Modulates Virion Trafficking. siRNA
21  2015 Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells. PtdIns3P, PX
22  2015 Sorting nexin 27 regulates basal and stimulated brush border trafficking of NHE3. ---
23  2014 A role for sorting nexin 27 in AMPA receptor trafficking. ---
24  2014 A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer. PDZ, VPS26A
25  2014 Sorting Nexin 27 regulates basal and activity-dependent trafficking of AMPARs. AMPARs, LTP
26  2014 Sorting nexin 27 regulation of G protein-gated inwardly rectifying K⁺ channels attenuates in vivo cocaine response. DA, VTA
27  2013 A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport. ---
28  2013 beta1-adrenergic receptor recycles via a membranous organelle, recycling endosome, by binding with sorting nexin27. beta1AR, ISO, PM, RE
29  2013 Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. ---
30  2013 Sorting nexin 27 (SNX27) associates with zonula occludens-2 (ZO-2) and modulates the epithelial tight junction. SNX, TJP2, ZO-2
31  2012 Sorting nexin 27 interacts with multidrug resistance-associated protein 4 (MRP4) and mediates internalization of MRP4. MRP4
32  2011 Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C). NMDA, NR2C, PX, SNXs
33  2011 Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27. PSD-95
34  2011 SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. beta2AR, WASH
35  2011 Sorting nexin 27 protein regulates trafficking of a p21-activated kinase (PAK) interacting exchange factor (beta-Pix)-G protein-coupled receptor kinase interacting protein (GIT) complex via a PDZ domain interaction. GIT, PAK
36  2011 Translocation dynamics of sorting nexin 27 in activated T cells. DGKzeta
37  2010 SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane. PDZ, PX
38  2007 A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction. PI3P
39  2007 Polarization of endosomal SNX27 in migrating and tumor-engaged natural killer cells. IS
40  2007 Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling. ---
41  2007 Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes. CASP
42  2007 Subunit-specific regulation of Kir3 channels by sorting nexin 27. ---