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Abbreviation : SOS1
Long Form : son of sevenless 1
No. Year Title Co-occurring Abbreviation
2020 A high-grade glioma with SOS1 amplification. ---
2020 High-Affinity Interactions of the nSH3/cSH3 Domains of Grb2 with the C-Terminal Proline-Rich Domain of SOS1. PR
2020 SOS1 interacts with Grb2 through regions that induce closed nSH3 conformations. cSH3, nSH3, PR, RasGEF
2020 Ubiquitin-specific peptide 22 acts as an oncogene in gastric cancer in a son of sevenless 1-dependent manner. USP22
2019 Adaptor Protein p66Shc: A Link Between Cytosolic and Mitochondrial Dysfunction in the Development of Diabetic Retinopathy. GEFs, ROS
2018 Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis. BMDCs, GEF, PDGF
2017 SOS1, ARHGEF1, and DOCK2 rho-GEFs Mediate JAK-Dependent LFA-1 Activation by Chemokines. DOCK, GEF
2015 Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion. EGFR, MAPK, PI3K
2014 CIIA negatively regulates the Ras-Erk1/2 signaling pathway through inhibiting the Ras-specific GEF activity of SOS1. EGF, GEF
10  2014 EGF receptor uses SOS1 to drive constitutive activation of NFkappaB in cancer cells. EGFR, NF-kappaB
11  2014 Non-syndromic hereditary gingival fibromatosis in three Chinese families is not due to SOS1 gene mutations. HGF
12  2014 The roles of miR-146a in the differentiation of Jurkat T-lymphoblasts. miRNA, STAT3, T-ALL
13  2013 A novel SOS1 mutation in Costello/CFC syndrome affects signaling in both RAS and PI3K pathways. CFC, EGF
14  2013 Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells. ERK, GEFs, MEK, TCR
15  2011 CIIA functions as a molecular switch for the Rac1-specific GEF activity of SOS1. GEF, TGF-beta
16  2011 Induction of the Ras activator Son of Sevenless 1 by environmental pollutants mediates their effects on cellular proliferation. AhR
17  2011 Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells. GPCR, TCDD
18  2011 Quantifying intramolecular binding in multivalent interactions: a structure-based synergistic study on Grb2-Sos1 complex. Grb2
19  2011 SOS1 over-expression in genital skin fibroblasts from hirsute women: a putative role of the SOS1/RAS pathway in the pathogenesis of hirsutism. AR, PCOS
20  2010 Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation. GEF, NS
21  2010 Phenethyl isothiocyanate inhibits migration and invasion of human gastric cancer AGS cells through suppressing MAPK and NF-kappaB signal pathways. COX-2, FAK, Grb2, iNOS, MEKK3, MKK7, MMP-2, NF-kappaB, PEITC, PKC, uPA, VEGF
22  2009 Isoform-selective interaction of the adaptor protein Tks5/FISH with Sos1 and dynamins. ---
23  2007 Dexamethasone modulates ErbB tyrosine kinase expression and signaling through multiple and redundant mechanisms in cultured rat hepatocytes. EGFR, RALT
24  2002 A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1. HGF, HGF1
25  1997 Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development. EGF, EGFR
26  1994 The transmembrane domain of the large subunit of HSV-2 ribonucleotide reductase (ICP10) is required for protein kinase activity and transformation-related signaling pathways that result in ras activation. PK, ras-GAP, TM