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Abbreviation : SREBP1
Long Form : sterol regulatory element-binding protein 1
No. Year Title Co-occurring Abbreviation
2020 Amelioration of the lipogenesis, oxidative stress and apoptosis of hepatocytes by a novel proteoglycan from Ganoderma lucidum. ACC, AMPK, CPT1, FASN, LDH, MDA, NAFLD, PA, ROS, SOD, T-AOC, TC, TG
2020 Ameliorative effects and molecular mechanisms of vine tea on western diet-induced NAFLD. AMPKalpha, CYP4A1, FAS, HO-1, NAFLD, ND, PPARalpha, VTP, WD, ZO-1
2020 Camellia (Camellia oleifera Abel.) seed oil promotes milk fat and protein synthesis-related gene expression in bovine mammary epithelial cells. CO, eIF4E, ELF5, FASN, JAK2, LPL, MAC-T, mTOR, p-mTOR, PI3K, S6K1, SCD, SO
2020 Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Abeta concentrations. ACL, AD, NADK, p-Ser422 Tau, p-Tau
2020 Dll4 Suppresses Transcytosis for Arterial Blood-Retinal Barrier Homeostasis. TJ, VEGF
2020 Effect of all-trans retinoic acid on casein and fatty acid synthesis in MAC-T cells. ATRA, JAK2, mTOR, PUFA, S6K1, SFA, STAT5-beta
2020 Effects of dietary carbohydrate sources on lipid metabolism and SUMOylation modification in the liver tissues of yellow catfish. SCD1, SUMO
2020 Influences of glycyrrhetinic acid (GA) dietary supplementation on growth, feed utilization, and expression of lipid metabolism genes in channel catfish (Ictalurus punctatus) fed a high-fat diet. ACO, FAS, GA, HDL, HFD, HSL, LDL, LXRalpha, MTTP, PPARalpha, TG
2020 Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells. 5caC, 5mC, AMPK, CoA, DNMT3A, T2DM, TDG
10  2020 Low molecular weight blue mussel hydrolysates inhibit adipogenesis in mouse mesenchymal stem cells through upregulating HO-1/Nrf2 pathway. BMH, HO-1, mMSC, PPARgamma
11  2020 Molecular characterization of GTP binding protein overexpressed in skeletal muscle (GEM) and its role in promoting adipogenesis in goat intramuscular preadipocytes. GEM, IMF, LPL, PPARgamma, Pref-1
12  2020 Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome. LDLR, S1P, S2P, SRE
13  2020 Placental Accumulation of Triacylglycerols in Gestational Diabetes Mellitus and Its Association with Altered Fetal Growth are Related to the Differential Expressions of Proteins of Lipid Metabolism. CPW, FAS, FFA, GDM, LPL, PI3K, PPAR, SCD1, TG
14  2020 Schaftoside alleviates HFD-induced hepatic lipid accumulation in mice via upregulating farnesoid X receptor. AST, CH, FXR, HFD, MPHs, NAFLD, OA, SS, TG
15  2020 Sodium butyrate promotes milk fat synthesis in bovine mammary epithelial cells via GPR41 and its downstream signalling pathways. AMPK, BMECs, GPR41, mTOR, S6K, SIRT1
16  2020 Srebf1 Controls Midbrain Dopaminergic Neurogenesis. ChIP-seq, LXRs, mDA
17  2020 SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/beta-catenin signaling pathway. ESCC, SCD1
18  2020 SREBP1 siRNA enhance the docetaxel effect based on a bone-cancer dual-targeting biomimetic nanosystem against bone metastatic castration-resistant prostate cancer. Bm, BmCRPC, BmCRPC, DTX, LA, LC, PCa
19  2020 Supplementation of Inulin with Various Degree of Polymerization Ameliorates Liver Injury and Gut Microbiota Dysbiosis in High Fat-Fed Obese Mice. ACC, DP, FAS, HFD, IL-6, NF-kappaB
20  2019 Activation of liver X receptor promotes fatty acid synthesis in goat mammary epithelial cells via modulation of SREBP1 expression. GMEC, LXR, TAG
21  2019 Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the Sirt1/AMPK and NF-kappaB signaling pathways. AITC, AMPKalpha, HFD, NF-kappaB, SIRT1
22  2019 Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD. COPD, HPF, IPA, NLRP3, PIR, PM, SIRT1
23  2019 Cholesterol attenuated the progression of DEN-induced hepatocellular carcinoma via inhibiting SCAP mediated fatty acid de novo synthesis. HCC, HCD, SCAP
24  2019 Cholesterol Starvation and Hypoxia Activate the FVII Gene via the SREBP1-GILZ Pathway in Ovarian Cancer Cells to Produce Procoagulant Microvesicles. CCC, EVs, FVII, GILZ, SSH
25  2019 Combined Exposure to Fructose and Bisphenol A Exacerbates Abnormal Lipid Metabolism in Liver of Developmental Male Rats. ACC1, ATGL, BPA, ERalpha, FAS, HSL, T-CHO, TG
26  2019 Dietary Bile Acids Enhance Growth, and Alleviate Hepatic Fibrosis Induced by a High Starch Diet via AKT/FOXO1 and cAMP/AMPK/SREBP1 Pathway in Micropterus salmoides. BA, FOXO1, HSI, WGR
27  2019 Dietary intake of probiotic kimchi ameliorated IL-6-driven cancer cachexia. ATGL, FAS, HSL, IL-6, JAK2, Mfn-2, MuRF1, STAT3
28  2019 Dietary leucine affects glucose metabolism and lipogenesis involved in TOR/PI3K/Akt signaling pathway for juvenile blunt snout bream Megalobrama amblycephala. ACC, FAS, G6Pase, G6PDH, GK, GLUT2, GS, IRS-1, PEPCK, PI3K, PK, S6K1, TC, TG, TOR
29  2019 Disruption of Cancer Metabolic SREBP1/miR-142-5p Suppresses Epithelial-Mesenchymal Transition and Stemness in Esophageal Carcinoma. VIM
30  2019 Effect of Epigallo-Catechin-3-Gallate on Lipid Metabolism Related Gene Expression and Yolk Fatty Acid Profiles of Laying Hens Exposed to Vanadium. EGCG, FAS, PPARgamma, PUFA, UFA
31  2019 Effects of dietary fenugreek seed extracts on growth performance, plasma biochemical parameters, lipid metabolism, Nrf2 antioxidant capacity and immune response of juvenile blunt snout bream (Megalobrama amblycephala). ACC, ALB, CAT, FAS, FCR, FSE, FW, GPx, GPX1, IGF-1, IgM, IL-10, IL-8, Keap1, MnSOD, Nrf2, S6K1, SGR, SOD, T-AOC, TNF-alpha, TOR, TP, WG
32  2019 Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells. cyt c, FASN, mRNA
33  2019 Expression patterns of hepatic genes involved in lipid metabolism in cows with subclinical or clinical ketosis. ACC1, ACSL1, BHB, CK, CPT1A, CPT2, DGAT1, DGAT2, FAS, PPARA, SCD1, SCK, TG
34  2019 Fibroblast growth factor 21 regulates lipid accumulation and adipogenesis in goat intramuscular adipocyte. aP2, FGF21, IMF, LPL, PPARgamma, Pref-1
35  2019 Gemfibrozil reduces lipid accumulation in SMMC-7721 cells via the involvement of PPARalpha and SREBP1. GEM, NAFLD, PPARalpha
36  2019 Glucose-6-phosphate dehydrogenase in blunt snout bream Megalobrama amblycephala: molecular characterization, tissue distribution, and the responsiveness to dietary carbohydrate levels. ACCalpha, FAS, G6PD, PPARgamma
37  2019 Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients. BMI, DNL
38  2019 High glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer. IHC, STZ
39  2019 High-Fat Diet Elevates Liver Docosahexaenoic Acid Possibly through Over-Expression of Very Long-Chain Fatty Acid Elongase 2 in C57BL/6J Mice. FAS, GPAT, HF, MTTP, PUFA
40  2019 Interplay of PKD3 with SREBP1 Promotes Cell Growth via Upregulating Lipogenesis in Prostate Cancer Cells. ACLY, PKD
41  2019 Isolation, characterization, and SREBP1 functional analysis of mammary epithelial cell in buffalo. ---
42  2019 l-carnitine and fat type in the maternal diet during gestation and lactation modify the fatty acid composition and expression of lipid metabolism-related genes in piglets. ACC, FA, FAS, PPAR-alpha, PUFA, SCD
43  2019 Leelamine Is a Novel Lipogenesis Inhibitor in Prostate Cancer Cells In Vitro and In Vivo. LLM
44  2019 LRG ameliorates steatohepatitis by activating the AMPK/mTOR/SREBP1 signaling pathway in C57BL/6J mice fed a high‑fat diet. AMPK, HFD, LRG, mTOR, NASH, p70S6K
45  2019 MicroRNAs Involved in the Regulation of LC-PUFA Biosynthesis in Teleosts: miR-33 Enhances LC-PUFA Biosynthesis in Siganus canaliculatus by Targeting insig1 which in Turn Upregulates srebp1. INSIG1
46  2019 Non-alcoholic Fatty Liver Disease Induced by Perinatal Exposure to Bisphenol a Is Associated With Activated mTOR and TLR4/NF-kappaB Signaling Pathways in Offspring Rats. ACC1, BPA, FAS, NAFLD
47  2019 Omics Insights into Metabolic Stress and Resilience of Rats in Response to Short-term Fructose Overfeeding. ERK, IPA, SFO
48  2019 Palmitate-Induced SREBP1 Expression and Activation Underlies the Increased BACE 1 Activity and Amyloid Beta Genesis. AD, ChIP, N2a
49  2019 Resveratrol enhances the chemotherapeutic response and reverses the stemness induced by gemcitabine in pancreatic cancer cells via targeting SREBP1. CSCs
50  2019 Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway. FAs, mTOR, SCD1
51  2019 SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERalpha breast cancer. AI, KRT80
52  2019 SREBP1 promotes the invasion of colorectal cancer accompanied upregulation of MMP7 expression and NF-kappaB pathway activation. CRC, DHE, ROS
53  2019 The anti-obesity effects of Tongbi-san in a high-fat diet-induced obese mouse model. AMPK, HFD, PPARgamma, qRT-PCR, TBS, WAT
54  2019 The Antiobesity Effects of Buginawa in 3T3-L1 Preadipocytes and in a Mouse Model of High-Fat Diet-Induced Obesity. Bugi, eWAT, PPARgamma, WAT
55  2019 Therapeutic effects of dimethyldiguanide combined with clomifene citrate in the treatment of polycystic ovary syndrome. PCOS
56  2019 Traditional Herbal Formula Taeeumjowi-Tang (TJ001) Inhibits p53-Mutant Prostate Cancer Cells Growth by Activating AMPK-Dependent Pathway. ACC, LDs, mTOR, PCas
57  2019 Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-gamma. IFN-gamma, TAMs, TME, Treg
58  2019 Valine increases milk fat synthesis in mammary gland of gilts through stimulating AKT/MTOR/SREBP1 pathway†. BCAA, PMECs
59  2018 A Novel Role of Id1 in Regulating Oscillatory Shear Stress-Mediated Lipid Uptake in Endothelial Cells. ID1, OSS
60  2018 Activation of sterol regulatory element-binding protein 1 (SREBP1)-mediated lipogenesis by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma. EBV, FASN, LMP1, mTOR, NPC, siRNA
61  2018 Akt Serine/Threonine Kinase 1 Regulates de Novo Fatty Acid Synthesis through the Mammalian Target of Rapamycin/Sterol Regulatory Element Binding Protein 1 Axis in Dairy Goat Mammary Epithelial Cells. GMECs, mTOR, PI3K
62  2018 Antiobesity Effect of Astilbe chinensis Franch. et Savet. Extract through Regulation of Adipogenesis and AMP-Activated Protein Kinase Pathways in 3T3-L1 Adipocyte and High-Fat Diet-Induced C57BL/6N Obese Mice. ACC, AMPK, NEFA, PPARgamma, TC, TG
63  2018 Autophagy dysregulation caused by ApoM deficiency plays an important role in liver lipid metabolic disorder. ACACA, ApoM, FASN
64  2018 CVB3 Nonstructural 2A Protein Modulates SREBP1a Signaling via the MEK/ERK Pathway. CVB3, siRNAs
65  2018 Fibroblast growth factor 10 (FGF10) promotes the adipogenesis of intramuscular preadipocytes in goat. FGF10, IMF, KLF, PPARgamma, Pref-1
66  2018 Hepatocellular Carcinoma-Associated Protein TD26 Interacts and Enhances Sterol Regulatory Element-Binding Protein 1 Activity to Promote Tumor Cell Proliferation and Growth. aa, AMP, flSREBP1, HCC, OS, RFS
67  2018 Hypolipidemic and Antioxidant Properties of Oryzanol Concentrate in Reducing Diabetic Nephropathy via SREBP1 Downregulation Rather than beta-Oxidation. DN, OC, TGF-beta
68  2018 Insulin as a hormone regulator of the synthesis and release of leptin by white adipose tissue. Sp1
69  2018 Ishige okamurae Extract Suppresses Obesity and Hepatic Steatosis in High Fat Diet-Induced Obese Mice. ATGL, DGAT1, FAS, HFD, HSL, IOE, PPARgamma, TG, WAT
70  2018 Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer. AIs, ERalpha, ILC, LTED, MM134, SUM44
71  2018 Leucodin attenuates inflammatory response in macrophages and lipid accumulation in steatotic hepatocytes via P2x7 receptor pathway: A potential role in alcoholic liver disease. ACC, AMPK
72  2018 LPS-induced reduction of triglyceride synthesis and secretion in dairy cow mammary epithelial cells via decreased SREBP1 expression and activity. DCMECs, LPS
73  2018 Methylxanthine Derivative-Rich Cacao Extract Suppresses Differentiation of Adipocytes through Downregulation of PPARgamma and C/EBPs. AMPK, CE, FAS, PPARgamma
74  2018 Overexpression of SREBF chaperone (SCAP) enhances nuclear SREBP1 translocation to upregulate fatty acid synthase (FASN) gene expression in bovine mammary epithelial cells. FASN, SCAP
75  2018 Protectin DX Ameliorates Hepatic Steatosis by Suppression of Endoplasmic Reticulum Stress via AMPK-Induced ORP150 Expression. AMPK, DHA, ER, ORP150, PDX
76  2018 SREBP1-driven lipid desaturation supports clear cell renal cell carcinoma growth through regulation of NF-kappaB signaling. ccRCC
77  2018 Sterol regulatory element binding protein 1 trans-activates 25-hydroxy vitamin D3 24-hydroxylase gene expression in renal proximal tubular cells. OK-P, pSREs
78  2018 Sterol regulatory element-binding protein 1 cooperates with c-Myc to promote epithelial-mesenchymal transition in colorectal cancer. CRC, qPCR
79  2018 Suppression of Lipogenesis via Reactive Oxygen Species-AMPK Signaling for Treating Malignant and Proliferative Diseases. BBR, G-R, NSCLC, RA, ROS
80  2018 Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity. ---
81  2018 The LINC01138 interacts with PRMT5 to promote SREBP1-mediated lipid desaturation and cell growth in clear cell renal cell carcinoma. ccRCC
82  2018 Zhiheshouwu ethanol extract induces intrinsic apoptosis and reduces unsaturated fatty acids via SREBP1 pathway in hepatocellular carcinoma cells. DeltaPsim, HCC
83  2017 Abnormal lipid/lipoprotein metabolism and high plasma testosterone levels in male but not female aromatase-knockout mice. AR, ArKO, TG, WT
84  2017 Are miRNA-103, miRNA-107 and miRNA-122 Involved in the Prevention of Liver Steatosis Induced by Resveratrol? CPT1a, FAS, miRNA
85  2017 Atherogenicity of amino acids in the lipid-laden macrophage model system in vitro and in atherosclerotic mice: a key role for triglyceride metabolism. AAs, DGAT1, ROS, VLDL
86  2017 Elevated sterol regulatory elementary binding protein 1 and GluA2 levels in the hippocampal nuclear fraction of Genetic Absence Epilepsy Rats from Strasbourg. AMPAR, GAERS, GAPDH, GluA2, NEC, NF
87  2017 Emodin alleviates hepatic steatosis by inhibiting sterol regulatory element binding protein 1 activity by way of the calcium/calmodulin-dependent kinase kinase-AMP-activated protein kinase-mechanistic target of rapamycin-p70 ribosomal S6 kinase signaling pathway. AMPK, CaMKK, HFD, mTOR, p70S6K
88  2017 Forkhead transcription factor 1 inhibits endometrial cancer cell proliferation via sterol regulatory element-binding protein 1. EC
89  2017 Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. alpha-KG, AMPK, ME2, PDAC
90  2017 Hypocholesterolemic Effects of Probiotic Mixture on Diet-Induced Hypercholesterolemic Rats. ACC, FAS, HDL, LDL, PM, TC, TG
91  2017 Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKalpha/SREBP1 signaling pathway. FASN, HFD, NAMPT, NMN
92  2017 Mutation of miR-21 targets endogenous lipoprotein receptor-related protein 6 and nonalcoholic fatty liver disease. ACC1, LRP6, LXRalpha, NAFLD
93  2017 Neuronal Activity-Induced Sterol Regulatory Element Binding Protein-1 (SREBP1) is Disrupted in Dysbindin-Null Mice-Potential Link to Cognitive Impairment in Schizophrenia. Arc, RDoC
94  2017 Sterol regulatory element binding protein-1 (SREBP1) gene expression is similarly increased in polycystic ovary syndrome and endometrial cancer. ---
95  2017 Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation. FAS, HMG-CoAR, SCD-1
96  2017 Variations in genes involved in fat metabolism and their association with ultrasonic and carcass traits in Japanese Black steers. SCD
97  2016 Berberine Alleviates Olanzapine-Induced Adipogenesis via the AMPKalpha-SREBP Pathway in 3T3-L1 Cells. AMPKalpha, BBR, FAS, HMGR, LDLR, OLZ, ORO, PPARgamma, TC, TG
98  2016 Cloning and Characterization of Lxr and Srebp1, and Their Potential Roles in Regulation of LC-PUFA Biosynthesis in Rabbitfish Siganus canaliculatus. Fad, LC-PUFA, LXR, PPARgamma
99  2016 Combination of deep sea water and Sesamum indicum leaf extract prevents high-fat diet-induced obesity through AMPK activation in visceral adipose tissue. ACC, AMPK, CD36, CPT1, DSW, HFC, HFD, PPAR-alpha, SIE, UCP2
100  2016 Depot- and sex-specific effects of maternal obesity in offspring's adipose tissue. BW, DOHaD, FAS, HF