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Abbreviation : Sp1
Long Form : stimulatory protein 1
No. Year Title Co-occurring Abbreviation
2022 Insulin can up-regulate LC-PUFA biosynthesis with the involvement of Srebp-1c and stimulatory protein 1 (Sp1) in marine teleost Siganus canaliculatus. INS, LC-PUFA, NF-Y, SCHL, SRE
2021 Regulation of long-chain polyunsaturated fatty acid biosynthesis in teleost fish. FADS, HNF4alpha, miRNA, SREBP1
2021 The MAPKinase Signaling and the Stimulatory Protein-1 (Sp1) Transcription Factor Are Involved in the Phototherapy Effect on Cytokines Secretion from Human Bronchial Epithelial Cells Stimulated with Cigarette Smoke Extract. CSE
2020 The requirements for sterol regulatory element-binding protein (Srebp) and stimulatory protein 1 (Sp1)-binding elements in the transcriptional activation of two freshwater fish Channa striata and Danio rerio elovl5 elongase. FADS, LC-PUFA, PUFA, SRE
2019 Sp1 is Involved in Vertebrate LC-PUFA Biosynthesis by Upregulating the Expression of Liver Desaturase and Elongase Genes. SCHL
2018 Characteristics of the fads2 gene promoter in marine teleost Epinephelus coioides and role of Sp1-binding site in determining promoter activity. LC-PUFA
2018 Cloning and characterization of ∆6/∆5 fatty acyl desaturase (Fad) gene promoter in the marine teleost Siganus canaliculatus. AP-1, C/EBP, Fad, HNF4alpha, LC-PUFA, NF-Y, NF1, PPARgamma, SRE, TF
2016 Spontaneous Glutamatergic Synaptic Activity Regulates Constitutive COX-2 Expression in Neurons: OPPOSING ROLES FOR THE TRANSCRIPTION FACTORS CREB (cAMP RESPONSE ELEMENT BINDING) PROTEIN AND Sp1 (STIMULATORY PROTEIN-1). CREB
2015 The Expression of Porcine Prdx6 Gene Is Up-Regulated by C/EBPbeta and CREB. 5' RACE, ChIP, CREB, EMSA, HSF, MyoD, Prdx6, TSS
10  2014 Identification and characterization of the minimal 5'-regulatory region of the human riboflavin transporter-3 (SLC52A3) in intestinal epithelial cells. RF
11  2013 Coffee reduces SULT1E1 expression in human colon carcinoma Caco-2 cells. SULT
12  2013 Early growth response gene-1 and hypoxia-inducible factor-1alpha affect tumor metastasis via regulation of tissue factor. ELISA, siRNA, TF, VEGF
13  2012 A possible gene silencing mechanism: hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cells. ChIP, Keap1
14  2011 Transcription factor Sp1 regulates basal transcription of the human DRG2 gene. DRG2
15  2010 HNE-induced 5-LO expression is regulated by NF-{kappa}B/ERK and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages. 5-LO, EGFR, ERK, HNE, MAPK, NF-kappaB, PDGFR
16  2010 Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. EGR-1, TPA
17  2009 Involvement of Sp1 binding sequences in basal transcription of the rat fibroblast growth factor-2 gene in neonatal cardiomyocytes. ChIP, EMSA, FGF-2
18  2009 S-Adenosylhomocysteine promotes the invasion of C6 glioma cells via increased secretion of matrix metalloproteinase-2 in murine microglial BV2 cells. CM, ERK, MMP-2, NF-kappaB, SAH, TIMP-2
19  2009 Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle. KLF4, SMCs, SRF
20  2009 Transcription factors in the pathogenesis of diabetic nephropathy. AP-1, CREB, NF, NFAT, USF1 and 2
21  2008 Bile acids repress E-cadherin through the induction of Snail and increase cancer invasiveness in human hepatobiliary carcinoma. CDCA, LCA, NF-Y, siRNA
22  2008 Cloning and functional characterization of the 5' regulatory region of ovine Hormone Sensitive Lipase (HSL) gene. 5'-UTR, AP-2, ATGL, cAMP, CBFs, CRE, FSE, GR, GRE, HSL, IRE, ovHSL, PKA
23  2008 Genomic structure, transcriptional control, and tissue distribution of HERG1 and KCNQ1 genes. KCNQ1
24  2007 Cloning, characterization and computational analysis of the 5' regulatory region of ovine glucose 6-phosphate dehydrogenase gene. AP-2, G6PD, GATA, HNF-4, HSF, MEP, RAR, RFX, SREBP, STRE, USF
25  2007 Modulation of gamma interferon receptor 1 by Mycobacterium tuberculosis: a potential immune response evasive mechanism. IFN-gammaR1, IFNGR1, PBMCs, pdTHP-1
26  2007 Synergistic activation of the human adrenomedullin gene promoter by Sp1 and AP-2alpha. AM, AP-2alpha
27  2006 Adrenomedullin in adipocyte differentiation of human mesenchymal stem cells. AM, hMSCs
28  2006 Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1. IGF-1R, MMP, NF-kappaB
29  2005 Genomic, cDNA, and embryonic expression analysis of zebrafish transforming growth factor beta 3 (tgfbeta3). tgfbeta3
30  2005 Regulation of human resistin gene expression in cell systems: an important role of stimulatory protein 1 interaction with a common promoter polymorphic site. Sp3
31  2004 Steroidogenic factor-1 interacts with cAMP response element-binding protein to mediate cAMP stimulation of CYP1B1 via a far upstream enhancer. AP-1, CRE, CREB, FUER, HEK, PKA, SF-1
32  2004 Transcriptional regulation of FGF-2 gene expression in cardiac myocytes. Egr-1, FGF-2, ISP, NRCM
33  2003 Egr-1 upregulates the Alzheimer's disease presenilin-2 gene in neuronal cells. AD, Egr-1, PSEN2, TPA
34  2003 Ets2 and protein kinase C epsilon are important regulators of parathyroid hormone-related protein expression in MCF-7 breast cancer cells. ERK, MAPK, PKC, PTHrP
35  2003 Oxidized phospholipids in oxidized low-density lipoprotein down-regulate thrombomodulin transcription in vascular endothelial cells through a decrease in the binding of RARbeta-RXRalpha heterodimers and Sp1 and Sp3 to their binding sequences in the TM promoter. ox-LDL, ox-PAPC, RXRalpha, TM
36  2002 Phorbol ester induction of angiotensin-converting enzyme transcription is mediated by Egr-1 and AP-1 in human endothelial cells via ERK1/2 pathway. ACE, AP-1, Egr-1, PMA
37  2000 Genomic structure and chromosomal localization of the rat protein kinase Cdelta-gene. AP-1, NF-kappaB, NGFI-C, PKCdelta
38  1998 Functional characterization of the human thiopurine S-methyltransferase (TPMT) gene promoter. TPMT
39  1998 Structure of the promoter and complete sequence of the gene coding for the rabbit translationally controlled tumor protein (TCTP) P23. AP-1, CAT, HRF, MZF1, NF1, TCTP
40  1994 Promoter function of the human glucose-6-phosphate dehydrogenase gene depends on two GC boxes that are cell specifically controlled. AP-2
41  1990 Characterization of the 5'-flanking region of the rat protein kinase C gamma gene. CREB, EnhC, PKC
42  1988 Binding of transcription factors to the promoter of the human U1 RNA gene studied by footprinting. AP-1, MLTF, OCTA, snRNA