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Abbreviation : T-bet
Long Form : T-box expressed in T cells
No. Year Title Co-occurring Abbreviation
2020 DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells. DP1, NEDD4L, PKA
2019 A role for Th1-like Th17 cells in the pathogenesis of inflammatory and autoimmune disorders. IFN, IL, RORgammat, Th17
2019 Essential Kinases and Transcriptional Regulators and Their Roles in Autoimmunity. FoxP3, JAK, RORgammat, TYK2
2019 NFATc1 is a Necessary Transcription Factor in Polarisation of T Helper Type 2 Lymphocytes Induced by Thymic Stromal Lymphopoietin. CD, DCs, GATA-3, IFN-gamma, IL, NFATc1, PBMCs, Th2, TSLP
2018 [Effects of Pim-1 inhibitor on mouse model of inflammatory bowel disease induced by TNBS]. FOXP3, GATA-3, RORgammat, TNBS
2017 Effect of Yiqi Tongyang Decoction () on blood T cell subsets in patients with chronic immune thrombocytopenia. cITP, GATA-3
2017 Hepatitis C viraemia reversibly maintains subset of antigen-specific T-bet+ tissue-like memory B cells. DAA
2017 Huai Qi Huang corrects the balance of Th1/Th2 and Treg/Th17 in an ovalbumin-induced asthma mouse model. BALF, EOSs, FOXP3, GATA-3, LYMs, MACs, NEUs, OVA, RORgammat, Th
2017 NO2 inhalation enhances asthma susceptibility in a rat model. ERK, GATA-3, ICAM-1, IFN, IgE, IL, IL-4R, JAK, NF-kappaB, OVA
10  2017 T-bet-mediated Tim-3 expression dampens monocyte function during chronic hepatitis C virus infection. HCV, JNK, Tim-3
11  2017 [Effect of Acupuncture on the Expression of Transcription Factor T-bet/GATA-3 in Plasma of Rats with Chronic Fatigue Syndrome]. CFS, GATA-3
12  2017 [Role of ash2 (absent, small, or homeotic)-like and Jumonji domain-containing protein 3 on histone methylation of interferon-gamma gene and their associations with vascular damage of Kawasaki disease]. H3K27me3, H3K4me3, IFN-gamma, IFN-gammaR1, IFN-gammaR2, IL-12, IL-12Rbeta1, IL-12Rbeta2, IL-18, IL-18Ralpha, IL-18Rbeta, JMJD3, KD, MyD88, pSTAT1, pSTAT4, RIP-1, Th1, TLR4, TNF-alpha, TNFR1
13  2017 [The expression of T-bet is negatively correlated with the expressions of IFN-gamma and TNF-alpha in CD4+ T cells of patients with active pulmonary tuberculosis]. ELISPOT, IFN-gamma, IL-2, Mtb, PBMCs, TNF-alpha
14  2016 Arid5a exacerbates IFN-gamma-mediated septic shock by stabilizing T-bet mRNA. AT, LPS
15  2016 Favorable prognostic influence of T-box transcription factor Eomesodermin in metastatic renal cell cancer patients. PB
16  2016 Granulocyte colony-stimulating factor decreases the Th1/Th2 ratio in peripheral blood mononuclear cells from patients with chronic immune thrombocytopenic purpura in vitro. G-CSF, G-CSFR, GATA-3, IFN, IL, ITP, PBMCs
17  2016 Interferon-gamma is increased in the gut of patients with irritable bowel syndrome and modulates serotonin metabolism. ACs, IBS, IFN, SERT
18  2016 mTOR Modulates Lymphocyte Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis in Rats. EOMES, IPA, mTOR
19  2016 RhIL-11 treatment normalized Th1/Th2 and T-bet/GATA-3 imbalance in in human immune thrombocytopenic purpura (ITP). GATA-3, ITP, ITP, PBMCs, rhIL-11, Th1
20  2016 Therapeutic and immunoregulatory effect of GATA-binding protein-3/T-box expressed in T-cells ratio of astragalus polysaccharides on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats. APS, GATA-3, MPO, Th1, Th2, TNBS
21  2015 Intranasal Administration of Lentiviral miR-135a Regulates Mast Cell and Allergen-Induced Inflammation by Targeting GATA-3. AR, GATA-3, LV, MC, miR-135a, OVA
22  2015 [Effect of beta2GPI immunization on mouse T helper cell subset differentiation]. abeta2GPI Ab, beta2GPI, GATA3, IFN-gamma, IL-4, NS, Treg
23  2015 [Th2 differentiation features of Mycobacterium tuberculosis heat resistant antigen-activated human gammadeltaT cells and the regulation of transcription factor T-bet/GATA-3 on differentiation]. GATA-3, MTB-HAg, MTBAT, PBMCs, RT-PCR
24  2014 Curcumin ameliorates autoimmune diabetes. Evidence in accelerated murine models of type 1 diabetes. CYP, IFN, NF, NO, NOD, TCR
25  2014 Effects of baicalin in CD4 + CD29 + T cell subsets of ulcerative colitis patients. IFN-gamma, IL, NF-kappaB, p-NF-kappaB, RORC, UC
26  2014 Regulatory effect of microRNA-135a on the Th1/Th2 imbalance in a murine model of allergic rhinitis. AR, GATA, IFN, IL, miR, OVA, Th
27  2014 Regulatory mechanisms that control T-follicular helper and T-helper 1 cell flexibility. BCL6, STAT, Tfh
28  2014 Staphylococcal enterotoxin burden determines the type of T helper cell response and pathology of the maxillary sinus mucosa in rabbits. ECP, GATA-3, IFN, IL, MPO, SE, SEA, Th
29  2014 [Effects of needle pricking therapy of Zhuang minority medicine on expression of pulmonary T-bet, GATA-binding protein 3 genes and thymic stromal lymphopoietin protein in the lung of asthma mice]. GATA-3, OVA, TSLP
30  2014 [Imbalance in the expression of Foxp3, T-bet and GATA-3 is correlated with inflammation of chronic obstructive pulmonary disease]. BALF, COPD, GATA3, IFN-gamma, IL-4, LPS
31  2014 [Losartan modulates T helper type 1 cells and T helper type 17 cells-mediated responses in a mouse model of lipopolysaccharide-induced acute lung injury]. ALI, AT1, ELISA, GATA-3, IFN-gamma, IL-6, LPS, LW/BW, PBS, RORgammat, RT-PCR, Th
32  2013 Angiotensin II-induced vascular dysfunction depends on interferon-gamma-driven immune cell recruitment and mutual activation of monocytes and NK-cells. ATII, IFN-gamma, NK
33  2013 Differential localization of T-bet and Eomes in CD8 T cell memory populations. ---
34  2013 Early time-dependent dynamic changes of TBET and GATA3 mRNA expressions in patients with acute coronary syndrome. ACS, AMI, GATA3
35  2013 Imbalanced expression of T-bet and T cell immunoglobulin mucin-3 in patients with aplastic anaemia. AA, ELISA, RT-PCR, Th, Tim-3
36  2013 Lymphocyte-derived catecholamines induce a shift of Th1/Th2 balance toward Th2 polarization. alpha-MT, CAs, Con A, GATA-3, IFN-gamma, IL-4, Th, TH
37  2013 Pitavastatin regulates helper T-cell differentiation and ameliorates autoimmune myocarditis in mice. EAM, RORgammaT, STAT, Th
38  2013 Steroidogenic enzyme Cyp11a1 regulates Type 2 CD8+ T cell skewing in allergic lung disease. GATA3
39  2013 The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells. BCL6, Blimp-1, Id, IRF4
40  2012 Expression of Th1 and Th2 cytokine-associated transcription factors, T-bet and GATA-3, in the eutopic endometrium of women with endometriosis. GATA-3, qPCR
41  2012 Intramucosal variant of nasal natural killer (NK)/T cell lymphoma has a better survival than does invasive variant: implication on loss of E26 transformation-specific sequence 1 (ETS-1) and T-box expressed in T cells (T-bet) with invasion. ETS-1, GB, NK, NNKTCL
42  2012 Lentivirally overexpressed T-bet regulates T-helper cell lineage commitment in chronic hepatitis B patients. AHB, CHB, ELISA, HBV, PCR, Th
43  2012 NKG2D signaling on CD8⁺ T cells represses T-bet and rescues CD4-unhelped CD8⁺ T cell memory recall but not effector responses. NKG2D
44  2012 Protective role of T-bet and Th1 cytokines in pulmonary graft-versus-host disease and peribronchiolar fibrosis. allo, GVHD, HCT, syn, Th, WT
45  2012 Xiaoyin recipe ( ) for psoriasis induces a Th1/Th2 balance drift toward Th2 in peripheral blood mononuclear cells of experimental autoimmune thyroiditis rats. B group, EAT, GATA-3, Glmn, IL-10, IL-27ralpha, N group, PBMCs, RT-PCR, STAT1, T group, TNF-alpha, TNFRSF4, TNFRSF5, TNFSF5
46  2012 [Effects of acupoint injection of autoblood on expression of pulmonary transcription factor GATA 3 and T-bet proteins and genes in asthma rats]. ABAI
47  2011 Helicobacter pylori-infected macrophages induce Th17 cell differentiation. RORgammat
48  2011 Requirement of GATA-binding protein 3 for II13 gene expression in IL-18-stimulated Th1 cells. GATA3
49  2011 Rhein ameliorates fatty liver disease through negative energy balance, hepatic lipogenic regulation, and immunomodulation in diet-induced obese mice. DIO, GATA-3, LXR, NAFLD, SREBP-1c, STAT6, Th
50  2011 Shikonin inhibited mitogen-activated IL-4 and IL-5 production on EL-4 cells through downregulation of GATA-3 and c-Maf induction. cAMP, ERK, GATA-3, IFN, IkappaB, IL, JNK, MAF, MAPK, NF, PMA
51  2010 Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio. foxp3, STAT6, Th1
52  2010 Plant-originated glycoprotein (36 kDa) suppresses interleukin-4 and -10 in bisphenol A-stimulated primary cultured mouse lymphocytes. BPA, GATA-3, IL, MAPK, ROS, RT-PCR
53  2010 [Effects of Cordyceps extract on cytokines and transcription factors in peripheral blood mononuclear cells of asthmatic children during remission stage]. Foxp3, GATA-3, IFN-gamma, IL-4, PBMCs
54  2009 Common themes emerge in the transcriptional control of T helper and developmental cell fate decisions regulated by the T-box, GATA and ROR families. RORgammat
55  2009 Dual role of shikonin in early and late stages of collagen type II arthritis. CIA, IL
56  2009 Epigenetics and T helper 1 differentiation. STAT4
57  2009 Glycoprotein isolated from Dioscorea batatas Decne modulates expressions of IL-4 and IL-10 in primary-cultured mouse lymphocytes. GATA-3, IFN, IL, MAPK, STAT, Th
58  2009 Role of Cybr, a cytohesin binder and regulator, in CD4(+) T-cell function and host immunity. Cybr, GATA-3
59  2009 Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells. aTreg, IL-6, STAT4
60  2009 T-box-expressed-in-T-cells (T-bet) expression by the tumor cells of hairy-cell leukemia correlates with interferon-gamma production. FACS, HCL, IFN-gamma, Th
61  2008 Excessive production of IFN-gamma in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator/B cell-activating factor/TNF ligand superfamily-13B. GATA-3, sBLyS, SLE
62  2008 Molecular cloning and expression analysis of T-bet in ginbuna crucian carp (Carassius auratus langsdorfii). HK, PBL, Th
63  2008 Network model of survival signaling in large granular lymphocyte leukemia. CTL, T-LGL
64  2008 T-bet plays a key role in NK-mediated control of melanoma metastatic disease. ---
65  2007 Dual roles of IL-15 in maintaining IL-7RalphalowCCR7- memory CD8+ T cells in humans via recovering the phosphatidylinositol 3-kinase/AKT pathway. IL-7Ralpha
66  2007 Elevated gene expression of Th1/Th2 associated transcription factors is correlated with disease activity in patients with systemic lupus erythematosus. GATA-3, IFN-gamma, IL-4, SLE
67  2007 GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells. mAbs
68  2007 IL-12-induced T-bet expression and IFNgamma release in lymphocytes from asthmatics--role of MAPkinases ERK-1/-2, p38(MAPK) and effect of dexamethasone. ERK, MAPK
69  2007 Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6. Tc2, Tnc17
70  2007 Interleukin-12 drives the Th1 signaling pathway in Helicobacter pylori-infected human gastric mucosa. IL-4, STAT4, Th1
71  2007 Interleukin-18 directly activates T-bet expression and function via p38 mitogen-activated protein kinase and nuclear factor-kappaB in acute myeloid leukemia-derived predendritic KG-1 cells. IL
72  2007 STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. FOXP3, IL-17, ROR gamma t, Th, THi
73  2007 TH2 and TH1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA. dsRNA, STAT
74  2007 The interleukin-10 inducing effect of transforming growth factor-beta on human naive CD4+ T cells from cord blood is restricted to the TH1 subset. CBMCs, FOXP3, IL, Th1
75  2007 Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13. ---
76  2006 Antisense oligonucleotides-induced local blockade of T-bet expression leads to airway inflammation in rats. AS-ODN, BALF, IFN-gamma, IL-4, OVA
77  2006 Effects of Astragalus membranaceus in promoting T-helper cell type 1 polarization and interferon-gamma production by up-regulating T-bet expression in patients with asthma. AM, IFN-gamma, IL-4, PBMCs, RT-PCR
78  2006 [Bifidobacterium DNA upregulates Th1 type response of umbilical cord blood mononuclear cell]. bDNA, CBMC, ELISA, ELISPOT, hDNA, RT-PCR
79  2005 Effects of CpG oligodeoxynucleotide on transcription factors GATA-3 and T-bet mRNA expression in asthmatic mice. BALF, CpG ODN, GATA-3
80  2005 Interleukin-12 and -18 levels in peritoneal dialysate effluent correlate with the outcome of peritonitis in patients undergoing peritoneal dialysis: implications for the Type I/Type II T-cell immune response. GATA, IFN-gamma, IL-12, mRNA, PD, PDE
81  2005 T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Th1
82  2004 Association study of 15 novel single-nucleotide polymorphisms of the T-bet locus among Finnish asthma families. SNPs, Th
83  2004 Differential expression of mRNA for Th1 and Th2 cytokine-associated transcription factors and suppressors of cytokine signalling in peripheral blood mononuclear cells of patients with atopic dermatitis. SOCS
84  2004 STAT4 activation in smokers and patients with chronic obstructive pulmonary disease. BAL, COPD, IFN, STAT
85  2004 T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn's disease. CD, IFN-gamma, IL, LPMCs, NL, PBMCs, UC
86  2003 Absence of the T-bet gene coding for the Th1-related transcription factor does not affect diabetes-associated phenotypes in Balb/c mice. IAA
87  2003 In vitro allergen-induced mRNA expression of signaling lymphocytic activation molecule by PBMC of patients with allergic rhinitis is increased during specific pollen immunotherapy. IL-12Rbeta2, SIT, SLAM
88  2003 T-bet/GATA-3 ratio as a measure of the Th1/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3. GATA-3, IFN-gamma, IL, RT-PCR, Th
89  2002 A role for the peroxisome proliferator-activated receptor alpha in T-cell physiology and ageing immunobiology. PPAR
90  2002 A two-step model of T cell subset commitment: antigen-independent commitment of T cells before encountering nominal antigen during pathogenic infections. ---
91  2002 T-Bet expression and failure of GATA-3 cross-regulation lead to default production of IFN-gamma by gammadelta T cells. ---