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Abbreviation : TOC
Long Form : tylosis with oesophageal cancer
No. Year Title Co-occurring Abbreviation
2017 Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16. iRHOM2
2016 iRhoms; Its Functions and Essential Roles. EGFR, ER, TNF-alpha
2015 Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17. TNF, TNFRs
2014 iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function. ---
2012 Analysis of a Finnish family confirms RHBDF2 mutations as the underlying factor in tylosis with esophageal cancer. ---
2012 RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome. EGFR
2007 Abnormalities of chromosome 17 in oesophageal cancer. LOH, MSI
2006 Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression. SCOC
2006 Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer. CYGB, MtI, NSCLC
10  2005 Infrequent mutation of the human envoplakin gene is closely linked to the tylosis oesophageal cancer locus in sporadic oesophageal squamous cell carcinomas. EVPL, LOH, OSC, RT-PCR SSCP
11  2004 An investigation of the tylosis with oesophageal cancer (TOC) locus in Iranian patients with oesophageal squamous cell carcinoma. AI
12  2004 Novel microsatellite markers and single nucleotide polymorphisms refine the tylosis with oesophageal cancer (TOC) minimal region on 17q25 to 42.5 kb: sequencing does not identify the causative gene. SNPs
13  2002 Characterization of a 500 kb region on 17q25 and the exclusion of candidate genes as the familial Tylosis Oesophageal Cancer (TOC) locus. MSF
14  1999 Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): the integration of genetic and physical maps of the TOC region on 17q25. EVPL, NEPPK
15  1999 The tylosis esophageal cancer (TOC) locus: more than just a familial cancer gene. BAC, EVPL, LOH
16  1998 Loss of heterozygosity in sporadic oesophageal tumors in the tylosis oesophageal cancer (TOC) gene region of chromosome 17q. LOH
17  1998 Tylosis esophageal cancer locus on chromosome 17q25.1 is commonly deleted in sporadic human esophageal cancer. ESCs, LOH
18  1996 Close mapping of the focal non-epidermolytic palmoplantar keratoderma (PPK) locus associated with oesophageal cancer (TOC). PPK