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Abbreviation : TSC2
Long Form : tuberous sclerosis 2
No. Year Title Co-occurring Abbreviation
2018 MTOR Suppresses Cigarette Smoke-Induced Epithelial Cell Death and Airway Inflammation in Chronic Obstructive Pulmonary Disease. COPD, CS, CSE, MTOR
2017 Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression. CDK4
2017 RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death. 5-ALA, MK2, PDT, RIP3
2017 TSC2/Rheb signaling mediates ERK-dependent regulation of mTORC1 activity in C2C12 myoblasts. ERK, MEK, mTOR, PKC, PMA, Rheb
2016 Focal Adhesion Kinase Directly Interacts with TSC2 Through Its FAT Domain and Regulates Cell Proliferation in Cashmere Goat Fetal Fibroblasts. FAK, FAT, GFbs
2016 Hyaline protoplasmic astrocytopathy in the setting of tuberous sclerosis. ---
2016 Transcriptional and post-translational modifications of B-Raf in quinol-thioether induced tuberous sclerosis renal cell carcinoma. TGHQ
2015 Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway. ESCs, mTORC1, RCC
2015 Antioxidant catalase rescues against high fat diet-induced cardiac dysfunction via an IKKbeta-AMPK-dependent regulation of autophagy. AMPK, IKKbeta, WT
10  2015 Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway. CRC, NuRD
11  2015 Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model. mTOR, RCC
12  2015 Point mutations of the mTOR-RHEB pathway in renal cell carcinoma. ccRCC, DEPTOR, FRAP-ATM-TTRAP, GAP, PRAS40
13  2015 TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium. DBZ
14  2014 Concomitant low-dose doxorubicin treatment and exercise. DOX, EX, HW, LV, SED
15  2014 Hyperplasia and fibrosis in mice with conditional loss of the TSC2 tumor suppressor in Mullerian duct mesenchyme-derived myometria. ---
16  2014 Progesterone and estradiol synergistically promote the lung metastasis of tuberin-deficient cells in a preclinical model of lymphangioleiomyomatosis. LAM
17  2014 Protein kinase C and P2Y12 take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets. ADP, IGF-1, mTORC1, PI 3-kinase, PKC
18  2014 Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis. ---
19  2013 Genetic control of renal tumorigenesis by the mouse Rtm1 locus. Rtm1
20  2013 Resistance exercise, but not endurance exercise, induces IKKbeta phosphorylation in human skeletal muscle of training-accustomed individuals. IKK, MAPKs, mTORC1, TSC1
21  2013 Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway. mTORC1
22  2012 Cathepsin K expression in the spectrum of perivascular epithelioid cell (PEC) lesions of the kidney. MITF, PEC, TSC1
23  2011 cAMP-dependent cytosolic mislocalization of p27(kip)-cyclin D1 during quinol-thioether-induced tuberous sclerosis renal cell carcinoma. QTRRE cells, siRNA, TGHQ
24  2011 Deficiency of the Erc/mesothelin gene ameliorates renal carcinogenesis in Tsc2 knockout mice. Erc
25  2011 Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling. ERK, MEK, mTORC1, PI3K
26  2011 ERK crosstalks with 4EBP1 to activate cyclin D1 translation during quinol-thioether-induced tuberous sclerosis renal cell carcinoma. mTOR, QTRRE, TGHQ
27  2011 IKKbeta and NF-kappaB transcription govern lymphoma cell survival through AKT-induced plasma membrane trafficking of GLUT1. AS160, GLUT1, IKKbeta
28  2011 Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway. DAPK, mTORC1
29  2010 AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation. AMPK, IRS-1, mTOR, p70S6K, PI3K
30  2010 Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage. ATGL, HSL, mTORC1, TORC1
31  2010 Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. FGF13, mTOR, PETs, PTEN, SSTR2
32  2010 Suppression of tumor suppressor Tsc2 and DNA repair glycosylase Nth1 during spontaneous liver tumorigenesis in Long-Evans Cinnamon rats. EBSs, LEA, LEC, WD
33  2009 Murine xenograft model for human uterine fibroids: an in vivo imaging approach. GFP
34  2007 Activation by insulin and amino acids of signaling components leading to translation initiation in skeletal muscle of neonatal pigs is developmentally regulated. eIF, mTOR, PKB
35  2007 Akt1 governs breast cancer progression in vivo. MEC
36  2007 c-myc Repression of TSC2 contributes to control of translation initiation and Myc-induced transformation. mTOR, rpS6
37  2007 Carcinogen-specific gene expression profiles in short-term treated Eker and wild-type rats indicative of pathways involved in renal tumorigenesis. AA, OTA
38  2006 Mutual information-based feature selection in studying perturbation of dendritic structure caused by TSC2 inactivation. RNAi
39  2006 Tuberin nuclear localization can be regulated by phosphorylation of its carboxyl terminus. CaM
40  2004 Chromosomal anomalies on 6p25 in iris hypoplasia and Axenfeld-Rieger syndrome patients defined on a purpose-built genomic microarray. DOP
41  2004 Tuberous sclerosis-2 tumor suppressor modulates ERK and B-Raf activity in transformed renal epithelial cells. QT-RRE
42  2003 Changes in gene expression during chemical-induced nephrocarcinogenicity in the Eker rat. ERK2, HQ, QT-RRE, RT, TGHQ
43  2003 Polycystic kidney disease as a result of loss of the tuberous sclerosis 2 tumor suppressor gene during development. PKD1
44  2003 Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. HIF-alpha, RCC, VEGF, VHL
45  2002 A calmodulin binding site in the tuberous sclerosis 2 gene product is essential for regulation of transcription events and is altered by mutations linked to tuberous sclerosis and lymphangioleiomyomatosis. CaM, LAM, TSC
46  2002 Identification of the coding sequences responsible for Tsc2-mediated tumor suppression using a transgenic rat system. Tg
47  2001 Analysis of the TSC2 gene in human medulloblastoma. MB
48  2001 Carcinogenicity of a nephrotoxic metabolite of the "nongenotoxic" carcinogen hydroquinone. HQ, LOH, TGHQ
49  2001 Determination of loss of heterozygosity in frozen and paraffin embedded tumors by denaturating high-performance liquid chromatography (DHPLC). AR, DHPLC, LOH, RCC
50  2001 Protective effect of pregnancy for development of uterine leiomyoma. ---
51  2001 The tuberous sclerosis 2 gene product can localize to nuclei in a phosphorylation-dependent manner. ---
52  2001 Tissue-specific expression and splicing of the rat polycystic kidney disease 1 gene. ADPKD, PKD1
53  2001 Transformation of kidney epithelial cells by a quinol thioether via inactivation of the tuberous sclerosis-2 tumor suppressor gene. HQ, TGHQ
54  2000 Chromosomal assignment of canine TSC2, PKD1 and CLN3 genes by radiation hybrid- and linkage analyses. PKD1
55  2000 The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. TSC1
56  1999 Genetic variants of the tuberous sclerosis 2 tumour suppressor gene in mouse t haplotypes. ---
57  1998 Cloning and characterization of a mouse homologue (mNthl1) of Escherichia coli endonuclease III. ---
58  1998 Estrogen treatment enhances hereditary renal tumor development in Eker rats. ---
59  1998 Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes. 8kb
60  1998 Identification of cDNAs induced by the tumor suppressor Tsc2 gene using a conditional expression system in Tsc2 mutant (Eker) rat renal carcinoma cells. RCs
61  1998 Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development. TSC
62  1998 Mutation and polymorphism analysis in the tuberous sclerosis 2 (TSC2) gene. TSC
63  1998 Novel intragenic polymorphisms in the tuberous sclerosis 2 (TSC2) gene. Mutations in brief no. 184. Online. ---
64  1997 A novel splice site associated polymorphism in the tuberous sclerosis 2 (TSC2) gene may predispose to the development of sporadic gangliogliomas. ---
65  1997 An EcoRV polymorphism in exon 40 of the tuberous sclerosis 2 (TSC2) gene. ---
66  1997 Expression of the TSC2 product tuberin and its target Rap1 in normal human tissues. TSC
67  1997 Identification of a leader exon and a core promoter for the rat tuberous sclerosis 2 (Tsc2) gene and structural comparison with the human homolog. ---
68  1997 [VHL gene and TSC 2 gene]. VHL
69  1996 Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus. TSC
70  1996 Comparative analysis and genomic structure of the tuberous sclerosis 2 (TSC2) gene in human and pufferfish. GAP
71  1996 Comparative analysis and genomic structure of the tuberous sclerosis 2 (TSC2) gene in human and pufferfish. ---
72  1996 Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region. GAP
73  1996 The mouse homologue of the polycystic kidney disease gene (Pkd1) is a single-copy gene. PKD1
74  1996 The tuberin (TSC2), autosomal dominant polycystic kidney disease (PKD1), and somatostatin type V receptor (SSTR5) genes form a synteny group in the Fugu genome. PKD1
75  1995 Allelic loss at the tuberous sclerosis 2 locus in spontaneous tumors in the Eker rat. LOH
76  1995 Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues. ---
77  1995 Germ-line Tsc2 mutation in a dominantly inherited cancer model defines a novel family of rat intracisternal-A particle elements. ERA, IAP
78  1995 Hereditary renal cell carcinoma in the Eker rat: a unique animal model for the study of cancer susceptibility. ---
79  1995 Identification of tuberous sclerosis 2 messenger RNA splice variants that are conserved and differentially expressed in rat and human tissues. ---
80  1995 Polycystic kidney disease. 1: Identification and analysis of the primary defect. ADPKD
81  1995 Rodent model of reproductive tract leiomyomata. Clinical and pathological features. ---
82  1995 The mouse homologue of the human tuberous sclerosis 2 (TSC2) gene maps to chromosome 17, but does not fall within the tw18 or th20 deletions. ---
83  1994 Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene. ---