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Abbreviation : TSIIA
Long Form : Tanshinone IIA
No. Year Title Co-occurring Abbreviation
2019 Tanshinone IIA attenuates estradiol-induced polycystic ovarian syndrome in mice by ameliorating FSHR expression in the ovary. FSHR, PCOS
2018 Blue light decreases tanshinone IIA content in Salvia miltiorrhiza hairy roots via genes regulation. LEDs, RA, SAB
2018 Research on the inhibiting effect of tanshinone IIA on colon cancer cell growth via COX-2-Wnt/beta-catenin signaling pathway. COX, ELISA, sq-PCR, VEGF
2017 Effect of tanshinone IIA on oxidative stress and apoptosis in a rat model of fatty liver. GSH-Px, MDA, ROS, T-SOD
2016 Design, synthesis, and antimicrobial activities of new tanshinone IIA esters. ---
2016 Simultaneous determination of tanshinones and polyphenolics in rat plasma by UPLC-MS/MS and its application to the pharmacokinetic interaction between them. CT, DSS, ESI, LLE, MRM, PAL, RA, Sal B, SMB, T-I
2016 Tanshinone II A stabilizes vulnerable plaques by suppressing RAGE signaling and NF-kappaB activation in apolipoprotein-E-deficient mice. APOE, MMPs, RAGE, VCAM-1
2016 Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats. EAE, IL, MS
2016 Treatment with tanshinone IIA suppresses disruption of the blood-brain barrier and reduces expression of adhesion molecules and chemokines in experimental autoimmune encephalomyelitis. BBB, EAE, GFAP, Iba-1, TJ
10  2015 Tanshinone IIA inhibits the proliferation, migration and invasion of ectopic endometrial stromal cells of adenomyosis via 14-3-3zeta downregulation. CCK-8, EESCs, ESCs, WB
11  2014 An attempt to stabilize tanshinone IIA solid dispersion by the use of ternary systems with nano-CaCO3 and poloxamer 188. DSC, FTIR, SDs, tSDs, XRPD
12  2014 Enhanced dissolution and stability of Tanshinone IIA base by solid dispersion system with nano-hydroxyapatite. nHAp, SD
13  2014 Enhanced local bioavailability of single or compound drugs delivery to the inner ear through application of PLGA nanoparticles via round window administration. NPs, PL, PLGA, PNS, RW, RWM, Sal B
14  2014 In vivo distribution and pharmacokinetics of multiple active components from Danshen and Sanqi and their combination via inner ear administration. CSF, DAD, IT, PL, Sal B
15  2014 Tanshinone IIA induces cytochrome c-mediated caspase cascade apoptosis in A549 human lung cancer cells via the JNK pathway. CCK-8, MMP, NSCLC
16  2014 Targeted delivery of tanshinone IIA-conjugated mPEG-PLGA-PLL-cRGD nanoparticles to hepatocellular carcinoma. NPs
17  2013 Novel multiple agents loaded PLGA nanoparticles for brain delivery via inner ear administration: in vitro and in vivo evaluation. CSF, I/R, IT, MDA, NOS, NPs, PNS, Sal B, SOD
18  2013 Preparation, characterization, and in vivo evaluation of tanshinone IIA solid dispersions with silica nanoparticles. SDs
19  2013 Tanshinone derivatives: a patent review (January 2006 - September 2012). STS
20  2012 Amelioration of atherosclerosis by tanshinone IIA in hyperlipidemic rabbits through attenuation of oxidative stress. GPx, MDA, oxLDL, SOD
21  2012 Antiandrogenic, maspin induction, and antiprostate cancer activities of tanshinone IIA and its novel derivatives with modification in ring A. AR
22  2012 Comparison of neuroprotective effects of five major lipophilic diterpenoids from Danshen extract against experimentally induced transient cerebral ischemic damage. CA1, CTs, DTsI, NeuN, TsI, TsIIB
23  2012 Rational design of core-shell molecularly imprinted polymer based on computational simulation and Doehlert experimental optimization: application to the separation of tanshinone IIA from Salvia miltiorrhiza Bunge. CS-MIP, SMB
24  2012 [Study on solid dispersion of binary vector of tanshinone II A]. DSC
25  2011 Tanshinone IIA attenuates atherosclerosis in ApoE(-/-) mice through down-regulation of scavenger receptor expression. oxLDL, PPARgamma, SR-A
26  2010 [Effect of tanshinone IIA pretreatment on IL-1beta and RelA mRNA expression in rats with focal cerebral ischemia]. IPC
27  2009 [Influence of solid dispersion technique combination on dissolution of tanshinone IIA]. DSC, PVP K30
28  2008 Novel polymeric nanoparticles containing tanshinone IIA for the treatment of hepatoma. MTT
29  2008 Pharmacokinetic interaction between tanshinones and polyphenolic extracts of salvia miltinorrhiza BUNGE after intravenous administration in rats. AUC, Sal B
30  2008 Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases. TSIIAG
31  2007 Complexation of tanshinone IIA with 2-hydroxypropyl-beta-cyclodextrin: effect on aqueous solubility, dissolution rate, and intestinal absorption behavior in rats. HP-beta-CD
32  2007 In situ intestinal absorption behaviors of tanshinone IIA from its inclusion complex with hydroxypropyl-beta-cyclodextrin. HP-beta-CD
33  2007 Tanshinone II A attenuates atherosclerotic calcification in rat model by inhibition of oxidative stress. AC, HCD, MDA, oxLDL
34  2005 Determination of cryptotanshinone and its metabolite in rat plasma by liquid chromatography-tandem mass spectrometry. APCI, CID, CTS, FOFB
35  2003 Neuroprotective effects of tanshinones in transient focal cerebral ischemia in mice. MCAO
36  2000 Tanshinone II-A inhibits low density lipoprotein oxidation in vitro. LDL, REM, TBARS
37  1996 Effect of natural antioxidant tanshinone II-A on DNA damage by lipid peroxidation in liver cells. BHT, SOD