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Abbreviation : TWL
Long Form : thermal withdrawal latency
No. Year Title Co-occurring Abbreviation
2020 Dexmedetomidine Alleviated Endoplasmic Reticulum Stress via Inducing ER-phagy in the Spinal Cord of Neuropathic Pain Model. 3-MA, 4-PBA, DEX, ER, GRP78, MWT, RAP, RVM, SD, SNL, TM, UPR
2020 Effect of olfactory ensheathing cells combined with chitosan on inhibition of P24 receptor over-expression-mediated neuropathic pain. CCI, CS, DRG, MWT, NPP, OECs, P2X4R
2020 IL-35 promotes microglial M2 polarization in a rat model of diabetic neuropathic pain. DNP, HAPI, IL, LPS, MWT, rIL-35
2020 Pulsed radiofrequency alleviated neuropathic pain by down-regulating the expression of substance P in chronic constriction injury rat model. C-P group, C-S group, CCI, CI, HWT, NP, PRF, S-P group, S-S group, SP
2020 Tanshinone II A Affects Diabetic Peripheral Neuropathic Pain via Spinal Dorsal Horn Neuronal Circuitry by Modulating Endoplasmic Reticulum Stress Pathways. DPN, DPNP, ERS, MWT, NP
2019 Agkistrodon ameliorates pain response and prevents cartilage degradation in monosodium iodoacetate-induced osteoarthritic rats by inhibiting chondrocyte hypertrophy and apoptosis. EAA, MIA, MMP13, MWT, OA, TCM
2019 Alteration of metabolic connectivity in a rat model of deafferentation pain: a 18F-FDG PET/CT study. MWT
2019 Antinociceptive and anti-inflammatory effects of cryptotanshinone through PI3K/Akt signaling pathway in a rat model of neuropathic pain. CCI, IL, PWMT, TNF
2019 Attenuation of vincristine-induced neuropathy by synthetic cyclohexenone-functionalized derivative in mice model. BHT, CHD, PWD, PWL, PWT, VCR
10  2019 Cerebral 18F-FDG metabolism alteration in a neuropathic pain model following brachial plexus avulsion: A PET/CT study in rats. 18F-FDG, BPA, PET, SUVs
11  2019 Effects of 1,8-cineole on neuropathic pain mediated by P2X2 receptor in the spinal cord dorsal horn. CCI, MWT, qRT-PCR, Sham
12  2019 Electroacupuncture alleviates morphine‑induced hyperalgesia by regulating spinal CB1receptors and ERK1/2 activity. CB1, EA, i.t, MIH, MWT
13  2019 Ipsi- and Contralateral Moxibustion Generate Similar Analgesic Effect on Inflammatory Pain. LBT
14  2019 MicroRNA-211-5p Enhances Analgesic Effect of Dexmedetomidine on Inflammatory Visceral Pain in Rats by Suppressing ERK Signaling. AWR, CIVP, DEX, miRNAs, MWT
15  2019 Moxibustion Eases Chronic Inflammatory Visceral Pain In Rats Via MAPK Signaling Pathway In The Spinal Cord. AWR, CIVP, FC, GO, KEGG, MAPK, MWT, TNBS
16  2019 P2Y6 Receptor-Mediated Spinal Microglial Activation in Neuropathic Pain. CCI, ELISA, NP, PWT, RT-PCR, SD
17  2019 Pregabalin on Hdac2 and Inpp5f levels in rats with CCI-induced neuropathic pain. CCI, MWT
18  2019 Pulsed radiofrequency inhibits expression of P2X3 receptors and alleviates neuropathic pain induced by chronic constriction injury in rats. CCI, DRG, HWT, NP, P2X3, PRF, SD
19  2019 Resveratrol inhibits paclitaxel-induced neuropathic pain by the activation of PI3K/Akt and SIRT1/PGC1alpha pathway. DRG, MDA, PI3K, PWT, RES, SDH, SIRT1, SOD
20  2019 Role of hesperidin in P2X3 receptor-mediated neuropathic pain in the dorsal root ganglia. CCI, DRG, MWT
21  2019 The Localization Research of Brain Plasticity Changes after Brachial Plexus Pain: Sensory Regions or Cognitive Regions? ALFF, MWT
22  2019 The Molecular Mechanisms Associated with the Effects of Propofol in a Rat Model of Pain Due to Inflammation Following Injection with Complete Freund's Adjuvant. ASC, CFA, ELISA, IL, MWT, NLRP3, qRT-PCR, TNF
23  2019 [Effect of autophagy on N-methy-D-aspartate receptor and hyperalgesia in a rat model of neuropathic pain]. 3-MA, LC3-II, MWT, NMDA, NP, RAP, SD
24  2019 [Effects of ginsenoside-Rg2 on mechanical allodynia, heat hyperalgeia, depressive state of rats with chronic sciatic nerve constriction injury]. ---
25  2018 Analgesic effects of TLR4/NF-kappaB signaling pathway inhibition on chronic neuropathic pain in rats following chronic constriction injury of the sciatic nerve. CCI, CNP, GDNF, GFAP, MWT, NF-kappaB, NGF, TLR4
26  2018 Catestatin Enhances Neuropathic Pain Mediated by P2X4 Receptor of Dorsal Root Ganglia in a Rat Model of Chronic Constriction Injury. CCI, CST, DRG, MWT, NPP, SGCs
27  2018 Cortical remodeling after electroacupuncture therapy in peripheral nerve repairing model. ALFF, EA, FC, MCMI, PNI
28  2018 Dexmedetomidine Relieves Acute Inflammatory Visceral Pain in Rats through the ERK Pathway, Toll-Like Receptor Signaling, and TRPV1 Channel. AIVP, AWR, DEX, EGM, ERK, hDEX, IL-1, lDEX, mDEX, MWT, PGE2, TLR, TNF-alpha, TRP, TRPV1
29  2018 Early hyperbaric oxygen effects on neuropathic pain and nitric oxide synthase isoforms in CCI rats. ATA, CCI, HBO, MWT, NOS
30  2018 Effect of electro-acupuncture on the BDNF-TrkB pathway in the spinal cord of CCI rats. BDNF, CCI, EA, Iba1, MWT
31  2018 Effects of palmatine on rats with comorbidity of diabetic neuropathic pain and depression. DNP, DP, IMFST, MWT, OFT, SPT
32  2018 Gardenoside suppresses the pain in rats model of chronic constriction injury by regulating the P2X3 and P2X7 receptors. CCI, CN, IL-1beta, iNOS, MWT, qRT-PCR, Sham, TNF-alpha
33  2018 Hydrogen-Rich Saline Activated Autophagy via HIF-1alpha Pathways in Neuropathic Pain Model. CCI, HRS, MWT
34  2018 Influence of intrathecal injection with dexmedetomidine on the behavioral ability and analgesic effects on rats with neuropathic pain and expression of protein kinase C in the spinal dorsal horn. MWT, PKC
35  2018 Injectable nanocomposite analgesic delivery system for musculoskeletal pain management. CCI, Cryo SEM
36  2018 Long Non-coding RNA BC168687 is Involved in TRPV1-mediated Diabetic Neuropathic Pain in Rats. DRG, ELISA, ERK, IL, lncRNAs, MAPK, MWT, siRNA, STZ, TNF, TRPV1, WB
37  2018 Mast cell deficiency attenuates acupuncture analgesia for mechanical pain using c-kit gene mutant rats. EA, MA, MCs, MWL, MWT, WT
38  2018 MicroRNA‑143‑3p contributes to the regulation of pain responses in collagen‑induced arthritis. CIA, DRG, miR, MWT, PG, PTGS2, RA, TNF
39  2018 Neuroprotective effect of tanshinone IIA against neuropathic pain in diabetic rats through the Nrf2/ARE and NF-kappaB signaling pathways. DNP, GSH-Px, HO-1, IkappaB, MDA, MWT, NCV, SOD, TSN
40  2018 Osthole alleviated diabetic neuropathic pain mediated by the P2X4 receptor in dorsal root ganglia. BDNF, DM, DNP, DRG, GFAP, IL-1beta, MWT, SGCs, TNF-alpha
41  2018 P2Y6 receptor activation is involved in the development of neuropathic pain induced by chronic constriction injury of the sciatic nerve in rats. CCI, MWT
42  2018 Pulsed Radiofrequency Applied to the Sciatic Nerve Improves Neuropathic Pain by Down-regulating The Expression of Calcitonin Gene-related Peptide in the Dorsal Root Ganglion. CGRP, DRG, ELISA, HWT, NP, PRF
43  2018 Pulsed Radiofrequency Improves Neuropathic Pain in Chronic Constriction Injury Rats through the Upregulation of the Transcription and Translation Levels of Glial Cell Line-Derived Neurotrophic Factor. CCI, CP, CS, ELISAs, GDNF, NP, PRF, RT-PCR, SNs, SP, SS
44  2018 PVT1 protects diabetic peripheral neuropathy via PI3K/AKT pathway. DPN, DRG, MWT, PVT1, qRT-PCR, SNCV, STZ
45  2018 The association between the expression of PAR2 and TMEM16A and neuropathic pain. CCI, DRG, PAR2
46  2018 [Effects of ShenFu Injection on Peripheral Neurotoxicity of Paclitaxel]. MWT, NGF, NS
47  2018 [The relationship between autophagy activation in spinal cord and type 2 diabetic neuropathic pain in rats]. DNP, LC3, MWT, STZ
48  2017 Dezocine Antagonizes Morphine Analgesia upon Simultaneous Administration in Rodent Models of Acute Nociception. MT, p-ERK, PWL
49  2017 Effect and mechanism of inhibition of PI3K/Akt/mTOR signal pathway on chronic neuropathic pain and spinal microglia in a rat model of chronic constriction injury. CCI, CNP, DMSO, GFAP, IOD, NGF, PWMT
50  2017 Effects of LncRNA BC168687 siRNA on Diabetic Neuropathic Pain Mediated by P2X7 Receptor on SGCs in DRG of Rats. DNP, lncRNA, MWT, NO
51  2017 Effects of lncRNA uc.48+ siRNA on the release of CGRP in the spinal cords of rats with diabetic neuropathic pain. CGRP, DNP, DNP, FBG, lncRNA, MWT, SCs
52  2017 Effects of niflumic acid on gamma-aminobutyric acid-induced currents in isolated dorsal root ganglion neurons of neuropathic pain rats. CCI, DRG, GABA, NFA, PAD
53  2017 Hyperbaric oxygen attenuates neuropathic pain and reverses inflammatory signaling likely via the Kindlin-1/Wnt-10a signaling pathway in the chronic pain injury model in rats. CCI, DRG, HBO, MWT, TNF
54  2017 Impact of Botox-A SNAP-25 protein expression and the mechanism of inhibitory neurotransmitter imbalance in chronic sciatic nerve pain rat model. CCI, MWT
55  2017 lncRNA NONRATT021972 siRNA Decreases Diabetic Neuropathic Pain Mediated by the P2X3 Receptor in Dorsal Root Ganglia. DM, DNP, DRG, lncRNAs, mRNA, MWT, siRNA, T2DM, TNF-alpha
56  2017 Minocycline attenuates the development of diabetic neuropathy by inhibiting spinal cord Notch signaling in rat. DNP, i.p, MWT, STZ
57  2017 Monocyte chemoattractant protein-1 contributes to morphine tolerance in rats with cancer-induced bone pain. MCP-1, MTBP rats, PWT, RT-qPCR
58  2017 Moxibustion eases chronic inflammatory visceral pain through regulating MEK, ERK and CREB in rats. AWR, CIVP, CREB, DMSO, ERK, HPM, MEK, MWT
59  2017 Nanoparticle-encapsulated emodin decreases diabetic neuropathic pain probably via a mechanism involving P2X3 receptor in the dorsal root ganglia. DM, DNP, DPN, DRG, mRNA, MWT, nano emodin, P2X3, T2DM
60  2017 Pharmacokinetic/pharmacodynamic evaluation of grapiprant in a carrageenan-induced inflammatory pain model in the rabbit. ---
61  2017 The effect of sinomenine in diabetic neuropathic pain mediated by the P2X3 receptor in dorsal root ganglia. DM, DNP, DRG, MWT, T2DM
62  2017 The Therapeutic Effect of Dexmedetomidine on Rat Diabetic Neuropathy Pain and the Mechanism. DNP, ELISA, IL, MWT, STZ, TNF
63  2017 [Effects of electroacupuncture on activation of microglia cells in spinal cord in rats with neuropathic pain]. BDNF, CCI, EA, MWT
64  2017 [The mechanism of RvD1 alleviates type 2 diabetic neuropathic pain by influencing microglia polarization in rats]. Arg1, DNP, iNOS, MWT, STZ, T2DM
65  2016 Carnosic acid attenuates neuropathic pain in rat through the activation of spinal sirtuin1 and down-regulation of p66shc expression. CA, CCI, MWT
66  2016 Celecoxib alleviates oxaliplatin-induced hyperalgesia through inhibition of spinal ERK1/2 signaling. COX-2, DRG, MWT, OXA
67  2016 Intra-amygdala microinfusion of neuropeptide S attenuates neuropathic pain and suppresses the response of spinal microglia and astrocytes after spinal nerve ligation in rats. MWT, NP, NPS, SNL
68  2016 Intrathecal injection of phosphodiesterase 4B-specific siRNA attenuates neuropathic pain in rats with L5 spinal nerve ligation. IL, MWT, p-ERK, PDE4, si, SNL
69  2016 LncRNA NONRATT021972 siRNA regulates neuropathic pain behaviors in type 2 diabetic rats through the P2X7 receptor in dorsal root ganglia. DM, DNP, DRG, lncRNAs, MWT, SGCs, siRNA, SNCV
70  2016 LncRNA uc.48+ is involved in diabetic neuropathic pain mediated by the P2X3 receptor in the dorsal root ganglia. DM, DNP, DRG, lncRNAs, mRNA, MWT, RT-PCR, siRNA
71  2016 Pulsed Radiofrequency Reduced Neuropathic Pain Behavior in Rats Associated with Upregulation of GDNF Expression. CCI, CP, CS, ELISA, GDNF, HWT, NP, PRF, SN, SS
72  2016 The 5-HT2A receptor potassium-chloride cotransporter 2 signaling pathway in a rat incision pain model. 5-HT2AR, DMSO, MWT
73  2016 [Role of DNA methyltransferases in the pathogenesis of neuropathic pain in rats]. CCI, DNMTs, MWT, NPP
74  2015 BDNF/TRK/KCC2 pathway in nicotine withdrawal-induced hyperalgesia. BDNF, DMSO, Trk
75  2015 Effect of pulsed radiofrequency on rat sciatic nerve chronic constriction injury: a preliminary study. CCI, MWT, NP, PRF, SN
76  2015 Effects of intermedin on dorsal root ganglia in the transmission of neuropathic pain in chronic constriction injury rats. AMD2, CCI, DRG, i.t, IMD, MWT, Sham
77  2015 Microinjection of calcitonin in midbrain periaqueductal gray attenuates hyperalgesia in a chronic constriction injury rat model. CCI, CT, CTR, MWT, PAG, sCT
78  2015 Pharmacokinetic/pharmacodynamic assessments of 10 mg/kg tramadol intramuscular injection in yellow-bellied slider turtles (Trachemys scripta scripta). PK/PD
79  2015 [Phosphorylation of protein kinase C in cerebrospinal fluid-contacting nucleus modulates the inflammatory pain in rats]. CFA, CSF-CN, PKC
80  2015 [The changes of monocarboxylate transporter-2 in spinal cord horn in a rat model of chronic inflammatory pain]. CFA group, MWT, NS group
81  2014 ASIC3 in the cerebrospinal fluid-contacting nucleus of brain parenchyma contributes to inflammatory pain in rats. ASIC3, CFA, CNS, CSF, i.c.v, MWT
82  2014 Effect of nicotine withdrawal on pain sensitivity in rats to mechanical stimulation and thermal stimulation. MWT, NS group, NT18 group, NT3 group, NT9 group
83  2014 Effects of curcumin on pain threshold and on the expression of nuclear factor kappa B and CX3C receptor 1 after sciatic nerve chronic constrictive injury in rats. CCI, Cur, CX3CR1, DRG, MWT, NF-kappaB, SC, SHAM
84  2014 Electroacupuncture and A-317491 depress the transmission of pain on primary afferent mediated by the P2X3 receptor in rats with chronic neuropathic pain states. CCI, EA, MWT
85  2014 Fucoidan attenuates the existing allodynia and hyperalgesia in a rat model of neuropathic pain. ERK, GFAP, IL, MAC-1, MWT, POD, SNL, TNF
86  2014 Radial shock wave therapy in the treatment of chronic constriction injury model in rats: a preliminary study. CCI, MWT, NP, RSWT, SFI
87  2014 [Effect of pre-amputation pain block on the spinal and anterior cingulated cortex NMDA receptor activation in amputated rats]. CFA
88  2014 [Targeted damage of the cerebrospinal fluid-contacting nucleus contributes to the pain behavior and the expression of 5-HT and c-Fos in spinal dorsal horn of rats]. 5-HT, CB-HRP, CB-SAP, CSF-contacting nucleus, MWT
89  2013 Effect of electroacupuncture on the pathomorphology of the sciatic nerve and the sensitization of P2X₃ receptors in the dorsal root ganglion in rats with chronic constrictive injury. alpha,beta-meATP, ATP, CCI, DRG, EA, MWT
90  2013 Increased pain in response to mechanical or thermal stimulation in a rat model of incision-induced pain with nicotine dependence and withdrawal. MWT
91  2013 P2X7 receptor mediates activation of microglial cells in prostate of chemically irritated rats. ATP, CFA, Iba1, IL-1beta, TNF-alpha
92  2013 Suppressing SNAP-25 and reversing glial glutamate transporters relieves neuropathic pain in rats by ameliorating imbalanced neurotransmission. CCI, GLT
93  2012 Analgesic effect of electroacupuncture on chronic neuropathic pain mediated by P2X3 receptors in rat dorsal root ganglion neurons. alpha,beta-meATP, ATP, CCI, DRG, EA, IHC, ISH, MWT
94  2012 Effect of Sangu Decoction () on metastatic bone destruction in rats with mammary cancer. BMC, BMD
95  2012 Role of puerarin in the signalling of neuropathic pain mediated by P2X3 receptor of dorsal root ganglion neurons. CCI, CTRL, DRG, MWT, Sham
96  2012 Vatalanib decrease the positive interaction of VEGF receptor-2 and P2X2/3 receptor in chronic constriction injury rats. CCI, DRG, MWT, VEGFR2
97  2012 [Clonidine and dexmedetomidine's effect on the altered expressions of growth associated protein-43 mRNA in rat dorsal root ganglion during the development of chronic neuropathic pain]. CL, Dex, MWT, RT-PCR
98  2012 [Effect of preamputation pain on the behavioral changes and spinal astrocytic activation in amputated rats]. CFA, GFAP
99  2011 Effect of lappaconitine on neuropathic pain mediated by P2X3 receptor in rat dorsal root ganglion. CCI, DRG, LA, MWT
100  2010 Effect of sodium ferulate on the hyperalgesia mediated by P2X3 receptor in the neuropathic pain rats. CCI, DRG, MWT, SF