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Abbreviation : TrkB
Long Form : tropomyosin-related kinase B
No. Year Title Co-occurring Abbreviation
2020 A TrkB receptor agonist N-acetyl serotonin provides cerebral protection after traumatic brain injury by mitigating apoptotic activation and autophagic dysfunction. BBB, MMP-9, NAS, TBI
2020 BDNF as a Promising Therapeutic Agent in Parkinson's Disease. BDNF, PD
2020 BDNF Controls Bidirectional Endocannabinoid Plasticity at Corticostriatal Synapses. BDNF, eCB
2020 BDNF-TrkB pathway mediates antidepressant-like roles of H2 S in diabetic rats via promoting hippocampal autophagy. BDNF, STZ
2020 Beneficial effects of sound exposure on auditory cortex development in a mouse model of Fragile X Syndrome. AE, ERPs, FXS, KO, PV, SE, WT
2020 Brain-derived Neurotrophic Factor and TrkB Levels in Mice that Lack Vesicular Zinc: Effects of Age and Sex. BDNF, ZnT3
2020 Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury. BDNF, mPFC, NAc, SNI
2020 Calycosin Preserves BDNF/TrkB Signaling and Reduces Post-Stroke Neurological Injury after Cerebral Ischemia by Reducing Accumulation of Hypertrophic and TNF-alpha-Containing Microglia in Rats. BDNF, MCAO, TNF-alpha
2020 Early life selective knockdown of the TrkB receptor and maternal separation modulates adult stress phenotype. BDNF, CUS
10  2020 EPA-enriched ethanolamine plasmalogen and EPA-enriched phosphatidylethanolamine enhance BDNF/TrkB/CREB signaling and inhibit neuronal apoptosis in vitro and in vivo. BDNF, CREB, EPA-PE, SYN
11  2020 Excessive Treadmill Training Enhances Brain-Specific MicroRNA-34a in the Mouse Hippocampus. BDNF, CON, EV, NT, OT
12  2020 Inhibition of TrkB kinase activity impairs transdiaphragmatic pressure generation. NMTF, Pdi
13  2020 Licochalcone A Inhibits BDNF and TrkB Gene Expression and Hypoxic Growth of Human Tumor Cell Lines. LicA
14  2020 Memory-enhancing effects of Ishige foliacea extract: In vitro and in vivo study. BDNF, EEI, SCO
15  2020 Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model. ATP, BDNF, CGRP, CM, IITC, NTG, p-ERK, p-p38 MAPK, P2X4Rs, TNC
16  2020 Neurotrophic interactions between neurons and astrocytes following AAV1-Rheb(S16H) transduction in the hippocampus in vivo. AD, BDNF, CNTF, CNTFRalpha
17  2020 Neurotrophic Receptor Tyrosine Kinase 2 (NTRK2) Alterations in Low-Grade Gliomas: Report of a Novel Gene Fusion Partner in a Pilocytic Astrocytoma and Review of the Literature. BDNF, CNS, NTRK2
18  2020 Peripheral brain-derived neurotrophic factor contributes to chronic osteoarthritis joint pain. BDNF, MIA, OA
19  2020 Receptor Tyrosine Kinases as Therapeutic Targets for Alcohol Use Disorder. ALK, AUD, EGFR, FGFR, RET, RTKs
20  2020 Regulation of BDNF-TrkB Signaling and Potential Therapeutic Strategies for Parkinson's Disease. BDNF, PD
21  2020 Sex-dependent opposite effects of a tropomyosin-related kinase B receptor (TrkB) agonist 7,8-dihydroxyflavone on cued fear extinction in mice. 7,8-DHF
22  2020 Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24h post-treatment) via inducing different brain-derived neurotrophic factor (BDNF) expression level in the hippocampus. BDNF
23  2020 The role of histone acetylation in the sevoflurane-induced inhibition of neurogenesis in the hippocampi of young mice. BDNF, MWM, NSCs, WB
24  2020 TrkB hyperactivity contributes to brain dysconnectivity, epileptogenesis, and anxiety in zebrafish model of Tuberous Sclerosis Complex. TANDs, TSC
25  2020 TrkB Signaling Influences Gene Expression in Cortistatin-Expressing Interneurons. BDNF, CORT
26  2019 3,3'-Diindolylmethane Promotes BDNF and Antioxidant Enzyme Formation via TrkB/Akt Pathway Activation for Neuroprotection against Oxidative Stress-Induced Apoptosis in Hippocampal Neuronal Cells. Akt, BDNF, DIM
27  2019 5-HTT independent effects of fluoxetine on neuroplasticity. BDNF, KO, WT
28  2019 7,8-Dihydroxyflavone potentiates ongoing epileptiform activity in mice brain slices. BDNF, DHF, EC
29  2019 Accumbens brain-derived neurotrophic factor (BDNF) transmission inhibits cocaine seeking. BDNF, NAcore
30  2019 Activation of cardiac TrkB receptor by its small molecular agonist 7,8-dihydroxyflavone inhibits doxorubicin-induced cardiotoxicity via enhancing mitochondrial oxidative phosphorylation. 7,8-DHF, AMPK, BDNF, DOX, ERK, OPA1, STAT3
31  2019 Activation of TrkB/Akt signaling by a TrkB receptor agonist improves long-term histological and functional outcomes in experimental intracerebral hemorrhage. 7,8-DHF, ICH
32  2019 Antibiotic treatment-induced dysbiosis differently affects BDNF and TrkB expression in the brain and in the gut of juvenile mice. BDNF, CNS, ENS, IBS
33  2019 Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation. ATP, BDNF, FRL, FSL, FST, P2X7R
34  2019 Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma. BDNF, ERK, MB, STAT3
35  2019 Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer's Disease Through Activation of BDNF-TrkB Signaling Pathway. AD, BDNF, ELISA, i.c.v, IL-1beta, NOR, p-TrkB, PCR, SYP, TNF-alpha
36  2019 BDNF activates TrkB/PLCgamma1 signaling pathway to promote proliferation and invasion of ovarian cancer cells through inhibition of apoptosis. BDNF
37  2019 Behavioral alterations induced by post-weaning isolation rearing of rats are accompanied by reduced VGF/BDNF/TrkB signaling in the hippocampus. BDNF, nNOS, NOS
38  2019 Brain Derived Neurotrophic Factor and Supraoptic Vasopressin Neurons in Hyponatremia. AVP, BDL, BDNF, CPP, KCC2, SON
39  2019 Brain-derived neurotrophic factor mimetic, 7,8-dihydroxyflavone, protects against myocardial ischemia by rebalancing optic atrophy 1 processing. 7,8-DHF, BDNF, IHD, MMP, OPA1
40  2019 Brain-derived Neurotrophic Factor Pathway after Downhill and Uphill Training in Rats. BDNF
41  2019 Brain-derived neurotrophic factor signaling mitigates the impact of acute social stress. BDNF
42  2019 Brain-derived neurotrophic factor stimulation of T-type Ca2+ channels in sensory neurons contributes to increased peripheral pain sensitivity. BDNF, MAPK, PI3K, PKA, TG
43  2019 Breast cancer: Occluded role of mitochondria N-acetylserotonin/melatonin ratio in co-ordinating pathophysiology. NAS
44  2019 Conditioned taste aversion memory extinction temporally induces insular cortical BDNF release and inhibits neuronal apoptosis. BDNF, CTA, ERK, IC, PTSD
45  2019 Cortistatin-expressing interneurons require TrkB signaling to suppress neural hyper-excitability. BDNF, CST, sEPSCs, SWA
46  2019 Curculigoside facilitates fear extinction and prevents depression-like behaviors in a mouse learned helplessness model through increasing hippocampal BDNF. Akt, BDNF, CUR, LH, mTOR
47  2019 Deciphering Molecular Mechanism of the Neuropharmacological Action of Fucosterol through Integrated System Pharmacology and In Silico Analysis. GR, MAPK, NDD, TLR, TNF
48  2019 Detection of exosomal tyrosine receptor kinase B as a potential biomarker in ovarian cancer. OC
49  2019 Differential Expression of miRNAs in the Hippocampi of Offspring Rats Exposed to Fluorine Combined with Aluminum during the Embryonic Stage and into Adulthood. BDNF, FA, miRNA
50  2019 Dihydromyricetin affects BDNF levels in the nervous system in rats with comorbid diabetic neuropathic pain and depression. BDNF, DHM, DNP, DP
51  2019 Distinct Impacts of Fullerene on Cognitive Functions of Dementia vs. Non-dementia Mice. BBB, BDNF, LTP, MWM, PSD-95, SIVD, SYP
52  2019 Downregulation of TrkB Expression and Signaling by Valproic Acid and Other Histone Deacetylase Inhibitors. BDNF, DZNep, HDAC, PRC2, VPA
53  2019 Early Downregulation of p75NTR by Genetic and Pharmacological Approaches Delays the Onset of Motor Deficits and Striatal Dysfunction in Huntington's Disease Mice. BDNF, HD, KI
54  2019 Effect of aerobic exercise on BDNF/proBDNF expression in the ischemic hippocampus and depression recovery of rats after stroke. ACTH, AE, BDNF, CORT, NPCs, p75NTR, proBDNF, PSD, SLT
55  2019 Effects of salt-loading on supraoptic vasopressin neurones assessed by ClopHensorN chloride imaging. AVP, EU, KCC2, NKCC1, SL, SL, SON
56  2019 Effects of vagus nerve stimulation are mediated in part by TrkB in a parkinson's disease model. BDNF, PD, VNS
57  2019 Ergothioneine-induced neuronal differentiation is mediated through activation of S6K1 and neurotrophin 4/5-TrkB signaling in murine neural stem cells. DG, ERGO, mTOR, NSCs, NT5, p-mTOR, p-S6K1, S6K1
58  2019 Erlotinib inhibits colon cancer metastasis through inactivation of TrkB-dependent ERK signaling pathway. CXCL8, EMT
59  2019 Exercise enhances the expression of brain-derived neurotrophic factor in the hippocampus accompanied by epigenetic alterations in senescence-accelerated mice prone 8. BDNF, HAT/HDAC, HATs, HDACs, SAM, SAMP8, SAMR1
60  2019 Expression of BDNF, TrkB, VEGF and CD105 is associated with pelvic lymph node metastasis and prognosis in IB2-stage squamous cell carcinoma. BDNF, SCC, VEGF
61  2019 Genistein Modifies Hamster Behavior and Expression of Inflammatory Factors following Subchronic Unpredictable Mild Stress. EPM, FST, HB, HIP, HSP70, NF-kappaB1
62  2019 Glioblastoma: Role of Mitochondria N-acetylserotonin/Melatonin Ratio in Mediating Effects of miR-451 and Aryl Hydrocarbon Receptor and in Coordinating Wider Biochemical Changes. AMPK, GBM, GSC, NAS
63  2019 GZD2202, a novel TrkB inhibitor, suppresses BDNF-mediated proliferation and metastasis in neuroblastoma models. BDNF, NB
64  2019 High-Intensity Interval Training on Neuroplasticity, Balance between Brain-Derived Neurotrophic Factor and Precursor Brain-Derived Neurotrophic Factor in Poststroke Depression Rats. HIIT, mBDNF, MICT, p75NTR, proBDNF, PSD, Smax, tPA
65  2019 Hippocampal BDNF signaling is required for the antidepressant effects of perillaldehyde. BDNF, CUMS, ERK
66  2019 hiPS Cell-Derived Neurons for High-Throughput Screening. GRINCH, hiPS, HTS, NP, RT-PCR
67  2019 Inactivation of P2YR12 contributes to isoflurane-induced neuronal injury by altering TLR-4/BDNF/TNF-alpha. BDNF, NF-kappaB, TLR4, TUNEL
68  2019 Infralimbic Estradiol Enhances Neuronal Excitability and Facilitates Extinction of Cocaine Seeking in Female Rats via a BDNF/TrkB Mechanism. BDNF, IL-mPFC
69  2019 Inhibition of tropomyosine receptor kinase B on the migration of human Schwann cell and dispersion of oral tongue squamous cell carcinoma in vitro. BDNF, PNI, SC
70  2019 Initiating TrkB/Akt Signaling Cascade Preserves Blood-Brain Barrier after Subarachnoid Hemorrhage in Rats. BBB, HIOC, NAS, SAH
71  2019 Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice. BDNF, CUMS, FST, HC, mPFC, mTOR, NSFT, PFC, SPT
72  2019 Kaempferide prevents cognitive decline via attenuation of oxidative stress and enhancement of brain-derived neurotrophic factor/tropomyosin receptor kinase B/cAMP response element-binding signaling pathway. BDNF, CREB, i.c.v, KF
73  2019 Lestaurtinib (CEP-701) modulates the effects of early life hypoxic seizures on cognitive and emotional behaviors in immature rats. EEG, FST, GFAP, HS, LDT, MAAV, MWM, OFT
74  2019 Loss of Shp2 Rescues BDNF/TrkB Signaling and Contributes to Improved Retinal Ganglion Cell Neuroprotection. AAV2, ER, RGC, Shp2
75  2019 Mahuang-Fuzi-Xixin Decoction Reverses Depression-Like Behavior in LPS-Induced Mice by Regulating NLRP3 Inflammasome and Neurogenesis. BDNF, LPS, MDD, MFX, TXNIP
76  2019 Mechanisms That Modulate and Diversify BDNF Functions: Implications for Hippocampal Synaptic Plasticity. BDNF, GCs
77  2019 Methyl 3,4-dihydroxybenzoate protects retina in a mouse model of acute ocular hypertension through multiple pathways. AOH, BDNF, HO-1, Nrf2, RGCs
78  2019 Myricetin attenuates the severity of seizures and neuroapoptosis in pentylenetetrazole kindled mice by regulating the of BDNF-TrkB signaling pathway and modulating matrix metalloproteinase-9 and GABAA. BDNF, GABA, MMP-9, PTZ
79  2019 N-Acetyl Serotonin Protects Neural Progenitor Cells Against Oxidative Stress-Induced Apoptosis and Improves Neurogenesis in Adult Mouse Hippocampus Following Traumatic Brain Injury. CREB, DG, LDH, MDA, NAS, NO, NPCs, ROS, TBI
80  2019 Neurogenesis within the hippocampus after chronic methylphenidate exposure. BDNF, GDNF, VEGF
81  2019 Nogo-A/Pir-B/TrkB Signaling Pathway Activation Inhibits Neuronal Survival and Axonal Regeneration After Experimental Intracerebral Hemorrhage in Rats. GAP43, ICH, NF200, Pir-B
82  2019 Novel BDNF-regulatory microRNAs in neurodegenerative disorders pathogenesis: An in silico study. BDNF, miRNAs
83  2019 Oligodendrocytes regulate presynaptic properties and neurotransmission through BDNF signaling in the mouse brainstem. BDNF
84  2019 Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2. AP-2, AP2M, BDNF
85  2019 Positive Allosteric Modulation of AMPAR by PF-4778574 Produced Rapid Onset Antidepressant Actions in Mice. AMPAR, BDNF, PFC, VGLUT1
86  2019 Rb1, the Primary Active Ingredient in Panax ginseng C.A. Meyer, Exerts Antidepressant-Like Effects via the BDNF-Trkb-CREB Pathway. 5-HTP, BDNF, cAMP, CUMS, ERK, FST, PFC, TST
87  2019 Regulation of Acetylcholine Quantal Release by Coupled Thrombin/BDNF Signaling in Mouse Motor Synapses. ACh, BDNF, EPPs, MEPPs, NMJs, PKA, PLC
88  2019 Repeated fluoxetine treatment induces long-lasting neurotrophic changes in the medial prefrontal cortex of adult rats. BDNF, FLX, mPFC
89  2019 Restoration of Cdk5, TrkB and Soluble N-ethylmaleimide-Sensitive Factor Attachment Protein Receptor Proteins after Chronic Methylphenidate Treatment in Spontaneous Hypertensive Rats, a Model for Attention-Deficit Hyperactivity Disorder. ADHD, Cdk5, MPH, SHRs, SNAP-25, STX1A, WKYs
90  2019 Ribosylation-Derived Advanced Glycation End Products Induce Tau Hyperphosphorylation Through Brain-Derived Neurotrophic Factor Reduction. AGEs, BDNF, RRSA
91  2019 Role of the BDNF-TrkB pathway in KCC2 regulation and rehabilitation following neuronal injury: A mini review. BDNF, KCC2
92  2019 Sensory Axon Growth Requires Spatiotemporal Integration of CaSR and TrkB Signaling. CaSR
93  2019 Sex-specific spatial memory deficits in mice with a conditional TrkB deletion on parvalbumin interneurons. BDNF, PV IN
94  2019 Sexual motivation in male rats is modulated by tropomyosin receptor kinase B (TrkB). BDNF
95  2019 Sitagliptin protects the cognition function of the Alzheimer's disease mice through activating glucagon-like peptide-1 and BDNF-TrkB signalings. AD, GLP-1
96  2019 Smooth muscle brain-derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma. AHR, ASM, BDNF
97  2019 Study on Antidepressant Activity of Pseudo-Ginsenoside HQ on Depression-Like Behavior in Mice. BDNF, DA, FST, GABA, LPS, NF-kappaB, SIRT1, TST
98  2019 Targeting BDNF/TrkB pathways for preventing or suppressing epilepsy. BDNF, SE, TBI
99  2019 Targeting the BDNF/TrkB pathway for the treatment of tumors. BDNF, NGF, NT-3
100  2019 The antidepressant effects of hesperidin on chronic unpredictable mild stress-induced mice. BDNF, CUMS, ELISA, FST, HMGB1, IL, MTT, OFT, RAGE, SPT, TNF, TST