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Abbreviation : TrkB
Long Form : tropomyosin-related kinase B
No. Year Title Co-occurring Abbreviation
2020 A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways. NTRKs
2020 A TrkB receptor agonist N-acetyl serotonin provides cerebral protection after traumatic brain injury by mitigating apoptotic activation and autophagic dysfunction. BBB, MMP-9, NAS, TBI
2020 Activation of brain-derived neurotrophic factor signaling in the basal forebrain reverses acute sleep deprivation-induced fear memory impairments. BDNF, PLC-gamma1
2020 Amelioration of BPSD-Like Phenotype and Cognitive Decline in SAMP8 Mice Model Accompanied by Molecular Changes after Treatment with I2-Imidazoline Receptor Ligand MCR5. AD, BPSD, cAMP, CNS, GSK3beta, I2-IRs, IL-1beta, IL-6, mTORC1, NGFR, NMDA, p-CDK5, pCREB, PKA, PSD-95, SAMP8, TNF-alpha
2020 Asparagus cochinchinensis extract ameliorates menopausal depression in ovariectomized rats under chronic unpredictable mild stress. AC, BDNF, CUMS
2020 Astragaloside IV prevents Abeta1-42 oligomers-induced memory impairment and hippocampal cell apoptosis by promoting PPARgamma/BDNF signaling pathway. AbetaO, AD, AS-IV, BDNF, PPARgamma
2020 BDNF as a Promising Therapeutic Agent in Parkinson's Disease. BDNF, PD
2020 BDNF Controls Bidirectional Endocannabinoid Plasticity at Corticostriatal Synapses. BDNF, eCB
2020 BDNF-TrkB pathway mediates antidepressant-like roles of H2 S in diabetic rats via promoting hippocampal autophagy. BDNF, STZ
10  2020 BDNF/TrkB/Akt Signaling Pathway Epithelial Odontogenic Tumors and Keratocyst: An Immunohistochemical Study Comparative With Dental Germs. AM, BDNF, OK, OL
11  2020 Beneficial effects of sound exposure on auditory cortex development in a mouse model of Fragile X Syndrome. AE, ERPs, FXS, KO, PV, SE, WT
12  2020 Brain-Derived Neurotrophic Factor and Supraoptic Vasopressin Neurons in Hyponatremia. AVP, BDL, BDNF, CPP, KCC2, SCR, shBDNF, SON
13  2020 Brain-derived Neurotrophic Factor and TrkB Levels in Mice that Lack Vesicular Zinc: Effects of Age and Sex. BDNF, ZnT3
14  2020 Brain-derived neurotrophic factor is a full endothelium-derived factor in rats. BDNF, EX, NO, SED
15  2020 Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury. BDNF, mPFC, NAc, SNI
16  2020 Bushenhuoxue improves cognitive function and activates brain-derived neurotrophic factor-mediated signaling in a rat model of vascular dementia. BCCAO, BDNF, BSHX, CREB, PI3K, RT-PCR, TEM, VD
17  2020 Calycosin Preserves BDNF/TrkB Signaling and Reduces Post-Stroke Neurological Injury after Cerebral Ischemia by Reducing Accumulation of Hypertrophic and TNF-alpha-Containing Microglia in Rats. BDNF, MCAO, TNF-alpha
18  2020 Cholinergic neuroplasticity in asthma driven by TrkB signaling. AHR, BDNF, OVA, PCLS, SNP, VAChT, WT
19  2020 Compact, "Clickable" Quantum Dots Photoligated with Multifunctional Zwitterionic Polymers for Immunofluorescence and In Vivo Imaging. BDNF, QDs
20  2020 COX-2/PGE2 axis regulates hippocampal BDNF/TrkB signaling via EP2 receptor after prolonged seizures. BDNF, COX-2, CREB, PGE2, SE
21  2020 Dysregulation of prostaglandine E2 and BDNF signaling mediated by estrogenic dysfunction induces primary hippocampal neuronal cell death after single and repeated paraquat treatment. BDNF, NAC, PGE2, PQ
22  2020 Early life selective knockdown of the TrkB receptor and maternal separation modulates adult stress phenotype. BDNF, CUS
23  2020 Effect of Electroacupuncture at GV20 on Sleep Deprivation-Induced Depression-Like Behavior in Mice. BDNF, EA, fEPSPs, FST, HFS, MWM, SDEP, TST
24  2020 Effect of vitamin D supplementation on CREB-TrkB-BDNF pathway in the hippocampus of diabetic rats. AMP, BDNF, i.p, PCR, T1DM
25  2020 Effects of Compound 511 on BDNF-TrkB Signaling in the Mice Ventral Tegmental Area in Morphine-Induced Conditioned Place Preference. BDNF, CPP
26  2020 EPA-enriched ethanolamine plasmalogen and EPA-enriched phosphatidylethanolamine enhance BDNF/TrkB/CREB signaling and inhibit neuronal apoptosis in vitro and in vivo. BDNF, CREB, EPA-PE, SYN
27  2020 Eucommia Leaf Extract Induces BDNF Production in Rat Hypothalamus and Enhances Lipid Metabolism and Aerobic Glycolysis in Rat Liver. BDNF, ELE
28  2020 Excessive Treadmill Training Enhances Brain-Specific MicroRNA-34a in the Mouse Hippocampus. BDNF, CON, EV, NT, OT
29  2020 Fibrinogen-cellular prion protein complex formation on astrocytes. Fg, NO, ROS, STM, TBI
30  2020 Function and Mechanisms of Truncated BDNF Receptor TrkB.T1 in Neuropathic Pain. BDNF, CNS
31  2020 Gait Deficits and Loss of Striatal Tyrosine Hydroxlase/Trk-B are Restored Following 7,8-Dihydroxyflavone Treatment in a Progressive MPTP Mouse Model of Parkinson's Disease. BDNF, DA, DHF, DL, MPTP, PD, SCG10, SN, TH
32  2020 Ginsenoside Rk1 alleviates LPS-induced depression-like behavior in mice by promoting BDNF and suppressing the neuroinflammatory response. BDNF, FST, IL, LPS, TNF, TST
33  2020 High Correlation between Glaucoma Treatment with Topical Prostaglandin Analogs and BDNF Immunoreactivity in Human Retina. BDNF, IOP, RGC, RNFL
34  2020 High-intensity exercise improves cognitive function and hippocampal brain-derived neurotrophic factor expression in obese mice maintained on high-fat diet. BDNF, HFD
35  2020 Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities. BDNF
36  2020 Human VGF-Derived Antidepressant Neuropeptide TLQP62 Promotes SH-SY5Y Neurite Outgrowth. BDNF, CREB
37  2020 Individual differences in stereotypy and neuron subtype translatome with TrkB deletion. D1-MSNs
38  2020 Inhibition of TrkB kinase activity impairs transdiaphragmatic pressure generation. NMTF, Pdi
39  2020 Integrated system pharmacology and in silico analysis elucidate neuropharmacological actions of Withania somnifera in the treatment of Alzheimer's disease. AD, GSK-3beta
40  2020 Intensity-dependent effects of consecutive treadmill exercise on spatial learning and memory through the p-CREB/BDNF/NMDAR signaling in hippocampus. BDNF, HICT, LICT, mBDNF, p75NTR, pCREB, proBDNF, tPA
41  2020 Learning-Dependent Transcriptional Regulation of BDNF by its Truncated Protein Isoform in Turtle. BDNF
42  2020 Licochalcone A Inhibits BDNF and TrkB Gene Expression and Hypoxic Growth of Human Tumor Cell Lines. LicA
43  2020 LMDS-1, a potential TrkB receptor agonist provides a safe and neurotrophic effect for early-phase Alzheimer's disease. AD
44  2020 Low-intensity pulsed ultrasound ameliorates depression-like behaviors in a rat model of chronic unpredictable stress. CUS, ERK, LIPUS, mTORC1, PFC, S6K
45  2020 Low-Level Inhibition of GABAergic Synapses Enhances Gene Expressions Crucial for Neuronal Plasticity in the Hippocampus After Ischemic Stroke. BDNF, BIC, CON, MCAO, PSCI, Sham, SYP
46  2020 Memory-enhancing effects of Ishige foliacea extract: In vitro and in vivo study. BDNF, EEI, SCO
47  2020 Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model. ATP, BDNF, CGRP, CM, IITC, NTG, p-ERK, p-p38 MAPK, P2X4Rs, TNC
48  2020 Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine. BDNF, NMDAR, TGF-beta1, US
49  2020 Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer. BDNF, CNS, p75NTR
50  2020 Neurotrophic interactions between neurons and astrocytes following AAV1-Rheb(S16H) transduction in the hippocampus in vivo. AD, BDNF, CNTF, CNTFRalpha
51  2020 Neurotrophic Receptor Tyrosine Kinase 2 (NTRK2) Alterations in Low-Grade Gliomas: Report of a Novel Gene Fusion Partner in a Pilocytic Astrocytoma and Review of the Literature. BDNF, CNS, NTRK2
52  2020 Neurotrophin signalling in amygdala-dependent cued fear learning. BDNF
53  2020 NMDA receptor partial agonist GLYX-13 alleviates chronic stress-induced depression-like behavior through enhancement of AMPA receptor function in the periaqueductal gray. FS, mTORC1, NMDA, vlPAG
54  2020 Optical Activation of TrkB Signaling. ---
55  2020 Optimized integration of fluoxetine and 7, 8-dihydroxyflavone as an efficient therapy for reversing depressive-like behavior in mice during the perimenopausal period. BDNF, CUMS, FLX, Iba-1, mTOR, NeuN, PI3K, RT-qPCR
56  2020 Orexin A injection into the ventral medial prefrontal cortex induces antidepressant-like effects: Possible involvement of local Orexin-1 and Trk receptors. CNS, FST, OFT, OX1R, OXA, vmPFC
57  2020 Ovarian BDNF promotes survival, migration, and attachment of tumor precursors originated from p53 mutant fallopian tube epithelial cells. BDNF, FTE, GOF, HGSOC, LOF
58  2020 Peripheral brain-derived neurotrophic factor contributes to chronic osteoarthritis joint pain. BDNF, MIA, OA
59  2020 Plasma Brain-Derived Neurotrophic Factor (BDNF) Concentration and BDNF/TrkB Gene Polymorphisms in Croatian Adults with Asthma. BDNF
60  2020 Porous Silicon Nanoparticles Embedded in Poly(lactic-co-glycolic acid) Nanofiber Scaffolds Deliver Neurotrophic Payloads to Enhance Neuronal Growth. NGF, pSiNPs, PTEN
61  2020 Protection of the Retinal Ganglion Cells: Intravitreal Injection of Resveratrol in Mouse Model of Ocular Hypertension. BDNF, IOP, MGCs, RGCs, RSV
62  2020 Receptor Tyrosine Kinases as Therapeutic Targets for Alcohol Use Disorder. ALK, AUD, EGFR, FGFR, RET, RTKs
63  2020 Reduced Dendritic Spines in the Visual Cortex Contralateral to the Optic Nerve Crush Eye in Adult Mice. FVEPs, ONC, RNFL
64  2020 Regulation and Roles of Autophagy in the Brain. PI3K
65  2020 Regulation of BDNF-TrkB Signaling and Potential Therapeutic Strategies for Parkinson's Disease. BDNF, PD
66  2020 Repeated maternal separation causes transient reduction in BDNF expression in the medial prefrontal cortex during early brain development, affecting inhibitory neuron development. Arc, BDNF, GAD, mPFC, MS
67  2020 Role of Tropomyosin-related kinase B receptor and brain-derived neurotrophic factor in cancer. BDNF, EMT, siRNA
68  2020 Sevoflurane leads to learning and memory dysfunction via breaking the balance of tPA/PAI-1. BDNF, GAP-43, PAI-1, PSD-95, pTrkB, tPA
69  2020 Sex-dependent opposite effects of a tropomyosin-related kinase B receptor (TrkB) agonist 7,8-dihydroxyflavone on cued fear extinction in mice. 7,8-DHF
70  2020 STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury. BDNF, MANCs
71  2020 Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24h post-treatment) via inducing different brain-derived neurotrophic factor (BDNF) expression level in the hippocampus. BDNF
72  2020 Targeting BDNF/TrkB pathways for preventing or suppressing epilepsy. BDNF, SE, TBI
73  2020 The antidepressant effect of 4-hydroxybenzyl alcohol 2-naphthoate through monoaminergic, GABAergic system and BDNF signaling pathway. BDNF, FST, HBA, TST
74  2020 The Downregulation of Truncated TrkB Receptors Modulated by MicroRNA-185 Activates Full-Length TrkB Signaling and Suppresses the Epileptiform Discharges in Cultured Hippocampal Neurons. SREDs, VGCCs
75  2020 The Role of Histone Acetylation in the Sevoflurane-induced Inhibition of Neurogenesis in the Hippocampi of Young Mice. BDNF, MWM, NSCs, WB
76  2020 Therapeutic Effects of Spirulina platensis Against Adolescent Stress-Induced Oxidative Stress, Brain-Derived Neurotrophic Factor Alterations and Morphological Remodeling in the Amygdala of Adult Female Rats. BDNF, BLA, SP
77  2020 Treadmill exercise ameliorates social isolation-induced memory impairment by enhancing silent information regulator-1 expression in rats. BDNF, SIRT-1
78  2020 TrkB hyperactivity contributes to brain dysconnectivity, epileptogenesis, and anxiety in zebrafish model of Tuberous Sclerosis Complex. TANDs, TSC
79  2020 TrkB Inhibits the BMP Signaling-Mediated Growth Inhibition of Cancer Cells. BMP, BMPRI, Keap1, PI3K, SMAD1
80  2020 TrkB Signaling Influences Gene Expression in Cortistatin-Expressing Interneurons. BDNF, CORT
81  2020 Tropomyosin Receptor Kinase B Expressed in Oligodendrocyte Lineage Cells Functions to Promote Myelin Following a Demyelinating Lesion. BDNF, OLG
82  2020 Yizhi Qingxin Formula Extract Ameliorates Cognitive Decline in Aged Rats via the Brain-Derived Neurotrophic Factor/Tropomyosin Receptor Kinase B Pathway. BDNF, ERK, IL, TNF-alpha, YQF
83  2019 3,3'-Diindolylmethane Promotes BDNF and Antioxidant Enzyme Formation via TrkB/Akt Pathway Activation for Neuroprotection against Oxidative Stress-Induced Apoptosis in Hippocampal Neuronal Cells. Akt, BDNF, DIM
84  2019 5-HTT independent effects of fluoxetine on neuroplasticity. BDNF, KO, WT
85  2019 7,8-Dihydroxyflavone potentiates ongoing epileptiform activity in mice brain slices. BDNF, DHF, EC
86  2019 Accumbens brain-derived neurotrophic factor (BDNF) transmission inhibits cocaine seeking. BDNF, NAcore
87  2019 Activation of cardiac TrkB receptor by its small molecular agonist 7,8-dihydroxyflavone inhibits doxorubicin-induced cardiotoxicity via enhancing mitochondrial oxidative phosphorylation. 7,8-DHF, AMPK, BDNF, DOX, ERK, OPA1, STAT3
88  2019 Activation of TrkB/Akt signaling by a TrkB receptor agonist improves long-term histological and functional outcomes in experimental intracerebral hemorrhage. 7,8-DHF, ICH
89  2019 Antibiotic treatment-induced dysbiosis differently affects BDNF and TrkB expression in the brain and in the gut of juvenile mice. BDNF, CNS, ENS, IBS
90  2019 Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation. ATP, BDNF, FRL, FSL, FST, P2X7R
91  2019 Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma. BDNF, ERK, MB, STAT3
92  2019 Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer's Disease Through Activation of BDNF-TrkB Signaling Pathway. AD, BDNF, ELISA, i.c.v, IL-1beta, NOR, p-TrkB, PCR, SYP, TNF-alpha
93  2019 BDNF activates TrkB/PLCgamma1 signaling pathway to promote proliferation and invasion of ovarian cancer cells through inhibition of apoptosis. BDNF
94  2019 Behavioral alterations induced by post-weaning isolation rearing of rats are accompanied by reduced VGF/BDNF/TrkB signaling in the hippocampus. BDNF, nNOS, NOS
95  2019 Brain-Derived Neurotrophic Factor and Oxytocin Signaling in Association With Clinical Symptoms in Adolescent Inpatients With Anorexia Nervosa-A Longitudinal Study. AN, BDNF, BMI, OXY
96  2019 Brain-derived neurotrophic factor mimetic, 7,8-dihydroxyflavone, protects against myocardial ischemia by rebalancing optic atrophy 1 processing. 7,8-DHF, BDNF, IHD, MMP, OPA1
97  2019 Brain-derived Neurotrophic Factor Pathway after Downhill and Uphill Training in Rats. BDNF
98  2019 Brain-derived neurotrophic factor signaling mitigates the impact of acute social stress. BDNF
99  2019 Brain-derived neurotrophic factor stimulation of T-type Ca2+ channels in sensory neurons contributes to increased peripheral pain sensitivity. BDNF, MAPK, PI3K, PKA, TG
100  2019 Breast cancer: Occluded role of mitochondria N-acetylserotonin/melatonin ratio in co-ordinating pathophysiology. NAS