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Abbreviation : TrkB
Long Form : tyrosine kinase receptor B
No. Year Title Co-occurring Abbreviation
2020 alpha-Lipoic Acid Maintains Brain Glucose Metabolism via BDNF/TrkB/HIF-1alpha Signaling Pathway in P301S Mice. AD, BDNF, GLUT3, HIF-1alpha, HK, HO-1, LA, PGC-1alpha, VEGF
2020 Anorexic action of fusarenon-x in the hypothalamus and intestine. BDNF, CART, CaSR, CCK, FX, IL-1beta, MC4R, NF-kappaB, POMC, TNF-alpha, TRPA1, TRPM5
2020 BDNF and nicotine dependence: associations and potential mechanisms. BDNF, MDS, nAChRs
2020 BDNF augments rat internal anal sphincter smooth muscle tone via RhoA/ROCK signaling and nonadrenergic noncholinergic relaxation via increased NO release. BDNF, IAS, NANC, NO, sGC, SMCs
2020 Blockade of BDNF signalling attenuates chronic visceral hypersensitivity in an IBS-like rat model. AMPAR, BDNF, CRD, EMG, IBS, NMS, PKMzeta, SDH, sEPSCs
2020 Calpain-2 plays a pivotal role in the inhibitory effects of propofol against TNF-alpha-induced autophagy in mouse hippocampal neurons. CaMKII, NMDA, TNF-alpha
2020 Lactobacillus casei improves depression-like behavior in chronic unpredictable mild stress-induced rats by the BDNF-TrkB signal pathway and the intestinal microbiota. BDNF, CUMS, L. casei
2020 Neuroprotective and preventative effects of molecular hydrogen. BDNF, ERbeta, ROS
2020 Serum Levels of BDNF in Cardiovascular Protection and in Response to Exercise. BDNF, CVD, ROS
10  2020 Treadmill Exercise Improves Motor Function and Short-term Memory by Enhancing Synaptic Plasticity and Neurogenesis in Photothrombotic Stroke Mice. BDNF
11  2019 Activation of BDNF/TrkB/Akt pathway is associated with aggressiveness and unfavorable survival in oral squamous cell carcinoma. BDNF, NOM, OL, OSCC, rpS6
12  2019 Brain-derived neurotrophic factor promotes proliferation and progesterone synthesis in bovine granulosa cells. BDNF, CCNA1, CCND1, CCNE2, CDK1, GCs, HSD3B1, StAR
13  2019 c-Fos, DeltaFosB, BDNF, trkB and Arc Expression in the Limbic System of Male Roman High- and Low-Avoidance Rats that Show Differences in Sexual Behavior: Effect of Sexual Activity. Acb, BDNF, mPFC, VTA
14  2019 Loss of TrkB Signaling Due to Status Epilepticus Induces a proBDNF-Dependent Cell Death. matBDNF, NTs, p75NTR, SE
15  2019 Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites. AMPAR, BDNF, mTORC1, NMDAR
16  2019 Prelimbic neuronal nitric oxide synthase inhibition exerts antidepressant-like effects independently of BDNF signalling cascades. mPFC, mTOR, NOS
17  2019 The activation of BDNF reduced inflammation in a spinal cord injury model by TrkB/p38 MAPK signaling. BBB, BDNF, COX, IL, iNOS, SCI, TNF
18  2018 7,8-dihydroxyflavone enhanced cholinergic contraction of rat gastric smooth muscle via augmenting muscarinic M3 receptor expression. 7,8-DHF, CCh, PLC
19  2018 Brain derived neurotrophic factor (BDNF), its tyrosine kinase receptor B (TrkB) and nicotine. BDNF
20  2018 Docosahexaenoic Acid Helps to Lessen Extinction Memory in Rats. BDNFR, CR, CS-tone, GRPR, LPO, NMDAR, PSD-95, ROS, VAChT
21  2018 Environmental Enrichment Reverses Tyrosine Kinase Inhibitor-Mediated Impairment Through BDNF-TrkB Pathway. BDNF, EE, VEGFR
22  2018 Improvement of symptoms in a rat model of depression through combined zinc and folic acid administration via up-regulation of the Trk B and NMDA. 5-HT, BDNF, DA, NE, NMDA
23  2018 Long-term Administration of Salicylate-induced Changes in BDNF Expression and CREB Phosphorylation in the Auditory Cortex of Rats. AC, BDNF, CREB, pCREB
24  2018 MNX1 reduces sensitivity to anoikis by activating TrkB in human glioma cells. MNX1
25  2018 Nasal obstruction during adolescence induces memory/learning impairments associated with BDNF/TrkB signaling pathway hypofunction and high corticosterone levels. BDNF, MAPK, UNO
26  2018 Uncovering the role of brain-derived neurotrophic factor/tyrosine kinase receptor B signaling in head and neck malignancies. BDNF
27  2017 Adolescent Corticosterone and TrkB Pharmaco-Manipulations Sex-Dependently Impact Instrumental Reversal Learning Later in Life. 7,8-DHF, CORT
28  2017 Antidepressant-like effects and cognitive enhancement of Schisandra chinensis in chronic unpredictable mild stress mice and its related mechanism. BDNF, CREB, CUMS, ERK, FST, GSK-3beta, PI3K, SCE, SPT
29  2017 Effect of hippocampal L‑NBP on BDNF and TrkB expression and neurological function of vascular dementia rats. BDNF, NMDAR, VD
30  2017 Paternal physical exercise improves spatial learning ability by enhancing hippocampal neuroplasticity in male pups born from obese maternal rats. BDNF
31  2017 Regulation of actions and habits by ventral hippocampal trkB and adolescent corticosteroid exposure. 7,8-DHF, CORT
32  2016 Analysis of the Expressions of TrkB and GLT-1 in Brain Tissues on a Rat Pentylenetetrazol Kindling Model of Chronic Epilepsy. BDNF, GFAP, GLT-1, OD, PTZ
33  2016 Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice. AT2-KO, AT2R, BDNF, GAP-43, MCAO
34  2016 Effects of novel small compounds targeting TrkB on neuronal cell survival and depression-like behavior. BDNF
35  2016 Expression and significance of ERbeta and TrkB in endometriosis. BDNF, EMs, ERs
36  2016 Imipramine protects retinal ganglion cells from oxidative stress through the tyrosine kinase receptor B signaling pathway. RGC
37  2016 NTRK2 is an oncogene and associated with microRNA-22 regulation in human gastric cancer cell lines. GC, miR-22, NTRK2, qRT-PCR
38  2016 p75 neurotrophin receptor and pro-BDNF promote cell survival and migration in clear cell renal cell carcinoma. BDNF, RCC
39  2016 Recurrent Moderate Hypoglycemia Suppresses Brain-Derived Neurotrophic Factor Expression in the Prefrontal Cortex and Impairs Sensorimotor Gating in the Posthypoglycemic Period in Young Rats. BDNF
40  2016 Rehabilitation Training and Resveratrol Improve the Recovery of Neurological and Motor Function in Rats after Cerebral Ischemic Injury through the Sirt1 Signaling Pathway. BDNF, MACO, SIRT1
41  2015 Adolescent maturation of inhibitory inputs onto cingulate cortex neurons is cell-type specific and TrkB dependent. Cg, mEPSCs
42  2015 Antenatal betamethasone produces protracted changes in anxiety-like behaviors and in the expression of microtubule-associated protein 2, brain-derived neurotrophic factor and the tyrosine kinase B receptor in the rat cerebellar cortex. BDNF, MAP2
43  2015 Association between Single-Nucleotide Polymorphisms of the Tyrosine Kinase Receptor B (TrkB) and Post-Stroke Depression in China. BDNF, HAM-D, NPSD patients, PSD, SNPs
44  2015 BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons. BDNF, DHF, DSI, eCBs
45  2015 BDNF-TrkB pathway mediates neuroprotection of hydrogen sulfide against formaldehyde-induced toxicity to PC12 cells. 4-HNE, BDNF, CNS, FA, MDA, ROS
46  2015 Brain-derived Neurotrophic Factor Signaling Pathway: Modulation by Acupuncture in Telomerase Knockout Mice. AD, BDNF, DG, NF-kappabeta, p75NTR, PD, ST-36, WT
47  2015 Effects of treadmill exercise-intensity on short-term memory in the rats born of the lipopolysaccharide-exposed maternal rats. BDNF, LPS
48  2015 Endothelial tyrosine kinase receptor B prevents VE-cadherin cleavage and protects against atherosclerotic lesion development in ApoE-/- mice. BDNF
49  2015 Intervention with 7,8-dihydroxyflavone blocks further striatal terminal loss and restores motor deficits in a progressive mouse model of Parkinson's disease. 7,8-DHF, DL, MPTP, PD, pTrkB, SCG10, SN, TH
50  2015 MPTP-induced changes in hippocampal synaptic plasticity and memory are prevented by memantine through the BDNF-TrkB pathway. BDNF, LTD, LTP, MPTP, PD
51  2015 The effect of adolescent testosterone on hippocampal BDNF and TrkB mRNA expression: relationship with cell proliferation. BDNF, SGZ
52  2015 The novel protein kinase C epsilon isoform at the adult neuromuscular synapse: location, regulation by synaptic activity-dependent muscle contraction through TrkB signaling and coupling to ACh release. BDNF, NMJ, PKC
53  2015 Treadmill exercise prevents GABAergic neuronal loss with suppression of neuronal activation in the pilocarpine-induced epileptic rats. BDNF, GABA
54  2015 Tyrosine kinase receptor B (TrkB) expression in colorectal cancers highlights anoikis resistance as a survival mechanism of tumour budding cells. CI, CIMP, EMT, KRAS
55  2015 Tyrosine kinase receptor B protects against coronary artery disease and promotes adult vasculature integrity by regulating Ets1-mediated VE-cadherin expression. CAD, VE-cadherin
56  2014 7,8-Dihydroxyflavone improves motor performance and enhances lower motor neuronal survival in a mouse model of amyotrophic lateral sclerosis. 7,8-DHF, ALS, BDNF, MNs
57  2014 Antioxidant action of 7,8-dihydroxyflavone protects PC12 cells against 6-hydroxydopamine-induced cytotoxicity. 7,8-DHF
58  2014 BDNF deletion or TrkB impairment in amygdala inhibits both appetitive and aversive learning. BDNF, CPP
59  2013 Activation of TrkB with TAM-163 results in opposite effects on body weight in rodents and non-human primates. BDNF, NT-4
60  2013 Apoptosis induction of human leukemia U937 cells by 7,8-dihydroxyflavone hydrate through modulation of the Bcl-2 family of proteins and the MAPKs signaling pathway. 7,8-DHF, ERK, JNK, MAPK
61  2013 BDNF-TrkB signaling and neuroprotection in schizophrenia. BDNF
62  2013 Brain-derived neurotrophic factor induces matrix metalloproteinase 9 expression in neurons via the serum response factor/c-Fos pathway. BDNF, MMP-9, shRNA, SRF
63  2013 Differential effects of neonatal maternal separation on the expression of neurotrophic factors in rat brain. II: Regional differences in the cerebellum versus the cerebral cortex. BDNF, IGF-1, PND
64  2013 Enhanced nicotine-seeking behavior following pre-exposure to repeated cocaine is accompanied by changes in BDNF in the nucleus accumbens of rats. BDNF, CRFR1, DYN, NPY, RT-PCR
65  2013 Opiate exposure and withdrawal dynamically regulate mRNA expression in the serotonergic dorsal raphe nucleus. BDNF, CRF, DRN, MOR, TPH2
66  2013 Stage-specific inhibition of TrkB activity leads to long-lasting and sexually dimorphic effects on body weight and hypothalamic gene expression. BDNF
67  2012 Activation of TrkB receptors by NGFbeta mimetic peptide conjugated polymersome nanoparticles. ---
68  2012 Cerebellar gene expression following human traumatic brain injury. GFAP, PCR, TBI
69  2012 Extinction of aversive memories associated with morphine withdrawal requires ERK-mediated epigenetic regulation of brain-derived neurotrophic factor transcription in the rat ventromedial prefrontal cortex. BDNF, CPA, CREB, ERK, HDAC, vmPFC
70  2012 Peptide-functionalized chitosan-DNA nanoparticles for cellular targeting. ---
71  2012 Prelimbic BDNF and TrkB signaling regulates consolidation of both appetitive and aversive emotional learning. BDNF, mPFC, PL
72  2012 The impact of the frequency of moderate exercise on memory and brain-derived neurotrophic factor signaling in young adult and middle-aged rats. BDNF
73  2012 [Effects of early environment on the expression of brain-derived neurotrophic factor and its receptor and brain development]. BDNF, EE group, IE group, NC group
74  2011 Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity. 7,8-DHF, ROS
75  2011 Brain-derived neurotrophic factor expression in granulosa lutein cells. BDNF, GLC
76  2011 Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder. BDNF, ChIP, FC, PTSD, SPS
77  2011 Expression of TrkB and BDNF in human cochlea-an immunohistochemical study. BDNF, SGNs
78  2011 Expression of tyrosine kinase receptor B in eutopic endometrium of women with adenomyosis. mRNA
79  2011 Glutamate induces de novo growth of functional spines in developing cortex. CaMKII, PKA
80  2011 Overexpression of tyrosine kinase receptor B promotes metastasis of ovarian serous adenocarcinoma by lymphangiogenesis. LVD
81  2011 Reduced TrkB expression results in precocious age-like changes in neuromuscular structure, neurotransmission, and muscle function. AChRs
82  2011 Roles of BDNF, dopamine D(3) receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization. BDNF, NAc
83  2011 [Effects of chaihu shugan powder on the behavior and expressions of BDNF and TrkB in the hippocampus, amygdala, and the frontal lobe in rat model of depression]. BDNF, CHSGP, FC, MC, NC
84  2010 A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. BDNF
85  2010 Chronic administration of cyclosporine A changes expression of BDNF and TrkB in rat hippocampus and midbrain. ATRA, BDNF, CsA
86  2010 Conditional downregulation of brain- derived neurotrophic factor and tyrosine kinase receptor B blocks epileptogenesis in the human temporal lobe epilepsy hippocampus. BDNF, TLE, VPA
87  2010 Placental BDNF/TrkB signaling system is modulated by fetal growth disturbances in rat and human. BDNF, IUGR, MU
88  2010 TrkB agonist antibody dose-dependently raises blood pressure in mice with diet-induced obesity. Ab, BDNF, BP, HR
89  2009 Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma. NT-4, RGCs
90  2009 Neonatal maternal separation increases brain-derived neurotrophic factor and tyrosine kinase receptor B expression in the descending pain modulatory system. BDNF, CRD, NMS, RVM
91  2009 The effect of exercise and oxidant-antioxidant intervention on the levels of neurotrophins and free radicals in spinal cord of rats. BDNF, FR, GDNF, PBN, ROS
92  2008 Eicosapentaenoic acid (EPA) increases cell viability and expression of neurotrophin receptors in retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cells. BDNF, EPA, RA
93  2008 Immunoelectron microscopic analysis of the distribution of tyrosine kinase receptor B in olfactory axons. BDNF, CP, ORC, PL, POP
94  2008 Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression. ADT, AMI, cAMP, CORT
95  2008 Targeting TrkB neurotrophin receptor to treat depression. BDNF
96  2008 [Anoikis-suppression and invasion induced by tyrosine kinase receptor B in OVCAR3 ovarian cancer cells]. RNAi, siRNA
97  2008 [Blocking TrkB-BDNF signal pathway decreases the livability of neuroblastoma cells]. ATRA, BDNF, FCM, MTT, NB, SY5Y, TEM
98  2008 [Relationship between the expression of TrkB and anoikis resistance in nasopharyngeal carcinoma line]. BDNF, CCK-8, p-Akt
99  2007 Both GnRH agonist and continuous oral progestin treatments reduce the expression of the tyrosine kinase receptor B and mu-opioid receptor in deep infiltrating endometriosis. DIE, MOR
100  2007 Hippocampal BDNF and TrkB expression in young rats after status epilepticus. BDNF, KA, KASE, SE