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Abbreviation : WKY
Long Form : Wistar-Kyoto
No. Year Title Co-occurring Abbreviation
2020 A "Western Diet" promotes symptoms of hepatic steatosis in spontaneously hypertensive rats. NAFLD, SHR
2020 A preliminary study of the effect of a high-salt diet on transcriptome dynamics in rat hypothalamic forebrain and brainstem cardiovascular control centers. BP, CV, HS, NTS, qRT-PCR, RVLM, SHRs, SSH
2020 A reinforcement-learning model of active avoidance behavior: Differences between Sprague Dawley and Wistar-Kyoto rats. RL, SD
2020 Acute hypotensive effect of diminazene aceturate in spontaneously hypertensive rats: role of NO and Mas receptor. ACE2, AUC, BP, DIZE, SHR
2020 Altered brain fluid management in a rat model of arterial hypertension. ADC, MRI, SHR
2020 Altered Retinal Hemodynamics and Mean Circulation Time in Spontaneously Hypertensive Rats. SHR
2020 Antihypertensive activity of a new c-Jun N-terminal kinase inhibitor in spontaneously hypertensive rats. IQ-1S, JNKs, SHRs
2020 Antioxidant, Angiotensin-Converting Enzyme Inhibitory Properties and Blood-Pressure-Lowering Effect of Rice Bran Protein Hydrolysates. ACE, DH, ORAC, RBPH, SBP, SHR, TPC
2020 Aqueous Fraction from Hibiscus sabdariffa Relaxes Mesenteric Arteries of Normotensive and Hypertensive Rats through Calcium Current Reduction and Possibly Potassium Channels Modulation. AF, HS, MA, SHR, TEA
10  2020 Arrhythmia susceptibility in a rat model of acute atrial dilation. ABD, AF, VSD
11  2020 Atorvastatin attenuates vascular remodelling in spontaneously hypertensive rats via the protein kinase D/extracellular signal-regulated kinase 5 pathway. CVF, ERK5, LD, MT, MT/LD, PKD, SHRs
12  2020 Berberine reduces endothelial injury and arterial stiffness in spontaneously hypertensive rats. aPWV, CFUs, EMPs, EPCs, SHRs
13  2020 Blockage of UCHL1 activity attenuates cardiac remodeling in spontaneously hypertensive rats. LV, SHRs, UCHL1
14  2020 Brain perivascular macrophages contribute to the development of hypertension in stroke-prone spontaneously hypertensive rats via sympathetic activation. PVMs, SHRSP
15  2020 Caduet enhances connexin 43 phosphorylation in left ventricular and thoracic aorta of SH model rats. BP, Cx43, HR, LVMI, SH, SHR, SHR-AM
16  2020 Calcitriol ameliorated autonomic dysfunction and hypertension by down-regulating inflammation and oxidative stress in the paraventricular nucleus of SHR. HMGB1, NF-kappaB, PVN, RAGE, SHR, TLR4
17  2020 Cannabinoid type 2 receptor agonist JWH133 decreases blood pressure of spontaneously hypertensive rats through relieving inflammation in the rostral ventrolateral medulla of the brain. AAV, BP, CB2, HR, RSNA, RVLM, SHRs
18  2020 Cell encapsulation enhances antidepressant effect of the mesenchymal stem cells and counteracts depressive-like behavior of treatment-resistant depressed rats. CNTF, DG, eMSCs, MSCs, SVZ, VEGF
19  2020 Changes to the gut microbiota induced by losartan contributes to its antihypertensive effects. BP, FMT, SHR
20  2020 Chronic exercise mediates epigenetic suppression of L-type Ca2+ channel and BKCa channel in mesenteric arteries of hypertensive rats. SHRs
21  2020 COMT-Catalyzed Palmitic Acid Methyl Ester Biosynthesis in Perivascular Adipose Tissue and its Potential Role Against Hypertension. AdoMet, Ang II, COMT, MB, PA, PAME, PVAT, SHRs
22  2020 Concomitant enlargement of perivascular spaces and decrease in glymphatic transport in an animal model of cerebral small vessel disease. AQP4, PVSs, SHRs
23  2020 D-galactose-induced toxicity associated senescence mitigated by alpinate oxyphyllae fructus fortified adipose-derived mesenchymal stem cells. ADMSCs, AOF
24  2020 Dataset of active avoidance in Wistar-Kyoto and Sprague Dawley rats: Experimental data and reinforcement learning model code and output. RL, SD
25  2020 Differential lung inflammation and injury with tobacco smoke exposure in Wistar Kyoto and spontaneously hypertensive rats. COPD, SH, TS
26  2020 Distinct long non-coding RNA and mRNA expression profiles in the hippocampus of an attention deficit hyperactivity disorder model in spontaneously hypertensive rats and control wistar Kyoto rats. ADHD, GO, KEGG, lncRNAs, RT-PCR, SHRs
27  2020 Dual pharmacological inhibitor of endocannabinoid degrading enzymes reduces depressive-like behavior in female rats. 2-AG, AEA, BDNF, FAAH, MAGL, MDD
28  2020 Effects of cyanidin 3-O-glucoside and hydrochlorothiazide on T-cell phenotypes and function in spontaneously hypertensive rats. C3G, HCT, SHR, Th
29  2020 Effects of eplerenone on cerebral aldosterone levels and brain lesions in spontaneously hypertensive rats. RAS, SHRs
30  2020 Effects of Radiation on Blood Pressure and Body Weight in the Spontaneously Hypertensive Rat Model. Are Radiation Effects on Blood Pressure Affected by Genetic Background? SBP, SHR
31  2020 Endothelium-Independent Vasodilatory Effect of Sailuotong (SLT) on Rat Isolated Tail Artery. SLT, VaD
32  2020 Enhanced Myogenic Constriction in the SHR Preglomerular Vessels Is Mediated by Thromboxane A2 Synthesis. MC, NO, SHR
33  2020 Exacerbated LPS/GalN-Induced Liver Injury in the Stress-Sensitive Wistar Kyoto Rat Is Associated with Changes in the Endocannabinoid System. ALI, AST, CB, GLDH, SD
34  2020 Exacerbated pressor and sympathoexcitatory effects of central Elabela in spontaneously hypertensive rats. AVP, ELA, HR, MAP, PI3K, PVN, RSNA, SHR
35  2020 Exercise training attenuates cardiac inflammation and fibrosis in hypertensive ovariectomized rats. CAT, COX-2, CTGF, ER, iNOS, MMP, SHR, SHR-O, SHR-S, TGF-beta, tPA
36  2020 GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension. GRK4, RPT, SHRs, siRNA
37  2020 Haemodynamic effects of the flavonoid quercetin in rats revisited. SHR
38  2020 Heart Failure Disturbs Gut-Blood Barrier and Increases Plasma Trimethylamine, a Toxic Bacterial Metabolite. SHHF, TMA, TMAO
39  2020 Hydroxysafflor yellow A actives BKCa channels and inhibits L-type Ca channels to induce vascular relaxation. Ca-L, HSYA, SHR
40  2020 Hypertension accelerates age-related intrarenal small artery (IRSA) remodelling and stiffness in rats with possible involvement of AGEs and RAGE. AGEs, IRSA, IRSAs, minRVR, RAAs, SHRs
41  2020 Hyporesponsivity to mu-opioid receptor agonism in the Wistar-Kyoto rat model of altered nociceptive responding associated with negative affective state. MOP, SD, vlPAG
42  2020 Hypoxia-mediated regulation of mitochondrial transcription factors in renal epithelial cells: implications for hypertensive renal physiology. HIF-1alpha, mtTFs, OXPHOS, PGC-1alpha, SHR
43  2020 Impaired hypotensive effects of centrally acting oxytocin in SHR and WKY rats exposed to chronic mild stress. AJS, CMS, MAP, OT, OTANT, SHR
44  2020 Impaired UTP-induced relaxation in the carotid arteries of spontaneously hypertensive rats. COX, NO, SHR, UTP
45  2020 Increased apelin receptor gene expression in the subfornical organ of spontaneously hypertensive rats. APLN, CVO, SFO, SHR
46  2020 Increased Notch2/NF-kappaB Signaling May Mediate the Depression Susceptibility: Evidence from Chronic Social Defeat Stress Mice and WKY Rats. CSDS
47  2020 Inhibition of RAGE by FPS-ZM1 alleviates renal injury in spontaneously hypertensive rats. NOX, RAS, SHR
48  2020 Integrated exosomal miRNA and transcriptome analysis of brain microvascular endothelial cells in spontaneously hypertensive rats. CAMs, SHRs
49  2020 Kefir ameliorates hypertension via gut-brain mechanisms in spontaneously hypertensive rats. SHRs
50  2020 LncRNA and mRNA expression profiles and functional networks of hyposalivation of the submandibular gland in hypertension. ceRNA, CNC, DE, lncRNAs, qRT-PCR, SHRs
51  2020 Long-term potentiation is differentially expressed in rostral and caudal neurons in the superior cervical ganglion of normal and hypertensive rats. LTP, SCG, SHR, wo
52  2020 Mas receptor is translocated to the nucleus upon agonist stimulation in brainstem neurons from spontaneously hypertensive rats but not normotensive rats. Ang, SHRs
53  2020 Maternal N-Acetylcysteine Therapy Prevents Hypertension in Spontaneously Hypertensive Rat Offspring: Implications of Hydrogen Sulfide-Generating Pathway and Gut Microbiota. 3-MST, BP, CBS, NAC, SHR
54  2020 Metabolomics study of the prefrontal cortex in a rat model of attention deficit hyperactivity disorder reveals the association between cholesterol metabolism disorder and hyperactive behavior. ADHD, MPH, PFC, SHR
55  2020 MiR155-5p in adventitial fibroblasts-derived extracellular vesicles inhibits vascular smooth muscle cell proliferation via suppressing angiotensin-converting enzyme expression. ACE, EVs, SHR, SHR, VSMCs
56  2020 MiR155-5p Inhibits Cell Migration and Oxidative Stress in Vascular Smooth Muscle Cells of Spontaneously Hypertensive Rats. ACE, Ang II, IL-1beta, NOX, SHR, TNF-alpha, VSMCs
57  2020 Partial Predictability in Avoidance Acquisition and Expression of Wistar-Kyoto and Sprague-Dawley Rats: Implications for Anxiety Vulnerability in Uncertain Situations. BI, CS, PTSD, SD, US
58  2020 Perinatal taurine exerts a hypotensive effect in male spontaneously hypertensive rats and down-regulates endothelial oxide nitric synthase in the aortic arch. NO, SHR
59  2020 Plasma small extracellular vesicles in hypertensive rats impair reactivity of isolated blood vessels. BP, EV, SHR
60  2020 Potential role of intermittent functioning of baroreflexes in the etiology of hypertension in spontaneously hypertensive rats. SHR
61  2020 Probiotics Prevent Dysbiosis and the Rise in Blood Pressure in Genetic Hypertension: Role of Short-Chain Fatty Acids. F/B, LPS, SHR, TLR4
62  2020 Protective effects of tadalafil on prostatic hyperplasia in spontaneously hypertensive rats. bFGF, IL-6, MDA, PBR, SHRs, TGF-beta1
63  2020 Quercetin improves vascular endothelial function through promotion of autophagy in hypertensive rats. ACh, DBP, SBP, SHRs, SNP
64  2020 Reduction of blood pressure elevation by losartan in spontaneously hypertensive rats through suppression of LARG expression in vascular smooth muscle cells. BP, LARG, MYPT1, qPCR, RhoGEFs, SHRs
65  2020 Relaxin reduces endothelium-derived vasoconstriction in hypertension: Revealing new therapeutic insights. SHR
66  2020 Retinal Vascular and Anatomical Features in the Spontaneously Hypertensive Rat. SHR
67  2020 Role of complement 3 in renin generation during the differentiation of mesenchymal stem cells to smooth muscle cells. KLF5, LXRalpha, MSCs, RAS, SHRs, SMCs
68  2020 Role of Neuropeptide S on Behavioural and Neurochemical Changes of an Animal Model of Attention-Deficit/Hyperactivity Disorder. ADHD, i.c.v, NPS, SHR
69  2020 Selective ETA vs. dual ETA/B receptor blockade for the prevention of sunitinib-induced hypertension and albuminuria in WKY rats. ET
70  2020 Sildenafil reduces aortic endothelial dysfunction and structural damage in spontaneously hypertensive rats: Role of NO, NADPH and COX-1 pathways. COX-1, ROS, SBP, SHR
71  2020 Small extracellular vesicles from rat plasma promote migration and proliferation of vascular smooth muscle cells. sEV, SHR, SMCs
72  2020 Stimulation of brain cannabinoid CB1 receptors can ameliorate hypertension in spontaneously hypertensive rats. i.c.v, SHRs
73  2020 Strain Differences in Responsiveness to Repeated Restraint Stress Affect Remote Contextual Fear Memory and Blood Transcriptomics. CFC, CRS, DEGs
74  2020 Stroke-prone spontaneously hypertensive rats have reduced hydroxysteroid 17-beta dehydrogenase 7 levels for low cholesterol biosynthesis. HSD17B7, MPD, SHRSP, SQE
75  2020 Superoxide anions modulate the effects of alarin in the paraventricular nucleus on sympathetic activity and blood pressure in spontaneously hypertensive rats. DBP, MAP, PVN, RSNA, SBP, SHRs
76  2020 The Glucagon-like peptide-1 receptor agonist, exendin-4, ameliorated gastrointestinal dysfunction in the Wistar Kyoto rat model of Irritable Bowel Syndrome. GLP-1, IBS
77  2020 The influence of hypertensive environment on adipose tissue remodeling measured by fluorescence lifetime imaging in spontaneously hypertensive rats. FLIM, HPA, HPT, ORR, SHR
78  2020 The Wistar-Kyoto rat model of endogenous depression: A tool for exploring treatment resistance with an urgent need to focus on sex differences. HPA, MDD, SSRIs
79  2020 Therapeutic Potential of Thrombomodulin in Renal Fibrosis of Nephrotoxic Serum Nephritis in Wistar-Kyoto Rats. GN, NTS-N, PAR1, rhTM
80  2020 Transcriptomic signature of gut microbiome-contacting cells in colon of spontaneously hypertensive rats. Cd3g, LCP2, SHR, TCR
81  2020 Wistar Kyoto Rats Display Anhedonia In Consumption but Retain Some Sensitivity to the Anticipation of Palatable Solutions. ---
82  2019 A comparison of the cutaneous microvascular properties of the Spontaneously Hypertensive and the Wistar-Kyoto rats by Spectral analysis of Laser Doppler. LDF, PORH, SBFOs, SHR
83  2019 A new approach to identifying hypertension-associated genes in the mesenteric artery of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats. SHR
84  2019 Aerobic exercise regulates synaptic transmission and reactive oxygen species production in the paraventricular nucleus of spontaneously hypertensive rats. NE, PVN, ROS, SHRs
85  2019 Aerobic exercise-induced inhibition of PKCalpha/CaV1.2 pathway enhances the vasodilation of mesenteric arteries in hypertension. SHRs, VSMCs
86  2019 AHU377+Valsartan (LCZ696) Modulates Renin-Angiotensin System (RAS) in the Cardiac of Female Spontaneously Hypertensive Rats Compared With Valsartan. ACE, ACE2, MasR, mRNA, RAS, SHRs
87  2019 Amplified cardiorespiratory activity by hypoxia in conscious spontaneously hypertensive rats. SHRs
88  2019 Angiotensin II inhibits DDAH1-nNOS signaling via AT1R and muOR dimerization to modulate blood pressure control in the central nervous system. Ang II, BP, DDAH1, GPCRs, muOR, nNOS, NO, NTS, SHRs
89  2019 Angiotensin-(1-7) induced vascular relaxation in spontaneously hypertensive rats. Ang, CA, MA, NO, PA, PKG, SHR
90  2019 Antiapoptotic and mitochondrial biogenetic effects of exercise training on ovariectomized hypertensive rat hearts. ER, PGC-1alpha, SHR, SHR-O, SHR-S
91  2019 Arrhythmogenic beta-adrenergic signaling in cardiac hypertrophy: The role of small-conductance calcium-activated potassium channels via activation of CaMKII. CaMKII, SHRs, SVAs
92  2019 Asymmetrical response of aminopeptidase A in the medial prefrontal cortex and striatum of 6-OHDA-unilaterally-lesioned Wistar Kyoto and spontaneously hypertensive rats. SHR
93  2019 Baicalin regulates the dopamine system to control the core symptoms of ADHD. ADHD, DA, MPH, PCR, PFC, SHR, SNAP25, TH, VMAT2
94  2019 beta‑estradiol alleviates hypertension‑ and concanavalin A‑mediated inflammatory responses via modulation of connexins in peripheral blood lymphocytes. CD, Con A, Cxs, GJs, SHR
95  2019 Brain Morphometry and Longitudinal Relaxation Time of Spontaneously Hypertensive Rats (SHRs) in Early and Intermediate Stages of Hypertension Investigated by 3D VFA-SPGR MRI. CC, CSF, GM, MRI, SHRs, SVD, WM
96  2019 Cannabidiol Affects the Bezold-Jarisch Reflex via TRPV1 and 5-HT3 Receptors and Has Peripheral Sympathomimetic Effects in Spontaneously Hypertensive and Normotensive Rats. CBD, DBP, HR, SBP, SHR
97  2019 Cardioprotection and improvement in endothelial-dependent vasodilation during late-phase of whole body hypoxic preconditioning in spontaneously hypertensive rats via VEGF and endothelin-1. I/R, SHR, VEGF-A
98  2019 Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats. EVOO, SHR
99  2019 CaSR participates in the regulation of vascular tension in the mesentery of hypertensive rats via thePLC‑IP3/AC‑V/cAMP/RAS pathway. cAMP, CaSR, MA, PLC, RAS, SHRs
100  2019 Central administration of aminooxyacetate, an inhibitor of H2S production, affects thermoregulatory but not cardiovascular and ventilatory responses to hypercapnia in spontaneously hypertensive rats. AOA, HR, MAP, SHR, Tb, VE