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Abbreviation : alpha-NF
Long Form : alpha-naphthoflavone
No. Year Title Co-occurring Abbreviation
2020 3-Methylcholanthrene impacts on the female germ cells of rats without causing systemic toxicity. 3-MC
2020 The interference of alpha- and beta-naphthoflavone with triclosan effects on viability, apoptosis and reactive oxygen species production in mouse neocortical neurons. beta-NF, ROS, TCS, XO
2019 Alpha-naphthoflavone induces apoptosis through endoplasmic reticulum stress via c-Src-, ROS-, MAPKs-, and arylhydrocarbon receptor-dependent pathways in HT22 hippocampal neuronal cells. AhR, CHOP, ER, MAPKs, ROS
2019 Particulate Matter-Induced Aryl Hydrocarbon Receptor Regulates Autophagy in Keratinocytes. AhR, LC3, PM
2018 Apoptosis induction and inhibition of HeLa cell proliferation by alpha-naphthoflavone and resveratrol are aryl hydrocarbon receptor-independent. AhR, E6AP
2018 Changes in the expression of genes involved in the ovarian function of rats caused by daily exposure to 3-methylcholanthrene and their prevention by alpha-naphthoflavone. 3-MC, AhR
2018 Norisoboldine, a natural aryl hydrocarbon receptor agonist, alleviates TNBS-induced colitis in mice, by inhibiting the activation of NLRP3 inflammasome. AhR, ATP, LPS, NOR, TNBS
2017 Aryl hydrocarbon receptor/cytochrome P4501A1 pathway mediates breast cancer stem cells expansion through PTEN inhibition and beta-Catenin and Akt activation. AhR, ALDH, CSCs, SP
2016 Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. AhR, CYP1A, FICZ
10  2016 The systemic and gonadal toxicity of 3-methylcholanthrene is prevented by daily administration of alpha-naphthoflavone. 3-MC
11  2015 alpha-Naphthoflavone Increases Lipid Accumulation in Mature Adipocytes and Enhances Adipocyte-Stimulated Endothelial Tube Formation. AhR, ARNT, BNF, CM, CYP1B1, ECs, ER, HSL, Nrf2, TCDD, TG, VEGF
12  2015 Constitutive expression of AhR and BRCA-1 promoter CpG hypermethylation as biomarkers of ERalpha-negative breast tumorigenesis. AhR, DMBA, ER, LUM-A, SAhRMs
13  2015 Norisoboldine, an Anti-Arthritis Alkaloid Isolated from Radix Linderae, Attenuates Osteoclast Differentiation and Inflammatory Bone Erosion in an Aryl Hydrocarbon Receptor-Dependent Manner. AhR, NOR, OC, RES
14  2014 alpha-Naphthoflavone modulates inflammatory response in adipocytes-macrophages interaction through NFkappaB signaling. IDM
15  2014 Solubility enhancement of alpha-naphthoflavone by synthesized hydroxypropyl cyclic-(1→2)-beta-D-glucans (cyclosophoroases). Cys, DSC, FTIR, HP Cys, MD, NMR, SEM
16  2013 alpha-Naphthoflavone inhibits 3T3-L1 pre-adipocytes differentiation via modulating p38MAPK signaling. PPARgamma
17  2013 Synergistic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and N-nitrosodiethylamine on cell malignant transformation. AhR, TCDD, TF
18  2012 Anti-ageing effects of alpha-naphthoflavone on normal and UVB-irradiated human skin fibroblasts. ---
19  2012 PCB126 induces apoptosis of chondrocytes via ROS-dependent pathways. AhR, ELISA, l-NMMA, NF-kB, NO, OA, PCB, ROS, TdT
20  2012 [Tissue-specific expression of hormonal carcinogenesis target genes in rats treated with polycyclic aromatic hydrocarbons]. BP, MC, PAHs
21  2011 Daily treatment with alpha-naphthoflavone enhances follicular growth and ovulation rate in the rat. AhR
22  2011 Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis. AhR, CYP1A1, DSS, PGE2
23  2011 Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-alpha-naphthoflavone. AhR, DiMNF, DRE, SAhRMs
24  2010 Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin-induced glucose uptake in 3T3-L1 cells. AhR, TCDD
25  2009 The arylhydrocarbon receptor is only marginally involved in the antileukemic effects of its ligand curcumin. AhR, AML, MNF
26  2009 The effect of in vivo co-exposure to estrone and AhR-ligands on estrogenic effect to vitellogenin production and EROD activity. beta-NF
27  2009 Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent. AhR, JNK, MCP-1
28  2008 Aminoflavone induces oxidative DNA damage and reactive oxidative species-mediated apoptosis in breast cancer cells. 8-oxodG, AhR, DPCs, NAC, ROS
29  2008 Benzo[a]pyrene induces intercellular adhesion molecule-1 through a caveolae and aryl hydrocarbon receptor mediated pathway. AhR, beta-NF, ICAM-1
30  2008 Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding. ---
31  2008 Experimental approaches to evaluate activities of cytochromes P450 3A. ---
32  2008 Induction of human UGT1A1 by bilirubin through AhR dependent pathway. hAhR, UGT1A1, XRE
33  2007 Abundance of aryl hydrocarbon receptor potentiates benzo[a]pyrene-induced apoptosis in Hepa1c1c7 cells via CYP1A1 activation. AhR, CYP1A1, CYP1B1, TMS
34  2007 Induction of EROD activity by 1-phenylimidazole and beta-naphthoflavone in rainbow trout cultured hepatocytes: a comparative study. AhR, beta-NF, CYP1A, PIM
35  2006 Antiproliferative and antiangiogenic effects of 3-methylcholanthrene, an aryl-hydrocarbon receptor agonist, in human umbilical vascular endothelial cells. 3-MC, FAK
36  2006 Enzymatic characteristics of CYP3A5 and CYP3A4: a comparison of in vitro kinetic and drug-drug interaction patterns. TFDOH
37  2006 Growth of a human mammary tumor cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down-regulation of cyclins D3, E, and A. AhR, ER
38  2005 alpha-Naphthoflavone, a potent antiplatelet flavonoid, is mediated through inhibition of phospholipase C activity and stimulation of cyclic GMP formation. ESR, VASP
39  2005 Benzo-[a]-pyrene increases invasion in MDA-MB-231 breast cancer cells via increased COX-II expression and prostaglandin E2 (PGE2) output. AhR, PGE2, RES
40  2005 Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study. MDZ
41  2005 Effects of TCDD and estradiol-17beta on the proliferation and Na+/glucose cotransporter in renal proximal tubule cells. AhR, alpha-MG, beta-NF, PCBs, PTCs
42  2005 Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites. PFT-alpha, PI-3
43  2005 Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity. 7-BQ, CYP3A4
44  2004 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits cell proliferation through arylhydrocarbon receptor-mediated G1 arrest in SK-N-SH human neuronal cells. AhR, MOP, TCDD
45  2004 3-Methylcholanthrene induces lymphocyte and phagocyte apoptosis in common carp (Cyprinus carpio L) in vitro. 3-MC, PAH
46  2004 Disruption of cell-cell contact maximally but transiently activates AhR-mediated transcription in 10T1/2 fibroblasts. AhR, TCDD
47  2004 Expression of the arylhydrocarbon receptor in the peri-implantation period of the mouse uterus and the impact of dioxin on mouse implantation. AhR, TCDD
48  2004 Identification of Na+/H+ exchange as a new target for toxic polycyclic aromatic hydrocarbons. NHE1
49  2004 Induction of cytochrome P4501A (CYP1A) by clotrimazole, a non-planar aromatic compound. Computational studies on structural features of clotrimazole and related imidazole derivatives. AhR, BIM, CYP1A, MEP, TCDD
50  2004 Polycyclic aromatic hydrocarbons induce both apoptotic and anti-apoptotic signals in Hepa1c1c7 cells. CP-PAH, CPP, PARP
51  2004 TCDD-induced homologous recombination: the role of the Ah receptor versus oxidative DNA damage. AhR, CHO, TCDD
52  2003 A role of aryl hydrocarbon receptor in the antiandrogenic effects of polycyclic aromatic hydrocarbons in LNCaP human prostate carcinoma cells. AhR, ANT, AP-1, AR, ARE, BaP, BkF, Chr, DHT, PAHs, PSA, PYR
53  2003 Alpha-naphthoflavone induces vasorelaxation through the induction of extracellular calcium influx and NO formation in endothelium. HUVECs, L-NAME
54  2003 Aryl hydrocarbon receptor ligands repress T-cadherin expression in vascular smooth muscle cells. BaP, DMBA, TCDD
55  2003 Bone marrow stromal-B cell interactions in polycyclic aromatic hydrocarbon-induced pro/pre-B cell apoptosis. AhR, DMBA, PAH
56  2003 Induction of CYP1A by the N-imidazole derivative, 1-benzylimidazole. AhR, beta-NF, BIM, CYP1A, EROD
57  2002 7-Benzyloxyquinoline oxidation by P450eryF A245T: finding of a new fluorescent substrate probe. 7-BQ
58  2002 A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction. 3-MC, beta-NF, EROD, NCEs
59  2002 In vitro mechanistic differences in benzo[a]pyrene-DNA adduct formation using fish liver and mussel digestive gland microsomal activating systems. BaP, beta-NF, CYP
60  2002 Presence on human chromosome 10 of omeprazole-sensitivity gene whose product mediates CYP1A1 induction. Ah, OP
61  2002 Protection by quercetin against cooking oil fumes-induced DNA damage in human lung adenocarcinoma CL-3 cells: role of COX-2. COF, COX-2
62  2001 3-Methylcholanthrene increases phorbol 12-myristate 13-acetate-induced respiratory burst activity and intracellular calcium levels in common carp (Cyprinus carpio L) macrophages. 3-MC, PKC, PMA, ROS
63  2001 A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4. ---
64  2001 alpha-Naphthoflavone acts as activator and reversible or irreversible inhibitor of rabbit microsomal CYP3A6. RIF
65  2001 Cooperativity of alpha-naphthoflavone in cytochrome P450 3A-dependent drug oxidation activities in hepatic and intestinal microsomes from mouse and human. ---
66  2000 A novel 4 S [3H]beta-naphthoflavone-binding protein in liver cytosol of female Sprague-Dawley rats treated with aryl hydrocarbon receptor agonists. 3-MC, AhR, beta-NF, PAH, TCDD, TCDF
67  2000 Activity of benzo[a]pyrene and its hydroxylated metabolites in an estrogen receptor-alpha reporter gene assay. PAH
68  2000 Inhibitory activity of vitamin E and alpha-naphthoflavone on beta-carotene-enhanced transformation of BALB/c 3T3 cells by benzo(a)pyrene and cigarette-smoke condensate. betaCT, Vit E
69  2000 The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1. AhR, ARNT, beta-NF, ER, TCDD, XRE
70  1999 Antioxidant protection against PCB-mediated endothelial cell activation. Ah, DCF, PDTC
71  1999 Chemoprevention of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine-induced mammary carcinogenesis in rats. beta-NF, DAD, DFMO, I3C, PCA, PhIP
72  1999 Differential in vivo effects of alpha-naphthoflavone and beta-naphthoflavone on CYP1A1 and CYP2E1 in rat liver, lung, heart, and kidney. AhR, beta-NF, EROD, PNP
73  1999 Priming effect of benzo[a]pyrene on monocyte oxidative metabolism: possible mechanisms. AhR, PAHs
74  1998 Effects of inhibitors of CYP1A and CYP2B on styrene metabolism in mouse liver and lung microsomes. MBA
75  1996 Characteristic properties of a retinoic acid synthetic cytochrome P-450 purified from liver microsomes of 3-methylcholanthrene-induced rats. 3-MC, 7-ECOD, 7-EROD
76  1996 Effect of inducer and inhibitor probes on DNA adduction of benzo[a]pyrene and 2-acetylaminofluorene and their roles in defining bioactivation mechanism(s). 2-AAF, beta-NF, BP, BPDE-dG, Chox
77  1995 Inhibition of DNA synthesis in primary cultures of adult rat hepatocytes by benzo[a]pyrene and related aromatic hydrocarbons: role of Ah receptor-dependent events. AhR, AHs, BaP, EROD, ET
78  1995 Possible involvement of the Ah receptor in the induction of cytochrome P-450IA1 under conditions of hydrodynamic shear in microcarrier-attached hepatoma cell lines. AhR, CYP1A1, PKC, ST, TCDD
79  1993 Modulation of protooncogene expression in rat aortic smooth muscle cells by benzo[a]pyrene. BaP, DRE, PAHs, SMCs
80  1992 NADPH-supported and arachidonic acid-supported metabolism of the enantiomers of trans-7,8-dihydrobenzo[a]pyrene-7,8-diol by human liver microsomal samples. ---
81  1988 Factors regulating activation and DNA alkylation by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and nitrosodimethylamine in rat lung and isolated lung cells, and the relationship to carcinogenicity. NDMA, O6MG, TCDD
82  1988 Synthesis of sex-specific forms of cytochrome P-450 in rat liver is transiently suppressed by hepatic monooxygenase inducers. MC, PB
83  1987 Benzo[a]pyrene metabolism in the Mongolian gerbil: influence of chlordecone and mirex induction. 3-MC, BP, PB
84  1987 Influence of chlordecone and mirex exposure on benzo[a]pyrene metabolism of rat-liver microsomes. 3-MC, BP, PB
85  1986 Differential induction of ethoxyresorufin-O-deethylase in tissues of the rat placenta. 3-MC, beta-NF, EROD
86  1986 Dioxin treatment of rats results in increased in vitro induction of sister chromatid exchanges by alpha-naphthoflavone: an animal model for human exposure to halogenated aromatics. SCE, TCDD
87  1985 Metabolism of 2-aminoanthracene by BALB/c and C57BL mammary epithelium in vitro. 2AA
88  1985 Microsomal metabolism of the carcinogen, N-2-fluorenylacetamide, by the mammary gland and liver of female rats. I. Ring- and N-hydroxylations of N-2-fluorenylacetamide. 2-FAA, 3-MC, beta-NF
89  1983 Modifications of carcinogen metabolism in hepatic microsomes of suckling young by 3-methylcholanthrene or beta-naphthoflavone administered to lactating rats. 2-FAA, 3-MC, beta-NF
90  1982 Induction and repair of DNA strand breaks in cultured human fibroblasts exposed to various phenols and dihydrodiols of benzo[a]pyrene. AraC, BP, ssDNA
91  1982 Induction of cytochrome P-450 related metabolic activities in the rat ventral prostate. 7-EOD, AHH, BNF, CO, PB
92  1980 The suppressive effect of hepatic 9,000 x G supernatant fraction from 3-methylcholanthrene-treated rats on the mutagenic activity of 2-acetylaminofluorene. AAF, MC, PB