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Abbreviation : alpha-TOS
Long Form : alpha-tocopheryl succinate
No. Year Title Co-occurring Abbreviation
2020 Enhanced Prevention of Breast Tumor Metastasis by Nanoparticle-Delivered Vitamin E in Combination with Interferon-Gamma. IFN-gamma, LCCP, NPs, PD-L1
2020 Mitophagy contributes to alpha-tocopheryl succinate toxicity in GSNOR-deficient hepatocellular carcinoma. HCC
2020 pH-sensitive pluronic micelles combined with oxidative stress amplification for enhancing multidrug resistance breast cancer therapy. MDR, OE, POT, ROS
2020 Poly(ester-thioether) microspheres co-loaded with erlotinib and alpha-tocopheryl succinate for combinational therapy of non-small cell lung cancer. EGFR, NSCLC
2019 alpha-Tocopherol Succinate-Anchored PEGylated Poly(amidoamine) Dendrimer for the Delivery of Paclitaxel: Assessment of in Vitro and in Vivo Therapeutic Efficacy. PDI, PEG, PTX
2019 Hyaluronic acid-targeted and pH-responsive drug delivery system based on metal-organic frameworks for efficient antitumor therapy. DDSs, HA, HAase, TME, ZIF-8
2019 Transferrin/alpha-tocopherol modified poly(amidoamine) dendrimers for improved tumor targeting and anticancer activity of paclitaxel. PEG, PTX
2018 alpha-Tocopheryl Succinate-Based Polymeric Nanoparticles for the Treatment of Head and Neck Squamous Cell Carcinoma. NPs, ROS
2018 alpha-Tocopheryl succinate-suppressed development of cerebral malaria in mice. BBB, ECM
10  2018 Cholesterol and vitamin E-conjugated PEGylated polymeric micelles for efficient delivery and enhanced anticancer activity of curcumin: evaluation in 2D monolayers and 3D spheroids. ---
11  2018 Enhanced antitumor efficacy of arginine modified amphiphilic nanoparticles co-delivering doxorubicin and iSur-pDNA via the multiple synergistic effect. DOX, TMC
12  2018 Mitochondria-targeting and cell-penetrating peptides-co-modified HPMA copolymers for enhancing therapeutic efficacy of alpha-tocopheryl succinate. HPMA
13  2017 A positive feedback strategy for enhanced chemotherapy based on ROS-triggered self-accelerating drug release nanosystem. AD-PEG, beta-CD, DDSs, DOX, MSNs, ROS, TK
14  2017 Alpha-Tocopheryl Succinate-Conjugated G5 PAMAM Dendrimer Enables Effective Inhibition of Ulcerative Colitis. Ac, PAMAM, UC
15  2017 Co-delivery nanocarriers targeting folate receptor and encapsulating 2-deoxyglucose and alpha-tocopheryl succinate enhance anti-tumor effect in vivo. 2-DG, FR, OXPHOS, TDF NPs
16  2017 Current trends in the use of vitamin E-based micellar nanocarriers for anticancer drug delivery. TPGS
17  2017 Multifunctional decoration of alpha-tocopheryl succinate-based NP for cancer treatment: effect of TPP and LTVSPWY peptide. HER2, NP, PEP, TPP
18  2017 PAIN-less identification and evaluation of small molecule inhibitors against protein tyrosine phosphatase 1B. PAINS, PTP1B
19  2017 Photothermal and photodynamic activity of polymeric nanoparticles based on alpha-tocopheryl succinate-RAFT block copolymers conjugated to IR-780. IR-NP-eIR, MTOS, NIR, NPs, NPs, PEG, ROS
20  2017 Selenite restores Pax6 expression in neuronal cells of chronically arsenic-exposed Golden Syrian hamsters. RT
21  2017 Succinate ester derivative of delta-tocopherol enhances the protective effects against 60Co gamma-ray-induced hematopoietic injury through granulocyte colony-stimulating factor induction in mice. alpha-TOH, G-CSF, TBI
22  2017 Tocopherol and selenite modulate the transplacental effects induced by sodium arsenite in hamsters. SS
23  2016 alpha-Tocopheryl succinate-based amphiphilic block copolymers obtained by RAFT and their nanoparticles for the treatment of cancer. macro-CTA, MTOS, NPs, PEG, RAFT, SORP
24  2016 Anticancer Effect of alpha-Tocopheryl Succinate Delivered by Mitochondria-Targeted Mesoporous Silica Nanoparticles. ATP, MSNPs, TPP
25  2016 Antioxidant and antitumor activity of trolox, trolox succinate, and alpha-tocopheryl succinate conjugates with nitroxides. TroS
26  2016 Dual-drug loaded nanoformulation with a galactosamine homing moiety for liver-targeted anticancer therapy. DDNP, PLGA, PPD
27  2016 Enhanced Bioactivity of alpha-Tocopheryl Succinate Based Block Copolymer Nanoparticles by Reduced Hydrophobicity. HEMA, MTOS, NPs, PEG
28  2016 Matrix metalloproteinases-2/9-sensitive peptide-conjugated polymer micelles for site-specific release of drugs and enhancing tumor accumulation: preparation and in vitro and in vivo evaluation. DTX, MMP, TGK
29  2016 Mitochondrially Targeted Nanoparticles Based on alpha-TOS for the Selective Cancer Treatment. HUVECs, NPs, VEGF
30  2016 Nanoemulsion enhances alpha-tocopherol succinate bioavailability in rats. alpha-TOS-NE, NE
31  2016 Novel Cs-Based Upconversion Nanoparticles as Dual-Modal CT and UCL Imaging Agents for Chemo-Photothermal Synergistic Therapy. Cs
32  2016 The Combination of alpha-Tocopheryl Succinate and Sodium Selenite on Breast Cancer: A Merit or a Demerit? SSe
33  2016 Turn up the cellular power generator with vitamin E analogue formulation. ATP, Bcl-2, IF1, OXPHOS, PKC, ROS
34  2015 Anticancer and antiangiogenic activity of surfactant-free nanoparticles based on self-assembled polymeric derivatives of vitamin E: structure-activity relationship. MTOS, NP, VP
35  2015 Dendrimer-entrapped gold nanoparticles modified with RGD peptide and alpha-tocopheryl succinate enable targeted theranostics of cancer cells. CT, FI, PEG
36  2015 Effect of alpha-tocopheryl succinate on the molecular damage induced by indomethacin in C6 glioma cells. NSAID, ROS
37  2015 Enhance Cancer Cell Recognition and Overcome Drug Resistance Using Hyaluronic Acid and alpha-Tocopheryl Succinate Based Multifunctional Nanoparticles. HA, HT, MDR, TPGS
38  2015 Liposomal delivery systems for anti-cancer analogues of vitamin E. alpha-TEA, VE
39  2015 Sub-apoptotic dosages of pro-oxidant vitamin cocktails sensitize human melanoma cells to NK cell lysis. NK, VK3
40  2015 Vitamin E containing polymer micelles for reducing normal cell cytotoxicity and enhancing chemotherapy efficacy. DOX
41  2014 Conjugation of vitamin E analog alpha-TOS to Pt(IV) complexes for dual-targeting anticancer therapy. ---
42  2014 Mitochondrial targeting of alpha-tocopheryl succinate enhances its anti-mesothelioma efficacy. MitoVES, MM
43  2014 Structural re-arrangement and peroxidase activation of cytochrome c by anionic analogues of vitamin E, tocopherol succinate and tocopherol phosphate. alpha-TOP, CL, mito-VES
44  2014 Targeted cancer theranostics using alpha-tocopheryl succinate-conjugated multifunctional dendrimer-entrapped gold nanoparticles. CT, FA, FAR, FI, PEG
45  2014 Targeting mitochondria by alpha-tocopheryl succinate overcomes hypoxia-mediated tumor cell resistance to treatment. ---
46  2014 The role of alpha tocopheryl succinate (alpha-TOS) as a potential anticancer agent. ---
47  2013 Alteration of alpha-tocopherol-associated protein (TAP) expression in human breast epithelial cells during breast cancer development. TAP
48  2013 Contrasting effects of alpha-tocopheryl succinate on cisplatin- and etoposide-induced apoptosis. ---
49  2013 Crosstalk between endoplasmic reticulum stress and oxidative stress in apoptosis induced by alpha-tocopheryl succinate in human gastric carcinoma cells. C/EBP, ER, GRP78, ROS
50  2013 Mitochondrial targeting overcomes ABCA1-dependent resistance of lung carcinoma to alpha-tocopheryl succinate. ---
51  2012 Alpha-tocopheryl succinate inhibits autophagic survival of prostate cancer cells induced by vitamin K3 and ascorbate to trigger cell death. AA, AIF, VK3
52  2012 alpha-Tocopheryloxyacetic acid is superior to alpha-tocopheryl succinate in suppressing HER2-high breast carcinomas due to its higher stability. alpha-TEA, VE
53  2012 Comparison of three tocopherol analogs as an inhibitor of production of proinflammatory mediators in macrophages. LPS, Tol
54  2012 Cyclooxygenase-2/prostaglandin E₂ inducing effects of alpha-tocopheryl polyethylene glycol succinate in lung epithelial cells. alphaTPGS, COX, PEG, ROS
55  2012 Inhibition of NF-kappaB nuclear translocation via HO-1 activation underlies alpha-tocopheryl succinate toxicity. HO-1, NF-kappaB, Nrf2, ROS
56  2012 Molecular mechanism for the selective impairment of cancer mitochondrial function by a mitochondrially targeted vitamin E analogue. alpha-TEA, CII, SMPs
57  2012 Targeting mitochondria by alpha-tocopheryl succinate kills neuroblastoma cells irrespective of MycN oncogene expression. ---
58  2011 Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells. CII, UbQ, VE
59  2011 Alpha-tocopheryl succinate enhances doxorubicin-induced apoptosis in human gastric cancer cells via promotion of doxorubicin influx and suppression of doxorubicin efflux. DOXO
60  2011 Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner. ---
61  2010 alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels. ROS
62  2010 alpha-Tocopheryl succinate induces apoptosis in erbB2-expressing breast cancer cell via NF-kappaB pathway. cIAP1, FLIP, hrTRAIL, TM
63  2010 alpha-Tocopheryl succinate promotes selective cell death induced by vitamin K3 in combination with ascorbate. AA, VK3
64  2010 Analogs of vitamin E epitomized by alpha-tocopheryl succinate for pancreatic cancer treatment: in vitro results induce caution for in vivo applications. 5-FU, FCSs, MEF, PC, WT
65  2010 Bid integrates intrinsic and extrinsic signaling in apoptosis induced by alpha-tocopheryl succinate in human gastric carcinoma cells. ---
66  2010 Combination of KIT gene silencing and tocopherol succinate may offer improved therapeutic approaches for human mastocytosis. ---
67  2010 Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression. VE
68  2010 Involvement of Ca2+ and ROS in alpha-tocopheryl succinate-induced mitochondrial permeabilization. MPT, ROS
69  2010 Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation. OLVs, SPC
70  2010 Tocopheryl succinate-based lipid nanospheres for paclitaxel delivery: preparation, characters, and in vitro release kinetics. ---
71  2009 Liposomal formulation of alpha-tocopheryl maleamide: in vitro and in vivo toxicological profile and anticancer effect against spontaneous breast carcinomas in mice. alpha-TAM
72  2009 Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II. CII
73  2008 Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II. CII, ROS, SDH, UbQ
74  2008 Alpha-Tocopheryl succinate: toxicity and lack of anti-tumour activity in immuno-competent mice. Vit E
75  2007 A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression. ---
76  2007 Alpha-tocopheryl succinate (alpha-TOS) modulates human prostate LNCaP xenograft growth and gene expression in BALB/c nude mice fed two levels of dietary soybean oil. PSA, RT-PCR, SSO, VEGF
77  2007 alpha-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling. ECs, FGF-2, MM
78  2007 alpha-Tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner. JNK
79  2007 Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II. ---
80  2007 Vitamin E analogues and immune response in cancer treatment. ---
81  2007 Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating endothelial cells: the role of oxidative stress. mtDNA, ROS
82  2006 Alpha-tocopheryl succinate alters cell cycle distribution sensitising human osteosarcoma cells to methotrexate-induced apoptosis. OS
83  2006 Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis. MM
84  2006 Alpha-tocopheryl succinate, in contrast to alpha-tocopherol and alpha-tocopheryl acetate, inhibits prostaglandin E2 production in human lung epithelial cells. AA, alpha-TOA, alphaTOL, COX, PGE2, PMA
85  2006 Dietary administration of the proapoptotic vitamin E analogue alpha-tocopheryloxyacetic acid inhibits metastatic murine breast cancer. alpha-TEA, V alpha-TEA
86  2006 Flavonoids and vitamin E reduce the release of the angiogenic peptide vascular endothelial growth factor from human tumor cells. VEGF
87  2006 Role of thioredoxin-1 in apoptosis induction by alpha-tocopheryl succinate and TNF-related apoptosis-inducing ligand in mesothelioma cells. MM, TRAIL, Trx-1
88  2006 Tocopherol-associated protein-1 accelerates apoptosis induced by alpha-tocopheryl succinate in mesothelioma cells. MM
89  2006 Vesiculated alpha-tocopheryl succinate enhances the anti-tumor effect of dendritic cell vaccines. nmDC, Valpha-TOS
90  2005 Alpha-tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1. ---
91  2005 Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress. FGF, MM
92  2005 Alpha-tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system? NB, VE
93  2005 Up-regulation of c-Jun-NH2-kinase pathway contributes to the induction of mitochondria-mediated apoptosis by alpha-tocopheryl succinate in human prostate cancer cells. JNK
94  2005 Vitamin E amides, a new class of vitamin E analogues with enhanced proapoptotic activity. VE
95  2005 Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway. ROS, VE
96  2005 [Effective molecular form of alpha-tocopheryl succinate in inducing apoptosis of SGC-7901 cells]. alpha-TOH
97  2004 Alpha-tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells. MM, TRAIL
98  2004 alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. FGFR1, MM
99  2004 alpha-Tocopheryl succinate sensitizes established tumors to vaccination with nonmatured dendritic cells. DCs, i.t, s.c
100  2004 Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects. ---