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Abbreviation : eIF2
Long Form : eukaryotic translation initiation factor 2
No. Year Title Co-occurring Abbreviation
2020 Genetic responses of inbred chicken lines illustrate importance of eIF2 family and immune-related genes in resistance to Newcastle disease virus. dpi, NDV
2020 Roles of the Translation Initiation Factor eIF2alpha Phosphorylation in Cell Structure and Function. ---
2019 Structural basis for eIF2B inhibition in integrated stress response. ---
2019 The third structural switch in the archaeal translation initiation factor 2 (aIF2) molecule and its possible role in the initiation of GTP hydrolysis and the removal of aIF2 from the ribosome. aIF2
2018 Dietary Intake of Curcumin Improves eIF2 Signaling and Reduces Lipid Levels in the White Adipose Tissue of Obese Mice. DAGs, ER, eWAT, NF-kappaB
2018 Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation. eIF2alpha
2018 Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2. eIF, GDI
2017 EIF2S3 Mutations Associated with Severe X-Linked Intellectual Disability Syndrome MEHMO. ISR
2017 Novel mechanisms of eIF2B action and regulation by eIF2alpha phosphorylation. GEF, ISR, TC
10  2017 The role of the innate immune response regulatory gene ABCF1 in mammalian embryogenesis and development. dpc, ES cells
11  2015 Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation. eEF2, ER
12  2013 Translation initiation requires cell division cycle 123 (Cdc123) to facilitate biogenesis of the eukaryotic initiation factor 2 (eIF2). Cdc123
13  2011 eIF2A mediates translation of hepatitis C viral mRNA under stress conditions. HCV, IRES
14  2010 The induction of G2/M cell-cycle arrest and apoptosis by cucurbitacin E is associated with increased phosphorylation of eIF2alpha in leukemia cells. ---
15  2010 Translation control by protein kinase R restricts minute virus of mice infection: role in parvovirus oncolysis. dsRNA, MEFs, MVM, PKR
16  2009 Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells. ER, OSCC, PP1, SAHA
17  2009 Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors. ---
18  2009 Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway. PKR
19  2009 [Eukaryotic translation initiation factor 2B and leukoencephalopathy with vanishing white matter]. AFT4, ER, UPR, VWM
20  2008 GCN2-dependent phosphorylation of eukaryotic translation initiation factor-2alpha in Arabidopsis. GCN2
21  2008 Induction of apoptosis in human cancer cells by candidaspongiolide, a novel sponge polyketide. CAN
22  2008 PERK and PKR: old kinases learn new tricks. ER, PKR
23  2006 Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast. eIF3, MFC
24  2005 Phylogenetic mapping of intron positions: a case study of translation initiation factor eIF2gamma. ---
25  2005 The archaeal eIF2 homologue: functional properties of an ancient translation initiation factor. ---
26  2004 GTP-dependent recognition of the methionine moiety on initiator tRNA by translation factor eIF2. ---
27  2004 Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR. MEFs, VSV
28  2004 Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B. ---
29  2004 Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. ATF4, ISR, uORFs
30  2003 Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK. ER, PERK
31  2001 Minimum requirements for the function of eukaryotic translation initiation factor 2. ---
32  2000 Conserved sequences in the beta subunit of archaeal and eukaryal translation initiation factor 2 (eIF2), absent from eIF5, mediate interaction with eIF2gamma. ---
33  2000 Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. hcPUS4
34  2000 Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2. HIV-1
35  1999 Association of protein kinase CK2 with eukaryotic translation initiation factor eIF-2 and with grp94/endoplasmin. ---
36  1999 The beta subunit of eukaryotic translation initiation factor 2 binds mRNA through the lysine repeats and a region comprising the C2-C2 motif. ---
37  1998 Identification and requirement of three ribosome binding domains in dsRNA-dependent protein kinase (PKR). ds, PKR, TAR
38  1997 The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase. GADD34, PKR
39  1996 A eukaryotic translation initiation factor 2-associated 67 kDa glycoprotein partially reverses protein synthesis inhibition by activated double-stranded RNA-dependent protein kinase in intact cells. ---
40  1996 Ligand interactions with eukaryotic translation initiation factor 2: role of the gamma-subunit. Met
41  1995 The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene. IFN
42  1993 A difference in the rate of ribosomal elongation balances the synthesis of eukaryotic translation initiation factor (eIF)-2 alpha and eIF-2 beta. eIF
43  1993 Guanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3. ---
44  1992 Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. ---
45  1992 The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon. ---
46  1992 Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2. ---
47  1985 The 90-kDa component of reticulocyte heme-regulated eIF-2 alpha (initiation factor 2 alpha-subunit) kinase is derived from the beta subunit of spectrin. ---