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Abbreviation : eIF2alpha
Long Form : eukaryotic initiation factor 2alpha
No. Year Title Co-occurring Abbreviation
2022 A bioisosteric approach to the discovery of novel N-aryl-N'-[4-(aryloxy)cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. ---
2022 Activation of the eIF2α-ATF4 Pathway by Chronic Paracetamol Treatment Is Prevented by Dietary Supplementation with Cysteine. ATF4, CARE, Cys
2022 Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2α and eEF2. AD, eEF2, FMR1, FMRP, PP1, PP2A
2022 Boric Acid Inhibits RANKL-Stimulated Osteoclastogenesis In Vitro and Attenuates LPS-Induced Bone Loss In Vivo. BA, GRP78, LPS, micro-CT, NFATc1, p-eIF2alpha, p-PERK, PKR, TRAP
2022 Cannabidiol exerts anti-proliferative activity via a cannabinoid receptor 2-dependent mechanism in human colorectal cancer cells. ATF3, BiP, CB2, CBD, CBDV, CBG, CBGV, CBL, CDK2, ER, IRE1alpha
2022 Detection of PERK Signaling in the Central Nervous System. CNS, ER, PERK
2022 Dynamic Regulation of the Nexus Between Stress Granules, Roquin, and Regnase-1 Underlies the Molecular Pathogenesis of Warfare Vesicants. ISRIB, PAO, RBPs, SGs
2022 Etiopathophysiological role of the renin-angiotensin-aldosterone system in age-related muscular weakening: RAAS-independent beneficial role of ACE2 in muscle weakness. ACE2, ATF4, ER
2022 Eukaryotic Initiation Factor 2α Kinases Regulate Virulence Functions, Stage Conversion, and the Stress Response in Entamoeba invadens. RNAi
10  2022 Metformin alleviates intestinal epithelial barrier damage by inhibiting endoplasmic reticulum stress-induced cell apoptosis in colitis cell model. CHOP, GRP, PERK
11  2022 Monitoring Virus-Induced Stress Granule Dynamics Using Long-Term Live-Cell Imaging. HCV, SGs, TIA-1, YFP
12  2022 Physical exercise positively modulates nonalcoholic steatohepatitis-related hepatic endoplasmic reticulum stress. ER, ET, HFD, IRE1alpha, NASH, p-eIF2alpha, SCLD, sXBP1, VPA
13  2022 Protective autophagy alleviates neurotoxin-gelsenicine induced apoptosis through PERK signaling pathway in Neuro-2a cells. 3-MA, ATF4, RNA, siRNA
14  2022 Protective effect of zinc supplementation on tricalcium phosphate particles-induced inflammatory osteolysis in mice. ATF4, GRP78, IL, IRE1alpha, p-eIF2alpha, p-PERK, PERK, TCP, TNF, Zn, ZnTCP
15  2022 Salubrinal Protects Against Cisplatin-Induced Cochlear Hair Cell Endoplasmic Reticulum Stress by Regulating Eukaryotic Translation Initiation Factor 2α Signalling. ERS, HEI-OC1
16  2022 Salubrinal-mediated activation of eIF2α signaling improves oxidative stress-induced BMSCs senescence and senile osteoporosis. BMSCs, ER stress, PERK, UPR
17  2022 Specific amino acids regulate Sestrin2 mRNA and protein levels in an ATF4-dependent manner in C2C12 myocytes. AF-DMEM, ATF4, mTORC1
18  2022 Stress Granules and Acute Ischemic Stroke: Beyond mRNA Translation. ER, SGs
19  2022 The beneficial effect of salubrinal on neuroinflammation and neuronal loss in intranigral LPS-induced hemi-Parkinson disease model in rats. COX, DUSP2, ERS, IL, iNOS, LPS, NF-kappaB, PD, PP1, SN
20  2022 The HMGB1-RAGE axis induces apoptosis in acute respiratory distress syndrome through PERK/eIF2α/ATF4-mediated endoplasmic reticulum stress. ARDS, ATF4, ERS, HMGB1, PERK, RAGE, rHMGB1
21  2022 The PERKs of mitochondria protection during stress: insights for PERK modulation in neurodegenerative and metabolic diseases. ER, Nrf2, OGT, PERK, TFEB
22  2022 Therapeutic effect and mechanism of 4-phenyl butyric acid on renal ischemia-reperfusion injury in mice. 4-PBA, CypD, GRP78, ICAM, RIRI, VCAM
23  2021 A Novel Selective PKR Inhibitor Restores Cognitive Deficits and Neurodegeneration in Alzheimer Disease Experimental Models. AbetaOs, AD, PKR
24  2021 Activation of the EGFR-PI3K-CaM pathway by PRL-1-overexpressing placenta-derived mesenchymal stem cells ameliorates liver cirrhosis via ER stress-dependent calcium. ATF4, BDL, CaM, CHOP, EGFR, ER, MCU, PI3K, PRL-1, SD, SERCA2b, TG, VDAC1
25  2021 AMP-activated protein kinase contributes to ROS-mediated p53 activation in cisplatin-induced nephrotoxicity. AMPK, ROS
26  2021 Antioxidative effects of polypyrimidine tract-binding protein-associated splicing factor against pathological retinal angiogenesis through promotion of mitochondrial function. 4-HNE, ATF4, CHOP, ER, ERK, HO-1, HRMECs, IRNV, PDI, PKR, PSF, ROS
27  2021 Berberine Improves Behavioral and Cognitive Deficits in a Mouse Model of Alzheimer's Disease via Regulation of beta-Amyloid Production and Endoplasmic Reticulum Stress. AD, BACE1, ER, PERK, UPR
28  2021 Berberine Reduces Abeta42 Deposition and Tau Hyperphosphorylation via Ameliorating Endoplasmic Reticulum Stress. Abeta42, AD, BACE1, ER stress, GSK-3beta, PERK
29  2021 Betulinic acid attenuates T-2 toxin-induced cytotoxicity in porcine kidney cells by blocking oxidative stress and endoplasmic reticulum stress. ATF4, BA, CAT, CHOP, GSH-Px, LDH, MDA, PERK, ROS, SOD
30  2021 Cardioprotective effect of Rosa canina L. methanolic extract on heat shock induced cardiomyocyte injury: An experimental study. CHOP, ER, HS, NS, PERK, RC, ROS
31  2021 Cereulide Exposure Caused Cytopathogenic Damages of Liver and Kidney in Mice. ER stress, IRE1alpha, PERK, ROS
32  2021 Circadian Clock Control of Translation Initiation Factor eIF2alpha Activity Requires eIF2gamma-Dependent Recruitment of Rhythmic PPP-1 Phosphatase in Neurospora crassa. p-eIF2alpha
33  2021 Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer's disease. AD, ISR
34  2021 Cytotoxic chemotherapeutic agents and the EGFR-TKI osimertinib induce calreticulin exposure in non-small cell lung cancer. DAMPs, ecto-CRT, EGFR, ICD, ICIs, NSCLC, TKIs
35  2021 Dexmedetomidine Preconditioning Reduces Myocardial Ischemia-Reperfusion Injury in Rats by Inhibiting the PERK Pathway. ATF4, CHOP, DEX, GRP78, I/R, KH, PERK, YOH
36  2021 eIF2-dependent translation initiation: Memory consolidation and disruption in Alzheimer's disease. AD
37  2021 Elucidation of the mechanism of NEFA-induced PERK-eIF2alpha signaling pathway regulation of lipid metabolism in bovine hepatocytes. apoB, CHOP, CPT1A, ERS, FASN, GRP78, LDLR, NEB, NEFA, PERK, PPARalpha, SREBP-1c, TG, VLDL
38  2021 ER stress associated TXNIP-NLRP3 inflammasome activation in hippocampus of human Alzheimer's disease. AD, ASC, BiP, CHOP, ER, NFTs, NLRP3, Trx, TXNIP
39  2021 Growth arrest and DNA damage-inducible protein 34 (GADD34) contributes to cerebral ischemic injury and can be detected in plasma exosomes. GADD34
40  2021 Hiding in Plain Sight: Formation and Function of Stress Granules During Microbial Infection of Mammalian Cells. SG
41  2021 Induction of the Proinflammatory Chemokine Interleukin-8 Is Regulated by Integrated Stress Response and AP-1 Family Proteins Activated during Coronavirus Infection. AP-1, COVID-19, IBV, IL-8, ISR, PKR, SARS-CoV-2
42  2021 Lysosomotropic agents including azithromycin, chloroquine and hydroxychloroquine activate the integrated stress response. ---
43  2021 MARK2 phosphorylates eIF2alpha in response to proteotoxic stress. ALS, Hsp90, MARK2, PKCdelta
44  2021 Melatonin Inhibits Glucose-Induced Apoptosis in Osteoblastic Cell Line Through PERK-eIF2alpha-ATF4 Pathway. ATF4, BiP, CHOP, ER, PERK
45  2021 NEFA Promotes Autophagosome Formation through Modulating PERK Signaling Pathway in Bovine Hepatocytes. ATF4, ATG7, BECN1, CHOP, ER, GRP78, LC3, NEB, NEFA, PERK
46  2021 Notice of Retraction: Acharya P, Engel JC, Correia MA (2009) Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: A consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2alpha (eIF2alpha)-kinase (PERK) and general control nonderepressible-2 eIF2alpha kinase (GCN2), and global translational shutoff. Mol Pharmacol 76(3):503-515; DOI: https://doi.org/10.1124/mol.109.056002. ER, GCN2
47  2021 Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2alpha/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells. ATF4, CPE, IDD, Ihh, NP, p-eIF2alpha, ROS, TNF
48  2021 Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs. ATF4, Bax, Bcl-2, Caspase-3, CHOP, CVD, DFPP, ER, FCM, GRP78, IL, LDL, PBMCs, PCSK9, ROS, sdLDL, TNF-alpha
49  2021 Protective effects of sodium butyrate on rotavirus inducing endoplasmic reticulum stress-mediated apoptosis via PERK-eIF2alpha signaling pathway in IPEC-J2 cells. CHOP, ER, ERS, GRP78, PERK, RV, SB
50  2021 Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4. ---
51  2021 Recombinant human growth hormone improves the immune status of rats with septic encephalopathy: The role of VEGFR2 in the prevalence of endoplasmic reticulum stress repair module. ATF4, BBB, CHOP, ERS, GADD153, GH, IRE1alpha, JNK, mTOR, PERK, rhGH, VEGFR2
52  2021 Roles of ERK/Akt signals in mitochondria-dependent and endoplasmic reticulum stress-triggered neuronal cell apoptosis induced by 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, a major active metabolite of bisphenol A. AFT, AIF, BPA, CHOP, ER, GRP, IRE, MBP, MMP, NDs, PERK, XBP
53  2021 Sappanone A Protects Against Inflammation, Oxidative Stress and Apoptosis in Cerebral Ischemia-Reperfusion Injury by Alleviating Endoplasmic Reticulum Stress. C/EBP, GRP78, MCAO, OGD/R, SA, TTC, TUNEL
54  2021 Selective activation of cannabinoid receptor-2 reduces white matter injury via PERK signaling in a rat model of traumatic brain injury. ATF4, CB2, DTI, ER, ER stress, MBP, MEPs, p-Akt, PKR, TBI, TEM, WMI
55  2021 Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL‑6/STAT3 signaling pathway. ADAM17, ROS, SKN, STAT3
56  2021 Subchronic exposure to acrylamide caused behaviour disorders and related pathological and molecular changes in rat cerebellum. ACR, ERK, P-GSK3beta, PERK
57  2021 Subtle genomic DNA damage induces intraneuronal production of amyloid-beta (1-42) by increasing beta-secretase activity. AD
58  2021 Suppression of alveolar bone resorption by salubrinal in a mouse model of periodontal disease. ER, HE, muCT, TRAP
59  2021 The integrated stress response in ischemic diseases. ISR
60  2021 The PERK/PKR-eIF2α Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule Formation. ER, ERS, IFN, MERS-CoV, N2a, PERK, PHEV, PKR, SARS-CoV, SARS-CoV-2, SGs, UPR
61  2021 The Potential Role of Protein Kinase R as a Regulator of Age-Related Neurodegeneration. AD, CNS, ISR, PKR
62  2021 The Relationship Between HCV-NS5A Gene Mutations and Resistance to Combination Therapy in Patients with HCV- Genotype 1-B. HCV, ISDR, PKR
63  2021 Therapeutic Role of Sirtuins Targeting Unfolded Protein Response, Coagulation, and Inflammation in Hypoxia-Induced Thrombosis. CAT, ER, FOXO3, G6PD, HIFs, NF-kappabeta, NLRP3, Nrf2, PERK, PGAM2, PGC-1alpha, ROS, SOD, UPR, XBP1
64  2020 A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol. CHOP
65  2020 AKT1 Regulates Endoplasmic Reticulum Stress and Mediates the Adaptive Response of Pancreatic beta Cells. ER, HFD
66  2020 alpha-Linolenic Acid-Enriched Cold-Pressed Perilla Oil Suppress High-Fat Diet-Induced Hepatic Steatosis through Amelioration of the ER Stress-Mediated Autophagy. aP2, C/EBP, CHOP, ER, ERK, FAS, HFD, IRE1, JNK, LC3, LEP, MAP, mTOR, PI3K, PPAR
67  2020 Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2alpha. AD
68  2020 Asperuloside exhibits a novel anti-leukemic activity by triggering ER stress-regulated apoptosis via targeting GRP78. AML, ASP, ATF6, CHOP, ER, GRP78, IP, p-IRE1, PERK, XBP1
69  2020 Asymmetrical dimethylarginine induces dysfunction of insulin signal transduction via endoplasmic reticulum stress in the liver of diabetic rats. ADMA, CHOP, ERS, GRP78, IR, IRS-1, PERK, XBP1
70  2020 CCT020312 Inhibits Triple-Negative Breast Cancer Through PERK Pathway-Mediated G1 Phase Cell Cycle Arrest and Apoptosis. ATF4, Bax, Bcl-2, C/EBP, CDK4, mTOR, PERK, TNBC
71  2020 Chronic Carbon Tetrachloride Applications Induced Hepatocyte Apoptosis in Lipocalin 2 Null Mice Through Endoplasmic Reticulum Stress and Unfolded Protein Response. ALT, BiP, CHOP, ER, GRP94, TM, TUNEL, UPR
72  2020 Effect of cis- and trans-Monounsaturated Fatty Acids on Palmitate Toxicity and on Palmitate-induced Accumulation of Ceramides and Diglycerides. DG, JNK, SAPK, TFAs
73  2020 EIF2AK2 Missense Variants Associated with Early Onset Generalized Dystonia. EIF2AK2, PKR
74  2020 Emulsified isoflurane protects beta cells against high glucose-induced apoptosis via inhibiting endoplasmic reticulum stress. ATF6, Bcl-2, EIso, ELISA, ERS, qRT-PCR, T2DM, XBP1
75  2020 Fibroblast Growth Factor 22 Inhibits ER Stress-Induced Apoptosis and Improves Recovery of Spinal Cord Injury. ER, FGF22, GAP43, GRP78, SCI, XBP1
76  2020 GCN2-Like Kinase Modulates Stress Granule Formation During Nutritional Stress in Trypanosoma cruzi. ---
77  2020 Glucagon Like Peptide-1 Receptor Agonists Alter Pancreatic and Hepatic Histology and Regulation of Endoplasmic Reticulum Stress in High-fat Diet Mouse Model. ATF4, CHOP, ER, GLP-1, GRP, NAFLD, NAFPD, NASH, PERK
78  2020 GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress. ATF4, GCN2
79  2020 HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection. CA16, HDAC6, IFN, PKR, SGs, SQSTM1, UBA, UBD
80  2020 Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2alpha/ATF4 and IRE1alpha. CRC, EGCG, ER, IRE1alpha, PERK
81  2020 Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570. ALL, DUB, UPR
82  2020 Inhibition of eIF2α Dephosphorylation Protects Hepatocytes from Apoptosis by Alleviating ER Stress in Acute Liver Injury. ER, PERK
83  2020 Interleukin-27 Gene Delivery Targeting IL-6Ralpha-Expressing Cells as a Stress Response Therapy. BH, eIF2, IFN, IL-27, IPA, IRF, JAK/STAT, p-eIF2alpha
84  2020 Intracellular XBP1-IL-24 axis dismantles cytotoxic unfolded protein response in the liver. CHOP, ER, IL-24, XBP1
85  2020 Involvement of eIF2alpha in halofuginone-driven inhibition of TGF-beta1-induced EMT. alpha-SMA, EMT, FN, HF, TCM, TGF-beta1, VIM
86  2020 Involvement of endoplasmic reticulum stress in amyloid beta (1-42)-induced Alzheimer's like neuropathological process in rat brain. AChE, AD, ER, GADD153, GRP78, i.c.v, Iba1, MAP-2
87  2020 Involvement of endoplasmic reticulum stress response and IRE1-mediated ASK1/JNK/Mcl-1 pathways in silver nanoparticle-induced apoptosis of human retinal pigment epithelial cells. ATF6, CHOP, ER, IRE1, MMP, PERK, RPE
88  2020 Isobacachalcone induces autophagy and improves the outcome of immunogenic chemotherapy. ISO, mTORC1, TFEB, UPR
89  2020 Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. ---
90  2020 Mitochondrial translation inhibition triggers ATF4 activation, leading to integrated stress response but not to mitochondrial unfolded protein response. ATF4, CAP, ER, ISR, mtDNA, mtUPR
91  2020 Mitoxantrone triggers immunogenic prostate cancer cell death via p53-dependent PERK expression. CALR, ChIP, DAMPs, HMGB1, ICD, MTX, shRNAs
92  2020 Molecular mechanisms underlying the effects of the small molecule AMC-04 on apoptosis: Roles of the activating transcription factor 4-C/EBP homologous protein-death receptor 5 pathway. ATF4, DR5, p38 MAPK, ROS, UPR
93  2020 Past Exposure to Cigarette Smoke Aggravates Cognitive Impairment in a Rat Model of Vascular Dementia via Neuroinflammation. CCH, IL-1beta, MWM, NLRP3, NOR
94  2020 PERK-eIF2alpha-ATF4 signaling contributes to osteogenic differentiation of periodontal ligament stem cells. ALP, ER, hPDLSCs, PERK
95  2020 PERK-Mediated Unfolded Protein Response Signaling Restricts Replication of the Tick-Borne Flavivirus Langat Virus. CHOP, ER, LGTV, MBFV, PKR, POWV, TBFV, UPR
96  2020 Phosphorylation of eIF2alpha Promotes Schwann Cell Differentiation and Myelination in CMT1B Mice with Activated UPR. CMT1B, ER, PERK
97  2020 Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) in autophagy. ---
98  2020 Polychlorinated Biphenyl Quinone Promotes Atherosclerosis through Lipid Accumulation and Endoplasmic Reticulum Stress via CD36. ER, i.p, IL-1beta, IL-6, p-PERK, PCBs, TNF-alpha
99  2020 Role of the AMPK/ACC Signaling Pathway in TRPP2-Mediated Head and Neck Cancer Cell Proliferation. ACC, AICAR, AMPK, PERK, TRPP2
100  2020 S-allyl-L-cysteine protects hepatocytes from indomethacin-induced apoptosis by attenuating endoplasmic reticulum stress. CHOP, DILI, ER, NSAIDs, SAC