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[Related PubMed/MEDLINE]
Total Number of Papers: 643
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| Abbreviation |
: eIF2alpha |
| Long Form |
: eukaryotic initiation factor 2alpha |
|
| No. |
Year |
Title |
Co-occurring Abbreviation |
| 1 |
2022 |
A bioisosteric approach to the discovery of novel N-aryl-N'-[4-(aryloxy)cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. |
--- |
| 2 |
2022 |
Activation of the eIF2α-ATF4 Pathway by Chronic Paracetamol Treatment Is Prevented by Dietary Supplementation with Cysteine. |
ATF4, CARE, Cys |
| 3 |
2022 |
Amyloid beta induces Fmr1-dependent translational suppression and hyposynchrony of neural activity via phosphorylation of eIF2α and eEF2. |
AD, eEF2, FMR1, FMRP, PP1, PP2A |
| 4 |
2022 |
Boric Acid Inhibits RANKL-Stimulated Osteoclastogenesis In Vitro and Attenuates LPS-Induced Bone Loss In Vivo. |
BA, GRP78, LPS, micro-CT, NFATc1, p-eIF2alpha, p-PERK, PKR, TRAP |
| 5 |
2022 |
Cannabidiol exerts anti-proliferative activity via a cannabinoid receptor 2-dependent mechanism in human colorectal cancer cells. |
ATF3, BiP, CB2, CBD, CBDV, CBG, CBGV, CBL, CDK2, ER, IRE1alpha |
| 6 |
2022 |
Detection of PERK Signaling in the Central Nervous System. |
CNS, ER, PERK |
| 7 |
2022 |
Dynamic Regulation of the Nexus Between Stress Granules, Roquin, and Regnase-1 Underlies the Molecular Pathogenesis of Warfare Vesicants. |
ISRIB, PAO, RBPs, SGs |
| 8 |
2022 |
Etiopathophysiological role of the renin-angiotensin-aldosterone system in age-related muscular weakening: RAAS-independent beneficial role of ACE2 in muscle weakness. |
ACE2, ATF4, ER |
| 9 |
2022 |
Eukaryotic Initiation Factor 2α Kinases Regulate Virulence Functions, Stage Conversion, and the Stress Response in Entamoeba invadens. |
RNAi |
| 10 |
2022 |
Metformin alleviates intestinal epithelial barrier damage by inhibiting endoplasmic reticulum stress-induced cell apoptosis in colitis cell model. |
CHOP, GRP, PERK |
| 11 |
2022 |
Monitoring Virus-Induced Stress Granule Dynamics Using Long-Term Live-Cell Imaging. |
HCV, SGs, TIA-1, YFP |
| 12 |
2022 |
Physical exercise positively modulates nonalcoholic steatohepatitis-related hepatic endoplasmic reticulum stress. |
ER, ET, HFD, IRE1alpha, NASH, p-eIF2alpha, SCLD, sXBP1, VPA |
| 13 |
2022 |
Protective autophagy alleviates neurotoxin-gelsenicine induced apoptosis through PERK signaling pathway in Neuro-2a cells. |
3-MA, ATF4, RNA, siRNA |
| 14 |
2022 |
Protective effect of zinc supplementation on tricalcium phosphate particles-induced inflammatory osteolysis in mice. |
ATF4, GRP78, IL, IRE1alpha, p-eIF2alpha, p-PERK, PERK, TCP, TNF, Zn, ZnTCP |
| 15 |
2022 |
Salubrinal Protects Against Cisplatin-Induced Cochlear Hair Cell Endoplasmic Reticulum Stress by Regulating Eukaryotic Translation Initiation Factor 2α Signalling. |
ERS, HEI-OC1 |
| 16 |
2022 |
Salubrinal-mediated activation of eIF2α signaling improves oxidative stress-induced BMSCs senescence and senile osteoporosis. |
BMSCs, ER stress, PERK, UPR |
| 17 |
2022 |
Specific amino acids regulate Sestrin2 mRNA and protein levels in an ATF4-dependent manner in C2C12 myocytes. |
AF-DMEM, ATF4, mTORC1 |
| 18 |
2022 |
Stress Granules and Acute Ischemic Stroke: Beyond mRNA Translation. |
ER, SGs |
| 19 |
2022 |
The beneficial effect of salubrinal on neuroinflammation and neuronal loss in intranigral LPS-induced hemi-Parkinson disease model in rats. |
COX, DUSP2, ERS, IL, iNOS, LPS, NF-kappaB, PD, PP1, SN |
| 20 |
2022 |
The HMGB1-RAGE axis induces apoptosis in acute respiratory distress syndrome through PERK/eIF2α/ATF4-mediated endoplasmic reticulum stress. |
ARDS, ATF4, ERS, HMGB1, PERK, RAGE, rHMGB1 |
| 21 |
2022 |
The PERKs of mitochondria protection during stress: insights for PERK modulation in neurodegenerative and metabolic diseases. |
ER, Nrf2, OGT, PERK, TFEB |
| 22 |
2022 |
Therapeutic effect and mechanism of 4-phenyl butyric acid on renal ischemia-reperfusion injury in mice. |
4-PBA, CypD, GRP78, ICAM, RIRI, VCAM |
| 23 |
2021 |
A Novel Selective PKR Inhibitor Restores Cognitive Deficits and Neurodegeneration in Alzheimer Disease Experimental Models. |
AbetaOs, AD, PKR |
| 24 |
2021 |
Activation of the EGFR-PI3K-CaM pathway by PRL-1-overexpressing placenta-derived mesenchymal stem cells ameliorates liver cirrhosis via ER stress-dependent calcium. |
ATF4, BDL, CaM, CHOP, EGFR, ER, MCU, PI3K, PRL-1, SD, SERCA2b, TG, VDAC1 |
| 25 |
2021 |
AMP-activated protein kinase contributes to ROS-mediated p53 activation in cisplatin-induced nephrotoxicity. |
AMPK, ROS |
| 26 |
2021 |
Antioxidative effects of polypyrimidine tract-binding protein-associated splicing factor against pathological retinal angiogenesis through promotion of mitochondrial function. |
4-HNE, ATF4, CHOP, ER, ERK, HO-1, HRMECs, IRNV, PDI, PKR, PSF, ROS |
| 27 |
2021 |
Berberine Improves Behavioral and Cognitive Deficits in a Mouse Model of Alzheimer's Disease via Regulation of beta-Amyloid Production and Endoplasmic Reticulum Stress. |
AD, BACE1, ER, PERK, UPR |
| 28 |
2021 |
Berberine Reduces Abeta42 Deposition and Tau Hyperphosphorylation via Ameliorating Endoplasmic Reticulum Stress. |
Abeta42, AD, BACE1, ER stress, GSK-3beta, PERK |
| 29 |
2021 |
Betulinic acid attenuates T-2 toxin-induced cytotoxicity in porcine kidney cells by blocking oxidative stress and endoplasmic reticulum stress. |
ATF4, BA, CAT, CHOP, GSH-Px, LDH, MDA, PERK, ROS, SOD |
| 30 |
2021 |
Cardioprotective effect of Rosa canina L. methanolic extract on heat shock induced cardiomyocyte injury: An experimental study. |
CHOP, ER, HS, NS, PERK, RC, ROS |
| 31 |
2021 |
Cereulide Exposure Caused Cytopathogenic Damages of Liver and Kidney in Mice. |
ER stress, IRE1alpha, PERK, ROS |
| 32 |
2021 |
Circadian Clock Control of Translation Initiation Factor eIF2alpha Activity Requires eIF2gamma-Dependent Recruitment of Rhythmic PPP-1 Phosphatase in Neurospora crassa. |
p-eIF2alpha |
| 33 |
2021 |
Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer's disease. |
AD, ISR |
| 34 |
2021 |
Cytotoxic chemotherapeutic agents and the EGFR-TKI osimertinib induce calreticulin exposure in non-small cell lung cancer. |
DAMPs, ecto-CRT, EGFR, ICD, ICIs, NSCLC, TKIs |
| 35 |
2021 |
Dexmedetomidine Preconditioning Reduces Myocardial Ischemia-Reperfusion Injury in Rats by Inhibiting the PERK Pathway. |
ATF4, CHOP, DEX, GRP78, I/R, KH, PERK, YOH |
| 36 |
2021 |
eIF2-dependent translation initiation: Memory consolidation and disruption in Alzheimer's disease. |
AD |
| 37 |
2021 |
Elucidation of the mechanism of NEFA-induced PERK-eIF2alpha signaling pathway regulation of lipid metabolism in bovine hepatocytes. |
apoB, CHOP, CPT1A, ERS, FASN, GRP78, LDLR, NEB, NEFA, PERK, PPARalpha, SREBP-1c, TG, VLDL |
| 38 |
2021 |
ER stress associated TXNIP-NLRP3 inflammasome activation in hippocampus of human Alzheimer's disease. |
AD, ASC, BiP, CHOP, ER, NFTs, NLRP3, Trx, TXNIP |
| 39 |
2021 |
Growth arrest and DNA damage-inducible protein 34 (GADD34) contributes to cerebral ischemic injury and can be detected in plasma exosomes. |
GADD34 |
| 40 |
2021 |
Hiding in Plain Sight: Formation and Function of Stress Granules During Microbial Infection of Mammalian Cells. |
SG |
| 41 |
2021 |
Induction of the Proinflammatory Chemokine Interleukin-8 Is Regulated by Integrated Stress Response and AP-1 Family Proteins Activated during Coronavirus Infection. |
AP-1, COVID-19, IBV, IL-8, ISR, PKR, SARS-CoV-2 |
| 42 |
2021 |
Lysosomotropic agents including azithromycin, chloroquine and hydroxychloroquine activate the integrated stress response. |
--- |
| 43 |
2021 |
MARK2 phosphorylates eIF2alpha in response to proteotoxic stress. |
ALS, Hsp90, MARK2, PKCdelta |
| 44 |
2021 |
Melatonin Inhibits Glucose-Induced Apoptosis in Osteoblastic Cell Line Through PERK-eIF2alpha-ATF4 Pathway. |
ATF4, BiP, CHOP, ER, PERK |
| 45 |
2021 |
NEFA Promotes Autophagosome Formation through Modulating PERK Signaling Pathway in Bovine Hepatocytes. |
ATF4, ATG7, BECN1, CHOP, ER, GRP78, LC3, NEB, NEFA, PERK |
| 46 |
2021 |
Notice of Retraction: Acharya P, Engel JC, Correia MA (2009) Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: A consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2alpha (eIF2alpha)-kinase (PERK) and general control nonderepressible-2 eIF2alpha kinase (GCN2), and global translational shutoff. Mol Pharmacol 76(3):503-515; DOI: https://doi.org/10.1124/mol.109.056002. |
ER, GCN2 |
| 47 |
2021 |
Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2alpha/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells. |
ATF4, CPE, IDD, Ihh, NP, p-eIF2alpha, ROS, TNF |
| 48 |
2021 |
Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs. |
ATF4, Bax, Bcl-2, Caspase-3, CHOP, CVD, DFPP, ER, FCM, GRP78, IL, LDL, PBMCs, PCSK9, ROS, sdLDL, TNF-alpha |
| 49 |
2021 |
Protective effects of sodium butyrate on rotavirus inducing endoplasmic reticulum stress-mediated apoptosis via PERK-eIF2alpha signaling pathway in IPEC-J2 cells. |
CHOP, ER, ERS, GRP78, PERK, RV, SB |
| 50 |
2021 |
Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4. |
--- |
| 51 |
2021 |
Recombinant human growth hormone improves the immune status of rats with septic encephalopathy: The role of VEGFR2 in the prevalence of endoplasmic reticulum stress repair module. |
ATF4, BBB, CHOP, ERS, GADD153, GH, IRE1alpha, JNK, mTOR, PERK, rhGH, VEGFR2 |
| 52 |
2021 |
Roles of ERK/Akt signals in mitochondria-dependent and endoplasmic reticulum stress-triggered neuronal cell apoptosis induced by 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, a major active metabolite of bisphenol A. |
AFT, AIF, BPA, CHOP, ER, GRP, IRE, MBP, MMP, NDs, PERK, XBP |
| 53 |
2021 |
Sappanone A Protects Against Inflammation, Oxidative Stress and Apoptosis in Cerebral Ischemia-Reperfusion Injury by Alleviating Endoplasmic Reticulum Stress. |
C/EBP, GRP78, MCAO, OGD/R, SA, TTC, TUNEL |
| 54 |
2021 |
Selective activation of cannabinoid receptor-2 reduces white matter injury via PERK signaling in a rat model of traumatic brain injury. |
ATF4, CB2, DTI, ER, ER stress, MBP, MEPs, p-Akt, PKR, TBI, TEM, WMI |
| 55 |
2021 |
Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL‑6/STAT3 signaling pathway. |
ADAM17, ROS, SKN, STAT3 |
| 56 |
2021 |
Subchronic exposure to acrylamide caused behaviour disorders and related pathological and molecular changes in rat cerebellum. |
ACR, ERK, P-GSK3beta, PERK |
| 57 |
2021 |
Subtle genomic DNA damage induces intraneuronal production of amyloid-beta (1-42) by increasing beta-secretase activity. |
AD |
| 58 |
2021 |
Suppression of alveolar bone resorption by salubrinal in a mouse model of periodontal disease. |
ER, HE, muCT, TRAP |
| 59 |
2021 |
The integrated stress response in ischemic diseases. |
ISR |
| 60 |
2021 |
The PERK/PKR-eIF2α Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule Formation. |
ER, ERS, IFN, MERS-CoV, N2a, PERK, PHEV, PKR, SARS-CoV, SARS-CoV-2, SGs, UPR |
| 61 |
2021 |
The Potential Role of Protein Kinase R as a Regulator of Age-Related Neurodegeneration. |
AD, CNS, ISR, PKR |
| 62 |
2021 |
The Relationship Between HCV-NS5A Gene Mutations and Resistance to Combination Therapy in Patients with HCV- Genotype 1-B. |
HCV, ISDR, PKR |
| 63 |
2021 |
Therapeutic Role of Sirtuins Targeting Unfolded Protein Response, Coagulation, and Inflammation in Hypoxia-Induced Thrombosis. |
CAT, ER, FOXO3, G6PD, HIFs, NF-kappabeta, NLRP3, Nrf2, PERK, PGAM2, PGC-1alpha, ROS, SOD, UPR, XBP1 |
| 64 |
2020 |
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol. |
CHOP |
| 65 |
2020 |
AKT1 Regulates Endoplasmic Reticulum Stress and Mediates the Adaptive Response of Pancreatic beta Cells. |
ER, HFD |
| 66 |
2020 |
alpha-Linolenic Acid-Enriched Cold-Pressed Perilla Oil Suppress High-Fat Diet-Induced Hepatic Steatosis through Amelioration of the ER Stress-Mediated Autophagy. |
aP2, C/EBP, CHOP, ER, ERK, FAS, HFD, IRE1, JNK, LC3, LEP, MAP, mTOR, PI3K, PPAR |
| 67 |
2020 |
Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2alpha. |
AD |
| 68 |
2020 |
Asperuloside exhibits a novel anti-leukemic activity by triggering ER stress-regulated apoptosis via targeting GRP78. |
AML, ASP, ATF6, CHOP, ER, GRP78, IP, p-IRE1, PERK, XBP1 |
| 69 |
2020 |
Asymmetrical dimethylarginine induces dysfunction of insulin signal transduction via endoplasmic reticulum stress in the liver of diabetic rats. |
ADMA, CHOP, ERS, GRP78, IR, IRS-1, PERK, XBP1 |
| 70 |
2020 |
CCT020312 Inhibits Triple-Negative Breast Cancer Through PERK Pathway-Mediated G1 Phase Cell Cycle Arrest and Apoptosis. |
ATF4, Bax, Bcl-2, C/EBP, CDK4, mTOR, PERK, TNBC |
| 71 |
2020 |
Chronic Carbon Tetrachloride Applications Induced Hepatocyte Apoptosis in Lipocalin 2 Null Mice Through Endoplasmic Reticulum Stress and Unfolded Protein Response. |
ALT, BiP, CHOP, ER, GRP94, TM, TUNEL, UPR |
| 72 |
2020 |
Effect of cis- and trans-Monounsaturated Fatty Acids on Palmitate Toxicity and on Palmitate-induced Accumulation of Ceramides and Diglycerides. |
DG, JNK, SAPK, TFAs |
| 73 |
2020 |
EIF2AK2 Missense Variants Associated with Early Onset Generalized Dystonia. |
EIF2AK2, PKR |
| 74 |
2020 |
Emulsified isoflurane protects beta cells against high glucose-induced apoptosis via inhibiting endoplasmic reticulum stress. |
ATF6, Bcl-2, EIso, ELISA, ERS, qRT-PCR, T2DM, XBP1 |
| 75 |
2020 |
Fibroblast Growth Factor 22 Inhibits ER Stress-Induced Apoptosis and Improves Recovery of Spinal Cord Injury. |
ER, FGF22, GAP43, GRP78, SCI, XBP1 |
| 76 |
2020 |
GCN2-Like Kinase Modulates Stress Granule Formation During Nutritional Stress in Trypanosoma cruzi. |
--- |
| 77 |
2020 |
Glucagon Like Peptide-1 Receptor Agonists Alter Pancreatic and Hepatic Histology and Regulation of Endoplasmic Reticulum Stress in High-fat Diet Mouse Model. |
ATF4, CHOP, ER, GLP-1, GRP, NAFLD, NAFPD, NASH, PERK |
| 78 |
2020 |
GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress. |
ATF4, GCN2 |
| 79 |
2020 |
HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection. |
CA16, HDAC6, IFN, PKR, SGs, SQSTM1, UBA, UBD |
| 80 |
2020 |
Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2alpha/ATF4 and IRE1alpha. |
CRC, EGCG, ER, IRE1alpha, PERK |
| 81 |
2020 |
Induction of ER Stress in Acute Lymphoblastic Leukemia Cells by the Deubiquitinase Inhibitor VLX1570. |
ALL, DUB, UPR |
| 82 |
2020 |
Inhibition of eIF2α Dephosphorylation Protects Hepatocytes from Apoptosis by Alleviating ER Stress in Acute Liver Injury. |
ER, PERK |
| 83 |
2020 |
Interleukin-27 Gene Delivery Targeting IL-6Ralpha-Expressing Cells as a Stress Response Therapy. |
BH, eIF2, IFN, IL-27, IPA, IRF, JAK/STAT, p-eIF2alpha |
| 84 |
2020 |
Intracellular XBP1-IL-24 axis dismantles cytotoxic unfolded protein response in the liver. |
CHOP, ER, IL-24, XBP1 |
| 85 |
2020 |
Involvement of eIF2alpha in halofuginone-driven inhibition of TGF-beta1-induced EMT. |
alpha-SMA, EMT, FN, HF, TCM, TGF-beta1, VIM |
| 86 |
2020 |
Involvement of endoplasmic reticulum stress in amyloid beta (1-42)-induced Alzheimer's like neuropathological process in rat brain. |
AChE, AD, ER, GADD153, GRP78, i.c.v, Iba1, MAP-2 |
| 87 |
2020 |
Involvement of endoplasmic reticulum stress response and IRE1-mediated ASK1/JNK/Mcl-1 pathways in silver nanoparticle-induced apoptosis of human retinal pigment epithelial cells. |
ATF6, CHOP, ER, IRE1, MMP, PERK, RPE |
| 88 |
2020 |
Isobacachalcone induces autophagy and improves the outcome of immunogenic chemotherapy. |
ISO, mTORC1, TFEB, UPR |
| 89 |
2020 |
Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. |
--- |
| 90 |
2020 |
Mitochondrial translation inhibition triggers ATF4 activation, leading to integrated stress response but not to mitochondrial unfolded protein response. |
ATF4, CAP, ER, ISR, mtDNA, mtUPR |
| 91 |
2020 |
Mitoxantrone triggers immunogenic prostate cancer cell death via p53-dependent PERK expression. |
CALR, ChIP, DAMPs, HMGB1, ICD, MTX, shRNAs |
| 92 |
2020 |
Molecular mechanisms underlying the effects of the small molecule AMC-04 on apoptosis: Roles of the activating transcription factor 4-C/EBP homologous protein-death receptor 5 pathway. |
ATF4, DR5, p38 MAPK, ROS, UPR |
| 93 |
2020 |
Past Exposure to Cigarette Smoke Aggravates Cognitive Impairment in a Rat Model of Vascular Dementia via Neuroinflammation. |
CCH, IL-1beta, MWM, NLRP3, NOR |
| 94 |
2020 |
PERK-eIF2alpha-ATF4 signaling contributes to osteogenic differentiation of periodontal ligament stem cells. |
ALP, ER, hPDLSCs, PERK |
| 95 |
2020 |
PERK-Mediated Unfolded Protein Response Signaling Restricts Replication of the Tick-Borne Flavivirus Langat Virus. |
CHOP, ER, LGTV, MBFV, PKR, POWV, TBFV, UPR |
| 96 |
2020 |
Phosphorylation of eIF2alpha Promotes Schwann Cell Differentiation and Myelination in CMT1B Mice with Activated UPR. |
CMT1B, ER, PERK |
| 97 |
2020 |
Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) in autophagy. |
--- |
| 98 |
2020 |
Polychlorinated Biphenyl Quinone Promotes Atherosclerosis through Lipid Accumulation and Endoplasmic Reticulum Stress via CD36. |
ER, i.p, IL-1beta, IL-6, p-PERK, PCBs, TNF-alpha |
| 99 |
2020 |
Role of the AMPK/ACC Signaling Pathway in TRPP2-Mediated Head and Neck Cancer Cell Proliferation. |
ACC, AICAR, AMPK, PERK, TRPP2 |
| 100 |
2020 |
S-allyl-L-cysteine protects hepatocytes from indomethacin-induced apoptosis by attenuating endoplasmic reticulum stress. |
CHOP, DILI, ER, NSAIDs, SAC |
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