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Abbreviation : hERG
Long Form : human ether-a-go-go
No. Year Title Co-occurring Abbreviation
2022 The utility of hERG channel inhibition data in the derivation of occupational exposure limits. OEL
2021 Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243. LQTS2
2021 Safety pharmacology of self-assembled-micelle inhibitory RNA-targeting amphiregulin (SAMiRNA-AREG), a novel siRNA nanoparticle platform. CHO, SAMiRNA-AREG
2021 Toward Reducing hERG Affinities for DAT Inhibitors with a Combined Machine Learning and Molecular Modeling Approach. DAT, QSAR
2018 Design, Synthesis, and Biological Evaluation of Novel 7-[(3 aS,7 aS)-3 a-Aminohexahydropyrano[3,4- c]pyrrol-2(3 H)-yl]-8-methoxyquinolines with Potent Antibacterial Activity against Respiratory Pathogens. PRSP, QR- E. coli, QR- MRSA
2018 Functional characterization of a novel hERG variant in a family with recurrent sudden infant death syndrome: Retracting a genetic diagnosis. LQTS, SIDS, WES
2018 New Scaffold for Lead Compounds to Treat Methamphetamine Use Disorders. VMAT2
2017 A helical segment makes potassium channels go-go. ---
2017 Age-dependent electrical and morphological remodeling of the Drosophila heart caused by hERG/seizure mutations. sei
10  2017 Antiarrhythmic properties of ivabradine in an experimental model of Short-QT- Syndrome. APD90, ERP, VF
11  2015 [Effects of midazolam on hERG K+ channel]. ---
12  2014 Hyperphosphorylation of RyRs underlies triggered activity in transgenic rabbit model of LQT2 syndrome. EADs, LQT2, RyR
13  2013 PIKfyve sensitivity of hERG channels. ---
14  2010 Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice. APs, EADs, LQTS, TdP
15  2009 Dexrazoxane protects the heart from acute doxorubicin-induced QT prolongation: a key role for I(Ks). ---
16  2009 Integrated risk assessment and predictive value to humans of non-clinical repolarization assays. TdeP
17  2009 Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels. ---
18  2008 Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain. DRG, TTX-R, VGSC
19  2008 Papaverine, a vasodilator, blocks the pore of the HERG channel at submicromolar concentration. Y652A
20  2007 Electrophysiological profile of propiverine--relationship to cardiac risk. OAB, TDPScreen
21  2007 Improved functional expression of recombinant human ether-a-go-go (hERG) K+ channels by cultivation at reduced temperature. ---
22  2006 Application of cryopreserved cells to HERG screening using a non-radioactive Rb+ efflux assay. ---
23  2006 Evaluation of the rubidium efflux assay for preclinical identification of HERG blockade. ---
24  2006 JNJ-10280205 and JNJ-10287069: Novel PDE5 inhibitors as clinical candidates for erectile dysfunction. PDE5
25  2006 The relationship between cleft lip, maxillary hypoplasia, hypoxia and phenytoin. CL
26  2006 Upregulation of HERG channels by the serum and glucocorticoid inducible kinase isoform SGK3. PI3, PKB, SGK
27  2003 In silico approaches to predicting drug metabolism, toxicology and beyond. ---
28  2003 Risperidone prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current. ---
29  2001 Gastrointestinal prokinetic drugs have different affinity for the human cardiac human ether-a-gogo K(+) channel. ---