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Abbreviation : hTS
Long Form : human TS
No. Year Title Co-occurring Abbreviation
2019 Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R. dTMP, TS
2019 Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. ChTS, TS
2017 Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states. TS
2017 Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. RTKs, TS
2013 Computational study of the effects of protein tyrosine nitrations on the catalytic activity of human thymidylate synthase. TS
2013 Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections. Tg, TS-DHFR
2011 Human thymidylate synthase with loop 181-197 stabilized in an inactive conformation: ligand interactions, phosphorylation, and inhibition profiles. CK2, PDPA, TS
2011 Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding. TS
2007 Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors. PDPA, TS
10  2007 Transgenic expression of human thymidylate synthase accelerates the development of hyperplasia and tumors in the endocrine pancreas. TS
11  2005 Improving specificity vs bacterial thymidylate synthases through N-dansyl modulation of didansyltyrosine. DDT, LcTS
12  2005 Novel 2-amino-4-oxo-5-arylthio-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase. DHFR, TS
13  2004 Effects of ligand binding and conformational switching on intracellular stability of human thymidylate synthase. TS
14  2003 ortho-Halogen naphthaleins as specific inhibitors of Lactobacillus casei thymidylate synthase. Conformational properties and biological activity. LcTS, SI, TS
15  2001 Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase. DDT, dUMP, ecTS, LcTS, TS
16  2001 Retroviral expression of Escherichia coli thymidylate synthase cDNA confers high-level antifolate resistance to hematopoietic cells. ecTS
17  2001 Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors. TS
18  1999 Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition. CnTS, PcTS
19  1999 Substitution at residue 214 of human thymidylate synthase alters nucleotide binding and isomerization of ligand-protein complexes. Gln214, kiso, TS