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Abbreviation : hTS
Long Form : human thymidylate synthase
No. Year Title Co-occurring Abbreviation
2019 Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth. CPs, TS
2019 Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R. dTMP, TS
2019 Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors. ---
2018 Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach. IF, PDPA, RTX, TS
2018 Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth. ---
2018 pH-Promoted Release of a Novel Anti-Tumour Peptide by "Stealth" Liposomes: Effect of Nanocarriers on the Drug Activity in Cis-Platinum Resistant Cancer Cells. PpHL
2017 Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones? ---
2017 Crystal structure of the active form of native human thymidylate synthase in the absence of bound substrates. dTMP, dUMP, meTHF
2015 Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase. ---
10  2014 2-[N-Alkyl(R-phenyl)-aminomethyl]-3-phenyl-7-trifluoromethylquinoxalines as anticancer agents inhibitors of folate enzymes. hDHFR, NCI
11  2013 A novel approach to cloning and expression of human thymidylate synthase. TS
12  2013 An innovative strategy for dual inhibitor design and its application in dual inhibition of human thymidylate synthase and dihydrofolate reductase enzymes. hDHFR
13  2012 Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase. ---
14  2012 Transcriptional activation and cell cycle block are the keys for 5-fluorouracil induced up-regulation of human thymidylate synthase expression. ---
15  2011 Evolution of metamorphism in thymidylate synthases within the primate lineages. ---
16  2011 The active-inactive transition of human thymidylate synthase: targeted molecular dynamics simulations. AS, TMD
17  2010 A novel rearrangement of fluorescent human thymidylate synthase inhibitor analogues in ESI tandem mass spectrometry. ---
18  2010 Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding. ---
19  2010 Fragment-based discovery of novel thymidylate synthase leads by NMR screening and group epitope mapping. NMR, STD
20  2010 Mechanism of influence of phosphorylation on serine 124 on a decrease of catalytic activity of human thymidylate synthase. ED, MD
21  2010 Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. AAs, PDGFRbeta, TGI, VEGFR2
22  2009 Variants of human thymidylate synthase with loop 181-197 stabilized in the inactive conformation. ---
23  2008 The R163K mutant of human thymidylate synthase is stabilized in an active conformation: structural asymmetry and reactivity of cysteine 195. ---
24  2006 Antibacterial agent discovery using thymidylate synthase biolibrary screening. TS, ThyA
25  2000 Escherichia coli thymidylate synthase expression protects human cells from the cytotoxic effects of 5-fluorodeoxyuridine more effectively than human thymidylate synthase overexpression. eTS, FdUrd, LV
26  1999 Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4. cat, ecTS, FdUMP, FdUrd
27  1999 Phthalein derivatives as a new tool for selectivity in thymidylate synthase inhibition. CnTS, PcTS
28  1995 Functional structure of the promoter region of the human thymidylate synthase gene and nuclear factors that regulate the expression of the gene. CAT
29  1993 Characterization of regulatory sequences and nuclear factors that function in cooperation with the promoter of the human thymidylate synthase gene. ---