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Abbreviation : mEH
Long Form : microsomal epoxide hydrolase
No. Year Title Co-occurring Abbreviation
2021 Ibuprofen alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers. COX, NSAIDs, sEH
2021 Missense Genetic Polymorphisms of Microsomal (EPHX1) and Soluble Epoxide Hydrolase (EPHX2) and Their Relation to the Risk of Large Artery Atherosclerotic Ischemic Stroke in a Turkish Population. EETs, sEH, SNPs
2021 Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues. EH3, EHs, EpFAs, sEH
2021 Role of Epoxide Hydrolases and Cytochrome P450s on Metabolism of KZR-616, a First-in-Class Selective Inhibitor of the Immunoproteasome. sEH
2020 Development of potent inhibitors of the human microsomal epoxide hydrolase. ---
2019 Association of Activity Altering Genotypes - Tyr113His and His139Arg in Microsomal Epoxide Hydrolase Enzyme with Esophageal Squamous Cell Carcinoma. ESCC
2019 Hip To Be Square: Oxetanes as Design Elements To Alter Metabolic Pathways. ---
2019 Protein kinase Cdelta mediates methamphetamine-induced dopaminergic neurotoxicity in mice via activation of microsomal epoxide hydrolase. MA, PKCdelta, WT
2018 Aflatoxin B1 metabolism: Regulation by phase I and II metabolizing enzymes and chemoprotective agents. AFAR, AFB1, AFBO, GST
10  2017 Evidence for a complex formation between CYP2J5 and mEH in living cells by FRET analysis of membrane protein interaction in the endoplasmic reticulum (FAMPIR). CYP, FAMPIR
11  2017 Microsomal epoxide hydrolase gene polymorphisms and susceptibility to prostate cancer: A systematic review. PCs
12  2017 Oxetane Substrates of Human Microsomal Epoxide Hydrolase. sEH
13  2016 Genetic enhancement of microsomal epoxide hydrolase improves metabolic detoxification but impairs cerebral blood flow regulation. CBV, DHETs, EETs, fMRI
14  2016 Modulatory effects of catechin hydrate against genotoxicity, oxidative stress, inflammation and apoptosis induced by benzo(a)pyrene in mice. PAH
15  2016 Naphthalene cytotoxicity in microsomal epoxide hydrolase deficient mice. NA, WT
16  2015 Are polymorphisms in metabolism protective or a risk for reduced white blood cell counts in a Chinese population with low occupational benzene exposures? CYP2E1, GSTP1, PCR, RFLP, WBCs
17  2015 Association of Functional Variants of Phase I and II Genes with Chronic Obstructive Pulmonary Disease in a Serbian Population. COPD, GST
18  2015 Dietary Doses of Sulforaphane Affect Hepatic Drug Metabolizing Enzymes in Spontaneously Hypertensive Rats. DME, SF, SHR
19  2015 Meta-analysis of microsomal epoxide hydrolase gene polymorphism and the risk of breast carcinoma. CIs, ORs
20  2015 Modulation of human cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADPH:cytochrome P450 oxidoreductase and cytochrome b5. BaP, HPLC
21  2015 Transcription of the Human Microsomal Epoxide Hydrolase Gene (EPHX1) Is Regulated by PARP-1 and Histone H1.2. Association with Sodium-Dependent Bile Acid Transport. PARP-1
22  2014 Hepatic bile acid metabolism and expression of cytochrome P450 and related enzymes are altered in Bsep (-/-) mice. CA
23  2014 Hepatitis B spliced protein (HBSP) promotes the carcinogenic effects of benzo [alpha] pyrene by interacting with microsomal epoxide hydrolase and enhancing its hydrolysis activity. BPDE, HBsAg, HBSP, HBV, HCC, HPLC
24  2014 Impact of epoxide hydrolase 1 polymorphisms on lung cancer susceptibility in Asian populations. ---
25  2014 Intronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal epoxide hydrolase gene (EPHX1) through a far upstream alternative promoter. ARE, SFN, tBHQ
26  2014 Localization of cytochrome P450 and related enzymes in adult rat testis and downregulation by estradiol and bisphenol A. HSD3B
27  2014 Try113His and His139Arg polymorphisms in the microsomal epoxide hydrolase gene are not associated with risk of breast cancer. CIs, ORs
28  2013 Association between environmental tobacco smoke exposure and lung cancer susceptibility: modification by antioxidant enzyme genetic polymorphisms. ETS, OR
29  2013 Discovery of soluble epoxide hydrolase inhibitors from natural products. sEH
30  2013 mEH Tyr113His polymorphism and the risk of ovarian cancer development. CIs, ORs
31  2013 Meta-analysis of microsomal epoxide hydrolase gene polymorphism and risk of hepatocellular carcinoma. HCC, ORs
32  2013 Oxidation of carcinogenic benzo[a]pyrene by human and rat cytochrome P450 1A1 and its influencing by cytochrome b5 - a comparative study. BaP, HPLC
33  2013 Transcription of the human microsomal epoxide hydrolase gene (EPHX1) is regulated by an HNF-4alpha/CAR/RXR/PSF complex. PSF
34  2012 Development of monoclonal antibodies to human microsomal epoxide hydrolase and analysis of "preneoplastic antigen"-like molecules. ER
35  2012 EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians. EAC, EC
36  2012 Low microsomal epoxide hydrolase expression is associated with bladder carcinogenesis and recurrence. ---
37  2012 Xenobiotic metabolizing gene variants and renal cell cancer: a multicenter study. COMT, RCC, UGT
38  2011 Association of CYP2E1, GST and mEH genetic polymorphisms with urinary acrylamide metabolites in workers exposed to acrylamide. AA, AAMA, CYP2E1, GA, PCR
39  2011 Benzo(a)pyrene-induced pulmonary inflammation, edema, surfactant dysfunction, and injuries in rats: alleviation by farnesol. BALF, BW, GST, LDH, NO
40  2011 Chromosomal damage and polymorphisms of metabolic genes among 1, 3-butadiene-exposed workers in a matched study in China. BD, CBMN, CI, CYP2E1, FR, GST, MNi, NPBs, PCR
41  2011 Colorectal polyp type and the association with charred meat consumption, smoking, and microsomal epoxide hydrolase polymorphisms. HPs, OR
42  2011 Comparison of styrene oxide enantiomers for hepatotoxic and pneumotoxic effects in microsomal epoxide hydrolase-deficient mice. SO
43  2011 Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies. ---
44  2011 Effects of poloxamer 407-induced hyperlipidemia on the pharmacokinetics of carbamazepine and its 10,11-epoxide metabolite in rats: Impact of decreased expression of both CYP3A1/2 and microsomal epoxide hydrolase. AUC, CBZ, CBZ-D, CBZ-E
45  2011 Genetic polymorphisms of glutathione-S-transferase and microsomal epoxide hydrolase in egyptian acquired aplastic anemia patients. AA, GST
46  2011 Genetically lowered microsomal epoxide hydrolase activity and tobacco-related cancer in 47,000 individuals. ---
47  2011 Ovarian expressed microsomal epoxide hydrolase: role in detoxification of 4-vinylcyclohexene diepoxide and regulation by phosphatidylinositol-3 kinase signaling. DMBA, PI3K, PND, VCD, VCH
48  2011 Polymorphisms in the microsomal epoxide hydrolase gene: role in lung cancer susceptibility and prognosis. PCR-RFLP
49  2010 Functional expression and magnetic nanoparticle-based Immobilization of a protein-engineered marine fish epoxide hydrolase of Mugil cephalus for enantioselective hydrolysis of racemic styrene oxide. ---
50  2010 Metabolism and toxicity of styrene in microsomal epoxide hydrolase-deficient mice. ---
51  2010 Microsomal epoxide hydrolase expression in the endometrial uterine corpus is regulated by progesterone during the menstrual cycle. ERalpha, MPA, PR
52  2009 Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism. DHETs, EETs, sEH
53  2009 Genetic polymorphisms of smoking-related carcinogen detoxifying enzymes and head and neck cancer susceptibility. GSTs, SCCHN, UDP
54  2009 Influence of some detoxification enzyme polymorphisms on cytogenetic biomarkers between individuals exposed to very low doses of 1,3-butadiene. SCE
55  2009 Mammalian epoxide hydrolases in xenobiotic metabolism and signalling. sEH
56  2009 Role of microsomal epoxide hydrolase in methamphetamine-induced drug dependence in mice. CYP, DA, METH, WT
57  2008 Development of metabolically stable inhibitors of Mammalian microsomal epoxide hydrolase. ---
58  2008 Differential subcellular distribution and colocalization of the microsomal and soluble epoxide hydrolases in cultured neonatal rat brain cortical astrocytes. GFAP, sEH
59  2008 Effect of CYP2E1 gene deletion in mice on expression of microsomal epoxide hydrolase in response to VCD exposure. CYP2E1, DMBA, VCD, VCH, VCM
60  2008 Expression of ovarian microsomal epoxide hydrolase and glutathione S-transferase during onset of VCD-induced ovotoxicity in B6C3F(1) mice. GST, PND4, VCD
61  2008 Genetic effects and biotoxicity monitoring of occupational styrene exposure. CAs, IARC, MA, MN, PGA, SCEs, SCGE, SO
62  2008 Microsomal epoxide hydrolase deletion enhances tyrosine hydroxylase phosphorylation in mice after MPTP treatment. KO, PD, pSer31, TH, WT
63  2008 Microsomal epoxide hydrolase genotypes and the risk for head and neck cancer. ---
64  2008 Schisandra fructus extract ameliorates doxorubicin-induce cytotoxicity in cardiomyocytes: altered gene expression for detoxification enzymes. CPT-1, DOX, GSTs, HO-1, ROS, SFE
65  2008 The 3,4-oxide is responsible for the DNA binding of benzo[ghi]perylene, a polycyclic aromatic hydrocarbon without a "classic" bay-region. 3,4,11,12-bisoxide, BghiP, PAH
66  2007 Association between allelic polymorphisms of metabolizing enzymes (CYP 1A1, CYP 1A2, CYP 2E1, mEH) and occurrence of colorectal cancer in Hungary. HAs, OR, PAHs, PCR, RFLP
67  2007 Associations between smoking, polymorphisms in polycyclic aromatic hydrocarbon (PAH) metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by race. GST, PAH
68  2007 Autoantibody response to microsomal epoxide hydrolase in hepatitis C and A. ---
69  2007 Cytochrome P4501A1 and microsomal epoxide hydrolase gene polymorphisms: gene-environment interaction and risk of prostate cancer. PCa, PCR/RFLP
70  2007 Genetic polymorphism and gene expression of microsomal epoxide hydrolase in non-small cell lung cancer. NSCLC, PCR, RT-PCR
71  2007 involvement of microsomal epoxide hydrolase enzyme in ovotoxicity caused by 7,12-dimethylbenz[a]anthracene. DMBA, PND
72  2007 p53 and ATM/ATR regulate 7,12-dimethylbenz[a]anthracene-induced immunosuppression. ATM, ATR, DMBA, DMBA-DE
73  2007 PAH-DNA adducts in a Chinese population: relationship to PAH exposure, smoking and polymorphisms of metabolic and DNA repair genes. ERCC2
74  2006 Acute effects of novel selenazolidines on murine chemoprotective enzymes. BSCA, Gsts, MSCA, OSCA, PhSCA, SCA, Tr, UGTs
75  2006 Cloning, expression and enantioselective hydrolytic catalysis of a microsomal epoxide hydrolase from a marine fish, Mugil cephalus. RACE
76  2006 Determinants of the variability of aflatoxin-albumin adduct levels in Ghanaians. AA, GSTs, HCC, HCV, HVB, SNPs
77  2006 Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: Insights from animal models examining human sensitivity to 1,3-butadiene. BD, BER, NER
78  2006 Expression of microsomal epoxide hydrolase is elevated in Alzheimer's hippocampus and induced by exogenous beta-amyloid and trimethyl-tin. AD
79  2006 Genetic polymorphisms of microsomal epoxide hydroxylase and glutathione S-transferases M1, T1 and P1, interactions with smoking, and risk for esophageal (Barrett) adenocarcinoma. BE, CI, EADC, GERD, GST, OR
80  2006 Hepatic chemoprotective enzyme responses to 2-substituted selenazolidine-4(R)-carboxylic acids. GPx, GST, i.g, i.p, NQO, SCAs, TR, UGT
81  2006 Inhibition of benzo[a]pyrene-activating enzymes and DNA binding in human bronchial epithelial BEAS-2B cells by methoxylated flavonoids. 5,7-DMF, BaP, PAHs, RV
82  2006 Noninvasive identification of interindividual variation in xenobiotic-metabolizing enzymes: implications for cancer epidemiology and biomarker studies. GST, H139R, HWE, PCR, RFLP, SNP, XMEs
83  2006 The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression. GST, MAPK, mTOR, p70S6 kinase, PKB, RTK
84  2005 Common genetic variants of microsomal epoxide hydrolase affect warfarin dose requirements beyond the effect of cytochrome P450 2C9. GGCX, GSTA1
85  2005 Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study. CYP2C9, NHS, PAHs, PHS
86  2005 Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients. CBZ-Diol, CBZ-epoxide, SNPs
87  2005 Microsomal biotransformation of benzo[ghi]perylene, a mutagenic polycyclic aromatic hydrocarbon without a "classic" bay region. BaP, BghiP, PAH
88  2005 The association between microsomal epoxide hydrolase genotypes and esophageal squamous-cell-carcinoma in Taiwan: interaction between areca chewing and smoking. ESCC
89  2005 Use of genetically modified mouse models to assess pathways of benzene-induced bone marrow cytotoxicity and genotoxicity. HSC, NQO1
90  2004 Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH. BPDE, CYP1A1, GSTM1, GSTP1
91  2004 CCAAT/enhancer-binding protein alpha (C/EBPalpha) activates transcription of the human microsomal epoxide hydrolase gene (EPHX1) through the interaction with DNA-bound NF-Y. NF-Y
92  2004 Effect of Fe(2)O(3) on the capacity of benzo(a)pyrene to induce polycyclic aromatic hydrocarbon-metabolizing enzymes in the respiratory tract of Sprague-Dawley rats. CYP1A1, EROD, PAHs
93  2004 Epoxide hydrolase polymorphisms, cigarette smoking and risk of colorectal adenoma in the Nurses' Health Study and the Health Professionals Follow-up Study. CI, HPFS, NHS, RR
94  2004 Functional protein-protein interaction of drug metabolizing enzymes. UGT
95  2004 Induction of gene expression of xenobiotic metabolism enzymes and ABC-transport proteins by PAH and a reconstituted PAH mixture in human Caco-2 cells. ABC, PAH, SULT, UGT1A6
96  2004 Microsomal epoxide hydrolase, endotoxin, and lung function decline in cotton textile workers. SE
97  2004 Regulation of human microsomal epoxide hydrolase gene (EPHX1) expression by the transcription factor GATA-4. ---
98  2004 Relationship between polymorphisms of genes encoding microsomal epoxide hydrolase and glutathione S-transferase P1 and chronic obstructive pulmonary disease. BMI, COPD, GST, GSTP1, OR, PCR-RFLP
99  2004 Skin and salivary gland carcinogenicity of 7,12-dimethylbenz[a]anthracene is equivalent in the presence or absence of aryl hydrocarbon receptor. AhR, DMBA, PAH
100  2004 The telltale structures of epoxide hydrolases. EH, sEH