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Abbreviation : mPGES-1
Long Form : microsomal PGE synthase-1
No. Year Title Co-occurring Abbreviation
2022 Green, Black and Rooibos Tea Inhibit Prostaglandin E2 Formation in Human Monocytes by Inhibiting Expression of Enzymes in the Prostaglandin E2 Pathway. COX-2, cPLA2, EGCG, LPS, NSAIDs, PGE2
2022 Imbalanced prostanoid release mediates cigarette smoke-induced human pulmonary artery cell proliferation. COPD, COX-2, CSE, PASMCs, PG, TX
2022 Inducible Prostaglandin E Synthase as a Pharmacological Target for Ischemic Stroke. IL-1beta, LPS, MCAO, OGD, PGE2, TNF-alpha
2021 Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression. CIII, CX3CR1, PGE2
2021 The Role of Prostaglandin E2 Synthesized in Rat Lateral Parabrachial Nucleus in LPS-Induced Fever. BAT, COX-2, EE, LPBN, LPS, PG
2020 Urothelial cancer of the prostate gland. Immunohistochemical analysis of two cases of rare canine cancer. CK-7,-20, COX-2, HMWCK, PSA, UCPG
2019 Biological characterization of new inhibitors of microsomal PGE synthase-1 in preclinical models of inflammation and vascular tone. ---
2019 Cyclooxygenase-2 Induced the beta-Amyloid Protein Deposition and Neuronal Apoptosis Via Upregulating the Synthesis of Prostaglandin E2 and 15-Deoxy-Delta12,14-prostaglandin J2. COX-2, L-PGDS, PGs, PS, TNF-alpha
2019 Ellagitannins from Punica granatum leaves suppress microsomal prostaglandin E synthase-1 expression and induce lung cancer cells to undergo apoptosis. COX-2, NSAIDs, PGE2
10  2018 Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH model. NAFLD, NASH, PGE2
11  2018 Inflammation increases MMP levels via PGE2 in human vascular wall and plasma of obese women. CA, CRP, IMA, MMPs, PGE2, PVAT, SV
12  2018 Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice. BM, EP4, I/R, PGE2, WT
13  2017 Co-localization of microsomal prostaglandin E synthase-1 with cyclooxygenase-1 in layer II of murine placental syncytiotrophoblasts. COX, GD, PG
14  2017 Endogenous prostaglandin E2 amplifies IL-33 production by macrophages through an E prostanoid (EP)2/EP4-cAMP-EPAC-dependent pathway. EP, Epac, PGE2, TLRs
15  2017 Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI2 : a safer alternative to COX-2 inhibition. COX-2, IMA, PG, SV
16  2017 Physiological and pathophysiological implications of PGE2 and the PGE2 synthases in the kidney. PGE2
17  2017 Prostaglandin terminal synthases as novel therapeutic targets. COX, NSAIDs, PG, PGIS
18  2016 Expression of Angiotensin II Types 1 and 2 Receptors in Endometriotic Lesions. AT, PG
19  2016 Inhibition of GSK-3 reduces prostaglandin E2 production by decreasing the expression levels of COX-2 and mPGES-1 in monocyte/macrophage lineage cells. COX-2, Egr-1, GSK-3, LPS, NF-kappaB, PGE2
20  2016 Nitric Oxide and PGE-2 Cross-Talk in EGFR-Driven Epithelial Tumor Cells. COX-2, EGFR, NO, PGE2
21  2015 Close teamwork between Nrf2 and peroxiredoxins 1 and 6 for the regulation of prostaglandin D2 and E2 production in macrophages in acute inflammation. HPGDS, L-PGDS
22  2015 Impaired E Prostanoid2 Expression and Resistance to Prostaglandin E2 in Nasal Polyp Fibroblasts from Subjects with Aspirin-Exacerbated Respiratory Disease. AERD, EP, PGE2
23  2015 Inhibition of cyclooxygenase-2 in hematopoietic cells results in salt-sensitive hypertension. BMT, COX-2, PG
24  2015 mPGES-1 in prostate cancer controls stemness and amplifies epidermal growth factor receptor-driven oncogenicity. EGFR, PCa, PGE2
25  2015 Non-cell autonomous effects of targeting inducible PGE2 synthesis during inflammation-associated colon carcinogenesis. DSS
26  2015 Relationship of the Topological Distances and Activities between mPGES-1 and COX-2 versus COX-1: Implications of the Different Post-Translational Endoplasmic Reticulum Organizations of COX-1 and COX-2. aa, COX, ER
27  2014 A cyclooxygenase-2-dependent prostaglandin E2 biosynthetic system in the Golgi apparatus. COXs, ER, PG
28  2014 COX-2, mPGES-1 and EP2 receptor immunohistochemical expression in canine and feline malignant mammary tumours. COX-2, PG
29  2014 Expression of mPGES-1 and IP mRNA is reduced by LLLT in both subplantar and brain tissues in the model of peripheral inflammation induced by carrageenan. IP, LLLT, mRNA
30  2014 Peptidylarginine deiminase from Porphyromonas gingivalis contributes to infection of gingival fibroblasts and induction of prostaglandin E2 -signaling pathway. COX-2, P. gingivalis, PGE2, PHGF, PPAD, qRT-PCR
31  2014 The role of PGE2 in intestinal inflammation and tumorigenesis. AA, cPLA2, DSS, PGs
32  2013 Cancer-induced anorexia in tumor-bearing mice is dependent on cyclooxygenase-1. COX, PGs
33  2013 Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily. PGE2
34  2013 Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis. COX/PG
35  2013 Necrosis in DU145 prostate cancer spheroids induces COX-2/mPGES-1-derived PGE2 to promote tumor growth and to inhibit T cell activation. COX, MCTS, NSAIDs, PGE2
36  2013 Reduced T cell-dependent humoral immune response in microsomal prostaglandin E synthase-1 null mice is mediated by nonhematopoietic cells. TD, WT
37  2012 CD14 and NFAT mediate lipopolysaccharide-induced skin edema formation in mice. NFAT
38  2012 Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. ALS
39  2012 COX/PGE(2) axis critically regulates effects of LPS on eosinophilia-associated cytokine production in nasal polyps. DNPCs, LPS, SEB
40  2012 Effect of sphingosine kinase 1 inhibition on blood pressure. Ang II, BP, COX-2, Egr-1, SphK1
41  2012 Immunohistochemical expression of COX-2, mPGES and EP2 receptor in normal and reactive canine bone and in canine osteosarcoma. COX
42  2012 Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2. HNSCC, PG
43  2012 mPGES-1 and prostaglandin E2: vital role in inflammation, hypoxic response, and survival. IL-1beta, WT
44  2012 Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E₂ produced in the brain. BCSFB, CSF, OAT3, PG
45  2011 Analysis of two major intracellular phospholipases A(2) (PLA(2)) in mast cells reveals crucial contribution of cytosolic PLA(2)alpha, not Ca(2+)-independent PLA(2)beta, to lipid mobilization in proximal mast cells and distal fibroblasts. AA, BMMCs
46  2011 Competitive enzymatic interactions determine the relative amounts of prostaglandins E2 and D2. PGs
47  2011 EGFR signaling upregulates expression of microsomal prostaglandin E synthase-1 in cancer cells leading to enhanced tumorigenicity. EGFR
48  2011 Glucosamine sulfate reduces prostaglandin E(2) production in osteoarthritic chondrocytes through inhibition of microsomal PGE synthase-1. COX-1, GS, OA, PPARgamma
49  2011 Interleukin 1beta-induced synthesis and secretion of prostaglandin E₂ in the porcine uterus during various periods of pregnancy and the estrous cycle. COX-2, IL-1beta
50  2011 Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice. CGPR, COX, LLCCs, PG, WT
51  2011 Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1. IL-6, OA, PGs, TLR4
52  2011 Tumor cells induce COX-2 and mPGES-1 expression in microvascular endothelial cells mainly by means of IL-1 receptor activation. AAc, cPGES, HMVEC, PG
53  2011 Variants of gene for microsomal prostaglandin E2 synthase show association with disease and severe inflammation in rheumatoid arthritis. EIRA, Leiden EAC, PTGES, RA, SNPs
54  2010 Anti-inflammatory role of microsomal prostaglandin E synthase-1 in a model of neuroinflammation. COX-2, EP, IL-1beta, LPS, TNF-alpha
55  2010 Cardiovascular biology of microsomal prostaglandin E synthase-1. COX
56  2010 Genetic deletion of mPGES-1 abolishes PGE2 production in murine dendritic cells and alters the cytokine profile, but does not affect maturation or migration. DC, KO, PG
57  2010 Inhibition of matrix metalloproteinase-3 and -13 synthesis induced by IL-1beta in chondrocytes from mice lacking microsomal prostaglandin E synthase-1. MMP
58  2010 Microsomal prostaglandin E synthase-1 and 5-lipoxygenase: potential drug targets in cancer. PG
59  2010 NF-kappaB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts. COX-2, EA, ET, MAPK, Uro
60  2009 Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1. COX, NSAIDs, PG
61  2009 Ellagic acid inhibits lipopolysaccharide-induced expression of enzymes involved in the synthesis of prostaglandin E2 in human monocytes. COX-2, cPLA2alpha
62  2009 Heme oxygenase-1 induction modulates microsomal prostaglandin E synthase-1 expression and prostaglandin E(2) production in osteoarthritic chondrocytes. CoPP, HO-1, IL-1beta, OA
63  2009 Microsomal prostaglandin E synthase 1 determines tumor growth in vivo of prostate and lung cancer cells. ---
64  2009 Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells. COX, IL, PG
65  2009 Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis. AA, EAE, MS, PGs
66  2008 Conceptus signals for establishment and maintenance of pregnancy in pigs - lipid signaling system. LPA, PG, PGFS
67  2008 Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice. COX-2, PG
68  2008 Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis. 15-PGDH, IL-1beta, OA, PGE2, RT-PCR, siRNA
69  2008 Defective generation of a humoral immune response is associated with a reduced incidence and severity of collagen-induced arthritis in microsomal prostaglandin E synthase-1 null mice. ---
70  2008 Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis. ACF, COX-2
71  2008 Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease. COX-2, PGs
72  2008 Microsomal prostaglandin synthase-1-derived prostaglandin E2 protects against angiotensin II-induced hypertension via inhibition of oxidative stress. Ang II, PG
73  2008 Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody-driven K/BxN serum-transfer arthritis. COX, PGs
74  2008 The CO-releasing molecule CORM-2 is a novel regulator of the inflammatory process in osteoarthritic chondrocytes. COX-2, HIF-1alpha, IL-1ra, NF-kappaB, NOS2
75  2007 Hydrogen peroxide stimulates chloride secretion in primary inner medullary collecting duct cells via mPGES-1-derived PGE2. CFTR, DPC, ENaC, IMCD, PKA
76  2007 Induction of prostaglandin E2 production by leukemia inhibitory factor promotes migration of first trimester extravillous trophoblast cell line, HTR-8/SVneo. COX-2, EVT, LIF, PGE2
77  2006 Co-localization of COX-2, CYP4F8, and mPGES-1 in epidermis with prominent expression of CYP4F8 mRNA in psoriatic lesions. COX-2, CYP4F8
78  2006 Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. PGHS-2
79  2006 Establishment of a cell-based drug screening system for identifying selective down-regulators of mPGES-1. COX-1
80  2006 Legionella pneumophila-induced PKCalpha-, MAPK-, and NF-kappaB-dependent COX-2 expression in human lung epithelium. COX
81  2006 Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury. KO, WT
82  2006 Short-term gene expression changes in cartilage explants stimulated with interleukin beta plus glucosamine and chondroitin sulfate. Agg, COX-2, CS, FBS, GLN, IL-1, iNOS, MMP, NO, PGE2, RT-PCR, TIMP-3
83  2005 Cytosolic phospholipase A2alpha regulates induction of brain cyclooxygenase-2 in a mouse model of inflammation. COX-2
84  2005 Molecular cloning and spatiotemporal expression of prostaglandin F synthase and microsomal prostaglandin E synthase-1 in porcine endometrium. PGFS, PGs
85  2005 Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor. COX-2, mEPSCs, PGE2
86  2005 Signal transduction for proteinase-activated receptor-2-triggered prostaglandin E2 formation in human lung epithelial cells. EGF, ERK, MAPKs, MEK, PKC
87  2004 Species-specific expression of microsomal prostaglandin E synthase-1 and cyclooxygenases in male monkey reproductive organs. COX
88  2002 Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs. COX