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Abbreviation : mPGES-1
Long Form : microsomal prostaglandin E synthase-1
No. Year Title Co-occurring Abbreviation
2022 (9S,13R)-12-oxo-phytodienoic acid attenuates inflammation by inhibiting mPGES-1 and modulating macrophage polarization via NF-κB and Nrf2/HO-1 pathways. HO-1, iNOS, NO, NSAIDs, PGI2, TXA2
2022 A High Body Mass Index and the Vacuum Phenomenon Upregulate Pain-Related Molecules in Human Degenerated Intervertebral Discs. BMI, CGRP, IL, IVDs, LBP, NGF, ODI, TNF-alpha, VP
2022 Biosynthesis of prostaglandin 15dPGJ2 -glutathione and -cysteine conjugates in macrophages and mast cells via MGST3: Biosynthesis of 15dPGJ2-conjugates. 15dPGJ2-Cys, COX, LPS, MGST3
2022 Computer-Aided Drug Design of Anti-inflammatory Agents Targeting Microsomal Prostaglandin E2 Synthase-1 (mPGES-1). CADD, PGE2
2022 Discovery and Optimization of Piperazine Urea Derivatives as Soluble Epoxide Hydrolase (sEH) Inhibitors. sEH
2022 Disruption of Prostaglandin E2 Signaling in Cancer-Associated Fibroblasts Limits Mammary Carcinoma Growth but Promotes Metastasis. CAF, EP3, PGE2
2022 Epithelial Cell-specific Deletion of Microsomal Prostaglandin E Synthase-1 Does Not Influence Colon Tumor Development in Mice. Car1, cKO, PGE2
2022 Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES-1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor. MD
2022 Facilitation of colonic T cell immune responses is associated with an exacerbation of dextran sodium sulfate-induced colitis in mice lacking microsomal prostaglandin E synthase-1. DSS, IBD, PG, Th, WT
10  2022 In Silico, In Vitro, and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from Salvia miltiorrhiza as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway. 5-LO, COX-2, CRY, CRY, EP3, PAFR, TIIA
11  2022 Ligstroside aglycon, an extra virgin olive oil secoiridoid, prevents inflammation by regulation of MAPKs, JAK/STAT, NF-κB, Nrf2/HO-1, and NLRP3 inflammasome signaling pathways in LPS-stimulated murine peritoneal macrophages. COX-2, ELISA, EVOO, HO-1, iNOS, LA, LPS, MAPKs, NF-kappaB, NO, NOD, Nox1, SRB
12  2022 Novel 1,2,4-triazoles derived from Ibuprofen: synthesis and in vitro evaluation of their mPGES-1 inhibitory and antiproliferative activity. ---
13  2022 Novel potent benzimidazole-based microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from BRP-201 that also inhibit leukotriene C4 synthase. CysLT, LTC4S
14  2022 Pre-clinical Studies Identifying Molecular Pathways of Neuroinflammation in Parkinson's Disease: A Systematic Review. LPS, MPTP, NF-kB, PD
15  2022 Rutin hydrate and extract from Castanopsis tribuloides reduces pyrexia via inhibiting microsomal prostaglandin E synthase-1. CTB
16  2022 Sinomenine increases the methylation level at specific GCG site in mPGES-1 promoter to facilitate its specific inhibitory effect on mPGES-1. 5-azaC, COX, NSAIDs, PGE2, SIN
17  2022 Specialized Pro-Resolving Mediators Do Not Inhibit the Synthesis of Inflammatory Mediators Induced by Tumor Necrosis Factor-α in Synovial Fibroblasts. COX-2, IL, MAPK, MaR1, MMP, RA, Rv, SPMs, TNF
18  2022 Staphylococcus aureus controls eicosanoid and specialized pro-resolving mediator production via lipoteichoic acid. COX-2, LMs, LTA, MDMs
19  2022 The microsomal prostaglandin E synthase-1/PGE2 axis induces recovery from ischemia via recruitment of regulatory T cells. FoxP3, FR4, PAD, PGE2, SDF-1, TGF-beta, WT
20  2022 The Role of mPGES-1 in Promoting Granulation Tissue Angiogenesis Through Regulatory T-cell Accumulation. Abs, FOXP3, FR4, PGE2, TGF-beta, VEGF, WT
21  2021 A Metalloproteinase Induces an Inflammatory Response in Preadipocytes with the Activation of COX Signalling Pathways and Participation of Endogenous Phospholipases A2. COX, cPLA2alpha, MCP-1, MMPs, PGE2, PGI2, PGs, sPLA2-IIA, SVMP
22  2021 Activation of alpha7 nicotinic acetylcholine receptor protects bovine endometrial tissue against LPS-induced inflammatory injury via JAK2/STAT3 pathway and COX-2 derived prostaglandin E2. CAP, COX-2, ELISA, IL-1beta, JAK2, LPS, PGE2, STAT3, TNF-alpha
23  2021 Clinical data mining reveals analgesic effects of lapatinib in cancer patients. CDM, ORs
24  2021 Discovery and Development of a Novel mPGES-1/5-LOX Dual Inhibitor LFA-9 for Prevention and Treatment of Chronic Inflammatory Diseases. 5-LOX, COX, LFA-9
25  2021 Discovery of N-amido-phenylsulfonamide derivatives as novel microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors. ---
26  2021 Enhanced mPGES-1 Contributes to PD-Related Peritoneal Fibrosis via Activation of the NLRP3 Inflammasome. PD, PGE2, RPMCs, UFF
27  2021 Inhibition of microsomal prostaglandin E synthase-1 ameliorates acute lung injury in mice. ALI, BAL, COX, LPS
28  2021 Microsomal prostaglandin E synthase-1 is involved in the metabolic and cardiovascular alterations associated with obesity. PVAT
29  2021 miR-708 Negatively Regulates TNFalpha/IL-1beta Signaling by Suppressing NF-kappaB and Arachidonic Acid Pathways. AA, COX-2, IKKbeta, IL-1beta, miRNA, NF-kappaB, RNAi, TNF-alpha
30  2021 miR-708-5p enhances erlotinib/paclitaxel efficacy and overcomes chemoresistance in lung cancer cells. COX-2, ERL, miRNA, NSCLC, PAC, PGE2
31  2021 Pathophysiological role of prostaglandin E synthases in liver diseases. COX, PGE2, PGESs, PGH2
32  2021 Sex-dependent compensatory mechanisms preserve blood pressure homeostasis in prostacyclin receptor-deficient mice. ANP, BP, HSD, Ipr, PGE2
33  2021 Simple heteroaryl modifications in the 4,5-diarylisoxazol-3-carboxylic acid scaffold favorably modulates the activity as dual mPGES-1/5-LO inhibitors with in vivo efficacy. 5-LO
34  2021 Sonlicromanol's active metabolite KH176m normalizes prostate cancer stem cell mPGES-1 overexpression and inhibits cancer spheroid growth. CSCs
35  2021 Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways. 5-LO, COX-1
36  2021 Targeted delivery of mPGES-1 inhibitors to macrophages via the folate receptor-β for inflammatory pain. COX, FRbeta, NSAIDs, PGE2
37  2021 Targeting microsomal prostaglandin E synthase 1 to develop drugs treating the inflammatory diseases. NSAIDs, PGE2
38  2021 Upregulation of prostaglandin E2 by inducible microsomal prostaglandin E synthase-1 in colon cancer. 15-PGDH, COX, PGE2, TNF
39  2021 [Research advances of prostaglandin E2 synthases and receptors in cardiovascular diseases]. COX-2, NSAIDs, PGE2
40  2020 2,5-dimethylcelecoxib improves immune microenvironment of hepatocellular carcinoma by promoting ubiquitination of HBx-induced PD-L1. DMC, HBV, HBx, HCC, PD-1
41  2020 A Combinatorial Virtual Screening Approach Driving the Synthesis of 2,4-Thiazolidinedione-Based Molecules as New Dual mPGES-1/5-LO Inhibitors. 5-LO
42  2020 DREAM-in-CDM Approach and Identification of a New Generation of Anti-inflammatory Drugs Targeting mPGES-1. ---
43  2020 Encapsulation of the dual FLAP/mPEGS-1 inhibitor BRP-187 into acetalated dextran and PLGA nanoparticles improves its cellular bioactivity. PLGA
44  2020 Establishment of an in vitro 3D model for neuroblastoma enables preclinical investigation of combined tumor-stroma drug targeting. PGE2
45  2020 Microsomal Prostaglandin E2 Synthase-1 Deletion Attenuates Isoproterenol-Induced Myocardial Fibrosis in Mice. beta-ARs
46  2020 miR-708-5p targets oncogenic prostaglandin E2 production to suppress a pro-tumorigenic phenotype in lung cancer cells. AA, COX-2, miRNAs, PGE2, UTRs
47  2020 Optimized Encapsulation of the FLAP/PGES-1 Inhibitor BRP-187 in PVA-Stabilized PLGA Nanoparticles Using Microfluidics. NSAIDs, PLGA, PVA
48  2020 Present Status and Future Trends of Natural-Derived Compounds Targeting T Helper (Th) 17 and Microsomal Prostaglandin E Synthase-1 (mPGES-1) as Alternative Therapies for Autoimmune and Inflammatory-Based Diseases. COXs, Th
49  2020 Prostaglandin E receptors as targets for ischemic stroke: Novel evidence and molecular mechanisms of efficacy. COX-2, GPCRs, PGE2
50  2020 Proteomics-Based Characterization of miR-574-5p Decoy to CUGBP1 Suggests Specificity for mPGES-1 Regulation in Human Lung Cancer Cells. CUGBP1, miRs, PGE2
51  2020 Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP). LTs, PGs, SBDD
52  2020 Targeting mPGES-1 by a Combinatorial Approach: Identification of the Aminobenzothiazole Scaffold to Suppress PGE2 Levels. ---
53  2020 The Expression of CD74-Regulated Inflammatory Markers in Stage IV Melanoma: Risk of CNS Metastasis and Patient Survival. COX, iNOS, MIF, NT, OS, TMA
54  2020 The functional link between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor gamma (PPARgamma) in the onset of inflammation. PG, PPARgamma
55  2020 Triazol-phenyl Antipyretic Derivatives Inhibit mPGES-1 mRNA Levels in LPS-Induced RAW 264.7 Macrophage Cells. PGE2
56  2020 What about COVID-19 and arachidonic acid pathway? AA, PGs
57  2019 A novel mPGES-1 inhibitor alleviates inflammatory responses by downregulating PGE2 in experimental models. AIA, LPS, OPG, PBCH, PGE-M, PGE2, RANKL, RF, TXA2
58  2019 A randomized clinical efficacy study targeting mPGES1 or EP4 in dogs with spontaneous osteoarthritis. CBPI, LOAD, OA, PIS
59  2019 A review on mPGES-1 inhibitors: From preclinical studies to clinical applications. COX, NSAIDs, PGE2
60  2019 Discovery of 3-hydroxy-3-pyrrolin-2-one-based mPGES-1 inhibitors using a multi-step virtual screening protocol. ---
61  2019 Divergent roles of prostacyclin and PGE2 in human tendinopathy. COX-1, IL-1beta, IP, PGE2
62  2019 Downregulation of microsomal prostaglandin E synthase-1 (mPGES-1) expression in chondrocytes is regulated by MAP kinase phosphatase-1 (MKP-1). MKP-1, OA, qRT-PCR, WT
63  2019 Effects of aging and lifelong aerobic exercise on basal and exercise-induced inflammation. CD16b, IL-1ra, MCP-1, TGF-beta, YE
64  2019 EP2/4 Receptors Promote the Synthesis of PGE2 Increasing Tissue Damage in Bovine Endometrial Explants Induced by Escherichia coli. COX-2, DAMPs, PGE2
65  2019 In Silico Observation of the Conformational Opening of the Glutathione-Binding Site of Microsomal Prostaglandin E2 Synthase-1. ---
66  2019 Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1. 20-HETE, AA, COX-2, ISL, PGE2, TCM
67  2019 Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis. ADMA, COX, NSAIDs
68  2019 Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b+Gr1+MDSCs from bone marrow. BM, CXCR4, MDSCs, mPGES-1KO, SDF-1, WT
69  2019 miR-574-5p as RNA decoy for CUGBP1 stimulates human lung tumor growth by mPGES-1 induction. CUGBP1, miRs
70  2019 Morphine, but not methadone, inhibits microsomal prostaglandin E synthase-1 and prostaglandin-endoperoxide synthase 2 in lipopolysaccharide-stimulated horse synoviocytes. LPS, OA, PTGS2
71  2019 mPGES-1 as a new target to overcome acquired resistance to gefitinib in non-small cell lung cancer cell lines. EGFR-TKIs, NSCLC, PGE2
72  2019 MPGES-1 derived PGE2 inhibits cell migration by regulating ARP2/3 in the pathogenesis of Hirschsprung disease. HSCR, PGE2, PTGER2
73  2019 Myeloid Cell mPges-1 Deletion Attenuates Mortality Without Affecting Remodeling After Acute Myocardial Infarction in Mice. MI
74  2019 Nardosinanone N suppresses LPS-induced macrophage activation by modulating the Nrf2 pathway and mPGES-1. COX-2, HO-1, iNOS, LPS, NAN, NO, Nrf2, NSAIDs, PGE2
75  2019 Regulatory roles of PGE2 in LPS-induced tissue damage in bovine endometrial explants. DAMPs, HABP1, HMGB1, IL-6, iNOS, LPS, NO, PGE2, PTGS-2
76  2019 Viscosine as a Potent and Safe Antipyretic Agent Evaluated by Yeast-Induced Pyrexia Model and Molecular Docking Studies. COX-1, COX-2
77  2018 A Multi-step Virtual Screening Protocol for the Identification of Novel Non-acidic Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors. MD, MM-PBSA, VS
78  2018 AH6809 decreases production of inflammatory mediators by PGE2 - EP2 - cAMP signaling pathway in an experimentally induced pure cerebral concussion in rats. cAMP, COX-1, COX-2, EP2, IL-1beta, iNOS, PCC, PGE2, TNF-alpha
79  2018 Alleviating CYP and hERG liabilities by structure optimization of dihydrofuran-fused tricyclic benzo[d]imidazole series - Potent, selective and orally efficacious microsomal prostaglandin E synthase-1 (mPGES-1) inhibitors: Part-2. hPXR, SAR
80  2018 Aminothiazoles inhibit osteoclastogenesis and PGE2 production in LPS-stimulated co-cultures of periodontal ligament and RAW 264.7 cells, and RANKL-mediated osteoclastogenesis and bone resorption in PBMCs. LPS, OPG, PBMCs, PDL, PGE2, TRAP
81  2018 Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH model. NAFLD, NASH, PGE2
82  2018 Dietary supplementation of n-3 polyunsaturated fatty acid alters endometrial expression of genes involved in prostaglandin biosynthetic pathway in breeding sows (Sus scrofa). CBR-1, PGFS
83  2018 Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation. 5-LO, LM, LTs, PG
84  2018 Down-regulation of microsomal prostaglandin E2 synthase-1 in the infrapatellar fat pad of osteoarthritis patients with hypercholesterolemia. COX-2, HCE, IL, IPFP, NCEP ATP III, OA, ST, TNF
85  2018 Endothelial Microsomal Prostaglandin E Synthetase-1 Upregulates Vascularity and Endothelial Interleukin-1beta in Deteriorative Progression of Experimental Autoimmune Encephalomyelitis. EAE, EP, IL-1beta, VECs, WT
86  2018 Fatty acid-binding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation. COX-2, FABPs, IL-1beta, PGE2
87  2018 Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury. DILI, RM
88  2018 Impaired lipid metabolism markers to assess the risk of neuroinflammation in autism spectrum disorder. ASD, CARS, COX-2, PGE2, SRS, SSP
89  2018 Inflammatory and cytotoxic effects of bifenthrin in primary microglia and organotypic hippocampal slice cultures. BF, CAT, CNS, COX-2, GPx, IL-6, LDH, MTT, NF-kappaB, Nrf2, OHSCs, PGE2, PI, ROS, SOD, TNF-alpha
90  2018 Inflammatory and oxidative mechanisms potentiate bifenthrin-induced neurological alterations and anxiety-like behavior in adult rats. AChE, BF, ChAT, COX-2, MAChR, NF-kBp65, Nrf2, OS, ROS, TNF-alpha
91  2018 Inhibition of COX-2/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate crystal-induced inflammation. 5-LOX, AA, COX-2, LTB4, MDMs, MSU, PGE2
92  2018 Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth. CAFs, PGE2
93  2018 Invalidation of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Reduces Diet-Induced Low-Grade Inflammation and Adiposity. PGE2
94  2018 Macrophage-derived inflammatory cytokines regulate growth factors and pain-related molecules in mice with intervertebral disc injury. COX, IL, IVD, NGF, TNF, VEGF
95  2018 Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen. ACh, CAP, ChAT, NE, VNS
96  2018 Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease. KO, PD, PGE2, WT
97  2018 Microsomal Prostaglandin E Synthase-1 Plays a Critical Role in Long-term Motility Dysfunction after Bowel Obstruction. BO, SMC
98  2018 MM-PBSA and per-residue decomposition energy studies on 7-Phenyl-imidazoquinolin-4(5H)-one derivatives: Identification of crucial site points at microsomal prostaglandin E synthase-1 (mPGES-1) active site. MD
99  2018 mPGES-1 and ALOX5/-15 in tumor-associated macrophages. COX-2, PGE2
100  2018 PGE2 increases inflammatory damage in Escherichia coli-infected bovine endometrial tissue in vitro via the EP4-PKA signaling pathway. 15-PGDH, AA, COX-2, DAMPs, PGE2, PKA, PLA2